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Q16864

- VATF_HUMAN

UniProt

Q16864 - VATF_HUMAN

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Protein
V-type proton ATPase subunit F
Gene
ATP6V1F, ATP6S14, VATF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. ATPase activity, uncoupled Source: UniProtKB
  2. hydrogen ion transmembrane transporter activity Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. proton-transporting ATPase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ATP hydrolysis coupled proton transport Source: InterPro
  3. cellular iron ion homeostasis Source: Reactome
  4. insulin receptor signaling pathway Source: Reactome
  5. interaction with host Source: Reactome
  6. phagosome maturation Source: Reactome
  7. proton transport Source: UniProtKB
  8. transferrin transport Source: Reactome
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS05192-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:ATP6V1F
Synonyms:ATP6S14, VATF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16832. ATP6V1F.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. membrane Source: UniProtKB
  4. proton-transporting V-type ATPase, V1 domain Source: InterPro
  5. proton-transporting two-sector ATPase complex Source: UniProtKB
  6. vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119V-type proton ATPase subunit F
PRO_0000144799Add
BLAST

Proteomic databases

MaxQBiQ16864.
PaxDbiQ16864.
PeptideAtlasiQ16864.
PRIDEiQ16864.

PTM databases

PhosphoSiteiQ16864.

Expressioni

Gene expression databases

ArrayExpressiQ16864.
BgeeiQ16864.
CleanExiHS_ATP6V1F.
GenevestigatoriQ16864.

Organism-specific databases

HPAiCAB009529.
HPA048700.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi114710. 40 interactions.
IntActiQ16864. 1 interaction.
MINTiMINT-1426240.
STRINGi9606.ENSP00000249289.

Structurei

3D structure databases

ProteinModelPortaliQ16864.
SMRiQ16864. Positions 7-91.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1436.
HOGENOMiHOG000056545.
HOVERGENiHBG004488.
InParanoidiQ16864.
KOiK02151.
OMAiRHVIDAH.
OrthoDBiEOG7JMGGM.
PhylomeDBiQ16864.
TreeFamiTF300080.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16864-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED    50
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA 100
AKDSILRRAR GMFTAEDLR 119
Length:119
Mass (Da):13,370
Last modified:February 20, 2007 - v2
Checksum:i9FE5A8BD249A85FA
GO
Isoform 2 (identifier: Q16864-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: F → FRSLGSLPGSVVEANPNQRDPPLWDEIDS

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):16,402
Checksum:i964BE12671E7C4DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241G → V.
Corresponds to variant rs10958 [ dbSNP | Ensembl ].
VAR_048348

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 521F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2.
VSP_045952

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81I → T in BAA08392. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49400 mRNA. Translation: BAA08392.1.
CR456896 mRNA. Translation: CAG33177.1.
AC025594 Genomic DNA. No translation available.
BC104230 mRNA. Translation: AAI04231.1.
BC104231 mRNA. Translation: AAI04232.1.
BC107854 mRNA. Translation: AAI07855.1.
BU956696 mRNA. No translation available.
CCDSiCCDS56511.1. [Q16864-2]
CCDS5807.1. [Q16864-1]
PIRiJC4193.
RefSeqiNP_001185838.1. NM_001198909.1. [Q16864-2]
NP_004222.2. NM_004231.3. [Q16864-1]
UniGeneiHs.78089.

Genome annotation databases

EnsembliENST00000249289; ENSP00000249289; ENSG00000128524. [Q16864-1]
ENST00000492758; ENSP00000417378; ENSG00000128524. [Q16864-2]
GeneIDi9296.
KEGGihsa:9296.
UCSCiuc003voc.2. human. [Q16864-1]

Polymorphism databases

DMDMi126302612.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49400 mRNA. Translation: BAA08392.1 .
CR456896 mRNA. Translation: CAG33177.1 .
AC025594 Genomic DNA. No translation available.
BC104230 mRNA. Translation: AAI04231.1 .
BC104231 mRNA. Translation: AAI04232.1 .
BC107854 mRNA. Translation: AAI07855.1 .
BU956696 mRNA. No translation available.
CCDSi CCDS56511.1. [Q16864-2 ]
CCDS5807.1. [Q16864-1 ]
PIRi JC4193.
RefSeqi NP_001185838.1. NM_001198909.1. [Q16864-2 ]
NP_004222.2. NM_004231.3. [Q16864-1 ]
UniGenei Hs.78089.

3D structure databases

ProteinModelPortali Q16864.
SMRi Q16864. Positions 7-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114710. 40 interactions.
IntActi Q16864. 1 interaction.
MINTi MINT-1426240.
STRINGi 9606.ENSP00000249289.

Protein family/group databases

TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei Q16864.

Polymorphism databases

DMDMi 126302612.

Proteomic databases

MaxQBi Q16864.
PaxDbi Q16864.
PeptideAtlasi Q16864.
PRIDEi Q16864.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249289 ; ENSP00000249289 ; ENSG00000128524 . [Q16864-1 ]
ENST00000492758 ; ENSP00000417378 ; ENSG00000128524 . [Q16864-2 ]
GeneIDi 9296.
KEGGi hsa:9296.
UCSCi uc003voc.2. human. [Q16864-1 ]

Organism-specific databases

CTDi 9296.
GeneCardsi GC07P128502.
HGNCi HGNC:16832. ATP6V1F.
HPAi CAB009529.
HPA048700.
MIMi 607160. gene.
neXtProti NX_Q16864.
PharmGKBi PA38421.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1436.
HOGENOMi HOG000056545.
HOVERGENi HBG004488.
InParanoidi Q16864.
KOi K02151.
OMAi RHVIDAH.
OrthoDBi EOG7JMGGM.
PhylomeDBi Q16864.
TreeFami TF300080.

Enzyme and pathway databases

BioCyci MetaCyc:HS05192-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikii ATP6V1F.
GenomeRNAii 9296.
NextBioi 34831.
PROi Q16864.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16864.
Bgeei Q16864.
CleanExi HS_ATP6V1F.
Genevestigatori Q16864.

Family and domain databases

Gene3Di 3.40.50.10580. 1 hit.
InterProi IPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view ]
PANTHERi PTHR13861. PTHR13861. 1 hit.
Pfami PF01990. ATP-synt_F. 1 hit.
[Graphical view ]
PIRSFi PIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMi SSF159468. SSF159468. 1 hit.
TIGRFAMsi TIGR01101. V_ATP_synt_F. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)."
    Fujiwara T., Kawai A., Shimizu F., Hirano H., Okuno S., Takeda S., Ozaki K., Shimada Y., Nagata M., Watanabe T., Takaichi A., Nakamura Y., Shin S.
    DNA Res. 2:107-111(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung adenocarcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVATF_HUMAN
AccessioniPrimary (citable) accession number: Q16864
Secondary accession number(s): C9J2K4, Q6IBA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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