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Q16AX0 (GCSP_ROSDO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RD1_1225
OrganismRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans) [Complete proteome] [HAMAP]
Taxonomic identifier375451 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 949949Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045604

Amino acid modifications

Modified residue6991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q16AX0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 10F342B1778B4019

FASTA949103,442
        10         20         30         40         50         60 
MSFKPIDYLP YDFANRRHIG PSPAEMTQML EVTGAANLDA LMDDTLPAAI RQKEPLAFGK 

        70         80         90        100        110        120 
AMSEREVLEH LRRVASKNQV LTSLIGQGYY GTVTPPAIQR NILENPAWYT AYTPYQPEIS 

       130        140        150        160        170        180 
QGRLEALLNF QTMVSDLTGL EVANASLLDE ATACAEAMTM AQRVSKSKSK AFFVDRDCHP 

       190        200        210        220        230        240 
QNIAVMQTRA APLGIEIIVG NPDKMDAEAV FGAIFQYPGT YGHVNDFTDH MAALHAHKAI 

       250        260        270        280        290        300 
GIVSADPLAL TLLKEPGAMG ADIAVGSTQR FGVPEGYGGP HAAYMACRDA YKRAMPGRIV 

       310        320        330        340        350        360 
GVSVDSHGHR AYRLSLQTRE QHIRREKATS NVCTAQALLA VMASMYAVFH GPEGLRAIAQ 

       370        380        390        400        410        420 
RIHRKAVRLA KGLEEAGFTV DPQAFFDTIT VDVGPLQAAV MKSAVDEGIN LRRVGETRVG 

       430        440        450        460        470        480 
ISLNERCRPD TLEAVWRAFG ITRADNDFRP DYRFPEEMLR TSDYLTHPIF HMNRAETEMM 

       490        500        510        520        530        540 
RYMRRLSDRD LALDRAMIPL GSCTMKLNSA AEMMPVSWRD FSLLHPFAPV DQAKGYTEMI 

       550        560        570        580        590        600 
DDLSAKLCQI TGYDQISMQP NSGAQGEYAG LLSIAGYHRA NGEAHRNICL IPMSAHGTNP 

       610        620        630        640        650        660 
ASAQMVGWTV VPIKSADNGD IDMADFAAKA EQHAANLAGC MITYPSTHGV FEETVTEVTR 

       670        680        690        700        710        720 
ITHQHGGQVY IDGANMNAMV GLSRPGDLGG DVSHLNLHKT FCIPHGGGGP GMGPIGVKSH 

       730        740        750        760        770        780 
LAPFLPGHEM TGGGEGAVSA APFGSPSLLP ISWAYCLMMG GDGLTQATRV AILNANYIAK 

       790        800        810        820        830        840 
RLEGAFDVLY RGPTGRVAHE CVIDVRPFEK SAGVSVEDIA KRLIDCGFHA PTMSWPVAGT 

       850        860        870        880        890        900 
LMVEPTESET KAELDRFCDA MLAIRAEIAD IEEGRMDAAN NPLKNAPHTV DDLVSDWDRP 

       910        920        930        940 
YSRDQGCFPP GAFRVDKYWP PVNRVDNVFG DRHLVCTCPP MEDYAEAAE 

« Hide

References

[1]"The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism."
Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H., Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K., O'Huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T., Touchman J.W.
J. Bacteriol. 189:683-690(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33942 / OCh 114.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000362 Genomic DNA. Translation: ABG30873.1.
RefSeqYP_681559.1. NC_008209.1.

3D structure databases

ProteinModelPortalQ16AX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING375451.RD1_1225.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG30873; ABG30873; RD1_1225.
GeneID4197472.
KEGGrde:RD1_1225.
PATRIC23360579. VBIRosDen86677_1183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycRDEN375451:GJIZ-1149-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_ROSDO
AccessionPrimary (citable) accession number: Q16AX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families