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Q16LK8 (Q16LK8_AEDAE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region128 – 1347Substrate binding By similarity

Sites

Metal binding2841Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3071Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1111Substrate By similarity
Binding site1431Substrate By similarity
Binding site1661Substrate By similarity PIRSR PIRSR000108-2
Site1731Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2441Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q16LK8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: D0CD44BF0485FBBF

FASTA32336,979
        10         20         30         40         50         60 
MARSLMRFGK YLGQNYTATA APSLSVTSVR NRSSDARIQV AKPVVEMDGD EMTRIIWQFI 

        70         80         90        100        110        120 
KEKLIFPYIK VECLYYDLGL PYRDQTNDQV TIDAAHAILK HNVGIKCATI TPDEARVEEF 

       130        140        150        160        170        180 
KLKKMWLSPN GTIRNILGGT VFREPILCSN IPRLVPGWTR PIIIGRHAHG DQYKAQDFVI 

       190        200        210        220        230        240 
PKPGTVKMVY TADDGTTQEF QLYKYKDGGV AMGMYNTDES IAAFAHSSFQ IALGKKWPLY 

       250        260        270        280        290        300 
LSTKNTILKR YDGRFKDIFQ EIYEKNYQKQ FEDAKIWYEH RLIDDMVAQA LKSDGAFVWS 

       310        320 
CKNYDGDVQS DIVAQASVDT HRW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH477902 Genomic DNA. Translation: EAT35200.1.
RefSeqXP_001662742.1. XM_001662692.1.
UniGeneAae.5066.

3D structure databases

ProteinModelPortalQ16LK8.
SMRQ16LK8. Positions 34-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7159.AAEL012614-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL012614-RA; AAEL012614-PA; AAEL012614.
GeneID5576561.
KEGGaag:AaeL_AAEL012614.
VectorBaseAAEL012614. Aedes aegypti.

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAHTEDFLE.
OrthoDBEOG7QNVKS.
PhylomeDBQ16LK8.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ16LK8_AEDAE
AccessionPrimary (citable) accession number: Q16LK8
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)