Q168P4 (GCH4_ROSDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	RD1_1941

Organism

Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans) [Complete proteome] [HAMAP]

Taxonomic identifier

375451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Roseobacter › Roseobacter denitrificans

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.
Sequence caution	The sequence ABG31549.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000289519
Sites
	Site	225	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q168P4 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: 7D3964D00E10495F	FASTA	367	41,167
	10 20 30 40 50 60 MNIHTPGLEL TPDRDEAQAA LDVLRQWAKQ ATPAEISELD PSVARLVPGM DGVEYPALSR 70 80 90 100 110 120 EYPSDFSLDD GYKETLPDLQ NGPSSLIRGT KQQIQHVGIS NFRLPIRFHT RSGGDITLET 130 140 150 160 170 180 SVTGSVSLEA DKKGINMSRI MRSFYKHAEE TFSFEVIEAA LDAYINDLES FDARIQMRFS 190 200 210 220 230 240 FPMKVDSLRS GLSGYQYYDI ALELVDQGGV RKKIMHLDYV YSSTCPCSLE LSEHARATRG 250 260 270 280 290 300 QLATPHSQRS VARISVEVEN DGQCLWFEDL IEACRRAVPT ETQVMVKRED EQAFAELNAA 310 320 330 340 350 360 NPIFVEDAAR LFCEQLHSDT RIGDFRVIAS HQESLHSHDA VSVLMEGETF KSESLDPKLF NTLFHVG

References

[1]

"The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism." Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H., Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K., O'Huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T., Touchman J.W. J. Bacteriol. 189:683-690(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33942 / OCh 114.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000362 Genomic DNA. Translation: ABG31549.1. Different initiation.
RefSeq	YP_682235.1. NC_008209.1.
3D structure databases
ProteinModelPortal	Q168P4.
ModBase	Search...
Protein-protein interaction databases
STRING	375451.RD1_1941.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG31549; ABG31549; RD1_1941.
GeneID	4196802.
KEGG	rde:RD1_1941.
PATRIC	23361949. VBIRosDen86677_1862.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	RDEN375451:GJIZ-1832-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_ROSDO

Accession

Primary (citable) accession number: Q168P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program