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Q16825 (PTN21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 21

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase D1
Gene names
Name:PTPN21
Synonyms:PTPD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1174 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Akap1O08715-52EBI-2860264,EBI-9117988From a different organism.
SRCP129312EBI-2860264,EBI-621482

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11741174Tyrosine-protein phosphatase non-receptor type 21
PRO_0000219439

Regions

Domain23 – 308286FERM
Domain896 – 1167272Tyrosine-protein phosphatase
Region1108 – 11147Substrate binding By similarity
Compositional bias340 – 3434Poly-Pro
Compositional bias565 – 57410Poly-Pro
Compositional bias712 – 7176Poly-Glu

Sites

Active site11081Phosphocysteine intermediate By similarity
Binding site10671Substrate Potential
Binding site11521Substrate By similarity

Amino acid modifications

Modified residue5771Phosphoserine By similarity
Modified residue6371Phosphoserine Ref.3
Modified residue8041Phosphoserine By similarity

Natural variations

Natural variant3851L → F. Ref.1
Corresponds to variant rs2401751 [ dbSNP | Ensembl ].
VAR_060341
Natural variant9061K → N.
Corresponds to variant rs12879993 [ dbSNP | Ensembl ].
VAR_055539
Natural variant9361V → A. Ref.1
Corresponds to variant rs2274736 [ dbSNP | Ensembl ].
VAR_060342

Sequences

Sequence LengthMass (Da)Tools
Q16825 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 5B746C824578F117

FASTA1,174133,281
        10         20         30         40         50         60 
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE 

        70         80         90        100        110        120 
VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG VVFYVPSVSQ LQQEITRYQY 

       130        140        150        160        170        180 
YLQLKKDILE GSIPCTLEQA IQLAGLAVQA DFGDFDQYES QDFLQKFALF PVGWLQDEKV 

       190        200        210        220        230        240 
LEEATQKVAL LHQKYRGLTA PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG 

       250        260        270        280        290        300 
IFVKHKNGRH PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR 

       310        320        330        340        350        360 
HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH YTEPYASSQD 

       370        380        390        400        410        420 
NLFVPNQNGY YCHSQTSLDR AQIDLNGRIR NGSVYSAHST NSLNNPQPYL QPSPMSSNPS 

       430        440        450        460        470        480 
ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD YETVMKQLNR GLVHAERQSH SLRNLNIGSS 

       490        500        510        520        530        540 
YAYSRPAALV YSQPEIREHA QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP 

       550        560        570        580        590        600 
ELTNAQLQAQ DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH 

       610        620        630        640        650        660 
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL RLKERTLSAS 

       670        680        690        700        710        720 
AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS LSDATMLIHS SEEEEDEDFE 

       730        740        750        760        770        780 
EESGARAPPA RAREPRPGLA QDPPGCPRVL LAGPLHILEP KAHVPDAEKR MMDSSPVRTT 

       790        800        810        820        830        840 
AEAQRPWRDG LLMPSMSESD LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK 

       850        860        870        880        890        900 
KTRVDAKKIG PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY 

       910        920        930        940        950        960 
ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDVRVEL VPTKENNTGY INASHIKVSV 

       970        980        990       1000       1010       1020 
SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE EGGREKSFRY WPRLGSRHNT 

      1030       1040       1050       1060       1070       1080 
VTYGRFKITT RFRTDSGCYA TTGLKMKHLL TGQERTVWHL QYTDWPEHGC PEDLKGFLSY 

      1090       1100       1110       1120       1130       1140 
LEEIQSVRRH TNSTSDPQSP NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL 

      1150       1160       1170 
DMLRQQRMML VQTLCQYTFV YRVLIQFLKS SRLI 

« Hide

References

« Hide 'large scale' references
[1]"Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain."
Moeller N.P.H., Moeller K.B., Lammers R., Kharitonenkov A., Sures I., Ullrich A.
Proc. Natl. Acad. Sci. U.S.A. 91:7477-7481(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-385 AND ALA-936.
Tissue: Skeletal muscle.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X79510 mRNA. Translation: CAA56042.1.
AL162171 Genomic DNA. No translation available.
CCDSCCDS9884.1.
PIRI38140.
RefSeqNP_008970.2. NM_007039.3.
XP_005267344.1. XM_005267287.1.
UniGeneHs.437040.

3D structure databases

ProteinModelPortalQ16825.
SMRQ16825. Positions 36-306, 882-1171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116280. 3 interactions.
IntActQ16825. 4 interactions.
STRING9606.ENSP00000330276.

PTM databases

PhosphoSiteQ16825.

Polymorphism databases

DMDM290457654.

Proteomic databases

MaxQBQ16825.
PaxDbQ16825.
PRIDEQ16825.

Protocols and materials databases

DNASU11099.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328736; ENSP00000330276; ENSG00000070778.
ENST00000556564; ENSP00000452414; ENSG00000070778.
GeneID11099.
KEGGhsa:11099.
UCSCuc001xwv.4. human.

Organism-specific databases

CTD11099.
GeneCardsGC14M088932.
H-InvDBHIX0037798.
HGNCHGNC:9651. PTPN21.
HPACAB011468.
HPA049110.
MIM603271. gene.
neXtProtNX_Q16825.
PharmGKBPA33994.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000115775.
HOVERGENHBG053757.
InParanoidQ16825.
KOK18025.
OMAAPNIMRT.
OrthoDBEOG7PK8XS.
PhylomeDBQ16825.
TreeFamTF315900.

Gene expression databases

ArrayExpressQ16825.
BgeeQ16825.
CleanExHS_PTPN21.
GenevestigatorQ16825.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPTPN21.
GenomeRNAi11099.
NextBio42194.
PROQ16825.
SOURCESearch...

Entry information

Entry namePTN21_HUMAN
AccessionPrimary (citable) accession number: Q16825
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 2, 2010
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM