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Q16819

- MEP1A_HUMAN

UniProt

Q16819 - MEP1A_HUMAN

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Protein

Meprin A subunit alpha

Gene
MEP1A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Enzyme regulationi

Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin.1 Publication

Kineticsi

  1. KM=110 µM for GRP1 Publication
  2. KM=18.0 µM for PTH 12-34
  3. KM=33.9 µM for secretin
  4. KM=41.3 µM for substance P
  5. KM=56.5 µM for LHRH
  6. KM=73.2 µM for orcokinin
  7. KM=292 µM for alpha-MSH
  8. KM=125 µM for bradykinin
  9. KM=200 µM for gastrin

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Zinc; catalytic By similarity
Metal bindingi155 – 1551Zinc; via tele nitrogen; catalytic By similarity
Active sitei156 – 1561 By similarity
Metal bindingi159 – 1591Zinc; via tele nitrogen; catalytic By similarity
Metal bindingi165 – 1651Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: ProtInc
  2. protein binding Source: IntAct
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. digestion Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ16819.

Protein family/group databases

MEROPSiM12.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Meprin A subunit alpha (EC:3.4.24.18)
Alternative name(s):
Endopeptidase-2
N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
PABA peptide hydrolase
PPH alpha
Gene namesi
Name:MEP1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:7015. MEP1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini66 – 712647Extracellular Reviewed predictionAdd
BLAST
Transmembranei713 – 74028Helical; Reviewed predictionAdd
BLAST
Topological domaini741 – 7466Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. extracellular space Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. meprin A complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarityAdd
BLAST
Propeptidei22 – 6544 By similarityPRO_0000028877Add
BLAST
Chaini66 – 746681Meprin A subunit alphaPRO_0000028878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 259 By similarity
Disulfide bondi128 ↔ 147 By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi269 ↔ 431 By similarity
Disulfide bondi277 – 277Interchain By similarity
Disulfide bondi308 – 308Interchain By similarity
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi539 – 5391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi674 ↔ 685 By similarity
Disulfide bondi679 ↔ 694 By similarity
Disulfide bondi696 ↔ 709 By similarity

Post-translational modificationi

N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ16819.
PRIDEiQ16819.

PTM databases

PhosphoSiteiQ16819.

Expressioni

Gene expression databases

BgeeiQ16819.
CleanExiHS_MEP1A.
GenevestigatoriQ16819.

Organism-specific databases

HPAiHPA029416.

Interactioni

Subunit structurei

Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers By similarity. Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
MMP9P147802EBI-8153734,EBI-1382326

Protein-protein interaction databases

BioGridi110387. 11 interactions.
IntActiQ16819. 1 interaction.
STRINGi9606.ENSP00000230588.

Structurei

3D structure databases

ProteinModelPortaliQ16819.
SMRiQ16819. Positions 62-259, 435-589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 433170MAMAdd
BLAST
Domaini434 – 593160MATHAdd
BLAST
Domaini670 – 71041EGF-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 263198MetalloproteaseAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.
Contains 1 EGF-like domain.
Contains 1 MAM domain.
Contains 1 MATH domain.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322115.
HOVERGENiHBG052457.
InParanoidiQ16819.
KOiK01395.
OMAiMIQGTRD.
OrthoDBiEOG73V6MT.
PhylomeDBiQ16819.
TreeFamiTF315280.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR000742. EG-like_dom.
IPR000998. MAM_dom.
IPR002083. MATH.
IPR008294. Meprin.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR008974. TRAF-like.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00008. EGF. 1 hit.
PF00629. MAM. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view]
PIRSFiPIRSF001196. Meprin. 1 hit.
PRINTSiPR00480. ASTACIN.
PR00020. MAMDOMAIN.
SMARTiSM00181. EGF. 1 hit.
SM00137. MAM. 1 hit.
SM00061. MATH. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50144. MATH. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16819-1 [UniParc]FASTAAdd to Basket

« Hide

MAWIRSTCIL FFTLLFAHIA AVPIKYLPEE NVHDADFGEQ KDISEINLAA    50
GLDLFQGDIL LQKSRNGLRD PNTRWTFPIP YILADNLGLN AKGAILYAFE 100
MFRLKSCVDF KPYEGESSYI IFQQFDGCWS EVGDQHVGQN ISIGQGCAYK 150
AIIEHEILHA LGFYHEQSRT DRDDYVNIWW DQILSGYQHN FDTYDDSLIT 200
DLNTPYDYES LMHYQPFSFN KNASVPTITA KIPEFNSIIG QRLDFSAIDL 250
ERLNRMYNCT TTHTLLDHCT FEKANICGMI QGTRDDTDWA HQDSAQAGEV 300
DHTLLGQCTG AGYFMQFSTS SGSAEEAALL ESRILYPKRK QQCLQFFYKM 350
TGSPSDRLVV WVRRDDSTGN VRKLVKVQTF QGDDDHNWKI AHVVLKEEQK 400
FRYLFQGTKG DPQNSTGGIY LDDITLTETP CPTGVWTVRN FSQVLENTSK 450
GDKLQSPRFY NSEGYGFGVT LYPNSRESSG YLRLAFHVCS GENDAILEWP 500
VENRQVIITI LDQEPDVRNR MSSSMVFTTS KSHTSPAIND TVIWDRPSRV 550
GTYHTDCNCF RSIDLGWSGF ISHQMLKRRS FLKNDDLIIF VDFEDITHLS 600
QTEVPTKGKR LSPQGLILQG QEQQVSEEGS GKAMLEEALP VSLSQGQPSR 650
QKRSVENTGP LEDHNWPQYF RDPCDPNPCQ NDGICVNVKG MASCRCISGH 700
AFFYTGERCQ AVQVHGSVLG MVIGGTAGVI FLTFSIIAIL SQRPRK 746
Length:746
Mass (Da):84,419
Last modified:July 22, 2008 - v2
Checksum:iB5F0812F2850F958
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti469 – 4691V → L.2 Publications
Corresponds to variant rs2274658 [ dbSNP | Ensembl ].
VAR_020056
Natural varianti476 – 4761R → G.1 Publication
Corresponds to variant rs12197930 [ dbSNP | Ensembl ].
VAR_033492
Natural varianti606 – 6061T → S.2 Publications
Corresponds to variant rs2297020 [ dbSNP | Ensembl ].
VAR_051583
Natural varianti634 – 6341M → V.
Corresponds to variant rs2297019 [ dbSNP | Ensembl ].
VAR_021846
Natural varianti726 – 7261T → M.1 Publication
Corresponds to variant rs1804211 [ dbSNP | Ensembl ].
VAR_033493

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261Y → H in AAA21338. 1 Publication
Sequence conflicti162 – 1621G → V in AAL85339. 1 Publication
Sequence conflicti306 – 3061G → E in BAF98731. 1 Publication
Sequence conflicti426 – 4261L → P in BAF98731. 1 Publication
Sequence conflicti518 – 5181R → Q in BAG37669. 1 Publication
Sequence conflicti546 – 5461R → S in BAF98731. 1 Publication
Sequence conflicti638 – 6381A → V in BAF98731. 1 Publication
Sequence conflicti711 – 7133AVQ → SAE in AAA21338. 1 Publication
Sequence conflicti711 – 7133AVQ → SAE no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M82962 mRNA. Translation: AAA21338.1.
AF478685 mRNA. Translation: AAL85339.1.
AK290282 mRNA. Translation: BAF82971.1.
AK315246 mRNA. Translation: BAG37669.1.
AK315840 mRNA. Translation: BAF98731.1.
AL161618 Genomic DNA. Translation: CAC21508.1.
CH471081 Genomic DNA. Translation: EAX04306.1.
BC131714 mRNA. Translation: AAI31715.1.
CCDSiCCDS4918.1.
PIRiS60193. HYHUMA.
RefSeqiNP_005579.2. NM_005588.2.
UniGeneiHs.179704.

Genome annotation databases

EnsembliENST00000230588; ENSP00000230588; ENSG00000112818.
GeneIDi4224.
KEGGihsa:4224.
UCSCiuc010jzh.1. human.

Polymorphism databases

DMDMi205830902.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M82962 mRNA. Translation: AAA21338.1 .
AF478685 mRNA. Translation: AAL85339.1 .
AK290282 mRNA. Translation: BAF82971.1 .
AK315246 mRNA. Translation: BAG37669.1 .
AK315840 mRNA. Translation: BAF98731.1 .
AL161618 Genomic DNA. Translation: CAC21508.1 .
CH471081 Genomic DNA. Translation: EAX04306.1 .
BC131714 mRNA. Translation: AAI31715.1 .
CCDSi CCDS4918.1.
PIRi S60193. HYHUMA.
RefSeqi NP_005579.2. NM_005588.2.
UniGenei Hs.179704.

3D structure databases

ProteinModelPortali Q16819.
SMRi Q16819. Positions 62-259, 435-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110387. 11 interactions.
IntActi Q16819. 1 interaction.
STRINGi 9606.ENSP00000230588.

Protein family/group databases

MEROPSi M12.002.

PTM databases

PhosphoSitei Q16819.

Polymorphism databases

DMDMi 205830902.

Proteomic databases

PaxDbi Q16819.
PRIDEi Q16819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230588 ; ENSP00000230588 ; ENSG00000112818 .
GeneIDi 4224.
KEGGi hsa:4224.
UCSCi uc010jzh.1. human.

Organism-specific databases

CTDi 4224.
GeneCardsi GC06P046807.
H-InvDB HIX0032798.
HGNCi HGNC:7015. MEP1A.
HPAi HPA029416.
MIMi 600388. gene.
neXtProti NX_Q16819.
PharmGKBi PA30749.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322115.
HOVERGENi HBG052457.
InParanoidi Q16819.
KOi K01395.
OMAi MIQGTRD.
OrthoDBi EOG73V6MT.
PhylomeDBi Q16819.
TreeFami TF315280.

Enzyme and pathway databases

SignaLinki Q16819.

Miscellaneous databases

GeneWikii MEP1A.
GenomeRNAii 4224.
NextBioi 16671.
PROi Q16819.
SOURCEi Search...

Gene expression databases

Bgeei Q16819.
CleanExi HS_MEP1A.
Genevestigatori Q16819.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR000742. EG-like_dom.
IPR000998. MAM_dom.
IPR002083. MATH.
IPR008294. Meprin.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR008974. TRAF-like.
[Graphical view ]
Pfami PF01400. Astacin. 1 hit.
PF00008. EGF. 1 hit.
PF00629. MAM. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view ]
PIRSFi PIRSF001196. Meprin. 1 hit.
PRINTSi PR00480. ASTACIN.
PR00020. MAMDOMAIN.
SMARTi SM00181. EGF. 1 hit.
SM00137. MAM. 1 hit.
SM00061. MATH. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50144. MATH. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Sterchi E.E.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-606.
    Tissue: Jejunum.
  2. "Expression of human meprin alpha."
    Haun R.S.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-469 AND MET-726.
    Tissue: Colon and Small intestine.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-469 AND GLY-476.
  7. "Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells."
    Dumermuth E., Eldering J.A., Gruenberg J., Jiang W., Sterchi E.E.
    FEBS Lett. 335:367-375(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-746, VARIANT SER-606.
    Tissue: Jejunum.
  8. "Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities."
    Bylander J.E., Bertenshaw G.P., Matters G.L., Hubbard S.J., Bond J.S.
    Biol. Chem. 388:1163-1172(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiMEP1A_HUMAN
AccessioniPrimary (citable) accession number: Q16819
Secondary accession number(s): A2RRM4
, B0AZP9, B2RCS2, Q8TDC9, Q9H1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi