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Q16825

- PTN21_HUMAN

UniProt

Q16825 - PTN21_HUMAN

Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

PTPN21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1067 – 10671SubstrateSequence Analysis
    Active sitei1108 – 11081Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1152 – 11521SubstrateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC
    2. protein dephosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase D1
    Gene namesi
    Name:PTPN21
    Synonyms:PTPD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9651. PTPN21.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33994.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11741174Tyrosine-protein phosphatase non-receptor type 21PRO_0000219439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei577 – 5771PhosphoserineBy similarity
    Modified residuei637 – 6371Phosphoserine1 Publication
    Modified residuei804 – 8041PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ16825.
    PaxDbiQ16825.
    PRIDEiQ16825.

    PTM databases

    PhosphoSiteiQ16825.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16825.
    BgeeiQ16825.
    CleanExiHS_PTPN21.
    GenevestigatoriQ16825.

    Organism-specific databases

    HPAiCAB011468.
    HPA049110.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Akap1O08715-52EBI-2860264,EBI-9117988From a different organism.
    SRCP129312EBI-2860264,EBI-621482

    Protein-protein interaction databases

    BioGridi116280. 3 interactions.
    IntActiQ16825. 4 interactions.
    STRINGi9606.ENSP00000330276.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16825.
    SMRiQ16825. Positions 36-306, 882-1171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 308286FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini896 – 1167272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1108 – 11147Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi340 – 3434Poly-Pro
    Compositional biasi565 – 57410Poly-Pro
    Compositional biasi712 – 7176Poly-Glu

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000115775.
    HOVERGENiHBG053757.
    InParanoidiQ16825.
    KOiK18025.
    OMAiAPNIMRT.
    OrthoDBiEOG7PK8XS.
    PhylomeDBiQ16825.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE     50
    AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG 100
    VVFYVPSVSQ LQQEITRYQY YLQLKKDILE GSIPCTLEQA IQLAGLAVQA 150
    DFGDFDQYES QDFLQKFALF PVGWLQDEKV LEEATQKVAL LHQKYRGLTA 200
    PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG IFVKHKNGRH 250
    PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR 300
    HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH 350
    YTEPYASSQD NLFVPNQNGY YCHSQTSLDR AQIDLNGRIR NGSVYSAHST 400
    NSLNNPQPYL QPSPMSSNPS ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD 450
    YETVMKQLNR GLVHAERQSH SLRNLNIGSS YAYSRPAALV YSQPEIREHA 500
    QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP ELTNAQLQAQ 550
    DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH 600
    HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL 650
    RLKERTLSAS AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS 700
    LSDATMLIHS SEEEEDEDFE EESGARAPPA RAREPRPGLA QDPPGCPRVL 750
    LAGPLHILEP KAHVPDAEKR MMDSSPVRTT AEAQRPWRDG LLMPSMSESD 800
    LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK KTRVDAKKIG 850
    PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY 900
    ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDVRVEL VPTKENNTGY 950
    INASHIKVSV SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE 1000
    EGGREKSFRY WPRLGSRHNT VTYGRFKITT RFRTDSGCYA TTGLKMKHLL 1050
    TGQERTVWHL QYTDWPEHGC PEDLKGFLSY LEEIQSVRRH TNSTSDPQSP 1100
    NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL DMLRQQRMML 1150
    VQTLCQYTFV YRVLIQFLKS SRLI 1174
    Length:1,174
    Mass (Da):133,281
    Last modified:March 2, 2010 - v2
    Checksum:i5B746C824578F117
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti385 – 3851L → F.1 Publication
    Corresponds to variant rs2401751 [ dbSNP | Ensembl ].
    VAR_060341
    Natural varianti906 – 9061K → N.
    Corresponds to variant rs12879993 [ dbSNP | Ensembl ].
    VAR_055539
    Natural varianti936 – 9361V → A.1 Publication
    Corresponds to variant rs2274736 [ dbSNP | Ensembl ].
    VAR_060342

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79510 mRNA. Translation: CAA56042.1.
    AL162171 Genomic DNA. No translation available.
    CCDSiCCDS9884.1.
    PIRiI38140.
    RefSeqiNP_008970.2. NM_007039.3.
    XP_005267344.1. XM_005267287.1.
    UniGeneiHs.437040.

    Genome annotation databases

    EnsembliENST00000328736; ENSP00000330276; ENSG00000070778.
    ENST00000556564; ENSP00000452414; ENSG00000070778.
    GeneIDi11099.
    KEGGihsa:11099.
    UCSCiuc001xwv.4. human.

    Polymorphism databases

    DMDMi290457654.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79510 mRNA. Translation: CAA56042.1 .
    AL162171 Genomic DNA. No translation available.
    CCDSi CCDS9884.1.
    PIRi I38140.
    RefSeqi NP_008970.2. NM_007039.3.
    XP_005267344.1. XM_005267287.1.
    UniGenei Hs.437040.

    3D structure databases

    ProteinModelPortali Q16825.
    SMRi Q16825. Positions 36-306, 882-1171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116280. 3 interactions.
    IntActi Q16825. 4 interactions.
    STRINGi 9606.ENSP00000330276.

    PTM databases

    PhosphoSitei Q16825.

    Polymorphism databases

    DMDMi 290457654.

    Proteomic databases

    MaxQBi Q16825.
    PaxDbi Q16825.
    PRIDEi Q16825.

    Protocols and materials databases

    DNASUi 11099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328736 ; ENSP00000330276 ; ENSG00000070778 .
    ENST00000556564 ; ENSP00000452414 ; ENSG00000070778 .
    GeneIDi 11099.
    KEGGi hsa:11099.
    UCSCi uc001xwv.4. human.

    Organism-specific databases

    CTDi 11099.
    GeneCardsi GC14M088932.
    H-InvDB HIX0037798.
    HGNCi HGNC:9651. PTPN21.
    HPAi CAB011468.
    HPA049110.
    MIMi 603271. gene.
    neXtProti NX_Q16825.
    PharmGKBi PA33994.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000115775.
    HOVERGENi HBG053757.
    InParanoidi Q16825.
    KOi K18025.
    OMAi APNIMRT.
    OrthoDBi EOG7PK8XS.
    PhylomeDBi Q16825.
    TreeFami TF315900.

    Miscellaneous databases

    GeneWikii PTPN21.
    GenomeRNAii 11099.
    NextBioi 42194.
    PROi Q16825.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16825.
    Bgeei Q16825.
    CleanExi HS_PTPN21.
    Genevestigatori Q16825.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain."
      Moeller N.P.H., Moeller K.B., Lammers R., Kharitonenkov A., Sures I., Ullrich A.
      Proc. Natl. Acad. Sci. U.S.A. 91:7477-7481(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-385 AND ALA-936.
      Tissue: Skeletal muscle.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTN21_HUMAN
    AccessioniPrimary (citable) accession number: Q16825
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3