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Q17094

- OPSD_ALLSU

UniProt

Q17094 - OPSD_ALLSU

Protein

Rhodopsin

Gene

RHO

Organism
Alloteuthis subulata (Squid) (Loligo subulata)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

    Absorptioni

    Abs(max)=499 nm

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Chromophore

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rhodopsin
    Gene namesi
    Name:RHO
    OrganismiAlloteuthis subulata (Squid) (Loligo subulata)
    Taxonomic identifieri54069 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeAlloteuthis

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›439›439RhodopsinPRO_0000197733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi1 – 11N-linked (GlcNAc...)Curated
    Disulfide bondi101 ↔ 179PROSITE-ProRule annotation
    Modified residuei298 – 2981N6-(retinylidene)lysineBy similarity
    Lipidationi329 – 3291S-palmitoyl cysteineBy similarity
    Lipidationi330 – 3301S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ17094.
    SMRiQ17094. Positions 1-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 26›26ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 25434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 2879ExtracellularSequence Analysis
    Topological domaini312 – ›439›128CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5125Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei64 – 9027Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12420Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16824Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 22028Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27824Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 31124Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi363 – 37311Met-richAdd
    BLAST
    Compositional biasi374 – 43663Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    IPR006031. XYPPX.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF02162. XYPPX. 3 hits.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q17094-1 [UniParc]FASTAAdd to Basket

    « Hide

    NETWWYNPYM DIHSHWKQFD QVPAAVYYSL GIFIAICGII GCAGNGIVIY    50
    LFTKTKSLQT PANMFIINLA FSDFTFSLVN GFPMMTISCF LKHWVFGQAA 100
    CKVYGLIGGI FGLTSIMTMT MISIDRYNVI RRPMSASKKM SHRKAFIMIV 150
    FVWIWSTIWA IGPIFGWGAY QLEGVLCNCS FDYITRDAST RSNIVCMYIF 200
    AFMFPIVVIF FCYFNIVMSV SNHEKEMAAM AKRLNAKELR KAQAGASAEM 250
    KLAKISIVIV TQSLLSWSPY AIVALLAQFG PIEWVTPYAA QLPVMFAKAS 300
    AIHNPMIYSV SHPKFREAIA SNFPWILTCC QYDEKEIEDD KDAEAEIPAA 350
    EQSGGESVDA AQMKEMMAMM QKMQAQQQQQ PAYPPQGYPP QGYPPPPPQG 400
    YPPQGYPPQG YPPQGYPPPP QGPPPQGPPP QAAPPQGVD 439
    Length:439
    Mass (Da):49,017
    Last modified:November 1, 1996 - v1
    Checksum:iB8167DFD8A00390E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei439 – 4391

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49108 Genomic DNA. Translation: CAA88923.1.
    PIRiS60755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49108 Genomic DNA. Translation: CAA88923.1 .
    PIRi S60755.

    3D structure databases

    ProteinModelPortali Q17094.
    SMRi Q17094. Positions 1-351.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    IPR006031. XYPPX.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF02162. XYPPX. 3 hits.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular basis of a spectral shift in the rhodopsins of two species of squid from different photic environments."
      Morris A., Bowmaker J.K., Hunt D.M.
      Proc. R. Soc. B 254:233-240(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Epidermis.

    Entry informationi

    Entry nameiOPSD_ALLSU
    AccessioniPrimary (citable) accession number: Q17094
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3