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Protein

Histone deacetylase

Gene

5574401

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Active sitei136Proton acceptorUniRule annotation1
Binding sitei144Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi171Divalent metal cationUniRule annotation1
Metal bindingi173Divalent metal cationUniRule annotation1
Metal bindingi260Divalent metal cationUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:5574401Imported
ORF Names:AAEL011117Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL011117-PA.

Structurei

3D structure databases

ProteinModelPortaliQ16QZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 314Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiQ16QZ8.
KOiK11404.
OMAiPRAWTHL.
OrthoDBiEOG091G067J.
PhylomeDBiQ16QZ8.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_domain.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16QZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKKVSYFF NPDVGNFHYG PGHPMKPHRL SVIHHLVMNY GLHKKMQIYR
60 70 80 90 100
PYKASAHDMC RFHSDEYIEF LQRVTPQNIQ GYTKCLSVFN VGDDCPVFDG
110 120 130 140 150
LFEFCAMYTG ASLEGAQKLN HNHSDICINW SGGLHHAKKF EASGFCYVND
160 170 180 190 200
IVIGILELLK YHPRVLYIDI DVHHGDGVQE AFYLTDRVMT VSFHKYGNYF
210 220 230 240 250
FPGTGDMYEI GAESGRYYSV NVPLKEGIDD QSYVQVFKPV ISAVMEFYQP
260 270 280 290 300
TAIVLQCGAD SLAGDRLGCF SLSTKGHGEC VKFVKDLNVP TLVVGGGGYT
310 320 330 340 350
LRNVARCWTY ETSLLIDETI SNELPMNDYL EFFAPDFTLH PDIPSRQDNA
360 370 380 390 400
NSKQYLEAIT RHVYDNLKMC QHAPSVQMFD IPEDALPEDV KVKDEPNPEA
410 420 430
RMTQDEEDKQ VEPKNEFFDG ENDNDKSENE P
Length:431
Mass (Da):49,008
Last modified:July 25, 2006 - v1
Checksum:i19C709A4B1EB4EA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477727 Genomic DNA. Translation: EAT36822.1.
RefSeqiXP_001655108.1. XM_001655058.1.
UniGeneiAae.2843.

Genome annotation databases

EnsemblMetazoaiAAEL011117-RA; AAEL011117-PA; AAEL011117.
GeneIDi5574401.
KEGGiaag:AaeL_AAEL011117.
VectorBaseiAAEL011117-RA; AAEL011117-PA; AAEL011117.

Similar proteinsi

Entry informationi

Entry nameiQ16QZ8_AEDAE
AccessioniPrimary (citable) accession number: Q16QZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported