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Q16E06

- SYL_ROSDO

UniProt

Q16E06 - SYL_ROSDO

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-45-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RD1_0049
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Leucine--tRNA ligasePRO_1000009419Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_0049.

Structurei

3D structure databases

ProteinModelPortaliQ16E06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16E06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRYTPAEIE ARWQKAWREN EVFKAIRSAD KPKYYVLEMF PYPSGRIHMG
60 70 80 90 100
HVRNYTMGDV IARYKLATGH NVLHPMGWDA FGMPAENAAM AIGGHPKDWT
110 120 130 140 150
YGNIKDMRDQ MKPLGLSIDW SREFATCDPE YYGQQQALFL DFLEAGLVYR
160 170 180 190 200
KNAIVNWDPV DMTVLANEQV EQGRGWRSGA LVERRELTQW FFKISDHSEE
210 220 230 240 250
LLSALDTLEN WPAKVRLMQE NWIGKSRGLQ FAFSTIDGPD GHDRIEVYTT
260 270 280 290 300
RPDTLLGASF VGISPDHPLA KLLERDNDNV AAFCAECRKG GTTEEAIETA
310 320 330 340 350
EKLGFDTGLR VRHPFDTAAE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE
360 370 380 390 400
FATKYDLPII STFLPSQDAD EVLSEAFVPA KTEKVFYNRG FAGAEFQTGL
410 420 430 440 450
EAIDAAIDFC ESNGIGQGVT KYRLRDWGLS RQRYWGCPIP VVHCDDCGVV
460 470 480 490 500
PEKKENLPIE LPYDVSFDTP GNPLNRHPTW RDTPCPACGK PAQRETDTMD
510 520 530 540 550
TFVDSSWYFA RFTAPRAETP TVMEDAQYWM NVDQYIGGIE HAILHLLYSR
560 570 580 590 600
FFARAMQMTG HLPQSAIEPF DALFTQGMVT HEIYQTRDAN GRPVYHLPED
610 620 630 640 650
VTDGRLADGT EVEIIPSAKM SKSKKNVVDP LGIIASYGAD TARWFVLSDS
660 670 680 690 700
PPERDVEWTA SGAEAAFKHL TRVWTLSERI GKMDKDAAGQ GDEDLLRAMH
710 720 730 740 750
VCIHDVTMGI ESFGFNAAIA KLYAFTAKLQ KSKAGYGAQR TAIMTLAQLM
760 770 780 790 800
SPMTPHLAED IWAHQGGDGL VTTAPWPRAD EAMLVSDTVT LPVQINGKRR
810 820 830 840
AEIVISADLS KEEVEKIALA DPAVIRSLNG ATPKKIIVVP GRIVNVVV
Length:848
Mass (Da):94,820
Last modified:July 25, 2006 - v1
Checksum:i50E5E9AC6461A4A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG29787.1.
RefSeqiYP_680473.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG29787; ABG29787; RD1_0049.
GeneIDi4198491.
KEGGirde:RD1_0049.
PATRICi23358281. VBIRosDen86677_0046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG29787.1 .
RefSeqi YP_680473.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q16E06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_0049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG29787 ; ABG29787 ; RD1_0049 .
GeneIDi 4198491.
KEGGi rde:RD1_0049.
PATRICi 23358281. VBIRosDen86677_0046.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RDEN375451:GJIZ-45-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiSYL_ROSDO
AccessioniPrimary (citable) accession number: Q16E06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3