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Protein
Submitted name:

Cytochrome P450 21-hydroxylase

Gene

P450-CYP21B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 21-hydroxylaseImported
Submitted name:
Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_bImported
Submitted name:
DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B))Imported
Submitted name:
Steroid 21-hydroxylaseImported
Submitted name:
cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNAImported
Gene namesi
Name:P450-CYP21BImported
Synonyms:CYP21A2Imported
ORF Names:hCG_1999926Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2600. CYP21A2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27096.

Expressioni

Gene expression databases

ExpressionAtlasiQ16874. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000408860.

Structurei

3D structure databases

SMRiQ16874. Positions 30-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOVERGENiHBG106944.
KOiK00513.
OMAiDYMLQVV.
OrthoDBiEOG7BCNBG.
PhylomeDBiQ16874.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL
60 70 80 90 100
GLTQKFGPIY RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL
110 120 130 140 150
VSRNYPDLSL GDYSLLWKAH KKLTRSALLL GIRDSMEPVV EQLTQEFCER
160 170 180 190 200
MRAQPGTPVA IEEEFSLLTC SIICYLTFGD KIKDDNLMPA YYKCIQEVLK
210 220 230 240 250
TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IEKRDHIVEM QLRQHKESLV
260 270 280 290 300
AGQWRDMMDY MLQGVAQPSM EEGSGQLLEG HVHMAAVDLL IGGTETTANT
310 320 330 340 350
LSWAVVFLLH HPEIQQRLQE ELDHELGPGA SSSRVPYKDR ARLPLLNATI
360 370 380 390 400
AEVLRLRPVV PLALPHRTTR PSSISGYDIP EGTVIIPNLQ GAHLDETVWE
410 420 430 440 450
RPHEFWPDRF LEPGKNSRAL AFGCGARVCL GEPLARLELF VVLTRLLQAF
460 470 480 490
TLLPSGDALP SLQPLPHCSV ILKMQPFQVR LQPRGMGAHS PGQSQ
Length:495
Mass (Da):56,001
Last modified:November 1, 1998 - v2
Checksum:iCE5C4EE9D3A0851C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA. No translation available.
AL662828 Genomic DNA. No translation available.
AL662849 Genomic DNA. No translation available.
AL844853 Genomic DNA. No translation available.
AL929593 Genomic DNA. No translation available.
CR753845 Genomic DNA. No translation available.
AF019413 Genomic DNA. Translation: AAB67982.1.
GQ222278 Genomic DNA. Translation: ACT35404.1.
GQ222283 Genomic DNA. Translation: ACT35409.1.
GQ222289 Genomic DNA. Translation: ACT35415.1.
GQ222295 Genomic DNA. Translation: ACT35421.1.
GQ222297 Genomic DNA. Translation: ACT35423.1.
GQ222312 Genomic DNA. Translation: ACT35438.1.
GQ222319 Genomic DNA. Translation: ACT35445.1.
GQ222320 Genomic DNA. Translation: ACT35446.1.
GQ222321 Genomic DNA. Translation: ACT35447.1.
GQ222323 Genomic DNA. Translation: ACT35449.1.
GQ222327 Genomic DNA. Translation: ACT35453.1.
GQ222334 Genomic DNA. Translation: ACT35460.1.
GQ222340 Genomic DNA. Translation: ACT35466.1.
JN034391 Genomic DNA. Translation: AFK10114.1.
JN034393 Genomic DNA. Translation: AFK10116.1.
JN034394 Genomic DNA. Translation: AFK10117.1.
JN034395 Genomic DNA. Translation: AFK10118.1.
JN034396 Genomic DNA. Translation: AFK10119.1.
JN034397 Genomic DNA. Translation: AFK10120.1.
JN034398 Genomic DNA. Translation: AFK10121.1.
JN034401 Genomic DNA. Translation: AFK10124.1.
JN034402 Genomic DNA. Translation: AFK10125.1.
JN034403 Genomic DNA. Translation: AFK10126.1.
JN034410 Genomic DNA. Translation: AFK10133.1.
JN034411 Genomic DNA. Translation: AFK10134.1.
KC493622 Genomic DNA. Translation: AHA59281.1.
AK314651 mRNA. Translation: BAG37212.1.
AL049547 Genomic DNA. Translation: CAB89301.1.
CH471081 Genomic DNA. Translation: EAX03571.1.
RefSeqiNP_000491.4. NM_000500.7.
UniGeneiHs.654479.

Genome annotation databases

EnsembliENST00000383322; ENSP00000372812; ENSG00000206338.
ENST00000418967; ENSP00000408860; ENSG00000231852.
ENST00000448478; ENSP00000416598; ENSG00000232414.
ENST00000456152; ENSP00000394942; ENSG00000233151.
GeneIDi1589.
KEGGihsa:1589.
UCSCiuc003nze.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA. No translation available.
AL662828 Genomic DNA. No translation available.
AL662849 Genomic DNA. No translation available.
AL844853 Genomic DNA. No translation available.
AL929593 Genomic DNA. No translation available.
CR753845 Genomic DNA. No translation available.
AF019413 Genomic DNA. Translation: AAB67982.1.
GQ222278 Genomic DNA. Translation: ACT35404.1.
GQ222283 Genomic DNA. Translation: ACT35409.1.
GQ222289 Genomic DNA. Translation: ACT35415.1.
GQ222295 Genomic DNA. Translation: ACT35421.1.
GQ222297 Genomic DNA. Translation: ACT35423.1.
GQ222312 Genomic DNA. Translation: ACT35438.1.
GQ222319 Genomic DNA. Translation: ACT35445.1.
GQ222320 Genomic DNA. Translation: ACT35446.1.
GQ222321 Genomic DNA. Translation: ACT35447.1.
GQ222323 Genomic DNA. Translation: ACT35449.1.
GQ222327 Genomic DNA. Translation: ACT35453.1.
GQ222334 Genomic DNA. Translation: ACT35460.1.
GQ222340 Genomic DNA. Translation: ACT35466.1.
JN034391 Genomic DNA. Translation: AFK10114.1.
JN034393 Genomic DNA. Translation: AFK10116.1.
JN034394 Genomic DNA. Translation: AFK10117.1.
JN034395 Genomic DNA. Translation: AFK10118.1.
JN034396 Genomic DNA. Translation: AFK10119.1.
JN034397 Genomic DNA. Translation: AFK10120.1.
JN034398 Genomic DNA. Translation: AFK10121.1.
JN034401 Genomic DNA. Translation: AFK10124.1.
JN034402 Genomic DNA. Translation: AFK10125.1.
JN034403 Genomic DNA. Translation: AFK10126.1.
JN034410 Genomic DNA. Translation: AFK10133.1.
JN034411 Genomic DNA. Translation: AFK10134.1.
KC493622 Genomic DNA. Translation: AHA59281.1.
AK314651 mRNA. Translation: BAG37212.1.
AL049547 Genomic DNA. Translation: CAB89301.1.
CH471081 Genomic DNA. Translation: EAX03571.1.
RefSeqiNP_000491.4. NM_000500.7.
UniGeneiHs.654479.

3D structure databases

SMRiQ16874. Positions 30-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000408860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383322; ENSP00000372812; ENSG00000206338.
ENST00000418967; ENSP00000408860; ENSG00000231852.
ENST00000448478; ENSP00000416598; ENSG00000232414.
ENST00000456152; ENSP00000394942; ENSG00000233151.
GeneIDi1589.
KEGGihsa:1589.
UCSCiuc003nze.3. human.

Organism-specific databases

CTDi1589.
HGNCiHGNC:2600. CYP21A2.
PharmGKBiPA27096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOVERGENiHBG106944.
KOiK00513.
OMAiDYMLQVV.
OrthoDBiEOG7BCNBG.
PhylomeDBiQ16874.
TreeFamiTF105095.

Miscellaneous databases

GenomeRNAii1589.

Gene expression databases

ExpressionAtlasiQ16874. baseline and differential.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Barlow K.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE.
  6. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adrenal glandImported.
  7. "Linkage analysis of the C4A/C4B copy number variation and polymorphisms of the adjacent steroid 21-hydroxylase gene in a healthy population."
    Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A.
    Mol. Immunol. 46:2623-2629(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  10. "Intraspecific evolution of human RCCX copy number variation traced by haplotypes of the CYP21A2 gene."
    Banlaki Z., Szabo J.A., Szilagyi A., Patocs A., Prohaszka Z., Fust G., Doleschall M.
    Genome Biol. Evol. 5:98-112(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Patterns of interallelic and non-allelic conversions of the CYP21A2 gene differ from each other in subregions under different positive and negative selection pressures."
    Szabo J.A., Szilagyi A., Doleschall Z., Patocs A., Farkas H., Prohaszka Z., Fust G., Doleschall M.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Ensembl
    Submitted (JUN-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ16874_HUMAN
AccessioniPrimary (citable) accession number: Q16874
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.