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Protein

Major royal jelly protein 3

Gene

MRJP3

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in honeybee nutrition. It is found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen.

Names & Taxonomyi

Protein namesi
Recommended name:
Major royal jelly protein 3
Short name:
MRJP-3
Alternative name(s):
Bee-milk protein
Royal jelly protein RJP57-1
Gene namesi
Name:MRJP3
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 544524Major royal jelly protein 3PRO_0000031045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ17060.
PRIDEiQ17060.

Expressioni

Tissue specificityi

Hypopharyngeal glands of nurse honey bees.

Developmental stagei

Produced by the cephalic glandular system of the nurse honey bee.

Structurei

3D structure databases

ProteinModelPortaliQ17060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati424 – 42851
Repeati429 – 43352
Repeati434 – 43853
Repeati439 – 44354
Repeati444 – 44855
Repeati449 – 45356
Repeati454 – 45857
Repeati459 – 46358
Repeati464 – 46859
Repeati469 – 473510
Repeati474 – 478511
Repeati479 – 483512
Repeati484 – 488513
Repeati489 – 493514
Repeati494 – 498515
Repeati499 – 503516
Repeati504 – 508517
Repeati509 – 513518
Repeati514 – 518519
Repeati519 – 523520

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni424 – 52310020 X 5 AA tandem repeats of [NKR]-Q-N-[AGD]-[DNG]Add
BLAST

Sequence similaritiesi

Belongs to the major royal jelly protein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KG2T. Eukaryota.
ENOG4110SQU. LUCA.
InParanoidiQ17060.
PhylomeDBiQ17060.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017996. Royal_jelly/Protein_yellow.
[Graphical view]
PANTHERiPTHR10009. PTHR10009. 1 hit.
PfamiPF03022. MRJP. 1 hit.
[Graphical view]
PRINTSiPR01366. ROYALJELLY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKWLLLVVC LGIACQDVTS AAVNHQRKSA NNLAHSMKVI YEWKHIDFDF
60 70 80 90 100
GSDERRDAAI KSGEFDHTKN YPFDVDRWRD KTFVTIERNN GVPSSLNVVT
110 120 130 140 150
NKKGKGGPLL RPYPDWSFAK YEDCSGIVSA FKIAVDKFDR LWVLDSGLVN
160 170 180 190 200
NNQPMCSPKL LTFDLKTSKL VKQVEIPHNI AVNATTGMGE LVSLAVQAID
210 220 230 240 250
RTNTMVYIAD EKGEGLIMYQ NSDDSFHRLT SNTFDYDPRY TKLTVAGESF
260 270 280 290 300
TVKNGIYGIA LSPVTNNLYY SPLLSHGLYY VDTEQFSNPQ YEENNVQYEG
310 320 330 340 350
SQDILNTQSF GKVVSKNGVL FLGLVGNSGI ACVNEHQVLQ RESFDVVAQN
360 370 380 390 400
EETLQMIVSM KIMENLPQSG RINDPEGNEY MLALSNRMQK IINNDFNFND
410 420 430 440 450
VNFRILGANV DDLMRNTRCG RYHNQNAGNQ NADNQNADNQ NANNQNADNQ
460 470 480 490 500
NANKQNGNRQ NDNRQNDNKQ NGNRQNDNKQ NGNRQNDNKQ NGNRQNGNKQ
510 520 530 540
NDNKQNGNRQ NDNKRNGNRQ NDNQNNQNDN NRNDNQVHHS SKLH
Length:544
Mass (Da):61,662
Last modified:November 1, 1996 - v1
Checksum:i4C8FFFC8A2759F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26318 mRNA. Translation: CAA81227.1.
PIRiS39193.
RefSeqiNP_001011601.1. NM_001011601.1.
UniGeneiAme.731.

Genome annotation databases

GeneIDi406121.
KEGGiame:406121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26318 mRNA. Translation: CAA81227.1.
PIRiS39193.
RefSeqiNP_001011601.1. NM_001011601.1.
UniGeneiAme.731.

3D structure databases

ProteinModelPortaliQ17060.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ17060.
PRIDEiQ17060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406121.
KEGGiame:406121.

Organism-specific databases

CTDi406121.

Phylogenomic databases

eggNOGiENOG410KG2T. Eukaryota.
ENOG4110SQU. LUCA.
InParanoidiQ17060.
PhylomeDBiQ17060.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017996. Royal_jelly/Protein_yellow.
[Graphical view]
PANTHERiPTHR10009. PTHR10009. 1 hit.
PfamiPF03022. MRJP. 1 hit.
[Graphical view]
PRINTSiPR01366. ROYALJELLY.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of two cDNAs from the head of the nurse honey bee (Apis mellifera L.) for coding related proteins of royal jelly."
    Klaudiny J., Hanes J., Kulifajova J., Albert S., Simuth J.
    J. Apic. Res. 33:105-111(1994)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head.
  2. "Newly discovered features of the updated sequence of royal jelly protein RJP571; longer repetitive region on C-terminus and homology to Drosophila melanogaster yellow protein."
    Albert S., Klaudiny J., Simuth J.
    J. Apic. Res. 35:63-68(1996)
    [AGRICOLA] [Europe PMC]
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-36.
    Tissue: Head.
  4. "Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L."
    Ohashi K., Natori S., Kubo T.
    Eur. J. Biochem. 249:797-802(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 45-59; 70-77; 106-120; 214-224 AND 243-253.
    Tissue: Hypopharyngeal gland.

Entry informationi

Entry nameiMRJP3_APIME
AccessioniPrimary (citable) accession number: Q17060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.