Reviewed,
UniProtKB/Swiss-Prot Q16864 (VATF_HUMAN)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: V-type proton ATPase subunit F Short name=V-ATPase subunit F Alternative name(s): Vacuolar proton pump subunit F V-ATPase 14 kDa subunit | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 119 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. |
| Subunit structure | V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). |
| Sequence similarities | Belongs to the V-ATPase F subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen ion transport Ion transport Transport |
| Coding sequence diversity | Polymorphism |
| Gene Ontology (GO) | |
| Biological process | ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro |
| Cellular component | membrane fraction Non-traceable author statement. Source: UniProtKB proton-transporting V-type ATPase, V1 domainInferred from electronic annotation. Source: InterPro vacuolar proton-transporting V-type ATPase complexInferred from direct assay. Source: UniProtKB |
| Molecular function | ATPase activity, uncoupled Ref.1 Non-traceable author statement. Source: UniProtKB hydrogen ion transporting ATP synthase activity, rotational mechanismInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: UniProtKB proton-transporting ATPase activity, rotational mechanismInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)." Fujiwara T., Kawai A., Shimizu F., Hirano H., Okuno S., Takeda S., Ozaki K., Shimada Y., Nagata M., Watanabe T., Takaichi A., Nakamura Y., Shin S. DNA Res. 2:107-111(1995) [PubMed: 8581736] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| [2] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| D49400 mRNA. Translation: BAA08392.1. CR456896 mRNA. Translation: CAG33177.1. BC104230 mRNA. Translation: AAI04231.1. BC104231 mRNA. Translation: AAI04232.1. BC107854 mRNA. Translation: AAI07855.1. | |
| IPI | IPI00004488. |
| PIR | JC4193. |
| RefSeq | NP_004222.2. |
| UniGene | Hs.78089 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q16864. 1 interaction. |
Protein family/group databases | |
| TCDB | 3.A.2.2.4. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily. |
Proteomic databases | |
| PeptideAtlas | Q16864. |
| PRIDE | Q16864. |
Genome annotation databases | |
| Ensembl | ENSG00000128524. Homo sapiens. [Contig view] |
| GeneID | 9296. |
| KEGG | hsa:9296. |
Organism-specific databases | |
| GeneCards | GC07P128290. |
| HGNC | HGNC:16832. ATP6V1F. |
| HPA | CAB009529. |
| MIM | 607160. gene. |
| PharmGKB | PA38421. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q16864. |
| HOVERGEN | Q16864. |
| OMA | Q16864. AILLINQ. |
Enzyme and pathway databases | |
| BRENDA | 3.6.3.14. 247. |
Gene expression databases | |
| Bgee | Q16864. |
| CleanEx | HS_ATP6V1F. |
| GermOnline | ENSG00000128524. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005772. ATPase_V1-cplx_fsu_euk. IPR008218. ATPase_V1/A1-cplx_fsu. [Graphical view] |
| PANTHER | PTHR13861. ATPase_V1_F_euk. 1 hit. |
| Pfam | PF01990. ATP-synt_F. 1 hit. [Graphical view] |
| PIRSF | PIRSF015945. ATPase_V1_F_euk. 1 hit. |
| TIGRFAMs | TIGR01101. V_ATP_synt_F. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 34831. |
| SOURCE | Search... |
Entry information
| Entry name | VATF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16864 Secondary accession number(s): Q6IBA8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


