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Q16854

- DGUOK_HUMAN

UniProt

Q16854 - DGUOK_HUMAN

Protein

Deoxyguanosine kinase, mitochondrial

Gene

DGUOK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.1 Publication

    Catalytic activityi

    ATP + deoxyguanosine = ADP + dGMP.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701SubstrateBy similarity
    Binding sitei100 – 1001Substrate
    Binding sitei111 – 1111Substrate
    Binding sitei118 – 1181Substrate
    Active sitei141 – 1411Proton acceptorSequence Analysis
    Binding sitei142 – 1421Substrate
    Binding sitei147 – 1471SubstrateBy similarity
    Binding sitei211 – 2111Substrate

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 539ATP
    Nucleotide bindingi206 – 2083ATP

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. deoxyguanosine kinase activity Source: UniProtKB
    3. nucleoside kinase activity Source: Reactome
    4. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    GO - Biological processi

    1. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
    2. dGTP metabolic process Source: Ensembl
    3. guanosine metabolic process Source: ProtInc
    4. negative regulation of neuron projection development Source: Ensembl
    5. nucleobase-containing small molecule metabolic process Source: Reactome
    6. nucleotide biosynthetic process Source: GOC
    7. protein phosphorylation Source: Ensembl
    8. purine-containing compound salvage Source: Reactome
    9. purine deoxyribonucleoside metabolic process Source: UniProtKB
    10. purine nucleobase metabolic process Source: Reactome
    11. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03819-MONOMER.
    BRENDAi2.7.1.113. 2681.
    ReactomeiREACT_1923. Purine salvage.
    SABIO-RKQ16854.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyguanosine kinase, mitochondrial (EC:2.7.1.113)
    Short name:
    dGK
    Gene namesi
    Name:DGUOK
    Synonyms:DGK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2858. DGUOK.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrial matrix Source: Reactome
    3. mitochondrion Source: ProtInc
    4. nucleus Source: UniProt

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Mitochondrial DNA depletion syndrome 3 (MTDPS3) [MIM:251880]: A disorder due to mitochondrial dysfunction characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti142 – 1421R → K in MTDPS3. 1 Publication
    VAR_019417
    Natural varianti227 – 2271E → K in MTDPS3. 1 Publication
    VAR_019418
    Natural varianti250 – 2501L → S in MTDPS3; significant reduction of activity. 1 Publication
    VAR_023789

    Keywords - Diseasei

    Disease mutation, Neuropathy

    Organism-specific databases

    MIMi251880. phenotype.
    Orphaneti329314. Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency.
    279934. Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency.
    PharmGKBiPA27319.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 277238Deoxyguanosine kinase, mitochondrialPRO_0000016840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ16854.
    PaxDbiQ16854.
    PRIDEiQ16854.

    PTM databases

    PhosphoSiteiQ16854.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ16854.
    BgeeiQ16854.
    CleanExiHS_DGUOK.
    GenevestigatoriQ16854.

    Organism-specific databases

    HPAiHPA034766.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi108062. 6 interactions.
    IntActiQ16854. 1 interaction.
    STRINGi9606.ENSP00000264093.

    Structurei

    Secondary structure

    1
    277
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 457
    Helixi51 – 6111
    Beta strandi65 – 684
    Helixi72 – 743
    Helixi95 – 1017
    Helixi103 – 12321
    Helixi128 – 1314
    Beta strandi137 – 1426
    Helixi144 – 1496
    Helixi151 – 1577
    Helixi163 – 17917
    Helixi181 – 1844
    Beta strandi188 – 1936
    Helixi196 – 20510
    Turni209 – 2135
    Helixi216 – 23015
    Helixi242 – 2443
    Beta strandi247 – 2515
    Turni256 – 2583
    Helixi260 – 27516

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OCPX-ray2.80A/B/C/D/E/F/G/H37-277[»]
    ProteinModelPortaliQ16854.
    SMRiQ16854. Positions 37-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ16854.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1428.
    HOGENOMiHOG000290165.
    HOVERGENiHBG006216.
    InParanoidiQ16854.
    KOiK00904.
    OMAiLLTKTYP.
    OrthoDBiEOG70PBZM.
    PhylomeDBiQ16854.
    TreeFamiTF324413.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16854-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGRLFLSR LRAPFSSMAK SPLEGVSSSR GLHAGRGPRR LSIEGNIAVG    50
    KSTFVKLLTK TYPEWHVATE PVATWQNIQA AGTQKACTAQ SLGNLLDMMY 100
    REPARWSYTF QTFSFLSRLK VQLEPFPEKL LQARKPVQIF ERSVYSDRYI 150
    FAKNLFENGS LSDIEWHIYQ DWHSFLLWEF ASRITLHGFI YLQASPQVCL 200
    KRLYQRAREE EKGIELAYLE QLHGQHEAWL IHKTTKLHFE ALMNIPVLVL 250
    DVNDDFSEEV TKQEDLMREV NTFVKNL 277
    Length:277
    Mass (Da):32,056
    Last modified:September 19, 2002 - v2
    Checksum:i53E4514BFC2CB5E5
    GO
    Isoform 2 (identifier: Q16854-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         149-236: Missing.

    Show »
    Length:189
    Mass (Da):21,439
    Checksum:i0E0CBD1BBBE34002
    GO
    Isoform 3 (identifier: Q16854-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-85: Missing.

    Show »
    Length:239
    Mass (Da):27,873
    Checksum:i786237AC41F6BF66
    GO
    Isoform 4 (identifier: Q16854-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-85: Missing.
         149-236: Missing.

    Show »
    Length:151
    Mass (Da):17,256
    Checksum:iAA10F42F818838E5
    GO
    Isoform 5 (identifier: Q16854-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-47: I → IGNILKQIRGRAPIQET
         48-85: Missing.

    Show »
    Length:255
    Mass (Da):29,649
    Checksum:i24ABF9B977115020
    GO
    Isoform 6 (identifier: Q16854-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-89: AVGKSTFVKL...AAGTQKACTA → GLHCPKSWKL...PPESTAGALP
         90-277: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:89
    Mass (Da):9,442
    Checksum:i32692C4B9DA9F035
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831T → N in AAC50624. (PubMed:8692979)Curated
    Sequence conflicti159 – 1591G → D in CAA66054. (PubMed:8706825)Curated
    Sequence conflicti212 – 2121K → E in CAA66054. (PubMed:8706825)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti142 – 1421R → K in MTDPS3. 1 Publication
    VAR_019417
    Natural varianti227 – 2271E → K in MTDPS3. 1 Publication
    VAR_019418
    Natural varianti250 – 2501L → S in MTDPS3; significant reduction of activity. 1 Publication
    VAR_023789

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 471I → IGNILKQIRGRAPIQET in isoform 5. CuratedVSP_003026
    Alternative sequencei48 – 8942AVGKS…KACTA → GLHCPKSWKLAGYDVPGAST MVLHIPDIFLFEPPESTAGA LP in isoform 6. 1 PublicationVSP_056026Add
    BLAST
    Alternative sequencei48 – 8538Missing in isoform 3, isoform 4 and isoform 5. CuratedVSP_003024Add
    BLAST
    Alternative sequencei90 – 277188Missing in isoform 6. 1 PublicationVSP_056027Add
    BLAST
    Alternative sequencei149 – 23688Missing in isoform 2 and isoform 4. CuratedVSP_003025Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41668 mRNA. Translation: AAC50624.1.
    AC073046 Genomic DNA. Translation: AAX88910.1.
    CH471053 Genomic DNA. Translation: EAW99704.1.
    CH471053 Genomic DNA. Translation: EAW99707.1.
    CH471053 Genomic DNA. Translation: EAW99709.1.
    BC015757 mRNA. Translation: AAH15757.1.
    BC024019 mRNA. Translation: AAH24019.1.
    X97386 mRNA. Translation: CAA66054.1.
    U81499 Genomic DNA. Translation: AAB39858.1.
    CCDSiCCDS1931.1. [Q16854-1]
    CCDS1932.1. [Q16854-2]
    PIRiJC6142.
    S71315.
    RefSeqiNP_550438.1. NM_080916.2. [Q16854-1]
    NP_550440.1. NM_080918.2. [Q16854-2]
    UniGeneiHs.469022.

    Genome annotation databases

    EnsembliENST00000264093; ENSP00000264093; ENSG00000114956. [Q16854-1]
    ENST00000348222; ENSP00000306964; ENSG00000114956. [Q16854-2]
    ENST00000418996; ENSP00000408209; ENSG00000114956.
    GeneIDi1716.
    KEGGihsa:1716.
    UCSCiuc002sjx.3. human. [Q16854-1]

    Polymorphism databases

    DMDMi23503050.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41668 mRNA. Translation: AAC50624.1 .
    AC073046 Genomic DNA. Translation: AAX88910.1 .
    CH471053 Genomic DNA. Translation: EAW99704.1 .
    CH471053 Genomic DNA. Translation: EAW99707.1 .
    CH471053 Genomic DNA. Translation: EAW99709.1 .
    BC015757 mRNA. Translation: AAH15757.1 .
    BC024019 mRNA. Translation: AAH24019.1 .
    X97386 mRNA. Translation: CAA66054.1 .
    U81499 Genomic DNA. Translation: AAB39858.1 .
    CCDSi CCDS1931.1. [Q16854-1 ]
    CCDS1932.1. [Q16854-2 ]
    PIRi JC6142.
    S71315.
    RefSeqi NP_550438.1. NM_080916.2. [Q16854-1 ]
    NP_550440.1. NM_080918.2. [Q16854-2 ]
    UniGenei Hs.469022.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OCP X-ray 2.80 A/B/C/D/E/F/G/H 37-277 [» ]
    ProteinModelPortali Q16854.
    SMRi Q16854. Positions 37-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108062. 6 interactions.
    IntActi Q16854. 1 interaction.
    STRINGi 9606.ENSP00000264093.

    Chemistry

    BindingDBi Q16854.
    ChEMBLi CHEMBL5997.

    PTM databases

    PhosphoSitei Q16854.

    Polymorphism databases

    DMDMi 23503050.

    Proteomic databases

    MaxQBi Q16854.
    PaxDbi Q16854.
    PRIDEi Q16854.

    Protocols and materials databases

    DNASUi 1716.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264093 ; ENSP00000264093 ; ENSG00000114956 . [Q16854-1 ]
    ENST00000348222 ; ENSP00000306964 ; ENSG00000114956 . [Q16854-2 ]
    ENST00000418996 ; ENSP00000408209 ; ENSG00000114956 .
    GeneIDi 1716.
    KEGGi hsa:1716.
    UCSCi uc002sjx.3. human. [Q16854-1 ]

    Organism-specific databases

    CTDi 1716.
    GeneCardsi GC02P074153.
    GeneReviewsi DGUOK.
    HGNCi HGNC:2858. DGUOK.
    HPAi HPA034766.
    MIMi 251880. phenotype.
    601465. gene.
    neXtProti NX_Q16854.
    Orphaneti 329314. Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency.
    279934. Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency.
    PharmGKBi PA27319.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1428.
    HOGENOMi HOG000290165.
    HOVERGENi HBG006216.
    InParanoidi Q16854.
    KOi K00904.
    OMAi LLTKTYP.
    OrthoDBi EOG70PBZM.
    PhylomeDBi Q16854.
    TreeFami TF324413.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS03819-MONOMER.
    BRENDAi 2.7.1.113. 2681.
    Reactomei REACT_1923. Purine salvage.
    SABIO-RK Q16854.

    Miscellaneous databases

    ChiTaRSi DGUOK. human.
    EvolutionaryTracei Q16854.
    GeneWikii DGUOK.
    GenomeRNAii 1716.
    NextBioi 6950.
    PROi Q16854.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16854.
    Bgeei Q16854.
    CleanExi HS_DGUOK.
    Genevestigatori Q16854.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of human deoxyguanosine kinase cDNA."
      Johansson M., Karlsson A.
      Proc. Natl. Acad. Sci. U.S.A. 93:7258-7262(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
      Tissue: B-cell and Urinary bladder.
    5. "Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA."
      Wang L., Hellman U., Eriksson S.
      FEBS Lett. 390:39-43(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-277, CATALYTIC ACTIVITY, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    6. Stegmann A.P.A., Mitchell B.S.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structural basis for substrate specificities of cellular deoxyribonucleoside kinases."
      Johansson K., Ramaswamy S., Ljungcrantz C., Knecht W., Piskur J., Munch-Petersen B., Eriksson S., Eklund H.
      Nat. Struct. Biol. 8:616-620(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-277 IN COMPLEX WITH DEOXYADENOSINE 5'-TRIPHOSPHATE, SUBUNIT.
    9. Cited for: VARIANTS MTDPS3 LYS-142 AND LYS-227.
    10. "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes."
      Wang L., Limongelli A., Vila M.R., Carrara F., Zeviani M., Eriksson S.
      Mol. Genet. Metab. 84:75-82(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MTDPS3 SER-250, CHARACTERIZATION OF VARIANT MTDPS3 SER-250.

    Entry informationi

    Entry nameiDGUOK_HUMAN
    AccessioniPrimary (citable) accession number: Q16854
    Secondary accession number(s): P78532
    , Q16759, Q4ZG09, Q7L1W9, Q96BC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3