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Q16A32

- RBKTP_ROSDO

UniProt

Q16A32 - RBKTP_ROSDO

Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

    Catalytic activityi

    ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase activity Source: InterPro
    3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
    4. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. organic phosphonate transport Source: UniProtKB-KW
    3. pyrimidine nucleobase metabolic process Source: InterPro
    4. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Alkylphosphonate uptake

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-1440-MONOMER.
    UniPathwayiUPA00087; UER00175.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
    Including the following 2 domains:
    Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
    Putative thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:phnN
    Ordered Locus Names:RD1_1528
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000314717Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_1528.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16A32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 187187Ribose 1,5-bisphosphokinaseAdd
    BLAST
    Regioni188 – 677490ThymidinephosphorylaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
    In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiGCIAWNG.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF00625. Guanylate_kin. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
    PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16A32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGTLFLIVG PSGVGKDTLL EGARDRLATS RWFSFPQRVV TRAADAGGED    50
    YIPVTPSEFE QQLAAGAFWH QWHAHGLSYG IPMQVARDLD NGINVVLNAS 100
    RNEIGAFRDK ATHVVTIGIS APPGIVEERL HERGRESEEE IKRRLARLVE 150
    QAPLTGYALE IVNDRTIEEG ITALVDLIAG ACDLNAEITR FPVTIGSKQV 200
    CLVHKGNQIA SRVLAGSSRV TLSLRGKSVS AELGETWSDE IVSQDLCALS 250
    EGAMAALDAV EGDVVSIERS PTPKSRSILQ KKVRGGELSH AEMEAFIHDL 300
    VNGRFSTSEI AGFLVAASNN LTMDEVISLT QVRAAFAHRH DWGKAIVVDK 350
    HSMGGVPGNR ITPIIIPILA AFGLTVPKTS SRAITSAAGT ADMMEVLSRV 400
    DLSPDEMKSV VEQTNGCIAW NGNLTHSPVD DVMNAINRPL GLQSTLLDVS 450
    SIMSKKLAAG STHVLIDMPV GPKAKTRTQG EAGALKNLFE SVGQGIGLNT 500
    KVQISDGTKP IGRGVGPVLE ALDVLSVLRG EAGAPTDLLD KSIGYAATIL 550
    EWSGAVSQGQ GAQVTRDLVS SGKAFEKLFE IRDAQGRQHD PLQPGQFTED 600
    ICADRSGRVE AIDIQGISEV ARLSGAPKDK AAGVVLNVQV GDQIAEKQPL 650
    LRVHSSSLRG IEEAVCAAQA QSAFKIL 677
    Length:677
    Mass (Da):72,031
    Last modified:July 25, 2006 - v1
    Checksum:i21D61E53D52766DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31161.1.
    RefSeqiYP_681847.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG31161; ABG31161; RD1_1528.
    GeneIDi4197184.
    KEGGirde:RD1_1528.
    PATRICi23361171. VBIRosDen86677_1476.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31161.1 .
    RefSeqi YP_681847.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q16A32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_1528.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG31161 ; ABG31161 ; RD1_1528 .
    GeneIDi 4197184.
    KEGGi rde:RD1_1528.
    PATRICi 23361171. VBIRosDen86677_1476.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi GCIAWNG.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00175 .
    BioCyci RDEN375451:GJIZ-1440-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF00625. Guanylate_kin. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiRBKTP_ROSDO
    AccessioniPrimary (citable) accession number: Q16A32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3