Q16QZ8 (Q16QZ8_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone deacetylase PIRNR PIRNR037913
EC=3.5.1.98 PIRNR PIRNR037913

Gene names

ORF Names:

AAEL011117 EMBL EAT36822.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome] EMBL EAT36822.1

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicomorpha › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913
Subcellular location	Nucleus By similarity PIRNR PIRNR037913.
Sequence similarities	Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR037913
Cellular component	Nucleus PIRNR PIRNR037913
Molecular function	Chromatin regulator PIRNR PIRNR037913 Hydrolase PIRNR PIRNR037913 SAAS SAAS023801
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: UniProtKB-EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: UniProtKB-EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: UniProtKB-EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: UniProtKB-EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q16QZ8 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 19C709A4B1EB4EA7	FASTA	431	49,008
	10 20 30 40 50 60 MSSKKVSYFF NPDVGNFHYG PGHPMKPHRL SVIHHLVMNY GLHKKMQIYR PYKASAHDMC 70 80 90 100 110 120 RFHSDEYIEF LQRVTPQNIQ GYTKCLSVFN VGDDCPVFDG LFEFCAMYTG ASLEGAQKLN 130 140 150 160 170 180 HNHSDICINW SGGLHHAKKF EASGFCYVND IVIGILELLK YHPRVLYIDI DVHHGDGVQE 190 200 210 220 230 240 AFYLTDRVMT VSFHKYGNYF FPGTGDMYEI GAESGRYYSV NVPLKEGIDD QSYVQVFKPV 250 260 270 280 290 300 ISAVMEFYQP TAIVLQCGAD SLAGDRLGCF SLSTKGHGEC VKFVKDLNVP TLVVGGGGYT 310 320 330 340 350 360 LRNVARCWTY ETSLLIDETI SNELPMNDYL EFFAPDFTLH PDIPSRQDNA NSKQYLEAIT 370 380 390 400 410 420 RHVYDNLKMC QHAPSVQMFD IPEDALPEDV KVKDEPNPEA RMTQDEEDKQ VEPKNEFFDG 430 ENDNDKSENE P

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477727 Genomic DNA. Translation: EAT36822.1.
RefSeq	XP_001655108.1. XM_001655058.1.
UniGene	Aae.2843.
3D structure databases
ProteinModelPortal	Q16QZ8.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	7159.AAEL011117-PA.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL011117-RA; AAEL011117-PA; AAEL011117.
GeneID	5574401.
KEGG	aag:AaeL_AAEL011117.
VectorBase	AAEL011117. Aedes aegypti.
Phylogenomic databases
eggNOG	COG0123.
HOGENOM	HOG000225180.
KO	K11404.
OMA	HRLSVIH.
OrthoDB	EOG7DNNTW.
PhylomeDB	Q16QZ8.
Family and domain databases
Gene3D	3.40.800.20. 1 hit.
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

Q16QZ8_AEDAE

Accession

Primary (citable) accession number: Q16QZ8

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)