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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

PTPN21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1067SubstrateSequence analysis1
Active sitei1108Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1152SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS01011-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiQ16825.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase D1
Gene namesi
Name:PTPN21
Synonyms:PTPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9651. PTPN21.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi11099.
OpenTargetsiENSG00000070778.
PharmGKBiPA33994.

Polymorphism and mutation databases

BioMutaiPTPN21.
DMDMi290457654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194391 – 1174Tyrosine-protein phosphatase non-receptor type 21Add BLAST1174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Modified residuei673PhosphoserineBy similarity1
Modified residuei710PhosphoserineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei797PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei804PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16825.
MaxQBiQ16825.
PaxDbiQ16825.
PeptideAtlasiQ16825.
PRIDEiQ16825.

PTM databases

DEPODiQ16825.
iPTMnetiQ16825.
PhosphoSitePlusiQ16825.

Expressioni

Gene expression databases

BgeeiENSG00000070778.
CleanExiHS_PTPN21.
ExpressionAtlasiQ16825. baseline and differential.
GenevisibleiQ16825. HS.

Organism-specific databases

HPAiCAB011468.
HPA049110.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Akap1O08715-52EBI-2860264,EBI-9117988From a different organism.
SRCP129312EBI-2860264,EBI-621482

Protein-protein interaction databases

BioGridi116280. 5 interactors.
IntActiQ16825. 29 interactors.
STRINGi9606.ENSP00000330276.

Structurei

3D structure databases

ProteinModelPortaliQ16825.
SMRiQ16825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 308FERMPROSITE-ProRule annotationAdd BLAST286
Domaini896 – 1167Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1108 – 1114Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 343Poly-Pro4
Compositional biasi565 – 574Poly-Pro10
Compositional biasi712 – 717Poly-Glu6

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0792. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00830000128259.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ16825.
KOiK18025.
OMAiDMETSKY.
OrthoDBiEOG091G00QP.
PhylomeDBiQ16825.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG
110 120 130 140 150
VVFYVPSVSQ LQQEITRYQY YLQLKKDILE GSIPCTLEQA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALF PVGWLQDEKV LEEATQKVAL LHQKYRGLTA
210 220 230 240 250
PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG IFVKHKNGRH
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR
310 320 330 340 350
HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH
360 370 380 390 400
YTEPYASSQD NLFVPNQNGY YCHSQTSLDR AQIDLNGRIR NGSVYSAHST
410 420 430 440 450
NSLNNPQPYL QPSPMSSNPS ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD
460 470 480 490 500
YETVMKQLNR GLVHAERQSH SLRNLNIGSS YAYSRPAALV YSQPEIREHA
510 520 530 540 550
QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP ELTNAQLQAQ
560 570 580 590 600
DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL
660 670 680 690 700
RLKERTLSAS AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS
710 720 730 740 750
LSDATMLIHS SEEEEDEDFE EESGARAPPA RAREPRPGLA QDPPGCPRVL
760 770 780 790 800
LAGPLHILEP KAHVPDAEKR MMDSSPVRTT AEAQRPWRDG LLMPSMSESD
810 820 830 840 850
LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK KTRVDAKKIG
860 870 880 890 900
PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY
910 920 930 940 950
ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDVRVEL VPTKENNTGY
960 970 980 990 1000
INASHIKVSV SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE
1010 1020 1030 1040 1050
EGGREKSFRY WPRLGSRHNT VTYGRFKITT RFRTDSGCYA TTGLKMKHLL
1060 1070 1080 1090 1100
TGQERTVWHL QYTDWPEHGC PEDLKGFLSY LEEIQSVRRH TNSTSDPQSP
1110 1120 1130 1140 1150
NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL DMLRQQRMML
1160 1170
VQTLCQYTFV YRVLIQFLKS SRLI
Length:1,174
Mass (Da):133,281
Last modified:March 2, 2010 - v2
Checksum:i5B746C824578F117
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060341385L → F.1 PublicationCorresponds to variant rs2401751dbSNPEnsembl.1
Natural variantiVAR_055539906K → N.Corresponds to variant rs12879993dbSNPEnsembl.1
Natural variantiVAR_060342936V → A.1 PublicationCorresponds to variant rs2274736dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79510 mRNA. Translation: CAA56042.1.
AL162171 Genomic DNA. No translation available.
CCDSiCCDS9884.1.
PIRiI38140.
RefSeqiNP_008970.2. NM_007039.3.
XP_005267344.1. XM_005267287.2.
XP_011534669.1. XM_011536367.2.
UniGeneiHs.437040.

Genome annotation databases

EnsembliENST00000328736; ENSP00000330276; ENSG00000070778.
ENST00000556564; ENSP00000452414; ENSG00000070778.
GeneIDi11099.
KEGGihsa:11099.
UCSCiuc001xwv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79510 mRNA. Translation: CAA56042.1.
AL162171 Genomic DNA. No translation available.
CCDSiCCDS9884.1.
PIRiI38140.
RefSeqiNP_008970.2. NM_007039.3.
XP_005267344.1. XM_005267287.2.
XP_011534669.1. XM_011536367.2.
UniGeneiHs.437040.

3D structure databases

ProteinModelPortaliQ16825.
SMRiQ16825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116280. 5 interactors.
IntActiQ16825. 29 interactors.
STRINGi9606.ENSP00000330276.

PTM databases

DEPODiQ16825.
iPTMnetiQ16825.
PhosphoSitePlusiQ16825.

Polymorphism and mutation databases

BioMutaiPTPN21.
DMDMi290457654.

Proteomic databases

EPDiQ16825.
MaxQBiQ16825.
PaxDbiQ16825.
PeptideAtlasiQ16825.
PRIDEiQ16825.

Protocols and materials databases

DNASUi11099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328736; ENSP00000330276; ENSG00000070778.
ENST00000556564; ENSP00000452414; ENSG00000070778.
GeneIDi11099.
KEGGihsa:11099.
UCSCiuc001xwv.5. human.

Organism-specific databases

CTDi11099.
DisGeNETi11099.
GeneCardsiPTPN21.
H-InvDBHIX0037798.
HGNCiHGNC:9651. PTPN21.
HPAiCAB011468.
HPA049110.
MIMi603271. gene.
neXtProtiNX_Q16825.
OpenTargetsiENSG00000070778.
PharmGKBiPA33994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0792. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00830000128259.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ16825.
KOiK18025.
OMAiDMETSKY.
OrthoDBiEOG091G00QP.
PhylomeDBiQ16825.
TreeFamiTF315900.

Enzyme and pathway databases

BioCyciZFISH:HS01011-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiQ16825.

Miscellaneous databases

GeneWikiiPTPN21.
GenomeRNAii11099.
PROiQ16825.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070778.
CleanExiHS_PTPN21.
ExpressionAtlasiQ16825. baseline and differential.
GenevisibleiQ16825. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN21_HUMAN
AccessioniPrimary (citable) accession number: Q16825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.