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Protein

Tumor protein D53

Gene

TPD52L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of apoptotic signaling pathway Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • positive regulation of MAP kinase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D53
Short name:
hD53
Alternative name(s):
Tumor protein D52-like 1
Gene namesi
Name:TPD52L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12006. TPD52L1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36687.

Polymorphism and mutation databases

BioMutaiTPD52L1.
DMDMi12585368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Tumor protein D53PRO_0000185741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineCombined sources
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei131 – 1311PhosphoserineCombined sources
Modified residuei146 – 1461PhosphothreonineCombined sources
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei174 – 1741PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16890.
MaxQBiQ16890.
PaxDbiQ16890.
PeptideAtlasiQ16890.
PRIDEiQ16890.
TopDownProteomicsiQ16890-3. [Q16890-3]

PTM databases

iPTMnetiQ16890.
PhosphoSiteiQ16890.

Expressioni

Gene expression databases

BgeeiENSG00000111907.
CleanExiHS_TPD52L1.
ExpressionAtlasiQ16890. baseline and differential.
GenevisibleiQ16890. HS.

Organism-specific databases

HPAiHPA027915.
HPA027916.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-717470,EBI-717470
TPD52P553273EBI-717470,EBI-782581
Tpd52Q623933EBI-717470,EBI-782591From a different organism.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi113017. 19 interactions.
IntActiQ16890. 12 interactions.
MINTiMINT-273476.
STRINGi9606.ENSP00000434142.

Structurei

3D structure databases

ProteinModelPortaliQ16890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili22 – 7352Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4010. Eukaryota.
ENOG4111M9H. LUCA.
GeneTreeiENSGT00390000015988.
HOVERGENiHBG058643.
InParanoidiQ16890.
PhylomeDBiQ16890.
TreeFamiTF317562.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16890-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI
60 70 80 90 100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH
110 120 130 140 150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF
160 170 180 190 200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE

ELQC
Length:204
Mass (Da):22,449
Last modified:November 1, 1996 - v1
Checksum:i6B3C336D5C0653C9
GO
Isoform 2 (identifier: Q16890-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-144: NS → RK
     145-204: Missing.

Show »
Length:144
Mass (Da):16,176
Checksum:iA1CEF878A98BAA63
GO
Isoform 3 (identifier: Q16890-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:131
Mass (Da):14,715
Checksum:iACBE38AD88FC4F52
GO
Isoform 4 (identifier: Q16890-4) [UniParc]FASTAAdd to basket
Also known as: +5hD53

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:102
Mass (Da):11,721
Checksum:iA2427192E12E4E62
GO
Isoform 5 (identifier: Q16890-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available. Gene prediction based of partial mRNA data.
Show »
Length:175
Mass (Da):19,456
Checksum:i55A40A9DE99E9B00
GO

Sequence cautioni

The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741N → T in BAF84576 (PubMed:14702039).Curated
Sequence conflicti107 – 1071G → E in BAF84561 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621R → K.
Corresponds to variant rs6905231 [ dbSNP | Ensembl ].
VAR_034568

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 4 and isoform 5. 1 PublicationVSP_036751Add
BLAST
Alternative sequencei129 – 1313SYS → RRK in isoform 3 and isoform 4. 3 PublicationsVSP_036752
Alternative sequencei132 – 20473Missing in isoform 3 and isoform 4. 3 PublicationsVSP_036753Add
BLAST
Alternative sequencei143 – 1442NS → RK in isoform 2. 1 PublicationVSP_036754
Alternative sequencei145 – 20460Missing in isoform 2. 1 PublicationVSP_036755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA. Translation: AAB40894.1.
U44428 mRNA. Translation: AAB40895.1.
AF004427 mRNA. Translation: AAC98475.1. Different initiation.
AF208012 mRNA. Translation: AAG49634.1.
AK291866 mRNA. Translation: BAF84555.1.
AK291872 mRNA. Translation: BAF84561.1.
AK291887 mRNA. Translation: BAF84576.1.
AL121938 Genomic DNA. Translation: CAI19645.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19649.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23004.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19647.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19648.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23002.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23003.1.
CH471051 Genomic DNA. Translation: EAW48142.1.
BC002375 mRNA. Translation: AAH02375.1.
CCDSiCCDS34527.1. [Q16890-2]
CCDS34528.1. [Q16890-3]
CCDS43502.1. [Q16890-5]
CCDS5130.1. [Q16890-1]
CCDS75514.1. [Q16890-4]
RefSeqiNP_001003395.1. NM_001003395.2. [Q16890-5]
NP_001003396.1. NM_001003396.2. [Q16890-2]
NP_001003397.1. NM_001003397.2. [Q16890-3]
NP_003278.1. NM_003287.3. [Q16890-1]
XP_005267179.1. XM_005267122.2. [Q16890-5]
UniGeneiHs.591347.

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907. [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907. [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907. [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907. [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907. [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907. [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907. [Q16890-4]
GeneIDi7164.
KEGGihsa:7164.
UCSCiuc003pzu.2. human. [Q16890-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA. Translation: AAB40894.1.
U44428 mRNA. Translation: AAB40895.1.
AF004427 mRNA. Translation: AAC98475.1. Different initiation.
AF208012 mRNA. Translation: AAG49634.1.
AK291866 mRNA. Translation: BAF84555.1.
AK291872 mRNA. Translation: BAF84561.1.
AK291887 mRNA. Translation: BAF84576.1.
AL121938 Genomic DNA. Translation: CAI19645.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19649.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23004.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19647.1.
AL121938, AL136128 Genomic DNA. Translation: CAI19648.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23002.1.
AL136128, AL121938 Genomic DNA. Translation: CAI23003.1.
CH471051 Genomic DNA. Translation: EAW48142.1.
BC002375 mRNA. Translation: AAH02375.1.
CCDSiCCDS34527.1. [Q16890-2]
CCDS34528.1. [Q16890-3]
CCDS43502.1. [Q16890-5]
CCDS5130.1. [Q16890-1]
CCDS75514.1. [Q16890-4]
RefSeqiNP_001003395.1. NM_001003395.2. [Q16890-5]
NP_001003396.1. NM_001003396.2. [Q16890-2]
NP_001003397.1. NM_001003397.2. [Q16890-3]
NP_003278.1. NM_003287.3. [Q16890-1]
XP_005267179.1. XM_005267122.2. [Q16890-5]
UniGeneiHs.591347.

3D structure databases

ProteinModelPortaliQ16890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113017. 19 interactions.
IntActiQ16890. 12 interactions.
MINTiMINT-273476.
STRINGi9606.ENSP00000434142.

PTM databases

iPTMnetiQ16890.
PhosphoSiteiQ16890.

Polymorphism and mutation databases

BioMutaiTPD52L1.
DMDMi12585368.

Proteomic databases

EPDiQ16890.
MaxQBiQ16890.
PaxDbiQ16890.
PeptideAtlasiQ16890.
PRIDEiQ16890.
TopDownProteomicsiQ16890-3. [Q16890-3]

Protocols and materials databases

DNASUi7164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907. [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907. [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907. [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907. [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907. [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907. [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907. [Q16890-4]
GeneIDi7164.
KEGGihsa:7164.
UCSCiuc003pzu.2. human. [Q16890-1]

Organism-specific databases

CTDi7164.
GeneCardsiTPD52L1.
HGNCiHGNC:12006. TPD52L1.
HPAiHPA027915.
HPA027916.
MIMi604069. gene.
neXtProtiNX_Q16890.
PharmGKBiPA36687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4010. Eukaryota.
ENOG4111M9H. LUCA.
GeneTreeiENSGT00390000015988.
HOVERGENiHBG058643.
InParanoidiQ16890.
PhylomeDBiQ16890.
TreeFamiTF317562.

Enzyme and pathway databases

ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

GeneWikiiTPD52L1.
GenomeRNAii7164.
PROiQ16890.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111907.
CleanExiHS_TPD52L1.
ExpressionAtlasiQ16890. baseline and differential.
GenevisibleiQ16890. HS.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPD53_HUMAN
AccessioniPrimary (citable) accession number: Q16890
Secondary accession number(s): A8K757
, A8K772, A8MUD2, A8MUJ7, A8MW70, F6V707, O43397, Q5TC99, Q5TDQ0, Q9BUQ6, Q9C054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.