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Q17094

- OPSD_ALLSU

UniProt

Q17094 - OPSD_ALLSU

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Protein
Rhodopsin
Gene
RHO
Organism
Alloteuthis subulata (Squid) (Loligo subulata)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

Absorptioni

Abs(max)=499 nm

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. photoreceptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Rhodopsin
Gene namesi
Name:RHO
OrganismiAlloteuthis subulata (Squid) (Loligo subulata)
Taxonomic identifieri54069 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeAlloteuthis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 26›26Extracellular Reviewed prediction
Add
BLAST
Transmembranei27 – 5125Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini52 – 6312Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei64 – 9027Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini91 – 10414Extracellular Reviewed prediction
Add
BLAST
Transmembranei105 – 12420Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini125 – 14420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei145 – 16824Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini169 – 19224Extracellular Reviewed prediction
Add
BLAST
Transmembranei193 – 22028Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini221 – 25434Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei255 – 27824Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini279 – 2879Extracellular Reviewed prediction
Transmembranei288 – 31124Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini312 – ›439›128Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›439›439Rhodopsin
PRO_0000197733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1 – 11N-linked (GlcNAc...) Inferred
Disulfide bondi101 ↔ 179 By similarity
Modified residuei298 – 2981N6-(retinylidene)lysine By similarity
Lipidationi329 – 3291S-palmitoyl cysteine By similarity
Lipidationi330 – 3301S-palmitoyl cysteine By similarity

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ17094.
SMRiQ17094. Positions 1-351.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi363 – 37311Met-rich
Add
BLAST
Compositional biasi374 – 43663Gln/Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
IPR006031. XYPPX.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF02162. XYPPX. 3 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q17094-1 [UniParc]FASTAAdd to Basket

« Hide

NETWWYNPYM DIHSHWKQFD QVPAAVYYSL GIFIAICGII GCAGNGIVIY    50
LFTKTKSLQT PANMFIINLA FSDFTFSLVN GFPMMTISCF LKHWVFGQAA 100
CKVYGLIGGI FGLTSIMTMT MISIDRYNVI RRPMSASKKM SHRKAFIMIV 150
FVWIWSTIWA IGPIFGWGAY QLEGVLCNCS FDYITRDAST RSNIVCMYIF 200
AFMFPIVVIF FCYFNIVMSV SNHEKEMAAM AKRLNAKELR KAQAGASAEM 250
KLAKISIVIV TQSLLSWSPY AIVALLAQFG PIEWVTPYAA QLPVMFAKAS 300
AIHNPMIYSV SHPKFREAIA SNFPWILTCC QYDEKEIEDD KDAEAEIPAA 350
EQSGGESVDA AQMKEMMAMM QKMQAQQQQQ PAYPPQGYPP QGYPPPPPQG 400
YPPQGYPPQG YPPQGYPPPP QGPPPQGPPP QAAPPQGVD 439
Length:439
Mass (Da):49,017
Last modified:November 1, 1996 - v1
Checksum:iB8167DFD8A00390E
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei439 – 4391

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49108 Genomic DNA. Translation: CAA88923.1.
PIRiS60755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49108 Genomic DNA. Translation: CAA88923.1 .
PIRi S60755.

3D structure databases

ProteinModelPortali Q17094.
SMRi Q17094. Positions 1-351.
ModBasei Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
IPR006031. XYPPX.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF02162. XYPPX. 3 hits.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The molecular basis of a spectral shift in the rhodopsins of two species of squid from different photic environments."
    Morris A., Bowmaker J.K., Hunt D.M.
    Proc. R. Soc. B 254:233-240(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Epidermis.

Entry informationi

Entry nameiOPSD_ALLSU
AccessioniPrimary (citable) accession number: Q17094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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