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Q16891

- MIC60_HUMAN

UniProt

Q16891 - MIC60_HUMAN

Protein

MICOS complex subunit MIC60

Gene

IMMT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. mitochondrial calcium ion homeostasis Source: Ensembl
    2. response to cold Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MICOS complex subunit MIC60
    Alternative name(s):
    Cell proliferation-inducing gene 4/52 protein
    Mitochondrial inner membrane protein
    Mitofilin
    p87/89
    Gene namesi
    Name:IMMT
    Synonyms:HMP, MIC60, MINOS2
    ORF Names:PIG4, PIG52
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6047. IMMT.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. mitochondrial inner membrane Source: UniProtKB
    4. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 758725MICOS complex subunit MIC60PRO_0000084184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei211 – 2111N6-acetyllysine1 Publication
    Modified residuei222 – 2221N6-acetyllysine1 Publication
    Modified residuei451 – 4511N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ16891.
    PaxDbiQ16891.
    PRIDEiQ16891.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00554469.
    Q16891.

    PTM databases

    PhosphoSiteiQ16891.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16891.
    BgeeiQ16891.
    GenevestigatoriQ16891.

    Organism-specific databases

    HPAiCAB022439.
    HPA036164.
    HPA036165.

    Interactioni

    Subunit structurei

    Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form By similarity. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KDM1AO603412EBI-473801,EBI-710124

    Protein-protein interaction databases

    BioGridi116185. 88 interactions.
    DIPiDIP-32517N.
    IntActiQ16891. 69 interactions.
    MINTiMINT-1034498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16891.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 4512Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini65 – 758694Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6419HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MICOS complex subunit Mic60 family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307662.
    HOVERGENiHBG039233.
    InParanoidiQ16891.
    KOiK17785.
    OMAiQKQKGDT.
    PhylomeDBiQ16891.
    TreeFamiTF312832.

    Family and domain databases

    InterProiIPR019133. Mt-IM_prot_Mitofilin.
    [Graphical view]
    PfamiPF09731. Mitofilin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16891-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG    50
    LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP 100
    KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT APTEAAQIIS 150
    AAGDTLSVPA PAVQPEESLK TDHPEIGEGK PTPALSEEAS SSSIRERPPE 200
    EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA AQNAAVQAVN 250
    AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE 300
    ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS 350
    EAKVVSQYHE LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD 400
    LNSLIAHAHR RIDQLNRELA EQKATEKQHI TLALEKQKLE EKRAFDSAVA 450
    KALEHHRSEI QAEQDRKIEE VRDAMENEMR TQLRRQAAAH TDHLRDVLRV 500
    QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN TAYARLRGIE 550
    QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK 600
    ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE 650
    TRNSLYQYFL SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH 700
    GDLELAAKFV NQLKGESRRV AQDWLKEARM TLETKQIVEI LTAYASAVGI 750
    GTTQVQPE 758
    Length:758
    Mass (Da):83,678
    Last modified:November 1, 1996 - v1
    Checksum:i357F25DCABB02E50
    GO
    Isoform 2 (identifier: Q16891-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-152: Missing.

    Show »
    Length:747
    Mass (Da):82,625
    Checksum:i93538DAF3109239E
    GO
    Isoform 3 (identifier: Q16891-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-219: EEASSSSIRERPPEEVAARLAQQEKQEQVKIES → A

    Show »
    Length:726
    Mass (Da):80,027
    Checksum:iA5125F3BA3333D1E
    GO
    Isoform 4 (identifier: Q16891-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         188-188: Missing.

    Show »
    Length:757
    Mass (Da):83,549
    Checksum:i3481C463522B8DDB
    GO

    Sequence cautioni

    The sequence CAH18389.1 differs from that shown. Reason: Erroneous termination at position 759. Translated as stop.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1518EAAQIISA → ARAPASLT in AAF73126. 1 PublicationCurated
    Sequence conflicti151 – 1511A → S in CAG33074. 1 PublicationCurated
    Sequence conflicti154 – 1541D → E in BAG35183. (PubMed:14702039)Curated
    Sequence conflicti173 – 1731H → Y in AAF73126. 1 PublicationCurated
    Sequence conflicti312 – 3121A → T in AAF73126. 1 PublicationCurated
    Sequence conflicti325 – 3251T → S in AAF73126. 1 PublicationCurated
    Sequence conflicti388 – 3936SVSDLA → T in AAF73126. 1 PublicationCurated
    Sequence conflicti432 – 4321L → S in CAH18389. (PubMed:17974005)Curated
    Sequence conflicti449 – 4491V → A in CAH18389. (PubMed:17974005)Curated
    Sequence conflicti731 – 7311T → A in CAH18389. (PubMed:17974005)Curated
    Sequence conflicti758 – 7581E → D in CAG33074. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti124 – 1241P → S.2 Publications
    Corresponds to variant rs6750289 [ dbSNP | Ensembl ].
    VAR_021530
    Natural varianti294 – 2941A → V.
    Corresponds to variant rs35233009 [ dbSNP | Ensembl ].
    VAR_051068

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei142 – 15211Missing in isoform 2. 1 PublicationVSP_013220Add
    BLAST
    Alternative sequencei187 – 21933EEASS…VKIES → A in isoform 3. 1 PublicationVSP_013221Add
    BLAST
    Alternative sequencei188 – 1881Missing in isoform 4. 1 PublicationVSP_047362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21091 mRNA. Translation: BAA04653.1.
    D21092 mRNA. Translation: BAA04654.1.
    D21093 mRNA. Translation: BAA04655.1.
    D21094 mRNA. Translation: BAA04656.1.
    L42572 mRNA. Translation: AAA85336.1.
    CR456793 mRNA. Translation: CAG33074.1.
    AK312251 mRNA. Translation: BAG35183.1.
    AY232292 mRNA. Translation: AAP69987.1.
    AY921637 mRNA. Translation: AAX10024.1.
    BX537369 mRNA. Translation: CAD97612.1.
    CR749590 mRNA. Translation: CAH18389.1. Different termination.
    BC002412 mRNA. Translation: AAH02412.1.
    BC027458 mRNA. Translation: AAH27458.1.
    AF148646 mRNA. Translation: AAF73126.1.
    CCDSiCCDS46355.1. [Q16891-1]
    CCDS46356.1. [Q16891-4]
    CCDS46357.1. [Q16891-2]
    RefSeqiNP_001093639.1. NM_001100169.1. [Q16891-4]
    NP_001093640.1. NM_001100170.1. [Q16891-2]
    NP_006830.2. NM_006839.2. [Q16891-1]
    XP_005264170.1. XM_005264113.1. [Q16891-3]
    UniGeneiHs.148559.

    Genome annotation databases

    EnsembliENST00000410111; ENSP00000387262; ENSG00000132305. [Q16891-1]
    ENST00000442664; ENSP00000407788; ENSG00000132305. [Q16891-4]
    ENST00000449247; ENSP00000396899; ENSG00000132305. [Q16891-2]
    GeneIDi10989.
    KEGGihsa:10989.
    UCSCiuc002sqy.4. human. [Q16891-1]
    uc002srb.4. human. [Q16891-2]

    Polymorphism databases

    DMDMi29427676.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21091 mRNA. Translation: BAA04653.1 .
    D21092 mRNA. Translation: BAA04654.1 .
    D21093 mRNA. Translation: BAA04655.1 .
    D21094 mRNA. Translation: BAA04656.1 .
    L42572 mRNA. Translation: AAA85336.1 .
    CR456793 mRNA. Translation: CAG33074.1 .
    AK312251 mRNA. Translation: BAG35183.1 .
    AY232292 mRNA. Translation: AAP69987.1 .
    AY921637 mRNA. Translation: AAX10024.1 .
    BX537369 mRNA. Translation: CAD97612.1 .
    CR749590 mRNA. Translation: CAH18389.1 . Different termination.
    BC002412 mRNA. Translation: AAH02412.1 .
    BC027458 mRNA. Translation: AAH27458.1 .
    AF148646 mRNA. Translation: AAF73126.1 .
    CCDSi CCDS46355.1. [Q16891-1 ]
    CCDS46356.1. [Q16891-4 ]
    CCDS46357.1. [Q16891-2 ]
    RefSeqi NP_001093639.1. NM_001100169.1. [Q16891-4 ]
    NP_001093640.1. NM_001100170.1. [Q16891-2 ]
    NP_006830.2. NM_006839.2. [Q16891-1 ]
    XP_005264170.1. XM_005264113.1. [Q16891-3 ]
    UniGenei Hs.148559.

    3D structure databases

    ProteinModelPortali Q16891.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116185. 88 interactions.
    DIPi DIP-32517N.
    IntActi Q16891. 69 interactions.
    MINTi MINT-1034498.

    PTM databases

    PhosphoSitei Q16891.

    Polymorphism databases

    DMDMi 29427676.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00554469.
    Q16891.

    Proteomic databases

    MaxQBi Q16891.
    PaxDbi Q16891.
    PRIDEi Q16891.

    Protocols and materials databases

    DNASUi 10989.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000410111 ; ENSP00000387262 ; ENSG00000132305 . [Q16891-1 ]
    ENST00000442664 ; ENSP00000407788 ; ENSG00000132305 . [Q16891-4 ]
    ENST00000449247 ; ENSP00000396899 ; ENSG00000132305 . [Q16891-2 ]
    GeneIDi 10989.
    KEGGi hsa:10989.
    UCSCi uc002sqy.4. human. [Q16891-1 ]
    uc002srb.4. human. [Q16891-2 ]

    Organism-specific databases

    CTDi 10989.
    GeneCardsi GC02M086282.
    HGNCi HGNC:6047. IMMT.
    HPAi CAB022439.
    HPA036164.
    HPA036165.
    MIMi 600378. gene.
    neXtProti NX_Q16891.
    PharmGKBi PA29858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307662.
    HOVERGENi HBG039233.
    InParanoidi Q16891.
    KOi K17785.
    OMAi QKQKGDT.
    PhylomeDBi Q16891.
    TreeFami TF312832.

    Miscellaneous databases

    ChiTaRSi IMMT. human.
    GeneWikii IMMT.
    GenomeRNAii 10989.
    NextBioi 41751.
    PROi Q16891.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16891.
    Bgeei Q16891.
    Genevestigatori Q16891.

    Family and domain databases

    InterProi IPR019133. Mt-IM_prot_Mitofilin.
    [Graphical view ]
    Pfami PF09731. Mitofilin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human gene that is preferentially transcribed in heart muscle."
      Icho T., Ikeda T., Matsumoto Y., Hanaoka F., Kaji K., Tsuchida N.
      Gene 144:301-306(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms."
      Gieffers C., Korioth F., Heimann P., Ungermann C., Frey J.
      Exp. Cell Res. 232:395-399(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-124.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Identification of a human cell proliferation gene."
      Kim J.W., Kim H.K., Shin S.M.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-758 (ISOFORM 3), VARIANT SER-124.
      Tissue: Colon endothelium and Fetal liver.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix and Muscle.
    8. Bienvenut W.V.
      Submitted (APR-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 85-101; 103-119; 123-130; 171-195; 223-229; 258-269; 287-297; 316-343; 345-366; 386-395; 428-436; 500-525; 548-564; 582-600; 624-632; 645-652 AND 720-726, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    9. "Detection of membrane-associated proteins using serum of mice immunized with membrane fractions of breast carcinoma cells."
      Weidenmueller U., Tur M.K., Tawadros S., Engert A., Barth S.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-758 (ISOFORM 1).
      Tissue: Mammary carcinoma.
    10. Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 354-366; 372-385; 517-525; 527-545; 548-564 AND 601-623, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
    11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-211; LYS-222 AND LYS-451, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function."
      Darshi M., Mendiola V.L., Mackey M.R., Murphy A.N., Koller A., Perkins G.A., Ellisman M.H., Taylor S.S.
      J. Biol. Chem. 286:2918-2932(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CHCHD3 AND OPA1.
    14. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
      Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
      Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MICOS COMPLEX, FUNCTION.
    15. "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."
      An J., Shi J., He Q., Lui K., Liu Y., Huang Y., Sheikh M.S.
      J. Biol. Chem. 287:7411-7426(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CHCHD6.
    16. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMIC60_HUMAN
    AccessioniPrimary (citable) accession number: Q16891
    Secondary accession number(s): B1H0U5
    , B2R5N6, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3