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Q16799 (RTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
Gene names
Name:RTN1
Synonyms:NSP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

Subunit structure

Interacts with NDRG1. Ref.6

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation. Ref.5

Post-translational modification

Isoforms RTN1-A and RTN1-B are phosphorylated.

Sequence similarities

Contains 1 reticulon domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuron differentiation

Inferred from expression pattern Ref.5. Source: UniProtKB

   Cellular_componentintegral component of endoplasmic reticulum membrane

Traceable author statement Ref.4. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform RTN1-A (identifier: Q16799-1)

Also known as: NSP-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform RTN1-B (identifier: Q16799-2)

Also known as: NSP-B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.
Isoform RTN1-C (identifier: Q16799-3)

Also known as: NSP-C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-568: Missing.
     569-588: GPGPLGPGAPPPLLFLNKQK → MQATADSTKMDCVWSNWKSQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 776776Reticulon-1
PRO_0000168158

Regions

Transmembrane603 – 62321Helical; Potential
Transmembrane705 – 72521Helical; Potential
Domain589 – 776188Reticulon
Compositional bias609 – 6124Poly-Leu

Amino acid modifications

Modified residue4871Phosphoserine Ref.7

Natural variations

Alternative sequence1 – 568568Missing in isoform RTN1-C.
VSP_005645
Alternative sequence1 – 420420Missing in isoform RTN1-B.
VSP_005644
Alternative sequence569 – 58820GPGPL…LNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-C.
VSP_005646
Natural variant2471G → E.
Corresponds to variant rs35645652 [ dbSNP | Ensembl ].
VAR_053630
Natural variant3571I → V.
Corresponds to variant rs35707243 [ dbSNP | Ensembl ].
VAR_053631

Sequences

Sequence LengthMass (Da)Tools
Isoform RTN1-A (NSP-A) [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CA5B6232353096FE

FASTA77683,618
        10         20         30         40         50         60 
MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG LGARAREAAS 

        70         80         90        100        110        120 
REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG EGSCYTSLIS DICYPPQEDS 

       130        140        150        160        170        180 
TYFTGILQKE NGHVTISESP EELGTPGPSL PDVPGIESRG LFSSDSGIEM TPAESTEVNK 

       190        200        210        220        230        240 
ILADPLDQMK AEAYKYIDIT RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD 

       250        260        270        280        290        300 
KPAPVEGKII KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT 

       310        320        330        340        350        360 
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS ISEDELITAI 

       370        380        390        400        410        420 
KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD HEASSAESGD SEIELVSEDP 

       430        440        450        460        470        480 
MAAEDALPSG YVSFGHVGGP PPSPASPSIQ YSILREEREA ELDSELIIES CDASSASEES 

       490        500        510        520        530        540 
PKREQDSPPM KPSALDAIRE ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD 

       550        560        570        580        590        600 
GALEPETPML PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ 

       610        620        630        640        650        660 
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK TDEGHPFKAY 

       670        680        690        700        710        720 
LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV DSLKFAVLMW LLTYVGALFN 

       730        740        750        760        770 
GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL GLVRTHINAV VAKIQAKIPG AKRHAE 

« Hide

Isoform RTN1-B (NSP-B) [UniParc].

Checksum: BE8956BC59FB6F08
Show »

FASTA35638,950
Isoform RTN1-C (NSP-C) [UniParc].

Checksum: 49C5668130635E17
Show »

FASTA20823,576

References

« Hide 'large scale' references
[1]"Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product."
Roebroek A.J.M., Van de Velde H.J.K., Van Bokhoven A., Broers J.L.V., Ramaekers F.C.S., Van de Ven W.J.M.
J. Biol. Chem. 268:13439-13447(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS RTN1-A; RTN1-B AND RTN1-C).
Tissue: Lung carcinoma.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS RTN1-A AND RTN1-C).
Tissue: Lung and PNS.
[4]"Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons."
Roebroek A.J.M., Ayoubi T.A.Y., Van de Velde H.J.K., Schoenmakers E.F.P.M., Pauli I.G.L., Van de Ven W.J.M.
Genomics 32:191-199(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[5]"Neuronal differentiation is accompanied by NSP-C expression."
Hens J., Nuydens R., Geerts H., Senden N.H., Van de Ven W.J.M., Roebroek A.J., van de Velde H.J.K., Ramaekers F.C., Broers J.L.
Cell Tissue Res. 292:229-237(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24."
Hunter M., Angelicheva D., Tournev I., Ingley E., Chan D.C., Watts G.F., Kremensky I., Kalaydjieva L.
Biochem. Biophys. Res. Commun. 332:982-992(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NDRG1.
[7]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10333 mRNA. Translation: AAA59950.1.
L10334 mRNA. Translation: AAA59951.1.
L10335 mRNA. Translation: AAA59952.1.
CH471061 Genomic DNA. Translation: EAW80762.1.
BC090862 mRNA. Translation: AAH90862.1.
BC000314 mRNA. Translation: AAH00314.2.
BC003003 mRNA. Translation: AAH03003.2.
PIRA46583.
I60904.
RefSeqNP_066959.1. NM_021136.2.
NP_996734.1. NM_206852.2.
UniGeneHs.368626.

3D structure databases

ProteinModelPortalQ16799.
SMRQ16799. Positions 639-704.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112165. 6 interactions.
IntActQ16799. 4 interactions.
MINTMINT-154554.
STRING9606.ENSP00000267484.

PTM databases

PhosphoSiteQ16799.

Polymorphism databases

DMDM12643733.

Proteomic databases

PaxDbQ16799.
PRIDEQ16799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267484; ENSP00000267484; ENSG00000139970. [Q16799-1]
ENST00000342503; ENSP00000340716; ENSG00000139970. [Q16799-3]
GeneID6252.
KEGGhsa:6252.
UCSCuc001xek.2. human. [Q16799-3]
uc001xem.1. human. [Q16799-2]
uc001xen.1. human. [Q16799-1]

Organism-specific databases

CTD6252.
GeneCardsGC14M060062.
HGNCHGNC:10467. RTN1.
HPACAB002745.
MIM600865. gene.
neXtProtNX_Q16799.
PharmGKBPA34880.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG306139.
HOGENOMHOG000134444.
HOVERGENHBG008971.
InParanoidQ16799.
OMAGEGSCYT.
OrthoDBEOG7CZK7J.
PhylomeDBQ16799.
TreeFamTF105431.

Gene expression databases

ArrayExpressQ16799.
BgeeQ16799.
CleanExHS_RTN1.
GenevestigatorQ16799.

Family and domain databases

InterProIPR003388. Reticulon.
[Graphical view]
PANTHERPTHR10994. PTHR10994. 1 hit.
PfamPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRTN1. human.
GeneWikiRTN1.
GenomeRNAi6252.
NextBio24277.
PROQ16799.
SOURCESearch...

Entry information

Entry nameRTN1_HUMAN
AccessionPrimary (citable) accession number: Q16799
Secondary accession number(s): Q16800 expand/collapse secondary AC list , Q16801, Q5BKZ4, Q9BQ59
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM