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Protein

78 kDa glucose-regulated protein

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 49ATPBy similarity4
Nucleotide bindingi236 – 238ATPBy similarity3
Nucleotide bindingi302 – 309ATPBy similarity8
Nucleotide bindingi373 – 376ATPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Alternative name(s):
BiP
Protein 1603
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001357223 – 66778 kDa glucose-regulated proteinAdd BLAST645

Proteomic databases

PRIDEiQ16956.

Structurei

3D structure databases

ProteinModelPortaliQ16956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi664 – 667Prevents secretion from ER4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRFTPFFLL VILFSSNLLV RADGDEEDEG DKKKSEVGTV IGIDLGTTYS
60 70 80 90 100
CVGVFKNGRV DIIANDQGNR ITPSYVAFTA DGERLIGDAA KNQLTSNPEN
110 120 130 140 150
TIFDVKRLIG RTFDDKSVQH DIKFYPFKVT NANNKPHIQA ATGEGDRSFA
160 170 180 190 200
PEEISAMVLS KMRDIAEEYL GKKITNAVVT VPAYFNDAQR QATKDAGTIA
210 220 230 240 250
GLNVMRIINE PTAAAIAYGL DKKEGEKNIL VFDLGGGTFD VSLLTIDNGV
260 270 280 290 300
FEVVSTNGDT HLGGEDFDQR VMEHFIKLYK KKKGKDIRKD NRAVQKLRRE
310 320 330 340 350
VEKAKRALSS AHQVRLEIES FFDGEDFSES LTRAKFEELN MDLFRSTMKP
360 370 380 390 400
VKQVLEDADL KTDDIDEIVL VGGSTRIPKV QQLVKEYFNG KEPSRGINPD
410 420 430 440 450
EAVAYGAAVQ AGVLSGEEDT GDLVLLDVNP LTMGIETVGG VMTKLIPRNT
460 470 480 490 500
VIPTKKSQIF STAADNQPTV TIQVYEGERS MTKDNHLLGK FDLTGIPPAP
510 520 530 540 550
RGVPQIEVTF EIDVNGILKV TAEDKGTGSK NQIVIQNDQN RLSPEDIERM
560 570 580 590 600
INDAEKYADE DKKVKEKVDA KNELESYAYS LKNQIGDKEK LGAKLSDEDK
610 620 630 640 650
EKITEAVDEA IKWLESNAEA ESEAFNEKKT ELEGIVQPIM TKLYEQSGGA
660
PPPSGEEESE EAEKDEL
Length:667
Mass (Da):73,698
Last modified:November 1, 1996 - v1
Checksum:iA59EC27AF188141D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15041 mRNA. Translation: CAA78759.1.
PIRiD44261.
S24782.
RefSeqiNP_001191581.1. NM_001204652.1.
UniGeneiAcl.6214.

Genome annotation databases

GeneIDi100533358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15041 mRNA. Translation: CAA78759.1.
PIRiD44261.
S24782.
RefSeqiNP_001191581.1. NM_001204652.1.
UniGeneiAcl.6214.

3D structure databases

ProteinModelPortaliQ16956.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ16956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533358.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRP78_APLCA
AccessioniPrimary (citable) accession number: Q16956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.