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Q16E06

- SYL_ROSDO

UniProt

Q16E06 - SYL_ROSDO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-45-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RD1_0049
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 848848Leucine--tRNA ligasePRO_1000009419Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_0049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16E06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16E06-1 [UniParc]FASTAAdd to Basket

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    MTRYTPAEIE ARWQKAWREN EVFKAIRSAD KPKYYVLEMF PYPSGRIHMG    50
    HVRNYTMGDV IARYKLATGH NVLHPMGWDA FGMPAENAAM AIGGHPKDWT 100
    YGNIKDMRDQ MKPLGLSIDW SREFATCDPE YYGQQQALFL DFLEAGLVYR 150
    KNAIVNWDPV DMTVLANEQV EQGRGWRSGA LVERRELTQW FFKISDHSEE 200
    LLSALDTLEN WPAKVRLMQE NWIGKSRGLQ FAFSTIDGPD GHDRIEVYTT 250
    RPDTLLGASF VGISPDHPLA KLLERDNDNV AAFCAECRKG GTTEEAIETA 300
    EKLGFDTGLR VRHPFDTAAE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE 350
    FATKYDLPII STFLPSQDAD EVLSEAFVPA KTEKVFYNRG FAGAEFQTGL 400
    EAIDAAIDFC ESNGIGQGVT KYRLRDWGLS RQRYWGCPIP VVHCDDCGVV 450
    PEKKENLPIE LPYDVSFDTP GNPLNRHPTW RDTPCPACGK PAQRETDTMD 500
    TFVDSSWYFA RFTAPRAETP TVMEDAQYWM NVDQYIGGIE HAILHLLYSR 550
    FFARAMQMTG HLPQSAIEPF DALFTQGMVT HEIYQTRDAN GRPVYHLPED 600
    VTDGRLADGT EVEIIPSAKM SKSKKNVVDP LGIIASYGAD TARWFVLSDS 650
    PPERDVEWTA SGAEAAFKHL TRVWTLSERI GKMDKDAAGQ GDEDLLRAMH 700
    VCIHDVTMGI ESFGFNAAIA KLYAFTAKLQ KSKAGYGAQR TAIMTLAQLM 750
    SPMTPHLAED IWAHQGGDGL VTTAPWPRAD EAMLVSDTVT LPVQINGKRR 800
    AEIVISADLS KEEVEKIALA DPAVIRSLNG ATPKKIIVVP GRIVNVVV 848
    Length:848
    Mass (Da):94,820
    Last modified:July 25, 2006 - v1
    Checksum:i50E5E9AC6461A4A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG29787.1.
    RefSeqiYP_680473.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG29787; ABG29787; RD1_0049.
    GeneIDi4198491.
    KEGGirde:RD1_0049.
    PATRICi23358281. VBIRosDen86677_0046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG29787.1 .
    RefSeqi YP_680473.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q16E06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_0049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG29787 ; ABG29787 ; RD1_0049 .
    GeneIDi 4198491.
    KEGGi rde:RD1_0049.
    PATRICi 23358281. VBIRosDen86677_0046.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RDEN375451:GJIZ-45-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiSYL_ROSDO
    AccessioniPrimary (citable) accession number: Q16E06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3