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Protein

Probable citrate synthase 2, mitochondrial

Gene

AAEL011789

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable citrate synthase 2, mitochondrial (AAEL011789), Probable citrate synthase 1, mitochondrial (AAEL002956)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303PROSITE-ProRule annotation1
Active sitei349PROSITE-ProRule annotation1
Active sitei404PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase 2, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:AAEL011789
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000291602? – 467Probable citrate synthase 2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiQ16P20

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7159.AAEL011789-PA

Structurei

3D structure databases

ProteinModelPortaliQ16P20
SMRiQ16P20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
HOGENOMiHOG000130831
InParanoidiQ16P20
KOiK01647
OMAiTVGWCAQ
OrthoDBiEOG091G068F
PhylomeDBiQ16P20

Family and domain databases

Gene3Di1.10.230.101 hit
1.10.580.102 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR010109 Citrate_synthase_euk
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01793 cit_synth_euk, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16P20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV
60 70 80 90 100
KNFRKQFGAT KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI
110 120 130 140 150
PECQKVLPKA PGGAEPLPEG LFWLLITGDV PTKAQVDALS REWANRAALP
160 170 180 190 200
SHVVTMLNNM PTTLHPMSQL SCAVTALNHE SKYAKAYSEG VHKSKYWEYV
210 220 230 240 250
YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA NFTKMLGYED
260 270 280 290 300
EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGLKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER
460
PKSMSTDGLM KAVGAAK
Length:467
Mass (Da):51,641
Last modified:July 25, 2006 - v1
Checksum:i402BB11312107CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477799 Genomic DNA Translation: EAT36098.1
CH477799 Genomic DNA Translation: EAT36099.1
RefSeqiXP_001655738.1, XM_001655688.1
XP_001655739.1, XM_001655689.1
UniGeneiAae.20979

Genome annotation databases

EnsemblMetazoaiAAEL011789-RA; AAEL011789-PA; AAEL011789
AAEL011789-RB; AAEL011789-PB; AAEL011789
GeneIDi5575386
KEGGiaag:5575386
VectorBaseiAAEL011789-RC; AAEL011789-PC; AAEL011789
AAEL011789-RD; AAEL011789-PD; AAEL011789

Similar proteinsi

Entry informationi

Entry nameiCISY2_AEDAE
AccessioniPrimary (citable) accession number: Q16P20
Secondary accession number(s): A6KW11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome