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Protein
Submitted name:

Potassium channel

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channelImported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei197 – 21822HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30322HelicalSequence analysisAdd
BLAST
Transmembranei353 – 37422HelicalSequence analysisAdd
BLAST
Transmembranei414 – 43522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A68X-ray1.80A66-159[»]
1EODX-ray2.45A66-165[»]
1EOEX-ray1.70A66-165[»]
1EOFX-ray2.38A66-165[»]
1T1DX-ray1.51A66-165[»]
ProteinModelPortaliQ16968.
SMRiQ16968. Positions 66-445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 16095BTB (POZ)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAMAGIEG NGGPAGYRDS YHSSQRPLLR SSNLPNSRSF PKLSEEDNAN
60 70 80 90 100
ENGMGVPGSD YDCSCERVVI NVSGLRFETQ LKTLNQFPDT LLGNPQKRNR
110 120 130 140 150
YYDPLRNEYF FDRNRPSFDA ILYFYQSGGR LRRPVNVPLD VFSEEIKFYE
160 170 180 190 200
LGENAFERYR EDEGFIKEEE KPLPQNEFQR RVWLLFEYPE SSAAARLCAI
210 220 230 240 250
FSVVIILLSI VIFCLETLPQ FKHYRVVNST ANDSKESIEE DDIPKFNEPF
260 270 280 290 300
FIIETCCIIW FTFELLVRFA SCPEKLGFFK NIMNCIDIVA IIPYFITLGT
310 320 330 340 350
VVADQSKSNN QAMSLAILRV IRLVRVFRIF KLSRHSKGLQ ILGQTLKASM
360 370 380 390 400
RELGLLIFFL FIGVILFSSA VYFAEADADQ THFKSIPDAF WWAVVTMTTV
410 420 430 440 450
GYGDMRPIGV WGKLVGSLCA IAGVLTIALP VPVIVSNFNY FYHREGESTD
460 470 480 490 500
KGQYKHVQSC PNYPEKKDSL DSECGSDIME MEEGNHSTPL TEKVKENHAI
510
KANNPGSDYG LETDV
Length:515
Mass (Da):58,540
Last modified:November 1, 1996 - v1
Checksum:i76F6579C4C4D91E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95914 mRNA. Translation: AAA27756.1.
RefSeqiNP_001191634.1. NM_001204705.1.
XP_012940084.1. XM_013084630.1.
UniGeneiAcl.18312.

Genome annotation databases

GeneIDi100533422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95914 mRNA. Translation: AAA27756.1.
RefSeqiNP_001191634.1. NM_001204705.1.
XP_012940084.1. XM_013084630.1.
UniGeneiAcl.18312.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A68X-ray1.80A66-159[»]
1EODX-ray2.45A66-165[»]
1EOEX-ray1.70A66-165[»]
1EOFX-ray2.38A66-165[»]
1T1DX-ray1.51A66-165[»]
ProteinModelPortaliQ16968.
SMRiQ16968. Positions 66-445.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533422.

Miscellaneous databases

EvolutionaryTraceiQ16968.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents."
    Pfaffinger P.J., Furukawa Y., Zhao B., Dugan D., Kandel E.R.
    J. Neurosci. 11:918-927(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Central nervous systemImported.
  2. "Crystal structure of the tetramerization domain of the Shaker potassium channel."
    Kreusch A., Pfaffinger P.J., Stevens C.F., Choe S.
    Nature 392:945-948(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 66-159.
  3. "Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels."
    Bixby K.A., Nanao M.H., Shen N.V., Kreusch A., Bellamy H., Pfaffinger P.J., Choe S.
    Nat. Struct. Biol. 6:38-43(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 66-165.
  4. "Voltage dependent activation of potassium channels is coupled to T1 domain structure."
    Cushman S.J., Nanao M.H., Jahng A.W., DeRubeis D., Choe S., Pfaffinger P.J.
    Nat. Struct. Biol. 7:403-407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 66-165.

Entry informationi

Entry nameiQ16968_APLCA
AccessioniPrimary (citable) accession number: Q16968
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.