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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRDEN375451:G1G6J-45-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RD1_0049
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
Proteomesi
  • UP000007029 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094191 – 848Leucine--tRNA ligaseAdd BLAST848

Proteomic databases

PRIDEiQ16E06

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_0049

Structurei

3D structure databases

ProteinModelPortaliQ16E06
SMRiQ16E06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q16E06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRYTPAEIE ARWQKAWREN EVFKAIRSAD KPKYYVLEMF PYPSGRIHMG
60 70 80 90 100
HVRNYTMGDV IARYKLATGH NVLHPMGWDA FGMPAENAAM AIGGHPKDWT
110 120 130 140 150
YGNIKDMRDQ MKPLGLSIDW SREFATCDPE YYGQQQALFL DFLEAGLVYR
160 170 180 190 200
KNAIVNWDPV DMTVLANEQV EQGRGWRSGA LVERRELTQW FFKISDHSEE
210 220 230 240 250
LLSALDTLEN WPAKVRLMQE NWIGKSRGLQ FAFSTIDGPD GHDRIEVYTT
260 270 280 290 300
RPDTLLGASF VGISPDHPLA KLLERDNDNV AAFCAECRKG GTTEEAIETA
310 320 330 340 350
EKLGFDTGLR VRHPFDTAAE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE
360 370 380 390 400
FATKYDLPII STFLPSQDAD EVLSEAFVPA KTEKVFYNRG FAGAEFQTGL
410 420 430 440 450
EAIDAAIDFC ESNGIGQGVT KYRLRDWGLS RQRYWGCPIP VVHCDDCGVV
460 470 480 490 500
PEKKENLPIE LPYDVSFDTP GNPLNRHPTW RDTPCPACGK PAQRETDTMD
510 520 530 540 550
TFVDSSWYFA RFTAPRAETP TVMEDAQYWM NVDQYIGGIE HAILHLLYSR
560 570 580 590 600
FFARAMQMTG HLPQSAIEPF DALFTQGMVT HEIYQTRDAN GRPVYHLPED
610 620 630 640 650
VTDGRLADGT EVEIIPSAKM SKSKKNVVDP LGIIASYGAD TARWFVLSDS
660 670 680 690 700
PPERDVEWTA SGAEAAFKHL TRVWTLSERI GKMDKDAAGQ GDEDLLRAMH
710 720 730 740 750
VCIHDVTMGI ESFGFNAAIA KLYAFTAKLQ KSKAGYGAQR TAIMTLAQLM
760 770 780 790 800
SPMTPHLAED IWAHQGGDGL VTTAPWPRAD EAMLVSDTVT LPVQINGKRR
810 820 830 840
AEIVISADLS KEEVEKIALA DPAVIRSLNG ATPKKIIVVP GRIVNVVV
Length:848
Mass (Da):94,820
Last modified:July 25, 2006 - v1
Checksum:i50E5E9AC6461A4A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA Translation: ABG29787.1
RefSeqiWP_011566409.1, NZ_FOOO01000011.1

Genome annotation databases

EnsemblBacteriaiABG29787; ABG29787; RD1_0049
KEGGirde:RD1_0049

Similar proteinsi

Entry informationi

Entry nameiSYL_ROSDO
AccessioniPrimary (citable) accession number: Q16E06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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