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Protein
Submitted name:

Furin-like prohormone convertase

Gene

afurin2

Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Furin-like prohormone convertaseImported
Gene namesi
Name:afurin2Imported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei762 – 78524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Miscellaneous databases

PMAP-CutDBQ16962.

Structurei

3D structure databases

ProteinModelPortaliQ16962.
SMRiQ16962. Positions 108-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9577S8_pro-domainInterPro annotationAdd
BLAST
Domaini141 – 424284Peptidase S8InterPro annotationAdd
BLAST
Domaini483 – 57189P_proproteinInterPro annotationAdd
BLAST
Domaini607 – 724118Furin-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation
Contains peptidase S8 domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00757. Furin-like. 1 hit.
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00261. FU. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLALVLGSV VGAEVYLNQF AVHISGGHSA ASRVARDTGF INLGQIGSLD
60 70 80 90 100
DHYLFEIPHR QRRSATHSHE HHTALTDHGE VGWFEQQVVK SRSKRDFHPR
110 120 130 140 150
DVAEQMSVLD PYWKNQWYLH GGAQGGYDMK VMEAWREGYT GKNIVVAILD
160 170 180 190 200
DGLEHNHPDL IKNYDPYASY DLNDHDNDPM PRYDASNENR HGTRCAGEVS
210 220 230 240 250
AEANNTACTI GIAPDSRIGG IRMLDGEVYD AVEAASLSFN RSHVDIYSAS
260 270 280 290 300
WGPDDDGKVV DGPGKLAKEA FIKGIENGRG GKGSIFVWAS GNGGSAHDSC
310 320 330 340 350
NCDGYANSIF TLSISSTSEN GIKPWYLEEC SSTLASTYSS GAYNERQIAT
360 370 380 390 400
TDLRQRCTTT HTGTSASAPL AAGIVALVLE ANRDLTWRDV QYITLMTSRS
410 420 430 440 450
DPIEDGQWIV NGVGRKVSLR YGYGLMDATE MVKLAKVWRQ VPEKHECLIT
460 470 480 490 500
SDVQNVPLAS GNKFSSQVLT NGCVGTSTEV NYLEHVQARI SLTHSQRGSV
510 520 530 540 550
VIYLTSPSGT RSKVLPARSN DVAPGGFDNW PLLSVHFWGE NPRGTWTLEI
560 570 580 590 600
EEANMYNRRS SGGKLASWSL VLHGTRVKPV RLLNETSPAT TTKTTAATTS
610 620 630 640 650
STSTTTTKKP STPKVEACHK ECAGGCTGTR PEDCNECKNF RVSSTRVCVS
660 670 680 690 700
QCPDGFYTSG DMCMPCDASC ATCSGPALTE CQSCHEGRHY HQLKDKHSVC
710 720 730 740 750
NIECVDGFFY STNSCLPCDV GCKHCESSAL HCTACRKGYS LKDDKCVSQA
760 770 780 790 800
AVVSVMFEHI TLSIVLISVI VLLVVFIFMG LLYMYRNQLF FWSDRKMYGP
810 820
VPREDEEAVV RLTYSDDFDE DFKS
Length:824
Mass (Da):90,535
Last modified:November 1, 1996 - v1
Checksum:i0145D7E14E6764E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38715 mRNA. Translation: AAA73903.1.
RefSeqiNP_001191402.1. NM_001204473.1.
UniGeneiAcl.6114.

Genome annotation databases

GeneIDi100533397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38715 mRNA. Translation: AAA73903.1.
RefSeqiNP_001191402.1. NM_001204473.1.
UniGeneiAcl.6114.

3D structure databases

ProteinModelPortaliQ16962.
SMRiQ16962. Positions 108-576.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533397.

Organism-specific databases

CTDi100533397.

Miscellaneous databases

PMAP-CutDBQ16962.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00757. Furin-like. 1 hit.
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00261. FU. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ16962_APLCA
AccessioniPrimary (citable) accession number: Q16962
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.