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Q168P4

- GCH4_ROSDO

UniProt

Q168P4 - GCH4_ROSDO

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, RD1_1941
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2251May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-1832-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:RD1_1941
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367GTP cyclohydrolase FolE2UniRule annotationPRO_0000289519Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_1941.

Structurei

3D structure databases

ProteinModelPortaliQ168P4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q168P4-1 [UniParc]FASTAAdd to Basket

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MNIHTPGLEL TPDRDEAQAA LDVLRQWAKQ ATPAEISELD PSVARLVPGM    50
DGVEYPALSR EYPSDFSLDD GYKETLPDLQ NGPSSLIRGT KQQIQHVGIS 100
NFRLPIRFHT RSGGDITLET SVTGSVSLEA DKKGINMSRI MRSFYKHAEE 150
TFSFEVIEAA LDAYINDLES FDARIQMRFS FPMKVDSLRS GLSGYQYYDI 200
ALELVDQGGV RKKIMHLDYV YSSTCPCSLE LSEHARATRG QLATPHSQRS 250
VARISVEVEN DGQCLWFEDL IEACRRAVPT ETQVMVKRED EQAFAELNAA 300
NPIFVEDAAR LFCEQLHSDT RIGDFRVIAS HQESLHSHDA VSVLMEGETF 350
KSESLDPKLF NTLFHVG 367
Length:367
Mass (Da):41,167
Last modified:May 29, 2007 - v2
Checksum:i7D3964D00E10495F
GO

Sequence cautioni

The sequence ABG31549.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG31549.1. Different initiation.
RefSeqiYP_682235.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG31549; ABG31549; RD1_1941.
GeneIDi4196802.
KEGGirde:RD1_1941.
PATRICi23361949. VBIRosDen86677_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG31549.1 . Different initiation.
RefSeqi YP_682235.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q168P4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_1941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG31549 ; ABG31549 ; RD1_1941 .
GeneIDi 4196802.
KEGGi rde:RD1_1941.
PATRICi 23361949. VBIRosDen86677_1862.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci RDEN375451:GJIZ-1832-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiGCH4_ROSDO
AccessioniPrimary (citable) accession number: Q168P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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