Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cytochrome P450 21-hydroxylase

Gene

CYP21A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 21-hydroxylaseImported
Submitted name:
Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_bImported
Submitted name:
DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B))Imported
Submitted name:
Steroid 21-hydroxylaseImported
Submitted name:
cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNAImported
Gene namesi
Name:CYP21A2Imported
Synonyms:CYP21BImported, P450-CYP21BImported
ORF Names:hCG_1999926Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000231852.6
HGNCiHGNC:2600 CYP21A2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231852
PharmGKBiPA27096

Expressioni

Gene expression databases

BgeeiENSG00000231852

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VBUX-ray3.31A/B/C30-495[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOVERGENiHBG106944
KOiK00513
OMAiWRDMMDY
OrthoDBiEOG091G074I
TreeFamiTF105095

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q16874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL
60 70 80 90 100
GLTQKFGPIY RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL
110 120 130 140 150
VSRNYPDLSL GDYSLLWKAH KKLTRSALLL GIRDSMEPVV EQLTQEFCER
160 170 180 190 200
MRAQPGTPVA IEEEFSLLTC SIICYLTFGD KIKDDNLMPA YYKCIQEVLK
210 220 230 240 250
TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IEKRDHIVEM QLRQHKESLV
260 270 280 290 300
AGQWRDMMDY MLQGVAQPSM EEGSGQLLEG HVHMAAVDLL IGGTETTANT
310 320 330 340 350
LSWAVVFLLH HPEIQQRLQE ELDHELGPGA SSSRVPYKDR ARLPLLNATI
360 370 380 390 400
AEVLRLRPVV PLALPHRTTR PSSISGYDIP EGTVIIPNLQ GAHLDETVWE
410 420 430 440 450
RPHEFWPDRF LEPGKNSRAL AFGCGARVCL GEPLARLELF VVLTRLLQAF
460 470 480 490
TLLPSGDALP SLQPLPHCSV ILKMQPFQVR LQPRGMGAHS PGQSQ
Length:495
Mass (Da):56,001
Last modified:November 1, 1998 - v2
Checksum:iCE5C4EE9D3A0851C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
AL929593 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
AF019413 Genomic DNA Translation: AAB67982.1
GQ222278 Genomic DNA Translation: ACT35404.1
GQ222283 Genomic DNA Translation: ACT35409.1
GQ222289 Genomic DNA Translation: ACT35415.1
GQ222295 Genomic DNA Translation: ACT35421.1
GQ222297 Genomic DNA Translation: ACT35423.1
GQ222312 Genomic DNA Translation: ACT35438.1
GQ222319 Genomic DNA Translation: ACT35445.1
GQ222320 Genomic DNA Translation: ACT35446.1
GQ222321 Genomic DNA Translation: ACT35447.1
GQ222323 Genomic DNA Translation: ACT35449.1
GQ222327 Genomic DNA Translation: ACT35453.1
GQ222334 Genomic DNA Translation: ACT35460.1
GQ222340 Genomic DNA Translation: ACT35466.1
JN034391 Genomic DNA Translation: AFK10114.1
JN034393 Genomic DNA Translation: AFK10116.1
JN034394 Genomic DNA Translation: AFK10117.1
JN034395 Genomic DNA Translation: AFK10118.1
JN034396 Genomic DNA Translation: AFK10119.1
JN034397 Genomic DNA Translation: AFK10120.1
JN034398 Genomic DNA Translation: AFK10121.1
JN034401 Genomic DNA Translation: AFK10124.1
JN034402 Genomic DNA Translation: AFK10125.1
JN034403 Genomic DNA Translation: AFK10126.1
JN034410 Genomic DNA Translation: AFK10133.1
JN034411 Genomic DNA Translation: AFK10134.1
KC493622 Genomic DNA Translation: AHA59281.1
KU302772 Genomic DNA Translation: APT40591.1
KU302773 Genomic DNA Translation: APT40592.1
AK314651 mRNA Translation: BAG37212.1
AL049547 Genomic DNA Translation: CAB89301.1
CH471081 Genomic DNA Translation: EAX03571.1
RefSeqiNP_000491.4, NM_000500.7
UniGeneiHs.654479

Genome annotation databases

EnsembliENST00000383322; ENSP00000372812; ENSG00000206338
ENST00000418967; ENSP00000408860; ENSG00000231852
ENST00000448478; ENSP00000416598; ENSG00000232414
ENST00000456152; ENSP00000394942; ENSG00000233151
GeneIDi1589
KEGGihsa:1589
UCSCiuc003nze.3 human

Similar proteinsi

Entry informationi

Entry nameiQ16874_HUMAN
AccessioniPrimary (citable) accession number: Q16874
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health