Q16956 (GRP78_APLCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 78 kDa glucose-regulated protein Short name=GRP-78 Alternative name(s): BiP Protein 1603
Organism	Aplysia californica (California sea hare)
Taxonomic identifier	6500 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Euopisthobranchia › Aplysiomorpha › Aplysioidea › Aplysiidae › Aplysia

Protein attributes

Sequence length	667 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular location	Endoplasmic reticulum lumen.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 667	645	78 kDa glucose-regulated protein		PRO_0000013572
Regions
	Motif	664 – 667	4	Prevents secretion from ER

Sequences

	Sequence		Length	Mass (Da)
	Q16956 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A59EC27AF188141D	FASTA	667	73,698
	10 20 30 40 50 60 MDRFTPFFLL VILFSSNLLV RADGDEEDEG DKKKSEVGTV IGIDLGTTYS CVGVFKNGRV 70 80 90 100 110 120 DIIANDQGNR ITPSYVAFTA DGERLIGDAA KNQLTSNPEN TIFDVKRLIG RTFDDKSVQH 130 140 150 160 170 180 DIKFYPFKVT NANNKPHIQA ATGEGDRSFA PEEISAMVLS KMRDIAEEYL GKKITNAVVT 190 200 210 220 230 240 VPAYFNDAQR QATKDAGTIA GLNVMRIINE PTAAAIAYGL DKKEGEKNIL VFDLGGGTFD 250 260 270 280 290 300 VSLLTIDNGV FEVVSTNGDT HLGGEDFDQR VMEHFIKLYK KKKGKDIRKD NRAVQKLRRE 310 320 330 340 350 360 VEKAKRALSS AHQVRLEIES FFDGEDFSES LTRAKFEELN MDLFRSTMKP VKQVLEDADL 370 380 390 400 410 420 KTDDIDEIVL VGGSTRIPKV QQLVKEYFNG KEPSRGINPD EAVAYGAAVQ AGVLSGEEDT 430 440 450 460 470 480 GDLVLLDVNP LTMGIETVGG VMTKLIPRNT VIPTKKSQIF STAADNQPTV TIQVYEGERS 490 500 510 520 530 540 MTKDNHLLGK FDLTGIPPAP RGVPQIEVTF EIDVNGILKV TAEDKGTGSK NQIVIQNDQN 550 560 570 580 590 600 RLSPEDIERM INDAEKYADE DKKVKEKVDA KNELESYAYS LKNQIGDKEK LGAKLSDEDK 610 620 630 640 650 660 EKITEAVDEA IKWLESNAEA ESEAFNEKKT ELEGIVQPIM TKLYEQSGGA PPPSGEEESE EAEKDEL

References

[1]

"Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER." Kuhl D., Kennedy T., Barzilai A., Kandel E. J. Cell Biol. 119:1069-1076(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 368-382.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z15041 mRNA. Translation: CAA78759.1.
PIR	D44261. S24782.
RefSeq	NP_001191581.1. NM_001204652.1.
UniGene	Acl.6214.
3D structure databases
ProteinModelPortal	Q16956.
SMR	Q16956. Positions 38-579.
ModBase	Search...
Proteomic databases
PRIDE	Q16956.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100533358.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRP78_APLCA

Accession

Primary (citable) accession number: Q16956

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)