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Q16CE0

- PUR9_ROSDO

UniProt

Q16CE0 - PUR9_ROSDO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, RD1_0655
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-614-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:RD1_0655
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057912Add
BLAST

Proteomic databases

PRIDEiQ16CE0.

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_0655.

Structurei

3D structure databases

ProteinModelPortaliQ16CE0.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16CE0-1 [UniParc]FASTAAdd to Basket

« Hide

MTDLAPLRRA LLSVSDKTGL VALGKALAAR GVELLSTGGT ARALRDAGLE    50
VKDVAEVTGF PEMMDGRVKT LHPAVHGGLL ALRDNDDHLA AMQEHGIAGI 100
DLVVVNLYPF EQTVAKGAQY DEVIENIDIG GPAMIRSAAK NHGFVSVVVD 150
VEDYDVLIAQ LEAYDGHTTY ALRQRLAQTA YARTAAYDTA VSTWMAAQVG 200
EPPRRRSFGG TLAQTLRYGE NPHQDAAFYL DGSNSPGVAT ARQLQGKELS 250
YNNINDTDAA FELVSEFDQG DGPACAIIKH ANPCGVARAE TLTEAYRRAF 300
DCDRTSAFGG IIALNQPLDG ATAEEISSIF TEVVIAPGAD AEAQEVFAKK 350
KNLRLLTTDG LADPTAPGLA IRQVSGGYLV QDRDTGRLSA DALQIVTKRA 400
PSDQEMADLM FAWTVAKHVK SNAIIYVKDG ATVGVGAGQM SRVDSTRIAA 450
RKAQDMAEAM GLPAPLTQGS VVASDAFFPF ADGLITAAEA GATALIQPGG 500
SMRDDEVIAA ADEAGLAMVF TGMRHFRH 528
Length:528
Mass (Da):55,891
Last modified:July 25, 2006 - v1
Checksum:iBC1267D670542EF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG30353.1.
RefSeqiYP_681039.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG30353; ABG30353; RD1_0655.
GeneIDi4198089.
KEGGirde:RD1_0655.
PATRICi23359477. VBIRosDen86677_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG30353.1 .
RefSeqi YP_681039.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q16CE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_0655.

Proteomic databases

PRIDEi Q16CE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG30353 ; ABG30353 ; RD1_0655 .
GeneIDi 4198089.
KEGGi rde:RD1_0655.
PATRICi 23359477. VBIRosDen86677_0642.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RDEN375451:GJIZ-614-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiPUR9_ROSDO
AccessioniPrimary (citable) accession number: Q16CE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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