Q16FX9 (Q16FX9_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase PIRNR PIRNR009283

Gene names

ORF Names:

AAEL014600, AaeL_AAEL014600 EMBL EAT33142.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 iron ion per subunit By similarity. PIRSR PIRSR009283-1
Sequence similarities	Belongs to the 4HPPD family. PIRSR PIRSR009283-1 PIRNR PIRNR009283

Ontologies

Keywords
Ligand	Iron PIRSR PIRSR009283-1 Metal-binding PIRSR PIRSR009283-1 Pyruvate EMBL EAT33142.1
Molecular function	Dioxygenase EMBL EAT33142.1 Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	183	1	Iron By similarity PIRSR PIRSR009283-1
	Metal binding	266	1	Iron By similarity PIRSR PIRSR009283-1
	Metal binding	349	1	Iron By similarity PIRSR PIRSR009283-1

Sequences

	Sequence		Length	Mass (Da)
	Q16FX9 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: B5B13D6F0AE858DB	FASTA	381	43,556
	10 20 30 40 50 60 MTTYTDKGPK PDGGKFLCFD HITFYVGNAK QAASYYTTRM GFTELAYQGL ETGSRKLAKH 70 80 90 100 110 120 VVRQNKIVFV FVSAYEPDNT ELGAHLVRHG DGVKDVAFTV EDLDVIVKRA KQRGAEVVRD 130 140 150 160 170 180 IWEESDEFGT VRFATVKTYG DTQHTFVERK NYKGLFLPGY KAPLYDDVLA KQLPATHLDF 190 200 210 220 230 240 IDHVVGNQPD LQMESVAAWY EKVLMFHRFW SVDDSQIHTE YSALRSIVMT NYEETVKMPI 250 260 270 280 290 300 NEPAKGKKKS QIEEYVDYYG GAGVQHIALN TSDIITAIEN LRARGMHFLS VPNTYYDQLR 310 320 330 340 350 360 ERLKSSKVKI QEDMDTLQKL NILIDYDEDG YLLQIFTKNM QDRPTLFLEV IQRHGHNGFG 370 380 AGNFKALFEA IEADQDKRGN L

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH478368 Genomic DNA. Translation: EAT33142.1.
RefSeq	XP_001649088.1. XM_001649038.1.
UniGene	Aae.23844.
3D structure databases
ProteinModelPortal	Q16FX9.
SMR	Q16FX9. Positions 8-366.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16FX9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL014600-RA; AAEL014600-PA; AAEL014600.
GeneID	5564745.
KEGG	aag:AaeL_AAEL014600.
VectorBase	AAEL014600. Aedes aegypti.
Phylogenomic databases
eggNOG	inNOG04037.
GeneTree	EMGT00050000016473.
OMA	HCVGNVE.
OrthoDB	EOG4X69QS.
PhylomeDB	Q16FX9.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase. [Graphical view]
KO	K00457.
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q16FX9_AEDAE

Accession

Primary (citable) accession number: Q16FX9

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)