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Q16829

- DUS7_HUMAN

UniProt

Q16829 - DUS7_HUMAN

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Protein

Dual specificity protein phosphatase 7

Gene

DUSP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei331 – 3311Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: GOC
  2. innate immune response Source: Reactome
  3. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  4. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  5. negative regulation of MAP kinase activity Source: UniProtKB
  6. neurotrophin TRK receptor signaling pathway Source: Reactome
  7. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  8. stress-activated MAPK cascade Source: Reactome
  9. toll-like receptor 10 signaling pathway Source: Reactome
  10. toll-like receptor 2 signaling pathway Source: Reactome
  11. toll-like receptor 3 signaling pathway Source: Reactome
  12. toll-like receptor 4 signaling pathway Source: Reactome
  13. toll-like receptor 5 signaling pathway Source: Reactome
  14. toll-like receptor 9 signaling pathway Source: Reactome
  15. toll-like receptor signaling pathway Source: Reactome
  16. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  17. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  18. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_12436. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 7 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase PYST2
Gene namesi
Name:DUSP7
Synonyms:PYST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3073. DUSP7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Dual specificity protein phosphatase 7PRO_0000094807Add
BLAST

Proteomic databases

MaxQBiQ16829.
PaxDbiQ16829.
PRIDEiQ16829.

PTM databases

PhosphoSiteiQ16829.

Expressioni

Tissue specificityi

Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.1 Publication

Gene expression databases

BgeeiQ16829.
CleanExiHS_DUSP7.
ExpressionAtlasiQ16829. baseline and differential.
GenevestigatoriQ16829.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GHRP109122EBI-1265847,EBI-286316
SPOPO437915EBI-1265847,EBI-743549

Protein-protein interaction databases

BioGridi108182. 8 interactions.
IntActiQ16829. 7 interactions.
STRINGi9606.ENSP00000296483.

Structurei

3D structure databases

ProteinModelPortaliQ16829.
SMRiQ16829. Positions 55-193, 243-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 187120RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini308 – 37669Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi192 – 24049Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000294079.
HOVERGENiHBG007347.
InParanoidiQ16829.
KOiK04459.
OMAiLRDDGCK.
OrthoDBiEOG793B7W.
PhylomeDBiQ16829.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: Q16829-1) [UniParc]FASTAAdd to Basket

Also known as: PYST2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG
60 70 80 90 100
AMPCKSAEWL QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM
110 120 130 140 150
LRRLRKGNLP IRSIIPNHAD KERFATRCKA ATVLLYDEAT AEWQPEPGAP
160 170 180 190 200
ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT EYSEHCETNV DSSSSPSSSP
210 220 230 240 250
PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS QPAFPVQILP
260 270 280 290 300
YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD
310 320 330 340 350
HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM
360 370 380 390 400
NLSLNDAYDF VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL
410
YFSTPTNHNL FPLNTLEST
Length:419
Mass (Da):44,957
Last modified:June 28, 2011 - v4
Checksum:i434467AC16A3F8BA
GO
Isoform 2 (identifier: Q16829-2) [UniParc]FASTAAdd to Basket

Also known as: PYST2-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Show »
Length:368
Mass (Da):40,551
Checksum:i097023C27EBC341C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351S → N.
Corresponds to variant rs34821455 [ dbSNP | Ensembl ].
VAR_051752

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 2. 1 PublicationVSP_012822Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508727 mRNA. Translation: AAM77606.1.
AF508728 mRNA. No translation available.
AC115284 Genomic DNA. No translation available.
AL556300 mRNA. No translation available.
BC019107 mRNA. Translation: AAH19107.2.
BC104880 mRNA. Translation: AAI04881.1.
BC104882 mRNA. Translation: AAI04883.1.
X93921 mRNA. Translation: CAA63814.1.
CCDSiCCDS33766.2. [Q16829-1]
RefSeqiNP_001938.2. NM_001947.3. [Q16829-1]
UniGeneiHs.591664.

Genome annotation databases

EnsembliENST00000495880; ENSP00000417183; ENSG00000164086. [Q16829-1]
GeneIDi1849.
KEGGihsa:1849.
UCSCiuc003dct.3. human. [Q16829-1]

Polymorphism databases

DMDMi338817906.

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508727 mRNA. Translation: AAM77606.1 .
AF508728 mRNA. No translation available.
AC115284 Genomic DNA. No translation available.
AL556300 mRNA. No translation available.
BC019107 mRNA. Translation: AAH19107.2 .
BC104880 mRNA. Translation: AAI04881.1 .
BC104882 mRNA. Translation: AAI04883.1 .
X93921 mRNA. Translation: CAA63814.1 .
CCDSi CCDS33766.2. [Q16829-1 ]
RefSeqi NP_001938.2. NM_001947.3. [Q16829-1 ]
UniGenei Hs.591664.

3D structure databases

ProteinModelPortali Q16829.
SMRi Q16829. Positions 55-193, 243-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108182. 8 interactions.
IntActi Q16829. 7 interactions.
STRINGi 9606.ENSP00000296483.

PTM databases

PhosphoSitei Q16829.

Polymorphism databases

DMDMi 338817906.

Proteomic databases

MaxQBi Q16829.
PaxDbi Q16829.
PRIDEi Q16829.

Protocols and materials databases

DNASUi 1849.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000495880 ; ENSP00000417183 ; ENSG00000164086 . [Q16829-1 ]
GeneIDi 1849.
KEGGi hsa:1849.
UCSCi uc003dct.3. human. [Q16829-1 ]

Organism-specific databases

CTDi 1849.
GeneCardsi GC03M052082.
H-InvDB HIX0003343.
HGNCi HGNC:3073. DUSP7.
MIMi 602749. gene.
neXtProti NX_Q16829.
PharmGKBi PA27530.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118902.
HOGENOMi HOG000294079.
HOVERGENi HBG007347.
InParanoidi Q16829.
KOi K04459.
OMAi LRDDGCK.
OrthoDBi EOG793B7W.
PhylomeDBi Q16829.
TreeFami TF105122.

Enzyme and pathway databases

Reactomei REACT_12436. ERKs are inactivated.

Miscellaneous databases

GeneWikii DUSP7.
GenomeRNAii 1849.
NextBioi 7575.
PROi Q16829.
SOURCEi Search...

Gene expression databases

Bgeei Q16829.
CleanExi HS_DUSP7.
ExpressionAtlasi Q16829. baseline and differential.
Genevestigatori Q16829.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the dual-specificity phosphatase PYST2 and its transcripts."
    Levy-Nissenbaum O., Sagi-Assif O., Witz I.P.
    Genes Chromosomes Cancer 39:37-47(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE, FUNCTION.
    Tissue: Monocyte.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-235 (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-419 (ISOFORM 1).
    Tissue: Brain and Lymph.
  5. "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase."
    Groom L.A., Sneddon A.A., Alessi D.R., Dowd S., Keyse S.M.
    EMBO J. 15:3621-3632(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 149-419 (ISOFORM 1).
    Tissue: Testis.
  6. "Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells."
    Levy-Nissenbaum O., Sagi-Assif O., Kapon D., Hantisteanu S., Burg T., Raanani P., Avigdor A., Ben-Bassat I., Witz I.P.
    Oncogene 22:7649-7660(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDUS7_HUMAN
AccessioniPrimary (citable) accession number: Q16829
Secondary accession number(s): Q2M3J7, Q8NFJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

An out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the alternative promoter. The expression of the in-frame product has not yet been shown.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3