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Q167K4

- PUR5_ROSDO

UniProt

Q167K4 - PUR5_ROSDO

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-2129-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:RD1_2252
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258398Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_2252.

    Structurei

    3D structure databases

    ProteinModelPortaliQ167K4.
    SMRiQ167K4. Positions 7-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiGEATCEV.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q167K4-1 [UniParc]FASTAAdd to Basket

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    MNLPKNGMTY ADAGVDIDAG NALVDRIKPA AKRTNRSGVM AGLGGFGALF    50
    DLKDAGYTDP ILVAATDGVG TKLRIAIDTG HVDGVGIDLV AMCVNDLVCQ 100
    GAEPLFFLDY FATGALETDK AARIIEGIAL GCERAGCALI GGETAEMPGM 150
    YPAGDFDLAG FSVGAMERGA ALPAHVAQGD VLLGLASDGV HSNGYSLVRK 200
    LVEVSGLSWD APCPWAEQSL GAELLTPTRL YVKQALAAID AGGVHALAHI 250
    TGGGLTENLP RVLPEGLGAD IDLSTWSLPA VFGWMAQTGG MQEAEMLKTF 300
    NCGIGMILVV AQEEADKLTQ LLASLGEDVA RIGHVSAREG VRYSGTLL 348
    Length:348
    Mass (Da):35,956
    Last modified:July 25, 2006 - v1
    Checksum:i9FED40727F8D5A3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31839.1.
    RefSeqiYP_682525.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG31839; ABG31839; RD1_2252.
    GeneIDi4196483.
    KEGGirde:RD1_2252.
    PATRICi23362545. VBIRosDen86677_2155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG31839.1 .
    RefSeqi YP_682525.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q167K4.
    SMRi Q167K4. Positions 7-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_2252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG31839 ; ABG31839 ; RD1_2252 .
    GeneIDi 4196483.
    KEGGi rde:RD1_2252.
    PATRICi 23362545. VBIRosDen86677_2155.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi GEATCEV.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci RDEN375451:GJIZ-2129-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiPUR5_ROSDO
    AccessioniPrimary (citable) accession number: Q167K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3