Q16968 (Q16968_APLCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Potassium channel EMBL AAA27756.1
Organism	Aplysia californica (California sea hare) EMBL AAA27756.1
Taxonomic identifier	6500 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Euopisthobranchia › Aplysiomorpha › Aplysioidea › Aplysiidae › Aplysia

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS003091
Ligand	Potassium
Molecular function	Ion channel Potassium channel SAAS SAAS003091 Voltage-gated channel SAAS SAAS003091
Technical term	3D-structure PDB 1EOE PDB 1A68 PDB 1T1D PDB 1EOF PDB 1EOD
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q16968 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 76F6579C4C4D91E4	FASTA	515	58,540
	10 20 30 40 50 60 MEVAMAGIEG NGGPAGYRDS YHSSQRPLLR SSNLPNSRSF PKLSEEDNAN ENGMGVPGSD 70 80 90 100 110 120 YDCSCERVVI NVSGLRFETQ LKTLNQFPDT LLGNPQKRNR YYDPLRNEYF FDRNRPSFDA 130 140 150 160 170 180 ILYFYQSGGR LRRPVNVPLD VFSEEIKFYE LGENAFERYR EDEGFIKEEE KPLPQNEFQR 190 200 210 220 230 240 RVWLLFEYPE SSAAARLCAI FSVVIILLSI VIFCLETLPQ FKHYRVVNST ANDSKESIEE 250 260 270 280 290 300 DDIPKFNEPF FIIETCCIIW FTFELLVRFA SCPEKLGFFK NIMNCIDIVA IIPYFITLGT 310 320 330 340 350 360 VVADQSKSNN QAMSLAILRV IRLVRVFRIF KLSRHSKGLQ ILGQTLKASM RELGLLIFFL 370 380 390 400 410 420 FIGVILFSSA VYFAEADADQ THFKSIPDAF WWAVVTMTTV GYGDMRPIGV WGKLVGSLCA 430 440 450 460 470 480 IAGVLTIALP VPVIVSNFNY FYHREGESTD KGQYKHVQSC PNYPEKKDSL DSECGSDIME 490 500 510 MEEGNHSTPL TEKVKENHAI KANNPGSDYG LETDV

References

[1]	"Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents." Pfaffinger P.J., Furukawa Y., Zhao B., Dugan D., Kandel E.R. J. Neurosci. 11:918-927(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Central nervous system EMBL AAA27756.1.
[2]	"Crystal structure of the tetramerization domain of the Shaker potassium channel." Kreusch A., Pfaffinger P.J., Stevens C.F., Choe S. Nature 392:945-948(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 66-159.
[3]	"Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels." Bixby K.A., Nanao M.H., Shen N.V., Kreusch A., Bellamy H., Pfaffinger P.J., Choe S. Nat. Struct. Biol. 6:38-43(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 66-165.
[4]	"Voltage dependent activation of potassium channels is coupled to T1 domain structure." Cushman S.J., Nanao M.H., Jahng A.W., DeRubeis D., Choe S., Pfaffinger P.J. Nat. Struct. Biol. 7:403-407(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 66-165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M95914 mRNA. Translation: AAA27756.1.

RefSeq

NP_001191634.1. NM_001204705.1.

UniGene

Acl.18312.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A68	X-ray	1.80	A	66-159	[»]
1EOD	X-ray	2.45	A	66-165	[»]
1EOE	X-ray	1.70	A	66-165	[»]
1EOF	X-ray	2.38	A	66-165	[»]
1T1D	X-ray	1.51	A	66-165	[»]

ProteinModelPortal

Q16968.

SMR

Q16968. Positions 66-445.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

100533422.

Family and domain databases

Gene3D

3.30.710.10. 1 hit.

InterPro

IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
[Graphical view]

PANTHER

PTHR11537. PTHR11537. 1 hit.

Pfam

PF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]

PRINTS

PR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.

SMART

SM00225. BTB. 1 hit.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q16968.

Entry information

Entry name

Q16968_APLCA

Accession

Primary (citable) accession number: Q16968

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)