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Q16864 (VATF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit F

Short name=V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene names
Name:ATP6V1F
Synonyms:ATP6S14, VATF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Sequence similarities

Belongs to the V-ATPase F subunit family.

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Non-traceable author statement Ref.1. Source: GOC

ATP hydrolysis coupled proton transport

Inferred from electronic annotation. Source: InterPro

cellular iron ion homeostasis

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

interaction with host

Traceable author statement. Source: Reactome

phagosome maturation

Traceable author statement. Source: Reactome

proton transport

Non-traceable author statement Ref.1. Source: UniProtKB

transferrin transport

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 19199708PubMed 23376485. Source: UniProt

membrane

Inferred from direct assay PubMed 18752060. Source: UniProtKB

proton-transporting V-type ATPase, V1 domain

Inferred from electronic annotation. Source: InterPro

proton-transporting two-sector ATPase complex

Non-traceable author statement Ref.1. Source: UniProtKB

vacuolar proton-transporting V-type ATPase complex

Inferred from direct assay PubMed 18752060. Source: UniProtKB

   Molecular_functionATPase activity, uncoupled

Non-traceable author statement Ref.1. Source: UniProtKB

hydrogen ion transmembrane transporter activity

Non-traceable author statement Ref.1. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 18752060. Source: UniProtKB

proton-transporting ATPase activity, rotational mechanism

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q16864-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q16864-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: F → FRSLGSLPGSVVEANPNQRDPPLWDEIDS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119V-type proton ATPase subunit F
PRO_0000144799

Natural variations

Alternative sequence521F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2.
VSP_045952
Natural variant241G → V.
Corresponds to variant rs10958 [ dbSNP | Ensembl ].
VAR_048348

Experimental info

Sequence conflict81I → T in BAA08392. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 9FE5A8BD249A85FA

FASTA11913,370
        10         20         30         40         50         60 
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED TFRQFLNRDD 

        70         80         90        100        110 
IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA AKDSILRRAR GMFTAEDLR 

« Hide

Isoform 2 [UniParc].

Checksum: 964BE12671E7C4DA
Show »

FASTA14716,402

References

« Hide 'large scale' references
[1]"Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)."
Fujiwara T., Kawai A., Shimizu F., Hirano H., Okuno S., Takeda S., Ozaki K., Shimada Y., Nagata M., Watanabe T., Takaichi A., Nakamura Y., Shin S.
DNA Res. 2:107-111(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Lung adenocarcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49400 mRNA. Translation: BAA08392.1.
CR456896 mRNA. Translation: CAG33177.1.
AC025594 Genomic DNA. No translation available.
BC104230 mRNA. Translation: AAI04231.1.
BC104231 mRNA. Translation: AAI04232.1.
BC107854 mRNA. Translation: AAI07855.1.
BU956696 mRNA. No translation available.
CCDSCCDS56511.1. [Q16864-2]
CCDS5807.1. [Q16864-1]
PIRJC4193.
RefSeqNP_001185838.1. NM_001198909.1. [Q16864-2]
NP_004222.2. NM_004231.3. [Q16864-1]
UniGeneHs.78089.

3D structure databases

ProteinModelPortalQ16864.
SMRQ16864. Positions 7-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114710. 40 interactions.
IntActQ16864. 1 interaction.
MINTMINT-1426240.
STRING9606.ENSP00000249289.

Protein family/group databases

TCDB3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteQ16864.

Polymorphism databases

DMDM126302612.

Proteomic databases

MaxQBQ16864.
PaxDbQ16864.
PeptideAtlasQ16864.
PRIDEQ16864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249289; ENSP00000249289; ENSG00000128524. [Q16864-1]
ENST00000492758; ENSP00000417378; ENSG00000128524. [Q16864-2]
GeneID9296.
KEGGhsa:9296.
UCSCuc003voc.2. human. [Q16864-1]

Organism-specific databases

CTD9296.
GeneCardsGC07P128502.
HGNCHGNC:16832. ATP6V1F.
HPACAB009529.
HPA048700.
MIM607160. gene.
neXtProtNX_Q16864.
PharmGKBPA38421.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1436.
HOGENOMHOG000056545.
HOVERGENHBG004488.
InParanoidQ16864.
KOK02151.
OMARHVIDAH.
OrthoDBEOG7JMGGM.
PhylomeDBQ16864.
TreeFamTF300080.

Enzyme and pathway databases

BioCycMetaCyc:HS05192-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ16864.
BgeeQ16864.
CleanExHS_ATP6V1F.
GenevestigatorQ16864.

Family and domain databases

Gene3D3.40.50.10580. 1 hit.
InterProIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERPTHR13861. PTHR13861. 1 hit.
PfamPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMSSF159468. SSF159468. 1 hit.
TIGRFAMsTIGR01101. V_ATP_synt_F. 1 hit.
ProtoNetSearch...

Other

GeneWikiATP6V1F.
GenomeRNAi9296.
NextBio34831.
PROQ16864.
SOURCESearch...

Entry information

Entry nameVATF_HUMAN
AccessionPrimary (citable) accession number: Q16864
Secondary accession number(s): C9J2K4, Q6IBA8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM