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Q16956

- GRP78_APLCA

UniProt

Q16956 - GRP78_APLCA

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Protein

78 kDa glucose-regulated protein

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 494ATPBy similarity
Nucleotide bindingi236 – 2383ATPBy similarity
Nucleotide bindingi302 – 3098ATPBy similarity
Nucleotide bindingi373 – 3764ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Alternative name(s):
BiP
Protein 1603
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 66764578 kDa glucose-regulated proteinPRO_0000013572Add
BLAST

Proteomic databases

PRIDEiQ16956.

Structurei

3D structure databases

ProteinModelPortaliQ16956.
SMRiQ16956. Positions 38-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi664 – 6674Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16956 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRFTPFFLL VILFSSNLLV RADGDEEDEG DKKKSEVGTV IGIDLGTTYS
60 70 80 90 100
CVGVFKNGRV DIIANDQGNR ITPSYVAFTA DGERLIGDAA KNQLTSNPEN
110 120 130 140 150
TIFDVKRLIG RTFDDKSVQH DIKFYPFKVT NANNKPHIQA ATGEGDRSFA
160 170 180 190 200
PEEISAMVLS KMRDIAEEYL GKKITNAVVT VPAYFNDAQR QATKDAGTIA
210 220 230 240 250
GLNVMRIINE PTAAAIAYGL DKKEGEKNIL VFDLGGGTFD VSLLTIDNGV
260 270 280 290 300
FEVVSTNGDT HLGGEDFDQR VMEHFIKLYK KKKGKDIRKD NRAVQKLRRE
310 320 330 340 350
VEKAKRALSS AHQVRLEIES FFDGEDFSES LTRAKFEELN MDLFRSTMKP
360 370 380 390 400
VKQVLEDADL KTDDIDEIVL VGGSTRIPKV QQLVKEYFNG KEPSRGINPD
410 420 430 440 450
EAVAYGAAVQ AGVLSGEEDT GDLVLLDVNP LTMGIETVGG VMTKLIPRNT
460 470 480 490 500
VIPTKKSQIF STAADNQPTV TIQVYEGERS MTKDNHLLGK FDLTGIPPAP
510 520 530 540 550
RGVPQIEVTF EIDVNGILKV TAEDKGTGSK NQIVIQNDQN RLSPEDIERM
560 570 580 590 600
INDAEKYADE DKKVKEKVDA KNELESYAYS LKNQIGDKEK LGAKLSDEDK
610 620 630 640 650
EKITEAVDEA IKWLESNAEA ESEAFNEKKT ELEGIVQPIM TKLYEQSGGA
660
PPPSGEEESE EAEKDEL
Length:667
Mass (Da):73,698
Last modified:November 1, 1996 - v1
Checksum:iA59EC27AF188141D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z15041 mRNA. Translation: CAA78759.1.
PIRiD44261.
S24782.
RefSeqiNP_001191581.1. NM_001204652.1.
UniGeneiAcl.6214.

Genome annotation databases

GeneIDi100533358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z15041 mRNA. Translation: CAA78759.1 .
PIRi D44261.
S24782.
RefSeqi NP_001191581.1. NM_001204652.1.
UniGenei Acl.6214.

3D structure databases

ProteinModelPortali Q16956.
SMRi Q16956. Positions 38-579.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q16956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100533358.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER."
    Kuhl D., Kennedy T., Barzilai A., Kandel E.
    J. Cell Biol. 119:1069-1076(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 368-382.

Entry informationi

Entry nameiGRP78_APLCA
AccessioniPrimary (citable) accession number: Q16956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3