Q16UH5 (Q16UH5_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551

Gene names

ORF Names:

AAEL009898, AaeL_AAEL009898 EMBL EAT38162.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551
Catalytic activity	Cleavage of peptide bonds with very broad specificity. RuleBase RU000551
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU000551.
Sequence similarities	Belongs to the peptidase T1A family. RuleBase RU000551

Ontologies

Keywords
Cellular component	Cytoplasm RuleBase RU000551 Nucleus SAAS SAAS000426 RuleBase RU000551 Proteasome RuleBase RU000551 EMBL EAT38162.1
Molecular function	Hydrolase Protease Threonine protease RuleBase RU000551
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q16UH5 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 44EFF35D4F6919ED	FASTA	246	27,680
	10 20 30 40 50 60 MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQEGLTSI ALKGKDVAVV ATQKKIPDKL 70 80 90 100 110 120 IDPTTVTHLY RLTKNIGCVM TGRIADSKSQ VQRARYEAAN WRYKYGYDMP VDVLCRRMAD 130 140 150 160 170 180 ISQVYTQNAE MRPLGCSMVL IAYDDENGPC VYKTDPAGYY CGYRAISVGV KQTEANSYLE 190 200 210 220 230 240 KKLKKKTDFN EKEAIQMAIT CLSTVLAVDF KPSEIELGVV SKDNPEFRTL TEDEIEVHLN AIAERE

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477622 Genomic DNA. Translation: EAT38162.1.
RefSeq	XP_001654091.1. XM_001654041.1.
UniGene	Aae.8123.
3D structure databases
ProteinModelPortal	Q16UH5.
SMR	Q16UH5. Positions 2-245.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16UH5.
Protein family/group databases
MEROPS	T01.971.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL009898-RA; AAEL009898-PA; AAEL009898.
GeneID	5572582.
KEGG	aag:AaeL_AAEL009898.
VectorBase	AAEL009898. Aedes aegypti.
Phylogenomic databases
eggNOG	inNOG06332.
GeneTree	EMGT00050000009409.
OMA	GKDCAVV.
OrthoDB	EOG4ZW3SZ.
PhylomeDB	Q16UH5.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q16UH5_AEDAE

Accession

Primary (citable) accession number: Q16UH5

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)