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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Binding sitei127UTPBy similarity1
Binding sitei190UTPBy similarity1
Binding sitei222UTP; via amide nitrogenBy similarity1
Binding sitei223SubstrateCombined sources1 Publication1
Metal bindingi253MagnesiumBy similarity1
Binding sitei253UTPBy similarity1
Binding sitei330SubstrateCombined sources1 Publication1
Active sitei396By similarity1
Binding sitei396UTPBy similarity1

GO - Molecular functioni

  • glucose binding Source: Ensembl
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • pyrimidine ribonucleotide binding Source: Ensembl
  • UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS10006-MONOMER.
ZFISH:HS10006-MONOMER.
BRENDAi2.7.7.9. 2681.
ReactomeiR-HSA-173599. Formation of the active cofactor, UDP-glucuronate.
R-HSA-3322077. Glycogen synthesis.
SABIO-RKQ16851.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP2
Synonyms:UGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12527. UGP2.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi123C → S: No significant loss of activity. 1 Publication1
Mutagenesisi218W → S: No significant loss of activity. 1 Publication1
Mutagenesisi266H → R: No significant loss of activity. 1 Publication1
Mutagenesisi333W → S: Loss of activity; possibly due to folding defect. 1 Publication1
Mutagenesisi389R → H: No significant loss of activity. 1 Publication1
Mutagenesisi391R → H: Loss of activity; possibly due to folding defect. 1 Publication1
Mutagenesisi422R → H: No significant loss of activity. 1 Publication1
Mutagenesisi445R → H: No significant loss of activity. 1 Publication1
Mutagenesisi502 – 503NL → PE: Abolishes oligomerization and significantly increases enzymatic activity. 1 Publication2

Organism-specific databases

DisGeNETi7360.
OpenTargetsiENSG00000169764.
PharmGKBiPA37172.

Polymorphism and mutation databases

BioMutaiUGP2.
DMDMi59803098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857521 – 508UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST508
Isoform 2 (identifier: Q16851-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei426PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei438N6-acetyllysineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Isoform 2 (identifier: Q16851-2)
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ16851.
MaxQBiQ16851.
PaxDbiQ16851.
PeptideAtlasiQ16851.
PRIDEiQ16851.

2D gel databases

REPRODUCTION-2DPAGEIPI00395676.
UCD-2DPAGEQ16851.

PTM databases

iPTMnetiQ16851.
PhosphoSitePlusiQ16851.
SwissPalmiQ16851.

Expressioni

Gene expression databases

BgeeiENSG00000169764.
CleanExiHS_UGP2.
ExpressionAtlasiQ16851. baseline and differential.
GenevisibleiQ16851. HS.

Organism-specific databases

HPAiHPA034696.
HPA034697.
HPA064836.

Interactioni

Subunit structurei

Homooctamer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-743729,EBI-743729
ARIH2O953766EBI-743729,EBI-711158
GLRX3O760033EBI-743729,EBI-374781
GRB2P629932EBI-743729,EBI-401755

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi113207. 54 interactors.
IntActiQ16851. 8 interactors.
MINTiMINT-1468909.
STRINGi9606.ENSP00000338703.

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 41Combined sources17
Helixi45 – 47Combined sources3
Helixi49 – 65Combined sources17
Helixi75 – 77Combined sources3
Beta strandi85 – 88Combined sources4
Helixi89 – 95Combined sources7
Helixi101 – 105Combined sources5
Beta strandi108 – 114Combined sources7
Turni118 – 122Combined sources5
Beta strandi124 – 126Combined sources3
Helixi127 – 129Combined sources3
Beta strandi130 – 133Combined sources4
Helixi138 – 153Combined sources16
Beta strandi158 – 163Combined sources6
Turni165 – 167Combined sources3
Helixi168 – 172Combined sources5
Helixi173 – 178Combined sources6
Beta strandi179 – 182Combined sources4
Beta strandi184 – 189Combined sources6
Beta strandi196 – 200Combined sources5
Helixi210 – 212Combined sources3
Helixi215 – 217Combined sources3
Helixi226 – 232Combined sources7
Helixi235 – 241Combined sources7
Beta strandi246 – 254Combined sources9
Helixi261 – 268Combined sources8
Helixi271 – 273Combined sources3
Beta strandi277 – 284Combined sources8
Beta strandi294 – 298Combined sources5
Beta strandi301 – 305Combined sources5
Helixi307 – 309Combined sources3
Helixi315 – 319Combined sources5
Turni321 – 323Combined sources3
Beta strandi326 – 335Combined sources10
Helixi336 – 344Combined sources9
Beta strandi353 – 359Combined sources7
Turni360 – 362Combined sources3
Beta strandi363 – 369Combined sources7
Helixi372 – 378Combined sources7
Beta strandi383 – 386Combined sources4
Helixi389 – 391Combined sources3
Helixi398 – 405Combined sources8
Beta strandi409 – 412Combined sources4
Beta strandi415 – 418Combined sources4
Beta strandi423 – 426Combined sources4
Beta strandi429 – 432Combined sources4
Helixi434 – 436Combined sources3
Helixi439 – 445Combined sources7
Beta strandi446 – 448Combined sources3
Beta strandi455 – 460Combined sources6
Beta strandi462 – 466Combined sources5
Beta strandi471 – 480Combined sources10
Beta strandi485 – 488Combined sources4
Beta strandi493 – 496Combined sources4
Beta strandi498 – 501Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R2WX-ray3.60A/B/C/D1-508[»]
3R3IX-ray3.57A/B/C/D1-508[»]
4R7PX-ray3.35A/B/C/D2-508[»]
ProteinModelPortaliQ16851.
SMRiQ16851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116UTP bindingBy similarity4
Regioni115 – 116Substrate bindingCombined sources1 Publication2
Regioni251 – 253Substrate bindingCombined sources1 Publication3
Regioni457 – 508OligomerizationAdd BLAST52
Regioni502 – 503Critical for end-to-end subunit interaction2

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638. Eukaryota.
COG4284. LUCA.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ16851.
KOiK00963.
PhylomeDBiQ16851.
TreeFamiTF300567.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM
360 370 380 390 400
EIIVNAKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,940
Last modified:January 23, 2007 - v5
Checksum:i60E54806807AB470
GO
Isoform 2 (identifier: Q16851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:497
Mass (Da):55,677
Checksum:i2B3FD9731E371E47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → L (PubMed:8354390).Curated1
Sequence conflicti44S → T (PubMed:8354390).Curated1
Sequence conflicti48F → Y (PubMed:8354390).Curated1
Sequence conflicti62F → Y (PubMed:8354390).Curated1
Sequence conflicti152T → S (PubMed:8354390).Curated1
Sequence conflicti202L → R (PubMed:8354390).Curated1
Sequence conflicti202L → R in AAB05640 (PubMed:8631325).Curated1
Sequence conflicti210Y → S (PubMed:8354390).Curated1
Sequence conflicti214N → S (PubMed:8354390).Curated1
Sequence conflicti240 – 241IG → LE (PubMed:8354390).Curated2
Sequence conflicti356A → P (PubMed:8354390).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033042268M → I.2 PublicationsCorresponds to variant rs1130982dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128341 – 11Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27460 mRNA. Translation: AAB05640.1.
BC000173 mRNA. Translation: AAH00173.2.
BC002954 mRNA. Translation: AAH02954.1.
BC047004 mRNA. Translation: AAH47004.1.
CCDSiCCDS1875.1. [Q16851-1]
CCDS42690.1. [Q16851-2]
PIRiS35692.
RefSeqiNP_001001521.1. NM_001001521.1. [Q16851-2]
NP_006750.3. NM_006759.3. [Q16851-1]
XP_005264594.1. XM_005264537.2. [Q16851-2]
XP_005264595.1. XM_005264538.1. [Q16851-2]
UniGeneiHs.516217.

Genome annotation databases

EnsembliENST00000337130; ENSP00000338703; ENSG00000169764. [Q16851-1]
ENST00000394417; ENSP00000377939; ENSG00000169764. [Q16851-2]
ENST00000467648; ENSP00000420793; ENSG00000169764. [Q16851-2]
GeneIDi7360.
KEGGihsa:7360.
UCSCiuc002scl.4. human. [Q16851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27460 mRNA. Translation: AAB05640.1.
BC000173 mRNA. Translation: AAH00173.2.
BC002954 mRNA. Translation: AAH02954.1.
BC047004 mRNA. Translation: AAH47004.1.
CCDSiCCDS1875.1. [Q16851-1]
CCDS42690.1. [Q16851-2]
PIRiS35692.
RefSeqiNP_001001521.1. NM_001001521.1. [Q16851-2]
NP_006750.3. NM_006759.3. [Q16851-1]
XP_005264594.1. XM_005264537.2. [Q16851-2]
XP_005264595.1. XM_005264538.1. [Q16851-2]
UniGeneiHs.516217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R2WX-ray3.60A/B/C/D1-508[»]
3R3IX-ray3.57A/B/C/D1-508[»]
4R7PX-ray3.35A/B/C/D2-508[»]
ProteinModelPortaliQ16851.
SMRiQ16851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113207. 54 interactors.
IntActiQ16851. 8 interactors.
MINTiMINT-1468909.
STRINGi9606.ENSP00000338703.

PTM databases

iPTMnetiQ16851.
PhosphoSitePlusiQ16851.
SwissPalmiQ16851.

Polymorphism and mutation databases

BioMutaiUGP2.
DMDMi59803098.

2D gel databases

REPRODUCTION-2DPAGEIPI00395676.
UCD-2DPAGEQ16851.

Proteomic databases

EPDiQ16851.
MaxQBiQ16851.
PaxDbiQ16851.
PeptideAtlasiQ16851.
PRIDEiQ16851.

Protocols and materials databases

DNASUi7360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337130; ENSP00000338703; ENSG00000169764. [Q16851-1]
ENST00000394417; ENSP00000377939; ENSG00000169764. [Q16851-2]
ENST00000467648; ENSP00000420793; ENSG00000169764. [Q16851-2]
GeneIDi7360.
KEGGihsa:7360.
UCSCiuc002scl.4. human. [Q16851-1]

Organism-specific databases

CTDi7360.
DisGeNETi7360.
GeneCardsiUGP2.
HGNCiHGNC:12527. UGP2.
HPAiHPA034696.
HPA034697.
HPA064836.
MIMi191750. gene.
191760. gene.
neXtProtiNX_Q16851.
OpenTargetsiENSG00000169764.
PharmGKBiPA37172.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2638. Eukaryota.
COG4284. LUCA.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ16851.
KOiK00963.
PhylomeDBiQ16851.
TreeFamiTF300567.

Enzyme and pathway databases

BioCyciMetaCyc:HS10006-MONOMER.
ZFISH:HS10006-MONOMER.
BRENDAi2.7.7.9. 2681.
ReactomeiR-HSA-173599. Formation of the active cofactor, UDP-glucuronate.
R-HSA-3322077. Glycogen synthesis.
SABIO-RKQ16851.

Miscellaneous databases

ChiTaRSiUGP2. human.
GenomeRNAii7360.
PROiQ16851.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169764.
CleanExiHS_UGP2.
ExpressionAtlasiQ16851. baseline and differential.
GenevisibleiQ16851. HS.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUGPA_HUMAN
AccessioniPrimary (citable) accession number: Q16851
Secondary accession number(s): Q07131
, Q0P6K2, Q86Y81, Q9BU15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 151 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The human genome was initially thought to contain 2 genes for UTP--glucose-1-phosphate uridylyltransferase: UGP1 and UGP2. However, the sequence defined as UGP1 (PubMed:8354390) probably does not exist and corresponds to UGP2.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.