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Protein

Reticulon-1

Gene

RTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

GO - Biological processi

  • neuron differentiation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
Gene namesi
Name:RTN1
Synonyms:NSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139970.16
HGNCiHGNC:10467 RTN1
MIMi600865 gene
neXtProtiNX_Q16799

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Transmembranei705 – 725HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6252
OpenTargetsiENSG00000139970
PharmGKBiPA34880

Polymorphism and mutation databases

BioMutaiRTN1
DMDMi12643733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681581 – 776Reticulon-1Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1

Post-translational modificationi

Isoforms RTN1-A and RTN1-B are phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16799
MaxQBiQ16799
PaxDbiQ16799
PeptideAtlasiQ16799
PRIDEiQ16799

PTM databases

iPTMnetiQ16799
PhosphoSitePlusiQ16799
SwissPalmiQ16799

Expressioni

Tissue specificityi

Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.1 Publication

Gene expression databases

BgeeiENSG00000139970
CleanExiHS_RTN1
ExpressionAtlasiQ16799 baseline and differential
GenevisibleiQ16799 HS

Organism-specific databases

HPAiCAB002745
HPA040945
HPA044249

Interactioni

Subunit structurei

Interacts with NDRG1 (PubMed:15922294). Isoform RTN1-A interacts with TMEM33 (PubMed:25612671).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005603EBI-10180131,EBI-727004

Protein-protein interaction databases

BioGridi112165, 29 interactors
IntActiQ16799, 5 interactors
STRINGi9606.ENSP00000267484

Structurei

3D structure databases

ProteinModelPortaliQ16799
SMRiQ16799
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 776ReticulonPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi609 – 612Poly-Leu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00390000009934
HOGENOMiHOG000134444
HOVERGENiHBG008971
InParanoidiQ16799
KOiK20721
OMAiEQDSPLM
OrthoDBiEOG091G0TIO
PhylomeDBiQ16799
TreeFamiTF105431

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RTN1-A (identifier: Q16799-1) [UniParc]FASTAAdd to basket
Also known as: NSP-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG
60 70 80 90 100
LGARAREAAS REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG
110 120 130 140 150
EGSCYTSLIS DICYPPQEDS TYFTGILQKE NGHVTISESP EELGTPGPSL
160 170 180 190 200
PDVPGIESRG LFSSDSGIEM TPAESTEVNK ILADPLDQMK AEAYKYIDIT
210 220 230 240 250
RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD KPAPVEGKII
260 270 280 290 300
KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT
310 320 330 340 350
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS
360 370 380 390 400
ISEDELITAI KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD
410 420 430 440 450
HEASSAESGD SEIELVSEDP MAAEDALPSG YVSFGHVGGP PPSPASPSIQ
460 470 480 490 500
YSILREEREA ELDSELIIES CDASSASEES PKREQDSPPM KPSALDAIRE
510 520 530 540 550
ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD GALEPETPML
560 570 580 590 600
PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ
610 620 630 640 650
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK
660 670 680 690 700
TDEGHPFKAY LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV
710 720 730 740 750
DSLKFAVLMW LLTYVGALFN GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL
760 770
GLVRTHINAV VAKIQAKIPG AKRHAE
Length:776
Mass (Da):83,618
Last modified:November 1, 1996 - v1
Checksum:iCA5B6232353096FE
GO
Isoform RTN1-B (identifier: Q16799-2) [UniParc]FASTAAdd to basket
Also known as: NSP-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:356
Mass (Da):38,950
Checksum:iBE8956BC59FB6F08
GO
Isoform RTN1-C (identifier: Q16799-3) [UniParc]FASTAAdd to basket
Also known as: NSP-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-568: Missing.
     569-588: GPGPLGPGAPPPLLFLNKQK → MQATADSTKMDCVWSNWKSQ

Show »
Length:208
Mass (Da):23,576
Checksum:i49C5668130635E17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053630247G → E. Corresponds to variant dbSNP:rs35645652Ensembl.1
Natural variantiVAR_053631357I → V. Corresponds to variant dbSNP:rs35707243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056451 – 568Missing in isoform RTN1-C. 2 PublicationsAdd BLAST568
Alternative sequenceiVSP_0056441 – 420Missing in isoform RTN1-B. 1 PublicationAdd BLAST420
Alternative sequenceiVSP_005646569 – 588GPGPL…LNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-C. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10333 mRNA Translation: AAA59950.1
L10334 mRNA Translation: AAA59951.1
L10335 mRNA Translation: AAA59952.1
CH471061 Genomic DNA Translation: EAW80762.1
BC090862 mRNA Translation: AAH90862.1
BC000314 mRNA Translation: AAH00314.2
BC003003 mRNA Translation: AAH03003.2
CCDSiCCDS9740.1 [Q16799-1]
CCDS9741.1 [Q16799-3]
PIRiA46583
I60904
RefSeqiNP_066959.1, NM_021136.2 [Q16799-1]
NP_996734.1, NM_206852.2 [Q16799-3]
UniGeneiHs.368626

Genome annotation databases

EnsembliENST00000267484; ENSP00000267484; ENSG00000139970 [Q16799-1]
ENST00000342503; ENSP00000340716; ENSG00000139970 [Q16799-3]
GeneIDi6252
KEGGihsa:6252
UCSCiuc001xek.3 human [Q16799-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRTN1_HUMAN
AccessioniPrimary (citable) accession number: Q16799
Secondary accession number(s): Q16800
, Q16801, Q5BKZ4, Q9BQ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health