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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:RD1_1225
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000045604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi375451.RD1_1225.

Structurei

3D structure databases

ProteinModelPortaliQ16AX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16AX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKPIDYLP YDFANRRHIG PSPAEMTQML EVTGAANLDA LMDDTLPAAI
60 70 80 90 100
RQKEPLAFGK AMSEREVLEH LRRVASKNQV LTSLIGQGYY GTVTPPAIQR
110 120 130 140 150
NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMVSDLTGL EVANASLLDE
160 170 180 190 200
ATACAEAMTM AQRVSKSKSK AFFVDRDCHP QNIAVMQTRA APLGIEIIVG
210 220 230 240 250
NPDKMDAEAV FGAIFQYPGT YGHVNDFTDH MAALHAHKAI GIVSADPLAL
260 270 280 290 300
TLLKEPGAMG ADIAVGSTQR FGVPEGYGGP HAAYMACRDA YKRAMPGRIV
310 320 330 340 350
GVSVDSHGHR AYRLSLQTRE QHIRREKATS NVCTAQALLA VMASMYAVFH
360 370 380 390 400
GPEGLRAIAQ RIHRKAVRLA KGLEEAGFTV DPQAFFDTIT VDVGPLQAAV
410 420 430 440 450
MKSAVDEGIN LRRVGETRVG ISLNERCRPD TLEAVWRAFG ITRADNDFRP
460 470 480 490 500
DYRFPEEMLR TSDYLTHPIF HMNRAETEMM RYMRRLSDRD LALDRAMIPL
510 520 530 540 550
GSCTMKLNSA AEMMPVSWRD FSLLHPFAPV DQAKGYTEMI DDLSAKLCQI
560 570 580 590 600
TGYDQISMQP NSGAQGEYAG LLSIAGYHRA NGEAHRNICL IPMSAHGTNP
610 620 630 640 650
ASAQMVGWTV VPIKSADNGD IDMADFAAKA EQHAANLAGC MITYPSTHGV
660 670 680 690 700
FEETVTEVTR ITHQHGGQVY IDGANMNAMV GLSRPGDLGG DVSHLNLHKT
710 720 730 740 750
FCIPHGGGGP GMGPIGVKSH LAPFLPGHEM TGGGEGAVSA APFGSPSLLP
760 770 780 790 800
ISWAYCLMMG GDGLTQATRV AILNANYIAK RLEGAFDVLY RGPTGRVAHE
810 820 830 840 850
CVIDVRPFEK SAGVSVEDIA KRLIDCGFHA PTMSWPVAGT LMVEPTESET
860 870 880 890 900
KAELDRFCDA MLAIRAEIAD IEEGRMDAAN NPLKNAPHTV DDLVSDWDRP
910 920 930 940
YSRDQGCFPP GAFRVDKYWP PVNRVDNVFG DRHLVCTCPP MEDYAEAAE
Length:949
Mass (Da):103,442
Last modified:July 25, 2006 - v1
Checksum:i10F342B1778B4019
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG30873.1.
RefSeqiWP_011567493.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG30873; ABG30873; RD1_1225.
KEGGirde:RD1_1225.
PATRICi23360579. VBIRosDen86677_1183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG30873.1.
RefSeqiWP_011567493.1. NC_008209.1.

3D structure databases

ProteinModelPortaliQ16AX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi375451.RD1_1225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG30873; ABG30873; RD1_1225.
KEGGirde:RD1_1225.
PATRICi23360579. VBIRosDen86677_1183.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1149-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiGCSP_ROSDO
AccessioniPrimary (citable) accession number: Q16AX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.