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Q16AX0

- GCSP_ROSDO

UniProt

Q16AX0 - GCSP_ROSDO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-1149-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:RD1_1225
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000045604Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi375451.RD1_1225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16AX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q16AX0-1 [UniParc]FASTAAdd to Basket

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    MSFKPIDYLP YDFANRRHIG PSPAEMTQML EVTGAANLDA LMDDTLPAAI    50
    RQKEPLAFGK AMSEREVLEH LRRVASKNQV LTSLIGQGYY GTVTPPAIQR 100
    NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMVSDLTGL EVANASLLDE 150
    ATACAEAMTM AQRVSKSKSK AFFVDRDCHP QNIAVMQTRA APLGIEIIVG 200
    NPDKMDAEAV FGAIFQYPGT YGHVNDFTDH MAALHAHKAI GIVSADPLAL 250
    TLLKEPGAMG ADIAVGSTQR FGVPEGYGGP HAAYMACRDA YKRAMPGRIV 300
    GVSVDSHGHR AYRLSLQTRE QHIRREKATS NVCTAQALLA VMASMYAVFH 350
    GPEGLRAIAQ RIHRKAVRLA KGLEEAGFTV DPQAFFDTIT VDVGPLQAAV 400
    MKSAVDEGIN LRRVGETRVG ISLNERCRPD TLEAVWRAFG ITRADNDFRP 450
    DYRFPEEMLR TSDYLTHPIF HMNRAETEMM RYMRRLSDRD LALDRAMIPL 500
    GSCTMKLNSA AEMMPVSWRD FSLLHPFAPV DQAKGYTEMI DDLSAKLCQI 550
    TGYDQISMQP NSGAQGEYAG LLSIAGYHRA NGEAHRNICL IPMSAHGTNP 600
    ASAQMVGWTV VPIKSADNGD IDMADFAAKA EQHAANLAGC MITYPSTHGV 650
    FEETVTEVTR ITHQHGGQVY IDGANMNAMV GLSRPGDLGG DVSHLNLHKT 700
    FCIPHGGGGP GMGPIGVKSH LAPFLPGHEM TGGGEGAVSA APFGSPSLLP 750
    ISWAYCLMMG GDGLTQATRV AILNANYIAK RLEGAFDVLY RGPTGRVAHE 800
    CVIDVRPFEK SAGVSVEDIA KRLIDCGFHA PTMSWPVAGT LMVEPTESET 850
    KAELDRFCDA MLAIRAEIAD IEEGRMDAAN NPLKNAPHTV DDLVSDWDRP 900
    YSRDQGCFPP GAFRVDKYWP PVNRVDNVFG DRHLVCTCPP MEDYAEAAE 949
    Length:949
    Mass (Da):103,442
    Last modified:July 25, 2006 - v1
    Checksum:i10F342B1778B4019
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG30873.1.
    RefSeqiYP_681559.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG30873; ABG30873; RD1_1225.
    GeneIDi4197472.
    KEGGirde:RD1_1225.
    PATRICi23360579. VBIRosDen86677_1183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG30873.1 .
    RefSeqi YP_681559.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q16AX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_1225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG30873 ; ABG30873 ; RD1_1225 .
    GeneIDi 4197472.
    KEGGi rde:RD1_1225.
    PATRICi 23360579. VBIRosDen86677_1183.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RDEN375451:GJIZ-1149-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiGCSP_ROSDO
    AccessioniPrimary (citable) accession number: Q16AX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3