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Protein
Submitted name:

Furin-like prohormone convertase

Gene

afurin2

Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Furin-like prohormone convertaseImported
Gene namesi
Name:afurin2Imported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei762 – 785HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Miscellaneous databases

PMAP-CutDBiQ16962

Structurei

3D structure databases

ProteinModelPortaliQ16962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini440 – 578P/Homo BInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00261 FU, 3 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q16962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLALVLGSV VGAEVYLNQF AVHISGGHSA ASRVARDTGF INLGQIGSLD
60 70 80 90 100
DHYLFEIPHR QRRSATHSHE HHTALTDHGE VGWFEQQVVK SRSKRDFHPR
110 120 130 140 150
DVAEQMSVLD PYWKNQWYLH GGAQGGYDMK VMEAWREGYT GKNIVVAILD
160 170 180 190 200
DGLEHNHPDL IKNYDPYASY DLNDHDNDPM PRYDASNENR HGTRCAGEVS
210 220 230 240 250
AEANNTACTI GIAPDSRIGG IRMLDGEVYD AVEAASLSFN RSHVDIYSAS
260 270 280 290 300
WGPDDDGKVV DGPGKLAKEA FIKGIENGRG GKGSIFVWAS GNGGSAHDSC
310 320 330 340 350
NCDGYANSIF TLSISSTSEN GIKPWYLEEC SSTLASTYSS GAYNERQIAT
360 370 380 390 400
TDLRQRCTTT HTGTSASAPL AAGIVALVLE ANRDLTWRDV QYITLMTSRS
410 420 430 440 450
DPIEDGQWIV NGVGRKVSLR YGYGLMDATE MVKLAKVWRQ VPEKHECLIT
460 470 480 490 500
SDVQNVPLAS GNKFSSQVLT NGCVGTSTEV NYLEHVQARI SLTHSQRGSV
510 520 530 540 550
VIYLTSPSGT RSKVLPARSN DVAPGGFDNW PLLSVHFWGE NPRGTWTLEI
560 570 580 590 600
EEANMYNRRS SGGKLASWSL VLHGTRVKPV RLLNETSPAT TTKTTAATTS
610 620 630 640 650
STSTTTTKKP STPKVEACHK ECAGGCTGTR PEDCNECKNF RVSSTRVCVS
660 670 680 690 700
QCPDGFYTSG DMCMPCDASC ATCSGPALTE CQSCHEGRHY HQLKDKHSVC
710 720 730 740 750
NIECVDGFFY STNSCLPCDV GCKHCESSAL HCTACRKGYS LKDDKCVSQA
760 770 780 790 800
AVVSVMFEHI TLSIVLISVI VLLVVFIFMG LLYMYRNQLF FWSDRKMYGP
810 820
VPREDEEAVV RLTYSDDFDE DFKS
Length:824
Mass (Da):90,535
Last modified:November 1, 1996 - v1
Checksum:i0145D7E14E6764E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38715 mRNA Translation: AAA73903.1
RefSeqiNP_001191402.1, NM_001204473.1
UniGeneiAcl.6114

Genome annotation databases

GeneIDi100533397

Similar proteinsi

Entry informationi

Entry nameiQ16962_APLCA
AccessioniPrimary (citable) accession number: Q16962
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health