Q16874 (Q16874_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytochrome P450 21-hydroxylase EMBL AAB67982.1

Submitted name:
Cytochrome P450, family 21, subfamily A, polypeptide 2 EMBL CAI41779.1
Submitted name:
Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b EMBL EAX03571.1
Submitted name:
DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)) EMBL CAB89301.1
Submitted name:
Steroid 21-hydroxylase EMBL ACT35404.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000416598 Ensembl ENSP00000408860 Ensembl ENSP00000372812 Ensembl ENSP00000394942
Submitted name:
cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA EMBL BAG37212.1

Gene names

Name:	P450-CYP21B EMBL AAB67982.1
Synonyms:	CYP21A2 EMBL ACT35404.1 Ensembl ENSP00000416598 Ensembl ENSP00000408860 Ensembl ENSP00000372812 Ensembl ENSP00000394942
ORF Names:	DADB-112B14.10-002 EMBL CAQ10921.1, DAQB-124C11.2-002 EMBL CAI41779.1, hCG_1999926 EMBL EAX03571.1

Organism

Homo sapiens (Human) EMBL AAB67982.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU003700 Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q16874 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: CE5C4EE9D3A0851C	FASTA	495	56,001
	10 20 30 40 50 60 MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL GLTQKFGPIY 70 80 90 100 110 120 RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL VSRNYPDLSL GDYSLLWKAH 130 140 150 160 170 180 KKLTRSALLL GIRDSMEPVV EQLTQEFCER MRAQPGTPVA IEEEFSLLTC SIICYLTFGD 190 200 210 220 230 240 KIKDDNLMPA YYKCIQEVLK TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IEKRDHIVEM 250 260 270 280 290 300 QLRQHKESLV AGQWRDMMDY MLQGVAQPSM EEGSGQLLEG HVHMAAVDLL IGGTETTANT 310 320 330 340 350 360 LSWAVVFLLH HPEIQQRLQE ELDHELGPGA SSSRVPYKDR ARLPLLNATI AEVLRLRPVV 370 380 390 400 410 420 PLALPHRTTR PSSISGYDIP EGTVIIPNLQ GAHLDETVWE RPHEFWPDRF LEPGKNSRAL 430 440 450 460 470 480 AFGCGARVCL GEPLARLELF VVLTRLLQAF TLLPSGDALP SLQPLPHCSV ILKMQPFQVR 490 LQPRGMGAHS PGQSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Linkage analysis of the C4A/C4B copy number variation and polymorphisms of the adjacent steroid 21-hydroxylase gene in a healthy population." Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A. Mol. Immunol. 46:2623-2629(2009) [PubMed: 19505723] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adrenal gland EMBL BAG37212.1.
[5]	Tracey A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	Wood J. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	Barlow K. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[8]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[9]	Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A. Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL645922 Genomic DNA. No translation available. AL662828 Genomic DNA. No translation available. AL662849 Genomic DNA. No translation available. AL844853 Genomic DNA. No translation available. AF019413 Genomic DNA. Translation: AAB67982.1. GQ222278 Genomic DNA. Translation: ACT35404.1. GQ222283 Genomic DNA. Translation: ACT35409.1. GQ222284 Genomic DNA. Translation: ACT35410.1. GQ222289 Genomic DNA. Translation: ACT35415.1. GQ222295 Genomic DNA. Translation: ACT35421.1. GQ222297 Genomic DNA. Translation: ACT35423.1. GQ222312 Genomic DNA. Translation: ACT35438.1. GQ222319 Genomic DNA. Translation: ACT35445.1. GQ222320 Genomic DNA. Translation: ACT35446.1. GQ222321 Genomic DNA. Translation: ACT35447.1. GQ222323 Genomic DNA. Translation: ACT35449.1. GQ222327 Genomic DNA. Translation: ACT35453.1. GQ222334 Genomic DNA. Translation: ACT35460.1. GQ222340 Genomic DNA. Translation: ACT35466.1. AK314651 mRNA. Translation: BAG37212.1. AL049547 Genomic DNA. Translation: CAB89301.1. AL929593 Genomic DNA. Translation: CAI41779.1. CR753845 Genomic DNA. Translation: CAQ10921.1. CH471081 Genomic DNA. Translation: EAX03571.1.
IPI	IPI00383631.
RefSeq	NP_000491.4. NM_000500.7.
UniGene	Hs.654479.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ProteinModelPortal	Q16874.
SMR	Q16874. Positions 27-485.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16874.
Proteomic databases
PRIDE	Q16874.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383322; ENSP00000372812; ENSG00000206338. ENST00000418967; ENSP00000408860; ENSG00000231852. ENST00000448478; ENSP00000416598; ENSG00000232414. ENST00000456152; ENSP00000394942; ENSG00000233151.
GeneID	1589.
KEGG	hsa:1589.
Organism-specific databases
CTD	1589.
HGNC	HGNC:2600. CYP21A2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG106944.
OMA	CSVILKM.
PhylomeDB	Q16874.
Gene expression databases
Bgee	Q16874.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K00513.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	6532.

Entry information

Entry name

Q16874_HUMAN

Accession

Primary (citable) accession number: Q16874

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.