Q16LK8 (Q16LK8_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
AAEL012614-PA EMBL EAT35200.1

Gene names

ORF Names:

AAEL012614

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome] EMBL EAT35200.1

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR000108-3 Manganese PIRSR PIRSR000108-3 Metal-binding PIRSR PIRSR000108-3
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	isocitrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	128 – 134	7	Substrate binding By similarity PIRSR PIRSR000108-2
Sites
	Metal binding	284	1	Magnesium or manganese By similarity PIRSR PIRSR000108-3
	Metal binding	307	1	Magnesium or manganese By similarity PIRSR PIRSR000108-3
	Binding site	111	1	Substrate By similarity PIRSR PIRSR000108-2
	Binding site	143	1	Substrate By similarity PIRSR PIRSR000108-2
	Binding site	166	1	Substrate By similarity PIRSR PIRSR000108-2
	Site	173	1	Critical for catalysis By similarity PIRSR PIRSR000108-1
	Site	244	1	Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

	Sequence		Length	Mass (Da)
	Q16LK8 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: D0CD44BF0485FBBF	FASTA	323	36,979
	10 20 30 40 50 60 MARSLMRFGK YLGQNYTATA APSLSVTSVR NRSSDARIQV AKPVVEMDGD EMTRIIWQFI 70 80 90 100 110 120 KEKLIFPYIK VECLYYDLGL PYRDQTNDQV TIDAAHAILK HNVGIKCATI TPDEARVEEF 130 140 150 160 170 180 KLKKMWLSPN GTIRNILGGT VFREPILCSN IPRLVPGWTR PIIIGRHAHG DQYKAQDFVI 190 200 210 220 230 240 PKPGTVKMVY TADDGTTQEF QLYKYKDGGV AMGMYNTDES IAAFAHSSFQ IALGKKWPLY 250 260 270 280 290 300 LSTKNTILKR YDGRFKDIFQ EIYEKNYQKQ FEDAKIWYEH RLIDDMVAQA LKSDGAFVWS 310 320 CKNYDGDVQS DIVAQASVDT HRW

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477902 Genomic DNA. Translation: EAT35200.1.
RefSeq	XP_001662742.1. XM_001662692.1.
UniGene	Aae.5066.
3D structure databases
ProteinModelPortal	Q16LK8.
SMR	Q16LK8. Positions 34-316.
ModBase	Search...
Protein-protein interaction databases
STRING	7159.AAEL012614-PA. Q16LK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL012614-RA; AAEL012614-PA; AAEL012614.
GeneID	5576561.
KEGG	aag:AaeL_AAEL012614.
VectorBase	AAEL012614. Aedes aegypti.
Phylogenomic databases
eggNOG	COG0538.
HOGENOM	HOG000019858.
KO	K00031.
OMA	LATMKYN.
PhylomeDB	Q16LK8.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR004790. Isocitrate_DH_NADP. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11822. PTHR11822. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMs	TIGR00127. nadp_idh_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q16LK8_AEDAE

Accession

Primary (citable) accession number: Q16LK8

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)