Q16938 (Q16938_ANCCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Anti-coagulant protein C2 EMBL AAC47080.1
Organism	Ancylostoma caninum (Dog hookworm) EMBL AAC47080.1
Taxonomic identifier	29170 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Strongylida › Ancylostomatoidea › Ancylostomatidae › Ancylostomatinae › Ancylostoma

Protein attributes

Sequence length	91 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Signal EMBL AAC47080.1
Technical term	3D-structure PDB 2H9E PDB 1COU
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 7	›7	Potential EMBL AAC47080.1
	Chain	8 – 91	84	anti-coagulant protein C2 EMBL AAC47080.1		PRO_5000144647
Experimental info
	Non-terminal residue	1	1	EMBL AAC47080.1

Sequences

	Sequence		Length	Mass (Da)
	Q16938 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: ECB11CB4597C24DA	FASTA	91	10,358
	10 20 30 40 50 60 LVSYCSGKAT MQCGENEKYD SCGSKECDKK CKYDGVEEED DEEPNVPCLV RVCHQDCVCE 70 80 90 EGFYRNKDDK CVSAEDCELD NMDFIYPGTR N

References

[1]	"Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI." Jespers L.S., Messens J.H., De Keyser A., Eeckhout D., Van den Brande I., Gansemans Y.G., Lauwereys M.J., Vlasuk G.P., Stanssens P.E. Biotechnology (N.Y.) 13:378-382(1995) [PubMed: 9634780] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Anticoagulant repertoire of the hookworm Ancylostoma caninum." Stassens P., Bergum P.W., Gansemans Y., Jespers L., Laroche Y., Huang S., Maki S., Messens J., Lauwereys M., Cappello M., Hotez P.J., Lasters I., Vlasuk G.P. Proc. Natl. Acad. Sci. U.S.A. 93:2149-2154(1996) [PubMed: 8700900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2." Duggan B.M., Dyson H.J., Wright P.E. Eur. J. Biochem. 265:539-548(1999) [PubMed: 10504384] [Abstract] Cited for: STRUCTURE BY NMR OF 8-91.
[4]	"Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematophagous nematode Ancylostoma caninum." Murakami M.T., Rios-Steiner J., Weaver S.E., Tulinsky A., Geiger J.H., Arni R.K. J. Mol. Biol. 366:602-610(2007) [PubMed: 17173931] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 8-91.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U30793 mRNA. Translation: AAC47080.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1COU	NMR	-	A	8-91	[»]
2H9E	X-ray	2.20	C	8-91	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q16938. 2 interactions.

Protein family/group databases

MEROPS

I08.010.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR002919. Prot_Inh_CR_TIL.
[Graphical view]

Pfam

PF01826. TIL. 1 hit.
[Graphical view]

SUPFAM

SSF57567. Cysrich_TIL. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q16938_ANCCA

Accession

Primary (citable) accession number: Q16938

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	October 19, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)