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Q168P4

- GCH4_ROSDO

UniProt

Q168P4 - GCH4_ROSDO

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2251May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-1832-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:RD1_1941
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367GTP cyclohydrolase FolE2PRO_0000289519Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_1941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ168P4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q168P4-1 [UniParc]FASTAAdd to Basket

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    MNIHTPGLEL TPDRDEAQAA LDVLRQWAKQ ATPAEISELD PSVARLVPGM    50
    DGVEYPALSR EYPSDFSLDD GYKETLPDLQ NGPSSLIRGT KQQIQHVGIS 100
    NFRLPIRFHT RSGGDITLET SVTGSVSLEA DKKGINMSRI MRSFYKHAEE 150
    TFSFEVIEAA LDAYINDLES FDARIQMRFS FPMKVDSLRS GLSGYQYYDI 200
    ALELVDQGGV RKKIMHLDYV YSSTCPCSLE LSEHARATRG QLATPHSQRS 250
    VARISVEVEN DGQCLWFEDL IEACRRAVPT ETQVMVKRED EQAFAELNAA 300
    NPIFVEDAAR LFCEQLHSDT RIGDFRVIAS HQESLHSHDA VSVLMEGETF 350
    KSESLDPKLF NTLFHVG 367
    Length:367
    Mass (Da):41,167
    Last modified:May 29, 2007 - v2
    Checksum:i7D3964D00E10495F
    GO

    Sequence cautioni

    The sequence ABG31549.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31549.1. Different initiation.
    RefSeqiYP_682235.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG31549; ABG31549; RD1_1941.
    GeneIDi4196802.
    KEGGirde:RD1_1941.
    PATRICi23361949. VBIRosDen86677_1862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31549.1 . Different initiation.
    RefSeqi YP_682235.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q168P4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_1941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG31549 ; ABG31549 ; RD1_1941 .
    GeneIDi 4196802.
    KEGGi rde:RD1_1941.
    PATRICi 23361949. VBIRosDen86677_1862.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci RDEN375451:GJIZ-1832-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiGCH4_ROSDO
    AccessioniPrimary (citable) accession number: Q168P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3