Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q16956 (GRP78_APLCA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein

Short name=GRP-78
Alternative name(s):
BiP
Protein 1603
OrganismAplysia californica (California sea hare)
Taxonomic identifier6500 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 66764578 kDa glucose-regulated protein
PRO_0000013572

Regions

Nucleotide binding46 – 494ATP By similarity
Nucleotide binding236 – 2383ATP By similarity
Nucleotide binding302 – 3098ATP By similarity
Nucleotide binding373 – 3764ATP By similarity
Motif664 – 6674Prevents secretion from ER

Sites

Binding site1061ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q16956 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A59EC27AF188141D

FASTA66773,698
        10         20         30         40         50         60 
MDRFTPFFLL VILFSSNLLV RADGDEEDEG DKKKSEVGTV IGIDLGTTYS CVGVFKNGRV 

        70         80         90        100        110        120 
DIIANDQGNR ITPSYVAFTA DGERLIGDAA KNQLTSNPEN TIFDVKRLIG RTFDDKSVQH 

       130        140        150        160        170        180 
DIKFYPFKVT NANNKPHIQA ATGEGDRSFA PEEISAMVLS KMRDIAEEYL GKKITNAVVT 

       190        200        210        220        230        240 
VPAYFNDAQR QATKDAGTIA GLNVMRIINE PTAAAIAYGL DKKEGEKNIL VFDLGGGTFD 

       250        260        270        280        290        300 
VSLLTIDNGV FEVVSTNGDT HLGGEDFDQR VMEHFIKLYK KKKGKDIRKD NRAVQKLRRE 

       310        320        330        340        350        360 
VEKAKRALSS AHQVRLEIES FFDGEDFSES LTRAKFEELN MDLFRSTMKP VKQVLEDADL 

       370        380        390        400        410        420 
KTDDIDEIVL VGGSTRIPKV QQLVKEYFNG KEPSRGINPD EAVAYGAAVQ AGVLSGEEDT 

       430        440        450        460        470        480 
GDLVLLDVNP LTMGIETVGG VMTKLIPRNT VIPTKKSQIF STAADNQPTV TIQVYEGERS 

       490        500        510        520        530        540 
MTKDNHLLGK FDLTGIPPAP RGVPQIEVTF EIDVNGILKV TAEDKGTGSK NQIVIQNDQN 

       550        560        570        580        590        600 
RLSPEDIERM INDAEKYADE DKKVKEKVDA KNELESYAYS LKNQIGDKEK LGAKLSDEDK 

       610        620        630        640        650        660 
EKITEAVDEA IKWLESNAEA ESEAFNEKKT ELEGIVQPIM TKLYEQSGGA PPPSGEEESE 


EAEKDEL 

« Hide

References

[1]"Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER."
Kuhl D., Kennedy T., Barzilai A., Kandel E.
J. Cell Biol. 119:1069-1076(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 368-382.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z15041 mRNA. Translation: CAA78759.1.
PIRD44261.
S24782.
RefSeqNP_001191581.1. NM_001204652.1.
UniGeneAcl.6214.

3D structure databases

ProteinModelPortalQ16956.
SMRQ16956. Positions 38-579.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ16956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100533358.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_APLCA
AccessionPrimary (citable) accession number: Q16956
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families