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Q16956

- GRP78_APLCA

UniProt

Q16956 - GRP78_APLCA

Protein

78 kDa glucose-regulated protein

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 494ATPBy similarity
    Nucleotide bindingi236 – 2383ATPBy similarity
    Nucleotide bindingi302 – 3098ATPBy similarity
    Nucleotide bindingi373 – 3764ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein
    Short name:
    GRP-78
    Alternative name(s):
    BiP
    Protein 1603
    OrganismiAplysia californica (California sea hare)
    Taxonomic identifieri6500 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 66764578 kDa glucose-regulated proteinPRO_0000013572Add
    BLAST

    Proteomic databases

    PRIDEiQ16956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16956.
    SMRiQ16956. Positions 38-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi664 – 6674Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16956-1 [UniParc]FASTAAdd to Basket

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    MDRFTPFFLL VILFSSNLLV RADGDEEDEG DKKKSEVGTV IGIDLGTTYS    50
    CVGVFKNGRV DIIANDQGNR ITPSYVAFTA DGERLIGDAA KNQLTSNPEN 100
    TIFDVKRLIG RTFDDKSVQH DIKFYPFKVT NANNKPHIQA ATGEGDRSFA 150
    PEEISAMVLS KMRDIAEEYL GKKITNAVVT VPAYFNDAQR QATKDAGTIA 200
    GLNVMRIINE PTAAAIAYGL DKKEGEKNIL VFDLGGGTFD VSLLTIDNGV 250
    FEVVSTNGDT HLGGEDFDQR VMEHFIKLYK KKKGKDIRKD NRAVQKLRRE 300
    VEKAKRALSS AHQVRLEIES FFDGEDFSES LTRAKFEELN MDLFRSTMKP 350
    VKQVLEDADL KTDDIDEIVL VGGSTRIPKV QQLVKEYFNG KEPSRGINPD 400
    EAVAYGAAVQ AGVLSGEEDT GDLVLLDVNP LTMGIETVGG VMTKLIPRNT 450
    VIPTKKSQIF STAADNQPTV TIQVYEGERS MTKDNHLLGK FDLTGIPPAP 500
    RGVPQIEVTF EIDVNGILKV TAEDKGTGSK NQIVIQNDQN RLSPEDIERM 550
    INDAEKYADE DKKVKEKVDA KNELESYAYS LKNQIGDKEK LGAKLSDEDK 600
    EKITEAVDEA IKWLESNAEA ESEAFNEKKT ELEGIVQPIM TKLYEQSGGA 650
    PPPSGEEESE EAEKDEL 667
    Length:667
    Mass (Da):73,698
    Last modified:November 1, 1996 - v1
    Checksum:iA59EC27AF188141D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z15041 mRNA. Translation: CAA78759.1.
    PIRiD44261.
    S24782.
    RefSeqiNP_001191581.1. NM_001204652.1.
    UniGeneiAcl.6214.

    Genome annotation databases

    GeneIDi100533358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z15041 mRNA. Translation: CAA78759.1 .
    PIRi D44261.
    S24782.
    RefSeqi NP_001191581.1. NM_001204652.1.
    UniGenei Acl.6214.

    3D structure databases

    ProteinModelPortali Q16956.
    SMRi Q16956. Positions 38-579.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q16956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100533358.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER."
      Kuhl D., Kennedy T., Barzilai A., Kandel E.
      J. Cell Biol. 119:1069-1076(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 368-382.

    Entry informationi

    Entry nameiGRP78_APLCA
    AccessioniPrimary (citable) accession number: Q16956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3