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Q16854

- DGUOK_HUMAN

UniProt

Q16854 - DGUOK_HUMAN

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Protein

Deoxyguanosine kinase, mitochondrial

Gene

DGUOK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.1 Publication

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701SubstrateBy similarity
Binding sitei100 – 1001Substrate
Binding sitei111 – 1111Substrate
Binding sitei118 – 1181Substrate
Active sitei141 – 1411Proton acceptorSequence Analysis
Binding sitei142 – 1421Substrate
Binding sitei147 – 1471SubstrateBy similarity
Binding sitei211 – 2111Substrate

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 539ATP
Nucleotide bindingi206 – 2083ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: UniProtKB
  3. nucleoside kinase activity Source: Reactome

GO - Biological processi

  1. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
  2. dGTP metabolic process Source: Ensembl
  3. guanosine metabolic process Source: ProtInc
  4. negative regulation of neuron projection development Source: Ensembl
  5. nucleobase-containing small molecule metabolic process Source: Reactome
  6. nucleotide biosynthetic process Source: GOC
  7. protein phosphorylation Source: Ensembl
  8. purine-containing compound salvage Source: Reactome
  9. purine deoxyribonucleoside metabolic process Source: UniProtKB
  10. purine nucleobase metabolic process Source: Reactome
  11. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS03819-MONOMER.
BRENDAi2.7.1.113. 2681.
ReactomeiREACT_1923. Purine salvage.
SABIO-RKQ16854.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase, mitochondrial (EC:2.7.1.113)
Short name:
dGK
Gene namesi
Name:DGUOK
Synonyms:DGK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2858. DGUOK.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrial matrix Source: Reactome
  3. mitochondrion Source: ProtInc
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Mitochondrial DNA depletion syndrome 3 (MTDPS3) [MIM:251880]: A disorder due to mitochondrial dysfunction characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421R → K in MTDPS3. 1 Publication
VAR_019417
Natural varianti227 – 2271E → K in MTDPS3. 1 Publication
VAR_019418
Natural varianti250 – 2501L → S in MTDPS3; significant reduction of activity. 1 Publication
VAR_023789

Keywords - Diseasei

Disease mutation, Neuropathy

Organism-specific databases

MIMi251880. phenotype.
Orphaneti329314. Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency.
279934. Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency.
PharmGKBiPA27319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 277238Deoxyguanosine kinase, mitochondrialPRO_0000016840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ16854.
PaxDbiQ16854.
PRIDEiQ16854.

PTM databases

PhosphoSiteiQ16854.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.1 Publication

Gene expression databases

BgeeiQ16854.
CleanExiHS_DGUOK.
ExpressionAtlasiQ16854. baseline and differential.
GenevestigatoriQ16854.

Organism-specific databases

HPAiHPA034766.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi108062. 68 interactions.
IntActiQ16854. 1 interaction.
STRINGi9606.ENSP00000264093.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 457
Helixi51 – 6111
Beta strandi65 – 684
Helixi72 – 743
Helixi95 – 1017
Helixi103 – 12321
Helixi128 – 1314
Beta strandi137 – 1426
Helixi144 – 1496
Helixi151 – 1577
Helixi163 – 17917
Helixi181 – 1844
Beta strandi188 – 1936
Helixi196 – 20510
Turni209 – 2135
Helixi216 – 23015
Helixi242 – 2443
Beta strandi247 – 2515
Turni256 – 2583
Helixi260 – 27516

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OCPX-ray2.80A/B/C/D/E/F/G/H37-277[»]
ProteinModelPortaliQ16854.
SMRiQ16854. Positions 37-277.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16854.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1428.
GeneTreeiENSGT00510000046588.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiQ16854.
KOiK00904.
OMAiLLTKTYP.
OrthoDBiEOG70PBZM.
PhylomeDBiQ16854.
TreeFamiTF324413.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16854-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGRLFLSR LRAPFSSMAK SPLEGVSSSR GLHAGRGPRR LSIEGNIAVG
60 70 80 90 100
KSTFVKLLTK TYPEWHVATE PVATWQNIQA AGTQKACTAQ SLGNLLDMMY
110 120 130 140 150
REPARWSYTF QTFSFLSRLK VQLEPFPEKL LQARKPVQIF ERSVYSDRYI
160 170 180 190 200
FAKNLFENGS LSDIEWHIYQ DWHSFLLWEF ASRITLHGFI YLQASPQVCL
210 220 230 240 250
KRLYQRAREE EKGIELAYLE QLHGQHEAWL IHKTTKLHFE ALMNIPVLVL
260 270
DVNDDFSEEV TKQEDLMREV NTFVKNL
Length:277
Mass (Da):32,056
Last modified:September 19, 2002 - v2
Checksum:i53E4514BFC2CB5E5
GO
Isoform 2 (identifier: Q16854-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-236: Missing.

Show »
Length:189
Mass (Da):21,439
Checksum:i0E0CBD1BBBE34002
GO
Isoform 3 (identifier: Q16854-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-85: Missing.

Show »
Length:239
Mass (Da):27,873
Checksum:i786237AC41F6BF66
GO
Isoform 4 (identifier: Q16854-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-85: Missing.
     149-236: Missing.

Show »
Length:151
Mass (Da):17,256
Checksum:iAA10F42F818838E5
GO
Isoform 5 (identifier: Q16854-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: I → IGNILKQIRGRAPIQET
     48-85: Missing.

Show »
Length:255
Mass (Da):29,649
Checksum:i24ABF9B977115020
GO
Isoform 6 (identifier: Q16854-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-89: AVGKSTFVKL...AAGTQKACTA → GLHCPKSWKL...PPESTAGALP
     90-277: Missing.

Note: No experimental confirmation available.

Show »
Length:89
Mass (Da):9,442
Checksum:i32692C4B9DA9F035
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831T → N in AAC50624. (PubMed:8692979)Curated
Sequence conflicti159 – 1591G → D in CAA66054. (PubMed:8706825)Curated
Sequence conflicti212 – 2121K → E in CAA66054. (PubMed:8706825)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421R → K in MTDPS3. 1 Publication
VAR_019417
Natural varianti227 – 2271E → K in MTDPS3. 1 Publication
VAR_019418
Natural varianti250 – 2501L → S in MTDPS3; significant reduction of activity. 1 Publication
VAR_023789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 471I → IGNILKQIRGRAPIQET in isoform 5. CuratedVSP_003026
Alternative sequencei48 – 8942AVGKS…KACTA → GLHCPKSWKLAGYDVPGAST MVLHIPDIFLFEPPESTAGA LP in isoform 6. 1 PublicationVSP_056026Add
BLAST
Alternative sequencei48 – 8538Missing in isoform 3, isoform 4 and isoform 5. CuratedVSP_003024Add
BLAST
Alternative sequencei90 – 277188Missing in isoform 6. 1 PublicationVSP_056027Add
BLAST
Alternative sequencei149 – 23688Missing in isoform 2 and isoform 4. CuratedVSP_003025Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41668 mRNA. Translation: AAC50624.1.
AC073046 Genomic DNA. Translation: AAX88910.1.
CH471053 Genomic DNA. Translation: EAW99704.1.
CH471053 Genomic DNA. Translation: EAW99707.1.
CH471053 Genomic DNA. Translation: EAW99709.1.
BC015757 mRNA. Translation: AAH15757.1.
BC024019 mRNA. Translation: AAH24019.1.
X97386 mRNA. Translation: CAA66054.1.
U81499 Genomic DNA. Translation: AAB39858.1.
CCDSiCCDS1931.1. [Q16854-1]
CCDS1932.1. [Q16854-2]
PIRiJC6142.
S71315.
RefSeqiNP_550438.1. NM_080916.2. [Q16854-1]
NP_550440.1. NM_080918.2. [Q16854-2]
UniGeneiHs.469022.

Genome annotation databases

EnsembliENST00000264093; ENSP00000264093; ENSG00000114956. [Q16854-1]
ENST00000348222; ENSP00000306964; ENSG00000114956. [Q16854-2]
ENST00000418996; ENSP00000408209; ENSG00000114956. [Q16854-6]
GeneIDi1716.
KEGGihsa:1716.
UCSCiuc002sjx.3. human. [Q16854-1]

Polymorphism databases

DMDMi23503050.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41668 mRNA. Translation: AAC50624.1 .
AC073046 Genomic DNA. Translation: AAX88910.1 .
CH471053 Genomic DNA. Translation: EAW99704.1 .
CH471053 Genomic DNA. Translation: EAW99707.1 .
CH471053 Genomic DNA. Translation: EAW99709.1 .
BC015757 mRNA. Translation: AAH15757.1 .
BC024019 mRNA. Translation: AAH24019.1 .
X97386 mRNA. Translation: CAA66054.1 .
U81499 Genomic DNA. Translation: AAB39858.1 .
CCDSi CCDS1931.1. [Q16854-1 ]
CCDS1932.1. [Q16854-2 ]
PIRi JC6142.
S71315.
RefSeqi NP_550438.1. NM_080916.2. [Q16854-1 ]
NP_550440.1. NM_080918.2. [Q16854-2 ]
UniGenei Hs.469022.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OCP X-ray 2.80 A/B/C/D/E/F/G/H 37-277 [» ]
ProteinModelPortali Q16854.
SMRi Q16854. Positions 37-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108062. 68 interactions.
IntActi Q16854. 1 interaction.
STRINGi 9606.ENSP00000264093.

Chemistry

BindingDBi Q16854.
ChEMBLi CHEMBL5997.
DrugBanki DB01280. Nelarabine.

PTM databases

PhosphoSitei Q16854.

Polymorphism databases

DMDMi 23503050.

Proteomic databases

MaxQBi Q16854.
PaxDbi Q16854.
PRIDEi Q16854.

Protocols and materials databases

DNASUi 1716.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264093 ; ENSP00000264093 ; ENSG00000114956 . [Q16854-1 ]
ENST00000348222 ; ENSP00000306964 ; ENSG00000114956 . [Q16854-2 ]
ENST00000418996 ; ENSP00000408209 ; ENSG00000114956 . [Q16854-6 ]
GeneIDi 1716.
KEGGi hsa:1716.
UCSCi uc002sjx.3. human. [Q16854-1 ]

Organism-specific databases

CTDi 1716.
GeneCardsi GC02P074153.
GeneReviewsi DGUOK.
HGNCi HGNC:2858. DGUOK.
HPAi HPA034766.
MIMi 251880. phenotype.
601465. gene.
neXtProti NX_Q16854.
Orphaneti 329314. Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency.
279934. Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency.
PharmGKBi PA27319.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1428.
GeneTreei ENSGT00510000046588.
HOGENOMi HOG000290165.
HOVERGENi HBG006216.
InParanoidi Q16854.
KOi K00904.
OMAi LLTKTYP.
OrthoDBi EOG70PBZM.
PhylomeDBi Q16854.
TreeFami TF324413.

Enzyme and pathway databases

BioCyci MetaCyc:HS03819-MONOMER.
BRENDAi 2.7.1.113. 2681.
Reactomei REACT_1923. Purine salvage.
SABIO-RK Q16854.

Miscellaneous databases

ChiTaRSi DGUOK. human.
EvolutionaryTracei Q16854.
GeneWikii DGUOK.
GenomeRNAii 1716.
NextBioi 6950.
PROi Q16854.
SOURCEi Search...

Gene expression databases

Bgeei Q16854.
CleanExi HS_DGUOK.
ExpressionAtlasi Q16854. baseline and differential.
Genevestigatori Q16854.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human deoxyguanosine kinase cDNA."
    Johansson M., Karlsson A.
    Proc. Natl. Acad. Sci. U.S.A. 93:7258-7262(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Tissue: B-cell and Urinary bladder.
  5. "Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA."
    Wang L., Hellman U., Eriksson S.
    FEBS Lett. 390:39-43(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-277, CATALYTIC ACTIVITY, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  6. Stegmann A.P.A., Mitchell B.S.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Structural basis for substrate specificities of cellular deoxyribonucleoside kinases."
    Johansson K., Ramaswamy S., Ljungcrantz C., Knecht W., Piskur J., Munch-Petersen B., Eriksson S., Eklund H.
    Nat. Struct. Biol. 8:616-620(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-277 IN COMPLEX WITH DEOXYADENOSINE 5'-TRIPHOSPHATE, SUBUNIT.
  9. Cited for: VARIANTS MTDPS3 LYS-142 AND LYS-227.
  10. "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes."
    Wang L., Limongelli A., Vila M.R., Carrara F., Zeviani M., Eriksson S.
    Mol. Genet. Metab. 84:75-82(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MTDPS3 SER-250, CHARACTERIZATION OF VARIANT MTDPS3 SER-250.

Entry informationi

Entry nameiDGUOK_HUMAN
AccessioniPrimary (citable) accession number: Q16854
Secondary accession number(s): P78532
, Q16759, Q4ZG09, Q7L1W9, Q96BC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3