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Q16LK8

- Q16LK8_AEDAE

UniProt

Q16LK8 - Q16LK8_AEDAE

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Protein
Submitted name: AAEL012614-PA
Gene
AAEL012614
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111Substrate By similarity
Binding sitei143 – 1431Substrate By similarity
Binding sitei166 – 1661Substrate By similarityUniRule annotation
Sitei173 – 1731Critical for catalysis By similarityUniRule annotation
Sitei244 – 2441Critical for catalysis By similarityUniRule annotation
Metal bindingi284 – 2841Magnesium or manganese By similarityUniRule annotation
Metal bindingi307 – 3071Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
AAEL012614-PAImported
Gene namesi
ORF Names:AAEL012614Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL012614-PA.

Structurei

3D structure databases

ProteinModelPortaliQ16LK8.
SMRiQ16LK8. Positions 34-316.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1347Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiHTEDFLE.
OrthoDBiEOG7QNVKS.
PhylomeDBiQ16LK8.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16LK8-1 [UniParc]FASTAAdd to Basket

« Hide

MARSLMRFGK YLGQNYTATA APSLSVTSVR NRSSDARIQV AKPVVEMDGD    50
EMTRIIWQFI KEKLIFPYIK VECLYYDLGL PYRDQTNDQV TIDAAHAILK 100
HNVGIKCATI TPDEARVEEF KLKKMWLSPN GTIRNILGGT VFREPILCSN 150
IPRLVPGWTR PIIIGRHAHG DQYKAQDFVI PKPGTVKMVY TADDGTTQEF 200
QLYKYKDGGV AMGMYNTDES IAAFAHSSFQ IALGKKWPLY LSTKNTILKR 250
YDGRFKDIFQ EIYEKNYQKQ FEDAKIWYEH RLIDDMVAQA LKSDGAFVWS 300
CKNYDGDVQS DIVAQASVDT HRW 323
Length:323
Mass (Da):36,979
Last modified:July 25, 2006 - v1
Checksum:iD0CD44BF0485FBBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477902 Genomic DNA. Translation: EAT35200.1.
RefSeqiXP_001662742.1. XM_001662692.1.
UniGeneiAae.5066.

Genome annotation databases

EnsemblMetazoaiAAEL012614-RA; AAEL012614-PA; AAEL012614.
GeneIDi5576561.
KEGGiaag:AaeL_AAEL012614.
VectorBaseiAAEL012614. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477902 Genomic DNA. Translation: EAT35200.1 .
RefSeqi XP_001662742.1. XM_001662692.1.
UniGenei Aae.5066.

3D structure databases

ProteinModelPortali Q16LK8.
SMRi Q16LK8. Positions 34-316.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7159.AAEL012614-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL012614-RA ; AAEL012614-PA ; AAEL012614 .
GeneIDi 5576561.
KEGGi aag:AaeL_AAEL012614.
VectorBasei AAEL012614. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi HTEDFLE.
OrthoDBi EOG7QNVKS.
PhylomeDBi Q16LK8.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiQ16LK8_AEDAE
AccessioniPrimary (citable) accession number: Q16LK8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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