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Q16P20

- CISY2_AEDAE

UniProt

Q16P20 - CISY2_AEDAE

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Protein

Probable citrate synthase 2, mitochondrial

Gene

AAEL011789

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase 2, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:AAEL011789
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 467Probable citrate synthase 2, mitochondrialPRO_0000291602
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7159.AAEL011789-PA.

Structurei

3D structure databases

ProteinModelPortaliQ16P20.
SMRiQ16P20. Positions 30-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
InParanoidiQ16P20.
KOiK01647.
OMAiELIYEDC.
OrthoDBiEOG73BVCB.
PhylomeDBiQ16P20.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16P20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV
60 70 80 90 100
KNFRKQFGAT KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI
110 120 130 140 150
PECQKVLPKA PGGAEPLPEG LFWLLITGDV PTKAQVDALS REWANRAALP
160 170 180 190 200
SHVVTMLNNM PTTLHPMSQL SCAVTALNHE SKYAKAYSEG VHKSKYWEYV
210 220 230 240 250
YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA NFTKMLGYED
260 270 280 290 300
EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGLKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER
460
PKSMSTDGLM KAVGAAK
Length:467
Mass (Da):51,641
Last modified:July 25, 2006 - v1
Checksum:i402BB11312107CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477799 Genomic DNA. Translation: EAT36098.1.
CH477799 Genomic DNA. Translation: EAT36099.1.
RefSeqiXP_001655738.1. XM_001655688.1.
XP_001655739.1. XM_001655689.1.
UniGeneiAae.18413.

Genome annotation databases

EnsemblMetazoaiAAEL011789-RA; AAEL011789-PA; AAEL011789.
AAEL011789-RB; AAEL011789-PB; AAEL011789.
GeneIDi5575386.
KEGGiaag:AaeL_AAEL011789.
VectorBaseiAAEL011789. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477799 Genomic DNA. Translation: EAT36098.1 .
CH477799 Genomic DNA. Translation: EAT36099.1 .
RefSeqi XP_001655738.1. XM_001655688.1.
XP_001655739.1. XM_001655689.1.
UniGenei Aae.18413.

3D structure databases

ProteinModelPortali Q16P20.
SMRi Q16P20. Positions 30-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL011789-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL011789-RA ; AAEL011789-PA ; AAEL011789 .
AAEL011789-RB ; AAEL011789-PB ; AAEL011789 .
GeneIDi 5575386.
KEGGi aag:AaeL_AAEL011789.
VectorBasei AAEL011789. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
InParanoidi Q16P20.
KOi K01647.
OMAi ELIYEDC.
OrthoDBi EOG73BVCB.
PhylomeDBi Q16P20.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiCISY2_AEDAE
AccessioniPrimary (citable) accession number: Q16P20
Secondary accession number(s): A6KW11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3