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Protein

L-lactate dehydrogenase

Gene

5575706

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (5575706)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:5575706Imported
ORF Names:AAEL012014Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ16ND1.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL012014-PA.

Structurei

3D structure databases

ProteinModelPortaliQ16ND1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 159Ldh_1_NInterPro annotationAdd BLAST139
Domaini162 – 323Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213793.
InParanoidiQ16ND1.
KOiK00016.
OMAiMDLMQTA.
OrthoDBiEOG091G0HME.
PhylomeDBiQ16ND1.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16ND1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKAKLMKE IAEPMATSGN KVTIVGIGQV GMACAFSILT QSVSSEVALI
60 70 80 90 100
DVNADKLKGE MLDLQHGSAF MKNAQINAST DFAVSAGSRL IVITAGVRQK
110 120 130 140 150
EGESRLNLVQ RNCDILKGII PKLVELSPDC ILLVVSNPVD ILTYVAWKLS
160 170 180 190 200
GLPKNRVIGS GTNLDSSRFR FLMSQRLGVA PTSCHGWIIG EHGDSSVPVW
210 220 230 240 250
SGVNVAGVRL SELNPSIGTA DDEEKWGELH YEVVNSAYEV IRLKGYTSWA
260 270 280 290 300
IGLSVASLAS ALLRNTYNVH AVSTLVNGEQ GITDEVYLSL PCVLGRNGVT
310 320 330
HVVKQILTEA ETKKLQESAR IMAEVQAGIK F
Length:331
Mass (Da):35,549
Last modified:July 25, 2006 - v1
Checksum:iA18158AA2EB4F1D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477829 Genomic DNA. Translation: EAT35843.1.
RefSeqiXP_001662150.1. XM_001662100.1.

Genome annotation databases

EnsemblMetazoaiAAEL012014-RA; AAEL012014-PA; AAEL012014.
GeneIDi5575706.
KEGGiaag:AaeL_AAEL012014.
VectorBaseiAAEL012014-RA; AAEL012014-PA; AAEL012014.

Similar proteinsi

Entry informationi

Entry nameiQ16ND1_AEDAE
AccessioniPrimary (citable) accession number: Q16ND1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported