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Q16AX0

- GCSP_ROSDO

UniProt

Q16AX0 - GCSP_ROSDO

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, RD1_1225
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RD1_1225
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi375451.RD1_1225.

Structurei

3D structure databases

ProteinModelPortaliQ16AX0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16AX0-1 [UniParc]FASTAAdd to Basket

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MSFKPIDYLP YDFANRRHIG PSPAEMTQML EVTGAANLDA LMDDTLPAAI    50
RQKEPLAFGK AMSEREVLEH LRRVASKNQV LTSLIGQGYY GTVTPPAIQR 100
NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMVSDLTGL EVANASLLDE 150
ATACAEAMTM AQRVSKSKSK AFFVDRDCHP QNIAVMQTRA APLGIEIIVG 200
NPDKMDAEAV FGAIFQYPGT YGHVNDFTDH MAALHAHKAI GIVSADPLAL 250
TLLKEPGAMG ADIAVGSTQR FGVPEGYGGP HAAYMACRDA YKRAMPGRIV 300
GVSVDSHGHR AYRLSLQTRE QHIRREKATS NVCTAQALLA VMASMYAVFH 350
GPEGLRAIAQ RIHRKAVRLA KGLEEAGFTV DPQAFFDTIT VDVGPLQAAV 400
MKSAVDEGIN LRRVGETRVG ISLNERCRPD TLEAVWRAFG ITRADNDFRP 450
DYRFPEEMLR TSDYLTHPIF HMNRAETEMM RYMRRLSDRD LALDRAMIPL 500
GSCTMKLNSA AEMMPVSWRD FSLLHPFAPV DQAKGYTEMI DDLSAKLCQI 550
TGYDQISMQP NSGAQGEYAG LLSIAGYHRA NGEAHRNICL IPMSAHGTNP 600
ASAQMVGWTV VPIKSADNGD IDMADFAAKA EQHAANLAGC MITYPSTHGV 650
FEETVTEVTR ITHQHGGQVY IDGANMNAMV GLSRPGDLGG DVSHLNLHKT 700
FCIPHGGGGP GMGPIGVKSH LAPFLPGHEM TGGGEGAVSA APFGSPSLLP 750
ISWAYCLMMG GDGLTQATRV AILNANYIAK RLEGAFDVLY RGPTGRVAHE 800
CVIDVRPFEK SAGVSVEDIA KRLIDCGFHA PTMSWPVAGT LMVEPTESET 850
KAELDRFCDA MLAIRAEIAD IEEGRMDAAN NPLKNAPHTV DDLVSDWDRP 900
YSRDQGCFPP GAFRVDKYWP PVNRVDNVFG DRHLVCTCPP MEDYAEAAE 949
Length:949
Mass (Da):103,442
Last modified:July 25, 2006 - v1
Checksum:i10F342B1778B4019
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG30873.1.
RefSeqiYP_681559.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG30873; ABG30873; RD1_1225.
GeneIDi4197472.
KEGGirde:RD1_1225.
PATRICi23360579. VBIRosDen86677_1183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG30873.1 .
RefSeqi YP_681559.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q16AX0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 375451.RD1_1225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG30873 ; ABG30873 ; RD1_1225 .
GeneIDi 4197472.
KEGGi rde:RD1_1225.
PATRICi 23360579. VBIRosDen86677_1183.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RDEN375451:GJIZ-1149-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiGCSP_ROSDO
AccessioniPrimary (citable) accession number: Q16AX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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