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Protein

Protein phosphatase 1 regulatory subunit 3A

Gene

PPP1R3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154415-MONOMER.
SIGNORiQ16821.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3A
Alternative name(s):
Protein phosphatase 1 glycogen-associated regulatory subunit
Protein phosphatase type-1 glycogen targeting subunit
Short name:
RG1
Gene namesi
Name:PPP1R3A
Synonyms:PP1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9291. PPP1R3A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1078 – 1098HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019699931A → E in NIDDM. 1 PublicationCorresponds to variant rs35449651dbSNPEnsembl.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNETi5506.
MalaCardsiPPP1R3A.
MIMi125853. phenotype.
OpenTargetsiENSG00000154415.
PharmGKBiPA33651.

Polymorphism and mutation databases

BioMutaiPPP1R3A.
DMDMi298286906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715001 – 1122Protein phosphatase 1 regulatory subunit 3AAdd BLAST1122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Phosphoserine; by GSK3By similarity1
Modified residuei42Phosphoserine; by GSK3By similarity1
Modified residuei46Phosphoserine; by PKA and ISPKBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei56PhosphothreonineBy similarity1
Modified residuei65Phosphoserine; by PKABy similarity1
Modified residuei844PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16821.
PaxDbiQ16821.
PeptideAtlasiQ16821.
PRIDEiQ16821.

PTM databases

iPTMnetiQ16821.
PhosphoSitePlusiQ16821.

Expressioni

Tissue specificityi

Skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000154415.
CleanExiHS_PPP1R3A.
ExpressionAtlasiQ16821. baseline and differential.
GenevisibleiQ16821. HS.

Interactioni

Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.By similarity

Protein-protein interaction databases

BioGridi111499. 45 interactors.
IntActiQ16821. 1 interactor.
STRINGi9606.ENSP00000284601.

Structurei

3D structure databases

ProteinModelPortaliQ16821.
SMRiQ16821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 230CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 65PP1-binding motif4

Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOVERGENiHBG053657.
InParanoidiQ16821.
KOiK07189.
OMAiLFTCQET.
OrthoDBiEOG091G00OC.
PhylomeDBiQ16821.
TreeFamiTF105537.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSEVPSQI SKDNFLEVPN LSDSLCEDEE VTFQPGFSPQ PSRRGSDSSE
60 70 80 90 100
DIYLDTPSSG TRRVSFADSF GFNLVSVKEF DCWELPSAST TFDLGTDIFH
110 120 130 140 150
TEEYVLAPLF DLPSSKEDLM QQLQIQKAIL ESTESLLGST SIKGIIRVLN
160 170 180 190 200
VSFEKLVYVR MSLDDWQTHY DILAEYVPNS CDGETDQFSF KIVLVPPYQK
210 220 230 240 250
DGSKVEFCIR YETSVGTFWS NNNGTNYTFI CQKKEQEPEP VKPWKEVPNR
260 270 280 290 300
QIKGCLKVKS SKEESSVTSE ENNFENPKNT DTYIPTIICS HEDKEDLEAS
310 320 330 340 350
NRNVKDVNRE HDEHNEKELE LMINQHLIRT RSTASRDERN TFSTDPVNFP
360 370 380 390 400
NKAEGLEKKQ IHGEICTDLF QRSLSPSSSA ESSVKGDFYC NEKYSSGDDC
410 420 430 440 450
THQPSEETTS NMGEIKPSLG DTSSDELVQL HTGSKEVLDD NANPAHGNGT
460 470 480 490 500
VQIPCPSSDQ LMAGNLNKKH EGGAKNIEVK DLGCLRRDFH SDTSACLKES
510 520 530 540 550
TEEGSSKEDY YGNGKDDEEQ RIYLGVNEKQ RKNFQTILHD QERKMGNPKI
560 570 580 590 600
SVAGIGASNR DLATLLSEHT AIPTRAITAD VSHSPRTNLS WEEAVLTPEH
610 620 630 640 650
HHLTSEGSAL GGITGQVCSS RTGNVLRNDY LFQVEEKSGG INSEDQDNSP
660 670 680 690 700
QHKQSWNVLE SQGKSRENKT NITEHIKGQT DCEDVWGKRD NTRSLKATTE
710 720 730 740 750
ELFTCQETVC CELSSLADHG ITEKAEAGTA YIIKTTSEST PESMSAREKA
760 770 780 790 800
IIAKLPQETA RSDRPIEVKE TAFDPHEGRN DDSHYTLCQR DTVGVIYDND
810 820 830 840 850
FEKESRLGIC NVRVDEMEKE ETMSMYNPRK THDREKCGTG NITSVEESSW
860 870 880 890 900
VITEYQKATS KLDLQLGMLP TDKTVFSENR DLRQVQELSK KTDSDAIVHS
910 920 930 940 950
AFNSDTNRAP QNSSPFSKHH TEISVSTNEQ AIAVENAVTT MASQPISTKS
960 970 980 990 1000
ENICNSTREI QGIEKHPYPE SKPEEVSRSS GIVTSGSRKE RCIGQIFQTE
1010 1020 1030 1040 1050
EYSVEKSLGP MILINKPLEN MEEARHENEG LVSSGQSLYT SGEKESDSSA
1060 1070 1080 1090 1100
STSLPVEESQ AQGNESLFSK YTNSKIPYFL LFLIFLITVY HYDLMIGLTF
1110 1120
YVLSLSWLSW EEGRQKESVK KK
Length:1,122
Mass (Da):125,767
Last modified:June 15, 2010 - v3
Checksum:iFACB2CEA7C00E75B
GO
Isoform 2 (identifier: Q16821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-74: GTRRVSFADSFGFNL → ERTRAGACKTMERSS
     75-1122: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:74
Mass (Da):8,187
Checksum:i16A09845C8C8273A
GO

Sequence cautioni

The sequence AAS07492 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02792945G → S.Corresponds to variant rs8192687dbSNPEnsembl.1
Natural variantiVAR_027930231C → Y.Corresponds to variant rs7801819dbSNPEnsembl.1
Natural variantiVAR_027931451V → M.4 PublicationsCorresponds to variant rs2974942dbSNPEnsembl.1
Natural variantiVAR_027932476N → K.4 PublicationsCorresponds to variant rs2974944dbSNPEnsembl.1
Natural variantiVAR_036287554G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057128627R → K.Corresponds to variant rs35067467dbSNPEnsembl.1
Natural variantiVAR_027933748E → K.Corresponds to variant rs4304271dbSNPEnsembl.1
Natural variantiVAR_027934882L → H.4 PublicationsCorresponds to variant rs2974938dbSNPEnsembl.1
Natural variantiVAR_019697883R → S.1 PublicationCorresponds to variant rs1800000dbSNPEnsembl.1
Natural variantiVAR_019698905D → Y Common polymorphism; can be associated with insulin resistance. 2 PublicationsCorresponds to variant rs1799999dbSNPEnsembl.1
Natural variantiVAR_019699931A → E in NIDDM. 1 PublicationCorresponds to variant rs35449651dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01158560 – 74GTRRV…FGFNL → ERTRAGACKTMERSS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_01158675 – 1122Missing in isoform 2. 1 PublicationAdd BLAST1048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024578, AF024576, AF024577 Genomic DNA. Translation: AAB94596.1.
AF024579 mRNA. Translation: AAB94597.1.
AC092465 Genomic DNA. Translation: AAS07492.1. Sequence problems.
AC093598 Genomic DNA. Translation: AAP22361.1.
CH236947 Genomic DNA. Translation: EAL24370.1.
BC126451 mRNA. Translation: AAI26452.1.
BC126453 mRNA. Translation: AAI26454.1.
X78578 mRNA. Translation: CAA55316.1.
CCDSiCCDS5759.1. [Q16821-1]
PIRiI38127.
RefSeqiNP_002702.2. NM_002711.3. [Q16821-1]
UniGeneiHs.458309.

Genome annotation databases

EnsembliENST00000284601; ENSP00000284601; ENSG00000154415. [Q16821-1]
ENST00000284602; ENSP00000284602; ENSG00000154415. [Q16821-2]
GeneIDi5506.
KEGGihsa:5506.
UCSCiuc010ljy.2. human. [Q16821-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024578, AF024576, AF024577 Genomic DNA. Translation: AAB94596.1.
AF024579 mRNA. Translation: AAB94597.1.
AC092465 Genomic DNA. Translation: AAS07492.1. Sequence problems.
AC093598 Genomic DNA. Translation: AAP22361.1.
CH236947 Genomic DNA. Translation: EAL24370.1.
BC126451 mRNA. Translation: AAI26452.1.
BC126453 mRNA. Translation: AAI26454.1.
X78578 mRNA. Translation: CAA55316.1.
CCDSiCCDS5759.1. [Q16821-1]
PIRiI38127.
RefSeqiNP_002702.2. NM_002711.3. [Q16821-1]
UniGeneiHs.458309.

3D structure databases

ProteinModelPortaliQ16821.
SMRiQ16821.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111499. 45 interactors.
IntActiQ16821. 1 interactor.
STRINGi9606.ENSP00000284601.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

PTM databases

iPTMnetiQ16821.
PhosphoSitePlusiQ16821.

Polymorphism and mutation databases

BioMutaiPPP1R3A.
DMDMi298286906.

Proteomic databases

EPDiQ16821.
PaxDbiQ16821.
PeptideAtlasiQ16821.
PRIDEiQ16821.

Protocols and materials databases

DNASUi5506.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284601; ENSP00000284601; ENSG00000154415. [Q16821-1]
ENST00000284602; ENSP00000284602; ENSG00000154415. [Q16821-2]
GeneIDi5506.
KEGGihsa:5506.
UCSCiuc010ljy.2. human. [Q16821-1]

Organism-specific databases

CTDi5506.
DisGeNETi5506.
GeneCardsiPPP1R3A.
H-InvDBHIX0033522.
HGNCiHGNC:9291. PPP1R3A.
MalaCardsiPPP1R3A.
MIMi125853. phenotype.
600917. gene.
neXtProtiNX_Q16821.
OpenTargetsiENSG00000154415.
PharmGKBiPA33651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOVERGENiHBG053657.
InParanoidiQ16821.
KOiK07189.
OMAiLFTCQET.
OrthoDBiEOG091G00OC.
PhylomeDBiQ16821.
TreeFamiTF105537.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154415-MONOMER.
SIGNORiQ16821.

Miscellaneous databases

GeneWikiiPPP1R3A.
GenomeRNAii5506.
PROiQ16821.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154415.
CleanExiHS_PPP1R3A.
ExpressionAtlasiQ16821. baseline and differential.
GenevisibleiQ16821. HS.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR3A_HUMAN
AccessioniPrimary (citable) accession number: Q16821
Secondary accession number(s): A0AVQ2
, A4D0T6, O43476, Q75LN8, Q7KYM8, Q86UI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.