ID   Q16ZR3_AEDAE            Unreviewed;       281 AA.
AC   Q16ZR3;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=trypsin {ECO:0000256|ARBA:ARBA00038868};
DE            EC=3.4.21.4 {ECO:0000256|ARBA:ARBA00038868};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:ACV07664.1};
RN   [1] {ECO:0000313|EMBL:ACV07664.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Rockefeller {ECO:0000313|EMBL:ACV07664.1};
RX   PubMed=20100490; DOI=10.1016/j.jinsphys.2010.01.003;
RA   Brackney D.E., Isoe J., W C B.IV., Zamora J., Foy B.D., Miesfeld R.L.,
RA   Olson K.E.;
RT   "Expression profiling and comparative analyses of seven midgut serine
RT   proteases from the yellow fever mosquito, Aedes aegypti.";
RL   J. Insect Physiol. 56:736-744(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00036320};
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC       {ECO:0000256|ARBA:ARBA00024195}.
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DR   EMBL; GQ398047; ACV07664.1; -; mRNA.
DR   RefSeq; XP_001653092.1; XM_001653042.1.
DR   AlphaFoldDB; Q16ZR3; -.
DR   SMR; Q16ZR3; -.
DR   STRING; 7159.Q16ZR3; -.
DR   MEROPS; S01.A35; -.
DR   PaxDb; 7159-AAEL008085-PA; -.
DR   VEuPathDB; VectorBase:AAEL013628; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   HOGENOM; CLU_006842_7_0_1; -.
DR   OMA; EIILHEA; -.
DR   PhylomeDB; Q16ZR3; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000313|EMBL:ACV07664.1};
KW   Protease {ECO:0000313|EMBL:ACV07664.1}.
FT   DOMAIN          29..270
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   281 AA;  29761 MW;  216DF2693624E83C CRC64;
     MWFSVKISKL LLLVAVSSVA ASVDNDVKII GGFPAQQSST RHQVSIRQKS VDLALFGSGH
     FCGGSLINDR TVLTAALCLV NEEGKRRVAS YFRVVGGGLN RLLQTQNTVI ANVSKVIIHE
     NYDPNTVAND IGLLILDKPV ESSHQTLRTI ELATSRPVAG SICQTTGWGT TVYGLPMVTV
     ELMAVNVTIQ PIESCNGTGS YNGIILDGML CAGEITGGKD SCQGDSGGPL VCGGFLAGIV
     SYGKGCGLAS YPGIYSDVVH FREWIDKHKH TSGGENVKFT V
//