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Q168P4

- GCH4_ROSDO

UniProt

Q168P4 - GCH4_ROSDO

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2251May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1832-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:RD1_1941
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367GTP cyclohydrolase FolE2PRO_0000289519Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_1941.

Structurei

3D structure databases

ProteinModelPortaliQ168P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q168P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIHTPGLEL TPDRDEAQAA LDVLRQWAKQ ATPAEISELD PSVARLVPGM
60 70 80 90 100
DGVEYPALSR EYPSDFSLDD GYKETLPDLQ NGPSSLIRGT KQQIQHVGIS
110 120 130 140 150
NFRLPIRFHT RSGGDITLET SVTGSVSLEA DKKGINMSRI MRSFYKHAEE
160 170 180 190 200
TFSFEVIEAA LDAYINDLES FDARIQMRFS FPMKVDSLRS GLSGYQYYDI
210 220 230 240 250
ALELVDQGGV RKKIMHLDYV YSSTCPCSLE LSEHARATRG QLATPHSQRS
260 270 280 290 300
VARISVEVEN DGQCLWFEDL IEACRRAVPT ETQVMVKRED EQAFAELNAA
310 320 330 340 350
NPIFVEDAAR LFCEQLHSDT RIGDFRVIAS HQESLHSHDA VSVLMEGETF
360
KSESLDPKLF NTLFHVG
Length:367
Mass (Da):41,167
Last modified:May 29, 2007 - v2
Checksum:i7D3964D00E10495F
GO

Sequence cautioni

The sequence ABG31549.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG31549.1. Different initiation.
RefSeqiYP_682235.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG31549; ABG31549; RD1_1941.
GeneIDi4196802.
KEGGirde:RD1_1941.
PATRICi23361949. VBIRosDen86677_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG31549.1 . Different initiation.
RefSeqi YP_682235.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q168P4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_1941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG31549 ; ABG31549 ; RD1_1941 .
GeneIDi 4196802.
KEGGi rde:RD1_1941.
PATRICi 23361949. VBIRosDen86677_1862.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci RDEN375451:GJIZ-1832-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiGCH4_ROSDO
AccessioniPrimary (citable) accession number: Q168P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3