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Q16LK8

- Q16LK8_AEDAE

UniProt

Q16LK8 - Q16LK8_AEDAE

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Protein
Submitted name:

AAEL012614-PA

Gene

AAEL012614

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Sitei244 – 2441Critical for catalysisUniRule annotation
Metal bindingi284 – 2841Magnesium or manganeseUniRule annotation
Metal bindingi307 – 3071Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
AAEL012614-PAImported
Gene namesi
ORF Names:AAEL012614Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL012614-PA.

Structurei

3D structure databases

ProteinModelPortaliQ16LK8.
SMRiQ16LK8. Positions 34-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1347Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
InParanoidiQ16LK8.
KOiK00031.
OMAiHTEDFLE.
OrthoDBiEOG7QNVKS.
PhylomeDBiQ16LK8.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16LK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSLMRFGK YLGQNYTATA APSLSVTSVR NRSSDARIQV AKPVVEMDGD
60 70 80 90 100
EMTRIIWQFI KEKLIFPYIK VECLYYDLGL PYRDQTNDQV TIDAAHAILK
110 120 130 140 150
HNVGIKCATI TPDEARVEEF KLKKMWLSPN GTIRNILGGT VFREPILCSN
160 170 180 190 200
IPRLVPGWTR PIIIGRHAHG DQYKAQDFVI PKPGTVKMVY TADDGTTQEF
210 220 230 240 250
QLYKYKDGGV AMGMYNTDES IAAFAHSSFQ IALGKKWPLY LSTKNTILKR
260 270 280 290 300
YDGRFKDIFQ EIYEKNYQKQ FEDAKIWYEH RLIDDMVAQA LKSDGAFVWS
310 320
CKNYDGDVQS DIVAQASVDT HRW
Length:323
Mass (Da):36,979
Last modified:July 25, 2006 - v1
Checksum:iD0CD44BF0485FBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477902 Genomic DNA. Translation: EAT35200.1.
RefSeqiXP_001662742.1. XM_001662692.1.
UniGeneiAae.5066.

Genome annotation databases

EnsemblMetazoaiAAEL012614-RA; AAEL012614-PA; AAEL012614.
GeneIDi5576561.
KEGGiaag:AaeL_AAEL012614.
VectorBaseiAAEL012614. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477902 Genomic DNA. Translation: EAT35200.1 .
RefSeqi XP_001662742.1. XM_001662692.1.
UniGenei Aae.5066.

3D structure databases

ProteinModelPortali Q16LK8.
SMRi Q16LK8. Positions 34-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL012614-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL012614-RA ; AAEL012614-PA ; AAEL012614 .
GeneIDi 5576561.
KEGGi aag:AaeL_AAEL012614.
VectorBasei AAEL012614. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
InParanoidi Q16LK8.
KOi K00031.
OMAi HTEDFLE.
OrthoDBi EOG7QNVKS.
PhylomeDBi Q16LK8.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12Imported.

Entry informationi

Entry nameiQ16LK8_AEDAE
AccessioniPrimary (citable) accession number: Q16LK8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3