Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MICOS complex subunit MIC60

Gene

IMMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC60
Alternative name(s):
Cell proliferation-inducing gene 4/52 protein
Mitochondrial inner membrane protein
Mitofilin
p87/89
Gene namesi
Name:IMMT
Synonyms:HMP, MIC60, MINOS2
ORF Names:PIG4, PIG52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6047. IMMT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 4512Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei46 – 6419HelicalSequence AnalysisAdd
BLAST
Topological domaini65 – 758694Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29858.

Polymorphism and mutation databases

BioMutaiIMMT.
DMDMi29427676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 758725MICOS complex subunit MIC60PRO_0000084184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031Phosphoserine1 Publication
Modified residuei211 – 2111N6-acetyllysine1 Publication
Modified residuei222 – 2221N6-acetyllysine1 Publication
Modified residuei390 – 3901Phosphoserine1 Publication
Modified residuei451 – 4511N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ16891.
PaxDbiQ16891.
PRIDEiQ16891.

2D gel databases

REPRODUCTION-2DPAGEIPI00554469.
Q16891.

PTM databases

PhosphoSiteiQ16891.

Expressioni

Gene expression databases

BgeeiQ16891.
ExpressionAtlasiQ16891. baseline and differential.
GenevisibleiQ16891. HS.

Organism-specific databases

HPAiCAB022439.
HPA036164.
HPA036165.

Interactioni

Subunit structurei

Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-473801,EBI-710124

Protein-protein interaction databases

BioGridi116185. 95 interactions.
DIPiDIP-32517N.
IntActiQ16891. 70 interactions.
MINTiMINT-1034498.

Structurei

3D structure databases

ProteinModelPortaliQ16891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic60 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307662.
GeneTreeiENSGT00390000002313.
HOVERGENiHBG039233.
InParanoidiQ16891.
KOiK17785.
OMAiYDILNRA.
PhylomeDBiQ16891.
TreeFamiTF312832.

Family and domain databases

InterProiIPR019133. Mt-IM_prot_Mitofilin.
[Graphical view]
PfamiPF09731. Mitofilin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16891-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG
60 70 80 90 100
LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP
110 120 130 140 150
KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT APTEAAQIIS
160 170 180 190 200
AAGDTLSVPA PAVQPEESLK TDHPEIGEGK PTPALSEEAS SSSIRERPPE
210 220 230 240 250
EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA AQNAAVQAVN
260 270 280 290 300
AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
310 320 330 340 350
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS
360 370 380 390 400
EAKVVSQYHE LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD
410 420 430 440 450
LNSLIAHAHR RIDQLNRELA EQKATEKQHI TLALEKQKLE EKRAFDSAVA
460 470 480 490 500
KALEHHRSEI QAEQDRKIEE VRDAMENEMR TQLRRQAAAH TDHLRDVLRV
510 520 530 540 550
QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN TAYARLRGIE
560 570 580 590 600
QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
610 620 630 640 650
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE
660 670 680 690 700
TRNSLYQYFL SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH
710 720 730 740 750
GDLELAAKFV NQLKGESRRV AQDWLKEARM TLETKQIVEI LTAYASAVGI

GTTQVQPE
Length:758
Mass (Da):83,678
Last modified:November 1, 1996 - v1
Checksum:i357F25DCABB02E50
GO
Isoform 2 (identifier: Q16891-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: Missing.

Show »
Length:747
Mass (Da):82,625
Checksum:i93538DAF3109239E
GO
Isoform 3 (identifier: Q16891-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-219: EEASSSSIRERPPEEVAARLAQQEKQEQVKIES → A

Show »
Length:726
Mass (Da):80,027
Checksum:iA5125F3BA3333D1E
GO
Isoform 4 (identifier: Q16891-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-188: Missing.

Show »
Length:757
Mass (Da):83,549
Checksum:i3481C463522B8DDB
GO

Sequence cautioni

The sequence CAH18389.1 differs from that shown. Reason: Erroneous termination at position 759. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1518EAAQIISA → ARAPASLT in AAF73126 (Ref. 9) Curated
Sequence conflicti151 – 1511A → S in CAG33074 (Ref. 3) Curated
Sequence conflicti154 – 1541D → E in BAG35183 (PubMed:14702039).Curated
Sequence conflicti173 – 1731H → Y in AAF73126 (Ref. 9) Curated
Sequence conflicti312 – 3121A → T in AAF73126 (Ref. 9) Curated
Sequence conflicti325 – 3251T → S in AAF73126 (Ref. 9) Curated
Sequence conflicti388 – 3936SVSDLA → T in AAF73126 (Ref. 9) Curated
Sequence conflicti432 – 4321L → S in CAH18389 (PubMed:17974005).Curated
Sequence conflicti449 – 4491V → A in CAH18389 (PubMed:17974005).Curated
Sequence conflicti731 – 7311T → A in CAH18389 (PubMed:17974005).Curated
Sequence conflicti758 – 7581E → D in CAG33074 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241P → S.2 Publications
Corresponds to variant rs6750289 [ dbSNP | Ensembl ].
VAR_021530
Natural varianti294 – 2941A → V.
Corresponds to variant rs35233009 [ dbSNP | Ensembl ].
VAR_051068

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 15211Missing in isoform 2. 1 PublicationVSP_013220Add
BLAST
Alternative sequencei187 – 21933EEASS…VKIES → A in isoform 3. 1 PublicationVSP_013221Add
BLAST
Alternative sequencei188 – 1881Missing in isoform 4. 1 PublicationVSP_047362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21091 mRNA. Translation: BAA04653.1.
D21092 mRNA. Translation: BAA04654.1.
D21093 mRNA. Translation: BAA04655.1.
D21094 mRNA. Translation: BAA04656.1.
L42572 mRNA. Translation: AAA85336.1.
CR456793 mRNA. Translation: CAG33074.1.
AK312251 mRNA. Translation: BAG35183.1.
AY232292 mRNA. Translation: AAP69987.1.
AY921637 mRNA. Translation: AAX10024.1.
BX537369 mRNA. Translation: CAD97612.1.
CR749590 mRNA. Translation: CAH18389.1. Different termination.
BC002412 mRNA. Translation: AAH02412.1.
BC027458 mRNA. Translation: AAH27458.1.
AF148646 mRNA. Translation: AAF73126.1.
CCDSiCCDS46355.1. [Q16891-1]
CCDS46356.1. [Q16891-4]
CCDS46357.1. [Q16891-2]
RefSeqiNP_001093639.1. NM_001100169.1. [Q16891-4]
NP_001093640.1. NM_001100170.1. [Q16891-2]
NP_006830.2. NM_006839.2. [Q16891-1]
XP_005264170.1. XM_005264113.1. [Q16891-3]
UniGeneiHs.148559.

Genome annotation databases

EnsembliENST00000410111; ENSP00000387262; ENSG00000132305. [Q16891-1]
ENST00000442664; ENSP00000407788; ENSG00000132305. [Q16891-4]
ENST00000449247; ENSP00000396899; ENSG00000132305. [Q16891-2]
GeneIDi10989.
KEGGihsa:10989.
UCSCiuc002sqy.4. human. [Q16891-1]
uc002srb.4. human. [Q16891-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21091 mRNA. Translation: BAA04653.1.
D21092 mRNA. Translation: BAA04654.1.
D21093 mRNA. Translation: BAA04655.1.
D21094 mRNA. Translation: BAA04656.1.
L42572 mRNA. Translation: AAA85336.1.
CR456793 mRNA. Translation: CAG33074.1.
AK312251 mRNA. Translation: BAG35183.1.
AY232292 mRNA. Translation: AAP69987.1.
AY921637 mRNA. Translation: AAX10024.1.
BX537369 mRNA. Translation: CAD97612.1.
CR749590 mRNA. Translation: CAH18389.1. Different termination.
BC002412 mRNA. Translation: AAH02412.1.
BC027458 mRNA. Translation: AAH27458.1.
AF148646 mRNA. Translation: AAF73126.1.
CCDSiCCDS46355.1. [Q16891-1]
CCDS46356.1. [Q16891-4]
CCDS46357.1. [Q16891-2]
RefSeqiNP_001093639.1. NM_001100169.1. [Q16891-4]
NP_001093640.1. NM_001100170.1. [Q16891-2]
NP_006830.2. NM_006839.2. [Q16891-1]
XP_005264170.1. XM_005264113.1. [Q16891-3]
UniGeneiHs.148559.

3D structure databases

ProteinModelPortaliQ16891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116185. 95 interactions.
DIPiDIP-32517N.
IntActiQ16891. 70 interactions.
MINTiMINT-1034498.

PTM databases

PhosphoSiteiQ16891.

Polymorphism and mutation databases

BioMutaiIMMT.
DMDMi29427676.

2D gel databases

REPRODUCTION-2DPAGEIPI00554469.
Q16891.

Proteomic databases

MaxQBiQ16891.
PaxDbiQ16891.
PRIDEiQ16891.

Protocols and materials databases

DNASUi10989.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000410111; ENSP00000387262; ENSG00000132305. [Q16891-1]
ENST00000442664; ENSP00000407788; ENSG00000132305. [Q16891-4]
ENST00000449247; ENSP00000396899; ENSG00000132305. [Q16891-2]
GeneIDi10989.
KEGGihsa:10989.
UCSCiuc002sqy.4. human. [Q16891-1]
uc002srb.4. human. [Q16891-2]

Organism-specific databases

CTDi10989.
GeneCardsiGC02M086282.
HGNCiHGNC:6047. IMMT.
HPAiCAB022439.
HPA036164.
HPA036165.
MIMi600378. gene.
neXtProtiNX_Q16891.
PharmGKBiPA29858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307662.
GeneTreeiENSGT00390000002313.
HOVERGENiHBG039233.
InParanoidiQ16891.
KOiK17785.
OMAiYDILNRA.
PhylomeDBiQ16891.
TreeFamiTF312832.

Miscellaneous databases

ChiTaRSiIMMT. human.
GeneWikiiIMMT.
GenomeRNAii10989.
NextBioi41751.
PROiQ16891.
SOURCEiSearch...

Gene expression databases

BgeeiQ16891.
ExpressionAtlasiQ16891. baseline and differential.
GenevisibleiQ16891. HS.

Family and domain databases

InterProiIPR019133. Mt-IM_prot_Mitofilin.
[Graphical view]
PfamiPF09731. Mitofilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene that is preferentially transcribed in heart muscle."
    Icho T., Ikeda T., Matsumoto Y., Hanaoka F., Kaji K., Tsuchida N.
    Gene 144:301-306(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms."
    Gieffers C., Korioth F., Heimann P., Ungermann C., Frey J.
    Exp. Cell Res. 232:395-399(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-124.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Identification of a human cell proliferation gene."
    Kim J.W., Kim H.K., Shin S.M.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-758 (ISOFORM 3), VARIANT SER-124.
    Tissue: Colon endothelium and Fetal liver.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix and Muscle.
  8. Bienvenut W.V.
    Submitted (APR-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 85-101; 103-119; 123-130; 171-195; 223-229; 258-269; 287-297; 316-343; 345-366; 386-395; 428-436; 500-525; 548-564; 582-600; 624-632; 645-652 AND 720-726, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  9. "Detection of membrane-associated proteins using serum of mice immunized with membrane fractions of breast carcinoma cells."
    Weidenmueller U., Tur M.K., Tawadros S., Engert A., Barth S.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-758 (ISOFORM 1).
    Tissue: Mammary carcinoma.
  10. Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 354-366; 372-385; 517-525; 527-545; 548-564 AND 601-623, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-211; LYS-222 AND LYS-451, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function."
    Darshi M., Mendiola V.L., Mackey M.R., Murphy A.N., Koller A., Perkins G.A., Ellisman M.H., Taylor S.S.
    J. Biol. Chem. 286:2918-2932(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHCHD3 AND OPA1.
  14. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
    Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
    Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, FUNCTION.
  15. "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."
    An J., Shi J., He Q., Lui K., Liu Y., Huang Y., Sheikh M.S.
    J. Biol. Chem. 287:7411-7426(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHCHD6.
  16. Cited for: NOMENCLATURE.
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMIC60_HUMAN
AccessioniPrimary (citable) accession number: Q16891
Secondary accession number(s): B1H0U5
, B2R5N6, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.