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Protein

Uridine phosphorylase 1

Gene

UPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.Curated1 Publication

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.1 Publication

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase 1 (UPP1), Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP2), Uridine phosphorylase 2 (UPP2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94PhosphateCombined sources1 Publication1
Binding sitei217Substrate2 Publications1
Binding sitei219Substrate2 Publications1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS00053-MONOMER.
ZFISH:HS00053-MONOMER.
BRENDAi2.4.2.3. 2681.
ReactomeiR-HSA-73614. Pyrimidine salvage reactions.
R-HSA-73621. Pyrimidine catabolism.
SABIO-RKQ16831.
SignaLinkiQ16831.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 1 (EC:2.4.2.31 Publication)
Short name:
UPase 1
Short name:
UrdPase 1
Gene namesi
Name:UPP1
Synonyms:UP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12576. UPP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7378.
OpenTargetsiENSG00000183696.
PharmGKBiPA365.

Chemistry databases

ChEMBLiCHEMBL4811.
DrugBankiDB00544. Fluorouracil.

Polymorphism and mutation databases

BioMutaiUPP1.
DMDMi2494059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631911 – 310Uridine phosphorylase 1Add BLAST310

Proteomic databases

EPDiQ16831.
MaxQBiQ16831.
PaxDbiQ16831.
PeptideAtlasiQ16831.
PRIDEiQ16831.

PTM databases

iPTMnetiQ16831.
PhosphoSitePlusiQ16831.

Expressioni

Inductioni

By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000183696.
CleanExiHS_UPP1.
ExpressionAtlasiQ16831. baseline and differential.
GenevisibleiQ16831. HS.

Organism-specific databases

HPAiHPA054040.
HPA055394.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi113224. 16 interactors.
IntActiQ16831. 3 interactors.
STRINGi9606.ENSP00000330032.

Chemistry databases

BindingDBiQ16831.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 28Combined sources3
Turni35 – 38Combined sources4
Turni41 – 43Combined sources3
Helixi46 – 50Combined sources5
Beta strandi55 – 60Combined sources6
Helixi62 – 76Combined sources15
Beta strandi81 – 83Combined sources3
Turni88 – 91Combined sources4
Beta strandi97 – 100Combined sources4
Beta strandi103 – 107Combined sources5
Helixi112 – 128Combined sources17
Beta strandi135 – 147Combined sources13
Beta strandi152 – 159Combined sources8
Beta strandi165 – 171Combined sources7
Beta strandi174 – 179Combined sources6
Helixi184 – 197Combined sources14
Beta strandi202 – 209Combined sources8
Helixi215 – 217Combined sources3
Beta strandi222 – 224Combined sources3
Helixi229 – 241Combined sources13
Beta strandi244 – 250Combined sources7
Helixi251 – 260Combined sources10
Beta strandi264 – 274Combined sources11
Helixi275 – 277Combined sources3
Helixi285 – 292Combined sources8
Helixi294 – 306Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EUEX-ray2.30A1-310[»]
3EUFX-ray1.90A/B/C/D1-310[»]
3NBQX-ray2.30A/B/C/D1-310[»]
ProteinModelPortaliQ16831.
SMRiQ16831.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16831.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 141Phosphate bindingCombined sources1 Publication4

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiKOG3728. Eukaryota.
COG2820. LUCA.
GeneTreeiENSGT00390000004400.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ16831.
KOiK00757.
OMAiDATFKPQ.
OrthoDBiEOG091G0EIO.
PhylomeDBiQ16831.
TreeFamiTF314310.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16831-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF
60 70 80 90 100
GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV
110 120 130 140 150
GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG
160 170 180 190 200
TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF
210 220 230 240 250
TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME
260 270 280 290 300
SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS
310
YFIKKKLSKA
Length:310
Mass (Da):33,934
Last modified:November 1, 1997 - v1
Checksum:i110CF678561E53F3
GO
Isoform 2 (identifier: Q16831-2) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: NDCPVRLLNPNIAKMKEDILYH → KSGARHCGHNRAGSGYLLQGRV
     37-310: Missing.

Note: Inactive.
Show »
Length:36
Mass (Da):3,694
Checksum:i5D38DC6FA1548616
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00127915 – 36NDCPV…DILYH → KSGARHCGHNRAGSGYLLQG RV in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00128037 – 310Missing in isoform 2. 1 PublicationAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90858 mRNA. Translation: CAA62369.1.
X90858 mRNA. Translation: CAA62370.1.
BT006699 mRNA. Translation: AAP35345.1.
CH471128 Genomic DNA. Translation: EAW60994.1.
CH471128 Genomic DNA. Translation: EAW60995.1.
BC001405 mRNA. Translation: AAH01405.1.
BC007348 mRNA. Translation: AAH07348.1.
BC053592 mRNA. Translation: AAH53592.1. Sequence problems.
CCDSiCCDS5507.1. [Q16831-1]
PIRiJC4343.
RefSeqiNP_001274355.1. NM_001287426.1. [Q16831-1]
NP_001274357.1. NM_001287428.1.
NP_001274358.1. NM_001287429.1.
NP_001274359.1. NM_001287430.1.
NP_003355.1. NM_003364.3. [Q16831-1]
XP_011513814.1. XM_011515512.2. [Q16831-1]
UniGeneiHs.488240.

Genome annotation databases

EnsembliENST00000331803; ENSP00000330032; ENSG00000183696. [Q16831-1]
ENST00000395560; ENSP00000378927; ENSG00000183696. [Q16831-2]
ENST00000395564; ENSP00000378931; ENSG00000183696. [Q16831-1]
ENST00000417464; ENSP00000413611; ENSG00000183696. [Q16831-2]
ENST00000457596; ENSP00000408899; ENSG00000183696. [Q16831-2]
GeneIDi7378.
KEGGihsa:7378.
UCSCiuc003tok.5. human. [Q16831-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90858 mRNA. Translation: CAA62369.1.
X90858 mRNA. Translation: CAA62370.1.
BT006699 mRNA. Translation: AAP35345.1.
CH471128 Genomic DNA. Translation: EAW60994.1.
CH471128 Genomic DNA. Translation: EAW60995.1.
BC001405 mRNA. Translation: AAH01405.1.
BC007348 mRNA. Translation: AAH07348.1.
BC053592 mRNA. Translation: AAH53592.1. Sequence problems.
CCDSiCCDS5507.1. [Q16831-1]
PIRiJC4343.
RefSeqiNP_001274355.1. NM_001287426.1. [Q16831-1]
NP_001274357.1. NM_001287428.1.
NP_001274358.1. NM_001287429.1.
NP_001274359.1. NM_001287430.1.
NP_003355.1. NM_003364.3. [Q16831-1]
XP_011513814.1. XM_011515512.2. [Q16831-1]
UniGeneiHs.488240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EUEX-ray2.30A1-310[»]
3EUFX-ray1.90A/B/C/D1-310[»]
3NBQX-ray2.30A/B/C/D1-310[»]
ProteinModelPortaliQ16831.
SMRiQ16831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113224. 16 interactors.
IntActiQ16831. 3 interactors.
STRINGi9606.ENSP00000330032.

Chemistry databases

BindingDBiQ16831.
ChEMBLiCHEMBL4811.
DrugBankiDB00544. Fluorouracil.

PTM databases

iPTMnetiQ16831.
PhosphoSitePlusiQ16831.

Polymorphism and mutation databases

BioMutaiUPP1.
DMDMi2494059.

Proteomic databases

EPDiQ16831.
MaxQBiQ16831.
PaxDbiQ16831.
PeptideAtlasiQ16831.
PRIDEiQ16831.

Protocols and materials databases

DNASUi7378.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331803; ENSP00000330032; ENSG00000183696. [Q16831-1]
ENST00000395560; ENSP00000378927; ENSG00000183696. [Q16831-2]
ENST00000395564; ENSP00000378931; ENSG00000183696. [Q16831-1]
ENST00000417464; ENSP00000413611; ENSG00000183696. [Q16831-2]
ENST00000457596; ENSP00000408899; ENSG00000183696. [Q16831-2]
GeneIDi7378.
KEGGihsa:7378.
UCSCiuc003tok.5. human. [Q16831-1]

Organism-specific databases

CTDi7378.
DisGeNETi7378.
GeneCardsiUPP1.
HGNCiHGNC:12576. UPP1.
HPAiHPA054040.
HPA055394.
MIMi191730. gene.
neXtProtiNX_Q16831.
OpenTargetsiENSG00000183696.
PharmGKBiPA365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3728. Eukaryota.
COG2820. LUCA.
GeneTreeiENSGT00390000004400.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ16831.
KOiK00757.
OMAiDATFKPQ.
OrthoDBiEOG091G0EIO.
PhylomeDBiQ16831.
TreeFamiTF314310.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633.
BioCyciMetaCyc:HS00053-MONOMER.
ZFISH:HS00053-MONOMER.
BRENDAi2.4.2.3. 2681.
ReactomeiR-HSA-73614. Pyrimidine salvage reactions.
R-HSA-73621. Pyrimidine catabolism.
SABIO-RKQ16831.
SignaLinkiQ16831.

Miscellaneous databases

ChiTaRSiUPP1. human.
EvolutionaryTraceiQ16831.
GeneWikiiUPP1.
GenomeRNAii7378.
PROiQ16831.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183696.
CleanExiHS_UPP1.
ExpressionAtlasiQ16831. baseline and differential.
GenevisibleiQ16831. HS.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPP1_HUMAN
AccessioniPrimary (citable) accession number: Q16831
Secondary accession number(s): D3DVM4, Q15362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.