UniProtKB - Q16QZ8 (Q16QZ8_AEDAE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Histone deacetylase
Gene
5574401
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Functioni
Catalytic activityi
Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 94 | SubstrateUniRule annotation | 1 | |
Active sitei | 136 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 144 | Substrate; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 171 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 173 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 260 | Divalent metal cationUniRule annotation | 1 | |
Binding sitei | 299 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation |
Biological process | Transcription, Transcription regulationUniRule annotationSAAS annotation |
Ligand | Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation) |
Gene namesi | Name:5574401Imported ORF Names:AAEL011117Imported |
Organismi | Aedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported |
Taxonomic identifieri | 7159 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 314 | Hist_deacetylInterPro annotationAdd BLAST | 292 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1342 Eukaryota COG0123 LUCA |
HOGENOMi | HOG000225180 |
InParanoidi | Q16QZ8 |
KOi | K11404 |
OMAi | PRAWTHL |
OrthoDBi | EOG091G067J |
PhylomeDBi | Q16QZ8 |
Family and domain databases
Gene3Di | 3.40.800.201 hit |
InterProi | View protein in InterPro IPR000286 His_deacetylse IPR003084 His_deacetylse_1 IPR023801 His_deacetylse_dom IPR037138 His_deacetylse_dom_sf IPR023696 Ureohydrolase_dom_sf |
PANTHERi | PTHR10625 PTHR10625, 1 hit |
Pfami | View protein in Pfam PF00850 Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913 His_deacetylse_1, 1 hit |
PRINTSi | PR01270 HDASUPER PR01271 HISDACETLASE |
SUPFAMi | SSF52768 SSF52768, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16QZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKKVSYFF NPDVGNFHYG PGHPMKPHRL SVIHHLVMNY GLHKKMQIYR
60 70 80 90 100
PYKASAHDMC RFHSDEYIEF LQRVTPQNIQ GYTKCLSVFN VGDDCPVFDG
110 120 130 140 150
LFEFCAMYTG ASLEGAQKLN HNHSDICINW SGGLHHAKKF EASGFCYVND
160 170 180 190 200
IVIGILELLK YHPRVLYIDI DVHHGDGVQE AFYLTDRVMT VSFHKYGNYF
210 220 230 240 250
FPGTGDMYEI GAESGRYYSV NVPLKEGIDD QSYVQVFKPV ISAVMEFYQP
260 270 280 290 300
TAIVLQCGAD SLAGDRLGCF SLSTKGHGEC VKFVKDLNVP TLVVGGGGYT
310 320 330 340 350
LRNVARCWTY ETSLLIDETI SNELPMNDYL EFFAPDFTLH PDIPSRQDNA
360 370 380 390 400
NSKQYLEAIT RHVYDNLKMC QHAPSVQMFD IPEDALPEDV KVKDEPNPEA
410 420 430
RMTQDEEDKQ VEPKNEFFDG ENDNDKSENE P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH477727 Genomic DNA Translation: EAT36822.1 |
RefSeqi | XP_001655108.1, XM_001655058.1 |
Genome annotation databases
EnsemblMetazoai | AAEL011117-RA; AAEL011117-PA; AAEL011117 |
GeneIDi | 5574401 |
KEGGi | aag:5574401 |
VectorBasei | AAEL011117-RA; AAEL011117-PA; AAEL011117 |
Similar proteinsi
Entry informationi
Entry namei | Q16QZ8_AEDAE | |
Accessioni | Q16QZ8Primary (citable) accession number: Q16QZ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 25, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | April 25, 2018 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |