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Q16A32

- RBKTP_ROSDO

UniProt

Q16A32 - RBKTP_ROSDO

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Protein
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Gene
phnN, RD1_1528
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity.UniRule annotation

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorylase activity Source: InterPro
  3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
  4. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. organic phosphonate transport Source: UniProtKB-KW
  3. pyrimidine nucleobase metabolic process Source: InterPro
  4. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Alkylphosphonate uptake

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1440-MONOMER.
UniPathwayiUPA00087; UER00175.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:RD1_1528
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylaseUniRule annotation
PRO_0000314717Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_1528.

Structurei

3D structure databases

ProteinModelPortaliQ16A32.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 187187Ribose 1,5-bisphosphokinaseUniRule annotation
Add
BLAST
Regioni188 – 677490ThymidinephosphorylaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiGCIAWNG.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF00625. Guanylate_kin. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
TIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16A32-1 [UniParc]FASTAAdd to Basket

« Hide

MPGTLFLIVG PSGVGKDTLL EGARDRLATS RWFSFPQRVV TRAADAGGED    50
YIPVTPSEFE QQLAAGAFWH QWHAHGLSYG IPMQVARDLD NGINVVLNAS 100
RNEIGAFRDK ATHVVTIGIS APPGIVEERL HERGRESEEE IKRRLARLVE 150
QAPLTGYALE IVNDRTIEEG ITALVDLIAG ACDLNAEITR FPVTIGSKQV 200
CLVHKGNQIA SRVLAGSSRV TLSLRGKSVS AELGETWSDE IVSQDLCALS 250
EGAMAALDAV EGDVVSIERS PTPKSRSILQ KKVRGGELSH AEMEAFIHDL 300
VNGRFSTSEI AGFLVAASNN LTMDEVISLT QVRAAFAHRH DWGKAIVVDK 350
HSMGGVPGNR ITPIIIPILA AFGLTVPKTS SRAITSAAGT ADMMEVLSRV 400
DLSPDEMKSV VEQTNGCIAW NGNLTHSPVD DVMNAINRPL GLQSTLLDVS 450
SIMSKKLAAG STHVLIDMPV GPKAKTRTQG EAGALKNLFE SVGQGIGLNT 500
KVQISDGTKP IGRGVGPVLE ALDVLSVLRG EAGAPTDLLD KSIGYAATIL 550
EWSGAVSQGQ GAQVTRDLVS SGKAFEKLFE IRDAQGRQHD PLQPGQFTED 600
ICADRSGRVE AIDIQGISEV ARLSGAPKDK AAGVVLNVQV GDQIAEKQPL 650
LRVHSSSLRG IEEAVCAAQA QSAFKIL 677
Length:677
Mass (Da):72,031
Last modified:July 25, 2006 - v1
Checksum:i21D61E53D52766DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG31161.1.
RefSeqiYP_681847.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG31161; ABG31161; RD1_1528.
GeneIDi4197184.
KEGGirde:RD1_1528.
PATRICi23361171. VBIRosDen86677_1476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG31161.1 .
RefSeqi YP_681847.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q16A32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_1528.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG31161 ; ABG31161 ; RD1_1528 .
GeneIDi 4197184.
KEGGi rde:RD1_1528.
PATRICi 23361171. VBIRosDen86677_1476.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi GCIAWNG.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00175 .
BioCyci RDEN375451:GJIZ-1440-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF00625. Guanylate_kin. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
TIGR02322. phosphon_PhnN. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiRBKTP_ROSDO
AccessioniPrimary (citable) accession number: Q16A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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