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Q16LK8

- Q16LK8_AEDAE

UniProt

Q16LK8 - Q16LK8_AEDAE

Protein
Submitted name:

AAEL012614-PA

Gene

AAEL012614

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Sitei173 – 1731Critical for catalysis
    Sitei244 – 2441Critical for catalysisUniRule annotation
    Metal bindingi284 – 2841Magnesium or manganeseUniRule annotation
    Metal bindingi307 – 3071Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AAEL012614-PAImported
    Gene namesi
    ORF Names:AAEL012614Imported
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Unassembled WGS sequence

    Interactioni

    Protein-protein interaction databases

    STRINGi7159.AAEL012614-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16LK8.
    SMRiQ16LK8. Positions 34-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1347Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiHTEDFLE.
    OrthoDBiEOG7QNVKS.
    PhylomeDBiQ16LK8.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q16LK8-1 [UniParc]FASTAAdd to Basket

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    MARSLMRFGK YLGQNYTATA APSLSVTSVR NRSSDARIQV AKPVVEMDGD    50
    EMTRIIWQFI KEKLIFPYIK VECLYYDLGL PYRDQTNDQV TIDAAHAILK 100
    HNVGIKCATI TPDEARVEEF KLKKMWLSPN GTIRNILGGT VFREPILCSN 150
    IPRLVPGWTR PIIIGRHAHG DQYKAQDFVI PKPGTVKMVY TADDGTTQEF 200
    QLYKYKDGGV AMGMYNTDES IAAFAHSSFQ IALGKKWPLY LSTKNTILKR 250
    YDGRFKDIFQ EIYEKNYQKQ FEDAKIWYEH RLIDDMVAQA LKSDGAFVWS 300
    CKNYDGDVQS DIVAQASVDT HRW 323
    Length:323
    Mass (Da):36,979
    Last modified:July 25, 2006 - v1
    Checksum:iD0CD44BF0485FBBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH477902 Genomic DNA. Translation: EAT35200.1.
    RefSeqiXP_001662742.1. XM_001662692.1.
    UniGeneiAae.5066.

    Genome annotation databases

    EnsemblMetazoaiAAEL012614-RA; AAEL012614-PA; AAEL012614.
    GeneIDi5576561.
    KEGGiaag:AaeL_AAEL012614.
    VectorBaseiAAEL012614. Aedes aegypti.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH477902 Genomic DNA. Translation: EAT35200.1 .
    RefSeqi XP_001662742.1. XM_001662692.1.
    UniGenei Aae.5066.

    3D structure databases

    ProteinModelPortali Q16LK8.
    SMRi Q16LK8. Positions 34-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7159.AAEL012614-PA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AAEL012614-RA ; AAEL012614-PA ; AAEL012614 .
    GeneIDi 5576561.
    KEGGi aag:AaeL_AAEL012614.
    VectorBasei AAEL012614. Aedes aegypti.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi HTEDFLE.
    OrthoDBi EOG7QNVKS.
    PhylomeDBi Q16LK8.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
      Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
      , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
      Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LVPib12Imported.

    Entry informationi

    Entry nameiQ16LK8_AEDAE
    AccessioniPrimary (citable) accession number: Q16LK8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3