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Q16864

- VATF_HUMAN

UniProt

Q16864 - VATF_HUMAN

Protein

V-type proton ATPase subunit F

Gene

ATP6V1F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. ATPase activity, uncoupled Source: UniProtKB
    2. hydrogen ion transmembrane transporter activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. proton-transporting ATPase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. ATP hydrolysis coupled proton transport Source: InterPro
    3. cellular iron ion homeostasis Source: Reactome
    4. insulin receptor signaling pathway Source: Reactome
    5. interaction with host Source: Reactome
    6. phagosome maturation Source: Reactome
    7. proton transport Source: UniProtKB
    8. transferrin transport Source: Reactome
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:HS05192-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit F
    Short name:
    V-ATPase subunit F
    Alternative name(s):
    V-ATPase 14 kDa subunit
    Vacuolar proton pump subunit F
    Gene namesi
    Name:ATP6V1F
    Synonyms:ATP6S14, VATF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16832. ATP6V1F.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. proton-transporting two-sector ATPase complex Source: UniProtKB
    5. proton-transporting V-type ATPase, V1 domain Source: InterPro
    6. vacuolar proton-transporting V-type ATPase complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38421.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119V-type proton ATPase subunit FPRO_0000144799Add
    BLAST

    Proteomic databases

    MaxQBiQ16864.
    PaxDbiQ16864.
    PeptideAtlasiQ16864.
    PRIDEiQ16864.

    PTM databases

    PhosphoSiteiQ16864.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16864.
    BgeeiQ16864.
    CleanExiHS_ATP6V1F.
    GenevestigatoriQ16864.

    Organism-specific databases

    HPAiCAB009529.
    HPA048700.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Protein-protein interaction databases

    BioGridi114710. 40 interactions.
    IntActiQ16864. 1 interaction.
    MINTiMINT-1426240.
    STRINGi9606.ENSP00000249289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16864.
    SMRiQ16864. Positions 7-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase F subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1436.
    HOGENOMiHOG000056545.
    HOVERGENiHBG004488.
    InParanoidiQ16864.
    KOiK02151.
    OMAiRHVIDAH.
    OrthoDBiEOG7JMGGM.
    PhylomeDBiQ16864.
    TreeFamiTF300080.

    Family and domain databases

    Gene3Di3.40.50.10580. 1 hit.
    InterProiIPR008218. ATPase_V1-cplx_f_g_su.
    IPR005772. ATPase_V1-cplx_fsu_euk.
    [Graphical view]
    PANTHERiPTHR13861. PTHR13861. 1 hit.
    PfamiPF01990. ATP-synt_F. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
    SUPFAMiSSF159468. SSF159468. 1 hit.
    TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16864-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED    50
    TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA 100
    AKDSILRRAR GMFTAEDLR 119
    Length:119
    Mass (Da):13,370
    Last modified:February 20, 2007 - v2
    Checksum:i9FE5A8BD249A85FA
    GO
    Isoform 2 (identifier: Q16864-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: F → FRSLGSLPGSVVEANPNQRDPPLWDEIDS

    Note: No experimental confirmation available.

    Show »
    Length:147
    Mass (Da):16,402
    Checksum:i964BE12671E7C4DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81I → T in BAA08392. (PubMed:8581736)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241G → V.
    Corresponds to variant rs10958 [ dbSNP | Ensembl ].
    VAR_048348

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 521F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2. 1 PublicationVSP_045952

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49400 mRNA. Translation: BAA08392.1.
    CR456896 mRNA. Translation: CAG33177.1.
    AC025594 Genomic DNA. No translation available.
    BC104230 mRNA. Translation: AAI04231.1.
    BC104231 mRNA. Translation: AAI04232.1.
    BC107854 mRNA. Translation: AAI07855.1.
    BU956696 mRNA. No translation available.
    CCDSiCCDS56511.1. [Q16864-2]
    CCDS5807.1. [Q16864-1]
    PIRiJC4193.
    RefSeqiNP_001185838.1. NM_001198909.1. [Q16864-2]
    NP_004222.2. NM_004231.3. [Q16864-1]
    UniGeneiHs.78089.

    Genome annotation databases

    EnsembliENST00000249289; ENSP00000249289; ENSG00000128524. [Q16864-1]
    ENST00000492758; ENSP00000417378; ENSG00000128524. [Q16864-2]
    GeneIDi9296.
    KEGGihsa:9296.
    UCSCiuc003voc.2. human. [Q16864-1]

    Polymorphism databases

    DMDMi126302612.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49400 mRNA. Translation: BAA08392.1 .
    CR456896 mRNA. Translation: CAG33177.1 .
    AC025594 Genomic DNA. No translation available.
    BC104230 mRNA. Translation: AAI04231.1 .
    BC104231 mRNA. Translation: AAI04232.1 .
    BC107854 mRNA. Translation: AAI07855.1 .
    BU956696 mRNA. No translation available.
    CCDSi CCDS56511.1. [Q16864-2 ]
    CCDS5807.1. [Q16864-1 ]
    PIRi JC4193.
    RefSeqi NP_001185838.1. NM_001198909.1. [Q16864-2 ]
    NP_004222.2. NM_004231.3. [Q16864-1 ]
    UniGenei Hs.78089.

    3D structure databases

    ProteinModelPortali Q16864.
    SMRi Q16864. Positions 7-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114710. 40 interactions.
    IntActi Q16864. 1 interaction.
    MINTi MINT-1426240.
    STRINGi 9606.ENSP00000249289.

    Protein family/group databases

    TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q16864.

    Polymorphism databases

    DMDMi 126302612.

    Proteomic databases

    MaxQBi Q16864.
    PaxDbi Q16864.
    PeptideAtlasi Q16864.
    PRIDEi Q16864.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249289 ; ENSP00000249289 ; ENSG00000128524 . [Q16864-1 ]
    ENST00000492758 ; ENSP00000417378 ; ENSG00000128524 . [Q16864-2 ]
    GeneIDi 9296.
    KEGGi hsa:9296.
    UCSCi uc003voc.2. human. [Q16864-1 ]

    Organism-specific databases

    CTDi 9296.
    GeneCardsi GC07P128502.
    HGNCi HGNC:16832. ATP6V1F.
    HPAi CAB009529.
    HPA048700.
    MIMi 607160. gene.
    neXtProti NX_Q16864.
    PharmGKBi PA38421.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1436.
    HOGENOMi HOG000056545.
    HOVERGENi HBG004488.
    InParanoidi Q16864.
    KOi K02151.
    OMAi RHVIDAH.
    OrthoDBi EOG7JMGGM.
    PhylomeDBi Q16864.
    TreeFami TF300080.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS05192-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    GeneWikii ATP6V1F.
    GenomeRNAii 9296.
    NextBioi 34831.
    PROi Q16864.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16864.
    Bgeei Q16864.
    CleanExi HS_ATP6V1F.
    Genevestigatori Q16864.

    Family and domain databases

    Gene3Di 3.40.50.10580. 1 hit.
    InterProi IPR008218. ATPase_V1-cplx_f_g_su.
    IPR005772. ATPase_V1-cplx_fsu_euk.
    [Graphical view ]
    PANTHERi PTHR13861. PTHR13861. 1 hit.
    Pfami PF01990. ATP-synt_F. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015945. ATPase_V1_F_euk. 1 hit.
    SUPFAMi SSF159468. SSF159468. 1 hit.
    TIGRFAMsi TIGR01101. V_ATP_synt_F. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)."
      Fujiwara T., Kawai A., Shimizu F., Hirano H., Okuno S., Takeda S., Ozaki K., Shimada Y., Nagata M., Watanabe T., Takaichi A., Nakamura Y., Shin S.
      DNA Res. 2:107-111(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Lung adenocarcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVATF_HUMAN
    AccessioniPrimary (citable) accession number: Q16864
    Secondary accession number(s): C9J2K4, Q6IBA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3