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Protein

Leukotriene C4 synthase

Gene

LTC4S

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30Glutathione2 Publications1
Active sitei31Proton donor1 Publication1
Active sitei104Proton acceptor1 Publication1

GO - Molecular functioni

  • enzyme activator activity Source: InterPro
  • glutathione peroxidase activity Source: GO_Central
  • glutathione transferase activity Source: GO_Central
  • identical protein binding Source: IntAct
  • leukotriene-C4 synthase activity Source: MGI
  • lipid binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLeukotriene biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:HS08566-MONOMER
BRENDAi4.4.1.20 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142700 Synthesis of Lipoxins (LX)
R-HSA-9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-HSA-9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
SABIO-RKiQ16873
SignaLinkiQ16873
SIGNORiQ16873

Chemistry databases

SwissLipidsiSLP:000001452

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:LTC4S
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000213316.9
HGNCiHGNC:6719 LTC4S
MIMi246530 gene
neXtProtiNX_Q16873

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Cytoplasmic6
Transmembranei7 – 27HelicalAdd BLAST21
Topological domaini28 – 48LumenalAdd BLAST21
Transmembranei49 – 69HelicalAdd BLAST21
Topological domaini70 – 73Cytoplasmic4
Transmembranei74 – 94HelicalAdd BLAST21
Topological domaini95 – 104Lumenal10
Transmembranei105 – 124HelicalAdd BLAST20
Topological domaini125 – 150CytoplasmicAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Organism-specific databases

DisGeNETi4056
MalaCardsiLTC4S
OpenTargetsiENSG00000213316
Orphaneti79507 Hypotonia - failure to thrive - microcephaly
PharmGKBiPA235

Chemistry databases

ChEMBLiCHEMBL1743183
DrugBankiDB00143 Glutathione
GuidetoPHARMACOLOGYi1391

Polymorphism and mutation databases

DMDMi2833283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177481 – 150Leukotriene C4 synthaseAdd BLAST150

Proteomic databases

PaxDbiQ16873
PeptideAtlasiQ16873
PRIDEiQ16873
ProteomicsDBi61112

PTM databases

iPTMnetiQ16873
PhosphoSitePlusiQ16873

Expressioni

Tissue specificityi

Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.1 Publication

Gene expression databases

BgeeiENSG00000213316
CleanExiHS_LTC4S
ExpressionAtlasiQ16873 baseline and differential
GenevisibleiQ16873 HS

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-12241118,EBI-12241118

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi110234, 4 interactors
DIPiDIP-48473N
IntActiQ16873, 1 interactor
STRINGi9606.ENSP00000292596

Chemistry databases

BindingDBiQ16873

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 32Combined sources31
Helixi44 – 73Combined sources30
Helixi76 – 99Combined sources24
Helixi101 – 104Combined sources4
Helixi105 – 145Combined sources41

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PNOX-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-150[»]
2UUHX-ray2.15A2-150[»]
2UUIX-ray2.00A2-150[»]
3B29X-ray3.20A1-150[»]
3HKKX-ray2.90A2-150[»]
3LEOX-ray2.10A2-150[»]
3PCVX-ray1.90A1-150[»]
4BPMX-ray2.08A131-150[»]
4J7TX-ray3.20A2-150[»]
4J7YX-ray2.90A2-150[»]
4JC7X-ray2.70A2-150[»]
4JCZX-ray2.75A2-150[»]
4JRZX-ray2.40A2-150[»]
4WABX-ray2.70A130-150[»]
5HV9X-ray3.00A2-150[»]
ProteinModelPortaliQ16873
SMRiQ16873
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16873

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 55Glutathione binding5
Regioni58 – 59Glutathione binding2
Regioni93 – 97Glutathione binding5

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5F Eukaryota
ENOG4111JV7 LUCA
GeneTreeiENSGT00430000030964
HOGENOMiHOG000116372
HOVERGENiHBG105513
InParanoidiQ16873
KOiK00807
OMAiAGIFFHQ
OrthoDBiEOG091G12NW
PhylomeDBiQ16873
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR001446 5_LipOase_AP
IPR018295 FLAP/GST2/LTC4S_CS
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
PRINTSiPR00488 5LPOXGNASEAP
SUPFAMiSSF161084 SSF161084, 1 hit
PROSITEiView protein in PROSITE
PS01297 FLAP_GST2_LTC4S, 1 hit

Sequencei

Sequence statusi: Complete.

Q16873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY
60 70 80 90 100
RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS
110 120 130 140 150
AQLRLAPLYA SARALWLLVA LAALGLLAHF LPAALRAALL GRLRTLLPWA
Length:150
Mass (Da):16,567
Last modified:November 1, 1996 - v1
Checksum:i04E269B475063037
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21Y → G AA sequence (PubMed:8446623).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042736142R → Q1 PublicationCorresponds to variant dbSNP:rs11541078Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09353 mRNA Translation: AAA20467.1
U11552 mRNA Translation: AAA50555.1
U50136 Genomic DNA Translation: AAC50476.1
U62025 Genomic DNA Translation: AAB06723.1
BC029498 mRNA Translation: AAH29498.1
CCDSiCCDS34316.1
PIRiI38595
JC5398
RefSeqiNP_665874.1, NM_145867.1
UniGeneiHs.706741

Genome annotation databases

EnsembliENST00000292596; ENSP00000292596; ENSG00000213316
ENST00000639087; ENSP00000492334; ENSG00000283887
GeneIDi4056
KEGGihsa:4056
UCSCiuc003mko.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLTC4S_HUMAN
AccessioniPrimary (citable) accession number: Q16873
Secondary accession number(s): Q8N6P0, Q9UC73, Q9UD18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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