Q16849 (PTPRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase-like N
Short name=R-PTP-N

Alternative name(s):
Islet cell antigen 512
Short name=ICA 512
Islet cell autoantigen 3
PTP IA-2

Gene names

Name:	PTPRN
Synonyms:	ICA3, ICA512

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	979 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Ref.6 Ref.7
Subunit structure	Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage. Ref.8
Subcellular location	Membrane; Single-pass type I membrane protein. Note: Neuroendocrine secretory granules.
Tissue specificity	Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. Ref.1
Post-translational modification	O-glycosylated with core 1 or possibly core 8 glycans. Ref.9 Ref.10 Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
Miscellaneous	Autoantigen in insulin-dependent diabetes mellitus (IDDM).
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara response to cAMP Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara response to reactive oxygen species Inferred from direct assay Ref.11. Source: UniProtKB
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MADD	Q8WXG6	4	EBI-728153,EBI-310528
PPIA	P62937	3	EBI-728153,EBI-437708
PTPRS	Q13332	5	EBI-728153,EBI-711536
PTPRT	O14522	3	EBI-728153,EBI-728180
SNX19	Q92543	4	EBI-728153,EBI-728232

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q16849-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16849-2)

The sequence of this isoform differs from the canonical sequence as follows:
     479-508: KPLSLAAGVKLLEILAEHVHMSSGSFINIS → N

Note: No experimental confirmation available.

Isoform 3 (identifier: Q16849-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

34

By similarity

Chain

35 – 979

945

Receptor-type tyrosine-protein phosphatase-like N

PRO_0000025451

Regions

Topological domain

35 – 575

541

Extracellular Potential

Transmembrane

576 – 600

25

Helical; Potential

Topological domain

601 – 979

379

Cytoplasmic Potential

Domain

709 – 969

261

Tyrosine-protein phosphatase

Region

909 – 915

7

Substrate binding By similarity

Sites

Active site

909

1

Phosphocysteine intermediate By similarity

Site

448 – 449

2

Cleavage Potential

Amino acid modifications

Glycosylation

441

1

O-linked (GalNAc...) Ref.9 Ref.10

Glycosylation

506

1

N-linked (GlcNAc...) Potential

Glycosylation

524

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1 – 90

90

Missing in isoform 3.

VSP_045867

Alternative sequence

479 – 508

30

KPLSL…FINIS → N in isoform 2.

VSP_043654

Natural variant

419

1

S → R.
Corresponds to variant rs35314717 [ dbSNP | Ensembl ].

VAR_051762

Experimental info

Sequence conflict

673

1

S → G in BAG59024. Ref.2

Secondary structure

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979

Helix Strand Turn

Details...

Beta strand

471 – 477

7

Helix

483 – 497

15

Helix

501 – 503

3

Beta strand

504 – 510

7

Beta strand

513 – 518

6

Helix

527 – 536

10

Helix

538 – 545

8

Beta strand

549 – 555

7

Helix

692 – 704

13

Helix

706 – 717

12

Helix

727 – 730

4

Turn

732 – 734

3

Helix

735 – 737

3

Helix

755 – 757

3

Beta strand

766 – 770

5

Beta strand

780 – 783

4

Helix

788 – 790

3

Helix

791 – 801

11

Beta strand

805 – 808

4

Beta strand

812 – 814

3

Beta strand

826 – 832

7

Beta strand

835 – 844

10

Beta strand

846 – 858

13

Turn

859 – 861

3

Beta strand

864 – 872

9

Beta strand

877 – 880

4

Helix

885 – 896

12

Beta strand

905 – 908

4

Beta strand

910 – 913

4

Helix

914 – 930

17

Helix

938 – 946

9

Helix

956 – 975

20

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A852B9063D29399D	FASTA	979	105,848
	10 20 30 40 50 60 MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG 70 80 90 100 110 120 QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 130 140 150 160 170 180 PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL 190 200 210 220 230 240 LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA 250 260 270 280 290 300 PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG 310 320 330 340 350 360 SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL 370 380 390 400 410 420 LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE 430 440 450 460 470 480 VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP 490 500 510 520 530 540 LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE 550 560 570 580 590 600 LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV 610 620 630 640 650 660 RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ 670 680 690 700 710 720 FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ 730 740 750 760 770 780 AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY 790 800 810 820 830 840 IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV 850 860 870 880 890 900 SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG 910 920 930 940 950 960 RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE 970 FALTAVAEEV NAILKALPQ
	Isoform 2 [UniParc]. Checksum: AA63FE699D560D7C	FASTA	950	102,817
	10 20 30 40 50 60 MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG 70 80 90 100 110 120 QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 130 140 150 160 170 180 PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL 190 200 210 220 230 240 LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA 250 260 270 280 290 300 PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG 310 320 330 340 350 360 SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL 370 380 390 400 410 420 LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE 430 440 450 460 470 480 VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQNV 490 500 510 520 530 540 VGPALTFRIR HNEQNLSLAD VTQQAGLVKS ELEAQTGLQI LQTGVGQREE AAAVLPQTAH 550 560 570 580 590 600 STSPMRSVLL TLVALAGVAG LLVALAVALC VRQHARQQDK ERLAALGPEG AHGDTTFEYQ 610 620 630 640 650 660 DLCRQHMATK SLFNRAEGPP EPSRVSSVSS QFSDAAQASP SSHSSTPSWC EEPAQANMDI 670 680 690 700 710 720 STGHMILAYM EDHLRNRDRL AKEWQALCAY QAEPNTCATA QGEGNIKKNR HPDFLPYDHA 730 740 750 760 770 780 RIKLKVESSP SRSDYINASP IIEHDPRMPA YIATQGPLSH TIADFWQMVW ESGCTVIVML 790 800 810 820 830 840 TPLVEDGVKQ CDRYWPDEGA SLYHVYEVNL VSEHIWCEDF LVRSFYLKNV QTQETRTLTQ 850 860 870 880 890 900 FHFLSWPAEG TPASTRPLLD FRRKVNKCYR GRSCPIIVHC SDGAGRTGTY ILIDMVLNRM 910 920 930 940 950 AKGVKEIDIA ATLEHVRDQR PGLVRSKDQF EFALTAVAEE VNAILKALPQ
	Isoform 3 [UniParc]. Checksum: BEEAF1F58AF81284	FASTA	889	96,261
	10 20 30 40 50 60 MSQGLSWHDD LTQYVISQEM ERIPRLRPPE PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA 70 80 90 100 110 120 PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL LPPLLEHLLL PPQPPHPSLS YEPALLQPYL 130 140 150 160 170 180 FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA PALFSRTASK GIFGDHPGHS YGDLPGPSPA 190 200 210 220 230 240 QLFQDSGLLY LAQELPAPSR ARVPRLPEQG SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ 250 260 270 280 290 300 PDAALQRLAA VLAGYGVELR QLTPEQLSTL LTLLQLLPKG AGRNPGGVVN VGADIKKTME 310 320 330 340 350 360 GPVEGRDTAE LPARTSPMPG HPTASPTSSE VQQVPSPVSS EPPKAARPPV TPVLLEKKSP 370 380 390 400 410 420 LGQSQPTVAG QPSARPAAEE YGYIVTDQKP LSLAAGVKLL EILAEHVHMS SGSFINISVV 430 440 450 460 470 480 GPALTFRIRH NEQNLSLADV TQQAGLVKSE LEAQTGLQIL QTGVGQREEA AAVLPQTAHS 490 500 510 520 530 540 TSPMRSVLLT LVALAGVAGL LVALAVALCV RQHARQQDKE RLAALGPEGA HGDTTFEYQD 550 560 570 580 590 600 LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ FSDAAQASPS SHSSTPSWCE EPAQANMDIS 610 620 630 640 650 660 TGHMILAYME DHLRNRDRLA KEWQALCAYQ AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR 670 680 690 700 710 720 IKLKVESSPS RSDYINASPI IEHDPRMPAY IATQGPLSHT IADFWQMVWE SGCTVIVMLT 730 740 750 760 770 780 PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF 790 800 810 820 830 840 HFLSWPAEGT PASTRPLLDF RRKVNKCYRG RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA 850 860 870 880 KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE FALTAVAEEV NAILKALPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma." Lan M.S., Lu J., Goto Y., Notkins A.L. DNA Cell Biol. 13:505-514(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Insulinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Thalamus.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases." Rabin D.U., Pleasic S.M., Shapiro J.A., Yoo-Warren H., Oles J., Hicks J.M., Goldstein D.E., Rae P.M. J. Immunol. 152:3183-3188(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 389-789, ROLE IN DIABETES MELLITUS. Tissue: Pancreatic islet.
[7]	"ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules." Solimena M., Dirkx R. Jr., Hermel J.-M., Pleasic-Williams S., Shapiro J.A., Caron L., Rabin D.U. EMBO J. 15:2102-2114(1996) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION, ROLE IN DIABETES MELLITUS.
[8]	"Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion." Ort T., Voronov S., Guo J., Zawalich K., Froehner S.C., Zawalich W., Solimena M. EMBO J. 20:4013-4023(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNTB2, PROTEOLYTIC PROCESSING, DEPHOSPHORYLATION.
[9]	"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD." Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G. Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT THR-441, STRUCTURE OF CARBOHYDRATES, MASS SPECTROMETRY.
[10]	"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins." Halim A., Ruetschi U., Larson G., Nilsson J. J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT THR-441, MASS SPECTROMETRY.
[11]	"Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2." Primo M.E., Klinke S., Sica M.P., Goldbaum F.A., Jakoncic J., Poskus E., Ermacora M.R. J. Biol. Chem. 283:4674-4681(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 468-558.
[12]	"Structural genomics of protein phosphatases." Almo S.C., Bonanno J.B., Sauder J.M., Emtage S., Dilorenzo T.P., Malashkevich V., Wasserman S.R., Swaminathan S., Eswaramoorthy S., Agarwal R., Kumaran D., Madegowda M., Ragumani S., Patskovsky Y., Alvarado J., Ramagopal U.A., Faber-Barata J., Chance M.R. , Sali A., Fiser A., Zhang Z.Y., Lawrence D.S., Burley S.K. J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 681-979.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L18983 mRNA. Translation: AAA90974.1.
AK296335 mRNA. Translation: BAG59024.1.
AC114803 Genomic DNA. Translation: AAY24038.1.
CH471063 Genomic DNA. Translation: EAW70724.1.
CH471063 Genomic DNA. Translation: EAW70726.1.
BC070053 mRNA. Translation: AAH70053.1.
X62899 mRNA. Translation: CAA44688.2.

IPI

IPI00004440.
IPI00916379.
IPI00917520.

PIR

I37577.

RefSeq

NP_001186692.1. NM_001199763.1.
NP_001186693.1. NM_001199764.1.
NP_002837.1. NM_002846.3.

UniGene

Hs.89655.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2I1Y	X-ray	2.23	A/B	681-979	[»]
2QT7	X-ray	1.30	A/B	468-558	[»]
3N01	X-ray	1.30	A/B	470-558	[»]
3N4W	X-ray	1.45	A/B	470-558	[»]
3NG8	X-ray	1.35	A/B	470-558	[»]
3NP5	X-ray	1.80	A/B/C/D	470-558	[»]

ProteinModelPortal

Q16849.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q16849. 9 interactions.

MINT

MINT-1350221.

STRING

9606.ENSP00000295718.

PTM databases

PhosphoSite

Q16849.

Polymorphism databases

DMDM

2499754.

Proteomic databases

PaxDb

Q16849.

PeptideAtlas

Q16849.

PRIDE

Q16849.

Protocols and materials databases

DNASU

5798.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000295718; ENSP00000295718; ENSG00000054356.
ENST00000409251; ENSP00000386638; ENSG00000054356.
ENST00000537666; ENSP00000444244; ENSG00000054356.
ENST00000539342; ENSP00000445579; ENSG00000054356.

GeneID

5798.

KEGG

hsa:5798.

UCSC

uc002vkz.3. human.
uc002vla.3. human.

Organism-specific databases

CTD

5798.

GeneCards

GC02M220118.

HGNC

HGNC:9676. PTPRN.

HPA

HPA007179.

MIM

601773. gene.

neXtProt

NX_Q16849.

PharmGKB

PA34021.

GenAtlas

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Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000243992.

HOVERGEN

HBG053762.

InParanoid

Q16849.

KO

K07817.

OMA

EVCIQDG.

OrthoDB

EOG4WDDBX.

PhylomeDB

Q16849.

Gene expression databases

ArrayExpress

Q16849.

Bgee

Q16849.

CleanEx

HS_PTPRN.

Genevestigator

Q16849.

GermOnline

ENSG00000054356. Homo sapiens.

Family and domain databases

InterPro

IPR021613. Receptor_IA-2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PRINTS

PR00700. PRTYPHPHTASE.

SMART

SM00194. PTPc. 1 hit.
[Graphical view]

PROSITE

PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q16849.

GenomeRNAi

5798.

NextBio

22580.

PMAP-CutDB

Q16849.

SOURCE

Search...

Entry information

Entry name

PTPRN_HUMAN

Accession

Primary (citable) accession number: Q16849
Secondary accession number(s): B4DK12 , F5GZS3, Q08319, Q53QD6, Q6NSL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 29, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.