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Q16831

- UPP1_HUMAN

UniProt

Q16831 - UPP1_HUMAN

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Protein
Uridine phosphorylase 1
Gene
UPP1, UP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171Substrate
Binding sitei219 – 2191Substrate

GO - Molecular functioni

  1. uridine phosphorylase activity Source: ProtInc

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. cellular response to glucose starvation Source: Ensembl
  3. nucleobase-containing compound metabolic process Source: ProtInc
  4. nucleobase-containing small molecule metabolic process Source: Reactome
  5. nucleotide catabolic process Source: InterPro
  6. pyrimidine nucleobase metabolic process Source: Reactome
  7. pyrimidine nucleoside catabolic process Source: Reactome
  8. pyrimidine nucleoside salvage Source: Reactome
  9. small molecule metabolic process Source: Reactome
  10. uridine metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS00053-MONOMER.
ReactomeiREACT_1023. Pyrimidine catabolism.
REACT_655. Pyrimidine salvage reactions.
SABIO-RKQ16831.
SignaLinkiQ16831.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 1 (EC:2.4.2.3)
Short name:
UPase 1
Short name:
UrdPase 1
Gene namesi
Name:UPP1
Synonyms:UP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:12576. UPP1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Uridine phosphorylase 1
PRO_0000063191Add
BLAST

Proteomic databases

MaxQBiQ16831.
PaxDbiQ16831.
PeptideAtlasiQ16831.
PRIDEiQ16831.

PTM databases

PhosphoSiteiQ16831.

Expressioni

Inductioni

By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma.

Gene expression databases

ArrayExpressiQ16831.
BgeeiQ16831.
CleanExiHS_UPP1.
GenevestigatoriQ16831.

Organism-specific databases

HPAiHPA055394.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi113224. 10 interactions.
IntActiQ16831. 1 interaction.
STRINGi9606.ENSP00000330032.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 283
Turni35 – 384
Turni41 – 433
Helixi46 – 505
Beta strandi55 – 606
Helixi62 – 7615
Beta strandi81 – 833
Turni88 – 914
Beta strandi97 – 1004
Beta strandi103 – 1075
Helixi112 – 12817
Beta strandi135 – 14713
Beta strandi152 – 1598
Beta strandi165 – 1717
Beta strandi174 – 1796
Helixi184 – 19714
Beta strandi202 – 2098
Helixi215 – 2173
Beta strandi222 – 2243
Helixi229 – 24113
Beta strandi244 – 2507
Helixi251 – 26010
Beta strandi264 – 27411
Helixi275 – 2773
Helixi285 – 2928
Helixi294 – 30613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUEX-ray2.30A1-310[»]
3EUFX-ray1.90A/B/C/D1-310[»]
3NBQX-ray2.30A/B/C/D1-310[»]
ProteinModelPortaliQ16831.
SMRiQ16831. Positions 16-309.

Miscellaneous databases

EvolutionaryTraceiQ16831.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2820.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ16831.
KOiK00757.
OMAiYHAKCSN.
PhylomeDBiQ16831.
TreeFamiTF314310.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16831-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF    50
GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV 100
GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG 150
TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF 200
TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME 250
SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS 300
YFIKKKLSKA 310
Length:310
Mass (Da):33,934
Last modified:November 1, 1997 - v1
Checksum:i110CF678561E53F3
GO
Isoform 2 (identifier: Q16831-2) [UniParc]FASTAAdd to Basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: NDCPVRLLNPNIAKMKEDILYH → KSGARHCGHNRAGSGYLLQGRV
     37-310: Missing.

Note: Inactive.

Show »
Length:36
Mass (Da):3,694
Checksum:i5D38DC6FA1548616
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 3622NDCPV…DILYH → KSGARHCGHNRAGSGYLLQG RV in isoform 2.
VSP_001279Add
BLAST
Alternative sequencei37 – 310274Missing in isoform 2.
VSP_001280Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90858 mRNA. Translation: CAA62369.1.
X90858 mRNA. Translation: CAA62370.1.
BT006699 mRNA. Translation: AAP35345.1.
CH471128 Genomic DNA. Translation: EAW60994.1.
CH471128 Genomic DNA. Translation: EAW60995.1.
BC001405 mRNA. Translation: AAH01405.1.
BC007348 mRNA. Translation: AAH07348.1.
BC053592 mRNA. Translation: AAH53592.1. Sequence problems.
CCDSiCCDS5507.1. [Q16831-1]
PIRiJC4343.
RefSeqiNP_001274355.1. NM_001287426.1. [Q16831-1]
NP_001274357.1. NM_001287428.1.
NP_001274358.1. NM_001287429.1.
NP_001274359.1. NM_001287430.1.
NP_003355.1. NM_003364.3. [Q16831-1]
UniGeneiHs.488240.

Genome annotation databases

EnsembliENST00000331803; ENSP00000330032; ENSG00000183696. [Q16831-1]
ENST00000341253; ENSP00000342878; ENSG00000183696. [Q16831-1]
ENST00000395560; ENSP00000378927; ENSG00000183696. [Q16831-2]
ENST00000395564; ENSP00000378931; ENSG00000183696. [Q16831-1]
ENST00000417464; ENSP00000413611; ENSG00000183696. [Q16831-2]
ENST00000457596; ENSP00000408899; ENSG00000183696. [Q16831-2]
GeneIDi7378.
KEGGihsa:7378.
UCSCiuc003toj.3. human. [Q16831-1]

Polymorphism databases

DMDMi2494059.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90858 mRNA. Translation: CAA62369.1 .
X90858 mRNA. Translation: CAA62370.1 .
BT006699 mRNA. Translation: AAP35345.1 .
CH471128 Genomic DNA. Translation: EAW60994.1 .
CH471128 Genomic DNA. Translation: EAW60995.1 .
BC001405 mRNA. Translation: AAH01405.1 .
BC007348 mRNA. Translation: AAH07348.1 .
BC053592 mRNA. Translation: AAH53592.1 . Sequence problems.
CCDSi CCDS5507.1. [Q16831-1 ]
PIRi JC4343.
RefSeqi NP_001274355.1. NM_001287426.1. [Q16831-1 ]
NP_001274357.1. NM_001287428.1.
NP_001274358.1. NM_001287429.1.
NP_001274359.1. NM_001287430.1.
NP_003355.1. NM_003364.3. [Q16831-1 ]
UniGenei Hs.488240.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EUE X-ray 2.30 A 1-310 [» ]
3EUF X-ray 1.90 A/B/C/D 1-310 [» ]
3NBQ X-ray 2.30 A/B/C/D 1-310 [» ]
ProteinModelPortali Q16831.
SMRi Q16831. Positions 16-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113224. 10 interactions.
IntActi Q16831. 1 interaction.
STRINGi 9606.ENSP00000330032.

Chemistry

BindingDBi Q16831.
ChEMBLi CHEMBL4811.

PTM databases

PhosphoSitei Q16831.

Polymorphism databases

DMDMi 2494059.

Proteomic databases

MaxQBi Q16831.
PaxDbi Q16831.
PeptideAtlasi Q16831.
PRIDEi Q16831.

Protocols and materials databases

DNASUi 7378.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331803 ; ENSP00000330032 ; ENSG00000183696 . [Q16831-1 ]
ENST00000341253 ; ENSP00000342878 ; ENSG00000183696 . [Q16831-1 ]
ENST00000395560 ; ENSP00000378927 ; ENSG00000183696 . [Q16831-2 ]
ENST00000395564 ; ENSP00000378931 ; ENSG00000183696 . [Q16831-1 ]
ENST00000417464 ; ENSP00000413611 ; ENSG00000183696 . [Q16831-2 ]
ENST00000457596 ; ENSP00000408899 ; ENSG00000183696 . [Q16831-2 ]
GeneIDi 7378.
KEGGi hsa:7378.
UCSCi uc003toj.3. human. [Q16831-1 ]

Organism-specific databases

CTDi 7378.
GeneCardsi GC07P048094.
HGNCi HGNC:12576. UPP1.
HPAi HPA055394.
MIMi 191730. gene.
neXtProti NX_Q16831.
PharmGKBi PA365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2820.
HOGENOMi HOG000231747.
HOVERGENi HBG047725.
InParanoidi Q16831.
KOi K00757.
OMAi YHAKCSN.
PhylomeDBi Q16831.
TreeFami TF314310.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00633 .
BioCyci MetaCyc:HS00053-MONOMER.
Reactomei REACT_1023. Pyrimidine catabolism.
REACT_655. Pyrimidine salvage reactions.
SABIO-RK Q16831.
SignaLinki Q16831.

Miscellaneous databases

ChiTaRSi UPP1. human.
EvolutionaryTracei Q16831.
GeneWikii UPP1.
GenomeRNAii 7378.
NextBioi 28890.
PROi Q16831.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16831.
Bgeei Q16831.
CleanExi HS_UPP1.
Genevestigatori Q16831.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01719. euk_UDPppase. 1 hit.
PROSITEi PS01232. PNP_UDP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human uridine phosphorylase."
    Watanabe S., Uchida T.
    Biochem. Biophys. Res. Commun. 216:265-272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary, Placenta and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy."
    Roosild T.P., Castronovo S., Fabbiani M., Pizzorno G.
    BMC Struct. Biol. 9:14-14(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) ALONE AND IN COMPLEX WITH INHIBITOR, SUBUNIT.
  7. "Active site conformational dynamics in human uridine phosphorylase 1."
    Roosild T.P., Castronovo S.
    PLoS ONE 5:E12741-E12741(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH 5-FLUOROURACIL, SUBSTRATE-BINDING SITES, SUBUNIT.

Entry informationi

Entry nameiUPP1_HUMAN
AccessioniPrimary (citable) accession number: Q16831
Secondary accession number(s): D3DVM4, Q15362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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