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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Gene

ST3GAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei240 – 2401SubstrateBy similarity
Binding sitei276 – 2761SubstrateBy similarity
Binding sitei280 – 2801Substrate; via amide nitrogenBy similarity
Binding sitei300 – 3001Substrate; via amide nitrogenBy similarity
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei326 – 3261SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.4. 2681.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-977068. Termination of O-glycan biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Chemistry

SwissLipidsiSLP:000001388.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (EC:2.4.99.4)
Short name:
Alpha 2,3-ST 2
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 2
Alternative name(s):
Gal-NAc6S
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
ST3Gal II
Short name:
ST3GalII
ST3GalA.2
Sialyltransferase 4B
Short name:
SIAT4-B
Gene namesi
Name:ST3GAL2
Synonyms:SIAT4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10863. ST3GAL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini28 – 350323LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35765.

Polymorphism and mutation databases

BioMutaiST3GAL2.
DMDMi21759433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2PRO_0000149258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 75By similarity
Disulfide bondi72 ↔ 149By similarity
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi152 ↔ 291By similarity
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ16842.
MaxQBiQ16842.
PaxDbiQ16842.
PeptideAtlasiQ16842.
PRIDEiQ16842.

PTM databases

iPTMnetiQ16842.
PhosphoSiteiQ16842.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.2 Publications

Gene expression databases

BgeeiENSG00000157350.
CleanExiHS_ST3GAL2.
ExpressionAtlasiQ16842. baseline and differential.
GenevisibleiQ16842. HS.

Organism-specific databases

HPAiHPA017270.

Interactioni

Protein-protein interaction databases

BioGridi112376. 9 interactions.
IntActiQ16842. 1 interaction.
MINTiMINT-1404038.
STRINGi9606.ENSP00000345477.

Structurei

3D structure databases

ProteinModelPortaliQ16842.
SMRiQ16842. Positions 68-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000126811.
HOVERGENiHBG054227.
InParanoidiQ16842.
KOiK03368.
OMAiDSHFNSN.
OrthoDBiEOG091G08DE.
PhylomeDBiQ16842.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSLRVWFL SVAFLLVFIM SLLFTYSHHS MATLPYLDSG ALDGTHRVKL
60 70 80 90 100
VPGYAGLQRL SKERLSGKSC ACRRCMGDAG ASDWFDSHFD GNISPVWTRE
110 120 130 140 150
NMDLPPDVQR WWMMLQPQFK SHNTNEVLEK LFQIVPGENP YRFRDPHQCR
160 170 180 190 200
RCAVVGNSGN LRGSGYGQDV DGHNFIMRMN QAPTVGFEQD VGSRTTHHFM
210 220 230 240 250
YPESAKNLPA NVSFVLVPFK VLDLLWIASA LSTGQIRFTY APVKSFLRVD
260 270 280 290 300
KEKVQIYNPA FFKYIHDRWT EHHGRYPSTG MLVLFFALHV CDEVNVYGFG
310 320 330 340 350
ADSRGNWHHY WENNRYAGEF RKTGVHDADF EAHIIDMLAK ASKIEVYRGN
Length:350
Mass (Da):40,173
Last modified:November 1, 1996 - v1
Checksum:iE7E40CF26D9CB725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63090 mRNA. Translation: AAB40389.1.
X96667 mRNA. Translation: CAA65447.1.
BC036777 mRNA. Translation: AAH36777.1.
CCDSiCCDS10890.1.
PIRiJC5251.
RefSeqiNP_008858.1. NM_006927.3.
UniGeneiHs.368611.

Genome annotation databases

EnsembliENST00000342907; ENSP00000345477; ENSG00000157350.
ENST00000393640; ENSP00000377257; ENSG00000157350.
GeneIDi6483.
KEGGihsa:6483.
UCSCiuc002eyw.3. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal II

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63090 mRNA. Translation: AAB40389.1.
X96667 mRNA. Translation: CAA65447.1.
BC036777 mRNA. Translation: AAH36777.1.
CCDSiCCDS10890.1.
PIRiJC5251.
RefSeqiNP_008858.1. NM_006927.3.
UniGeneiHs.368611.

3D structure databases

ProteinModelPortaliQ16842.
SMRiQ16842. Positions 68-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112376. 9 interactions.
IntActiQ16842. 1 interaction.
MINTiMINT-1404038.
STRINGi9606.ENSP00000345477.

Chemistry

SwissLipidsiSLP:000001388.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ16842.
PhosphoSiteiQ16842.

Polymorphism and mutation databases

BioMutaiST3GAL2.
DMDMi21759433.

Proteomic databases

EPDiQ16842.
MaxQBiQ16842.
PaxDbiQ16842.
PeptideAtlasiQ16842.
PRIDEiQ16842.

Protocols and materials databases

DNASUi6483.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342907; ENSP00000345477; ENSG00000157350.
ENST00000393640; ENSP00000377257; ENSG00000157350.
GeneIDi6483.
KEGGihsa:6483.
UCSCiuc002eyw.3. human.

Organism-specific databases

CTDi6483.
GeneCardsiST3GAL2.
HGNCiHGNC:10863. ST3GAL2.
HPAiHPA017270.
MIMi607188. gene.
neXtProtiNX_Q16842.
PharmGKBiPA35765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000126811.
HOVERGENiHBG054227.
InParanoidiQ16842.
KOiK03368.
OMAiDSHFNSN.
OrthoDBiEOG091G08DE.
PhylomeDBiQ16842.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.99.4. 2681.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiST3GAL2. human.
GenomeRNAii6483.
PROiQ16842.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157350.
CleanExiHS_ST3GAL2.
ExpressionAtlasiQ16842. baseline and differential.
GenevisibleiQ16842. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA4B_HUMAN
AccessioniPrimary (citable) accession number: Q16842
Secondary accession number(s): O00654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.