5574401

Functionⁱ

Catalytic activityⁱ

Hydrolysis of an N₆-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	94	SubstrateUniRule annotation	1
Active siteⁱ	136	Proton acceptorUniRule annotation	1
Binding siteⁱ	144	Substrate; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	171	Divalent metal cationUniRule annotation	1
Metal bindingⁱ	173	Divalent metal cationUniRule annotation	1
Metal bindingⁱ	260	Divalent metal cationUniRule annotation	1
Binding siteⁱ	299	SubstrateUniRule annotation	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation
Ligand	Metal-bindingUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesⁱ	Name:5574401Imported ORF Names:AAEL011117Imported
Organismⁱ	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifierⁱ	7159 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia
Proteomesⁱ	UP000008820 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	7159.AAEL011117-PA

STRINGⁱ

7159.AAEL011117-PA

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16QZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 314	Hist_deacetylInterPro annotationAdd BLAST		292

Sequence similaritiesⁱ

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1342 Eukaryota COG0123 LUCA
HOGENOMⁱ	HOG000225180
InParanoidⁱ	Q16QZ8
KEGG Orthology (KO) More...KOⁱ	K11404
OMAⁱ	PRAWTHL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067J
PhylomeDBⁱ	Q16QZ8

Family and domain databases

Gene3Dⁱ	3.40.800.201 hit
InterProⁱ	View protein in InterPro IPR000286 His_deacetylse IPR003084 His_deacetylse_1 IPR023801 His_deacetylse_dom IPR037138 His_deacetylse_dom_sf IPR023696 Ureohydrolase_dom_sf
PANTHERⁱ	PTHR10625 PTHR10625, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00850 Hist_deacetyl, 1 hit
PIRSFⁱ	PIRSF037913 His_deacetylse_1, 1 hit
PRINTSⁱ	PR01270 HDASUPER PR01271 HISDACETLASE
SUPFAMⁱ	SSF52768 SSF52768, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16QZ8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSKKVSYFF NPDVGNFHYG PGHPMKPHRL SVIHHLVMNY GLHKKMQIYR 
        60         70         80         90        100
PYKASAHDMC RFHSDEYIEF LQRVTPQNIQ GYTKCLSVFN VGDDCPVFDG 
       110        120        130        140        150
LFEFCAMYTG ASLEGAQKLN HNHSDICINW SGGLHHAKKF EASGFCYVND 
       160        170        180        190        200
IVIGILELLK YHPRVLYIDI DVHHGDGVQE AFYLTDRVMT VSFHKYGNYF 
       210        220        230        240        250
FPGTGDMYEI GAESGRYYSV NVPLKEGIDD QSYVQVFKPV ISAVMEFYQP 
       260        270        280        290        300
TAIVLQCGAD SLAGDRLGCF SLSTKGHGEC VKFVKDLNVP TLVVGGGGYT 
       310        320        330        340        350
LRNVARCWTY ETSLLIDETI SNELPMNDYL EFFAPDFTLH PDIPSRQDNA 
       360        370        380        390        400
NSKQYLEAIT RHVYDNLKMC QHAPSVQMFD IPEDALPEDV KVKDEPNPEA 
       410        420        430 
RMTQDEEDKQ VEPKNEFFDG ENDNDKSENE P

Length:431

Mass (Da):49,008

Last modified:July 25, 2006 - v1

Checksum:ⁱ19C709A4B1EB4EA7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH477727 Genomic DNA Translation: EAT36822.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001655108.1, XM_001655058.1

Genome annotation databases

EnsemblMetazoaⁱ	AAEL011117-RA; AAEL011117-PA; AAEL011117
GeneIDⁱ	5574401
KEGGⁱ	aag:5574401
VectorBaseⁱ	AAEL011117-RA; AAEL011117-PA; AAEL011117

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q16QZ8	B0X1P4 A0A182HK42 Q7PX00 A0A182L8D0 A0A182TF68 A0A182VGB9 A0A182PR77 A0A182JRG3 A0A182YNC5 A0A182IW81 +17	Culex quinquefasciatus (Southern house mosquito) (Culex pungens) Anopheles arabiensis (Mosquito) Anopheles gambiae (African malaria mosquito) Anopheles coluzzii Anopheles melas Anopheles merus (Mosquito) Anopheles epiroticus Anopheles christyi Anopheles stephensi (Indo-Pakistan malaria mosquito) Anopheles atroparvus And more	431	UniRef90_B0X1P4	Cluster: Histone deacetylase	28

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q16QZ8	A0A0F4X8F4 A0A1E5R491 A0A1E5RG65 A0A1B7SZ62 A0A1L0D234 UPI0007348F2A M1BJP2 K4BK95 A0A024FZJ9 A0A024FZT6 +124	Hanseniaspora uvarum DSM 2768 Hanseniaspora uvarum (Yeast) (Kloeckera apiculata) Hanseniaspora opuntiae Hanseniaspora valbyensis NRRL Y-1626 Hanseniaspora guilliermondii Solanum pennellii (Tomato) (Lycopersicon pennellii) Solanum tuberosum (Potato) Solanum lycopersicum (Tomato) (Lycopersicon esculentum) Albugo candida Albugo laibachii Nc14 And more	432	UniRef50_A0A0F4X8F4	Cluster: Histone deacetylase	135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH477727 Genomic DNA Translation: EAT36822.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001655108.1, XM_001655058.1

3D structure databases

ProteinModelPortalⁱ	Q16QZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	7159.AAEL011117-PA

STRINGⁱ

7159.AAEL011117-PA

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	AAEL011117-RA; AAEL011117-PA; AAEL011117
GeneIDⁱ	5574401
KEGGⁱ	aag:5574401
VectorBaseⁱ	AAEL011117-RA; AAEL011117-PA; AAEL011117

Phylogenomic databases

eggNOGⁱ	KOG1342 Eukaryota COG0123 LUCA
HOGENOMⁱ	HOG000225180
InParanoidⁱ	Q16QZ8
KEGG Orthology (KO) More...KOⁱ	K11404
OMAⁱ	PRAWTHL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067J
PhylomeDBⁱ	Q16QZ8

Family and domain databases

Gene3Dⁱ	3.40.800.201 hit
InterProⁱ	View protein in InterPro IPR000286 His_deacetylse IPR003084 His_deacetylse_1 IPR023801 His_deacetylse_dom IPR037138 His_deacetylse_dom_sf IPR023696 Ureohydrolase_dom_sf
PANTHERⁱ	PTHR10625 PTHR10625, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00850 Hist_deacetyl, 1 hit
PIRSFⁱ	PIRSF037913 His_deacetylse_1, 1 hit
PRINTSⁱ	PR01270 HDASUPER PR01271 HISDACETLASE
SUPFAMⁱ	SSF52768 SSF52768, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q16QZ8_AEDAE
Accessionⁱ	Q16QZ8Primary (citable) accession number: Q16QZ8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 25, 2006
	Last sequence update:	July 25, 2006
	Last modified:	April 25, 2018
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - Q16QZ8 (Q16QZ8_AEDAE)

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Histone deacetylase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Nucleus

Nucleus

Keywords - Cellular componentⁱ

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16QZ8 (Q16QZ8_AEDAE)

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Histone deacetylase

5574401

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ