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Q16798

- MAON_HUMAN

UniProt

Q16798 - MAON_HUMAN

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Protein
NADP-dependent malic enzyme, mitochondrial
Gene
ME3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NADP+ = pyruvate + CO2 + NADPH.
Oxaloacetate = pyruvate + CO2.

Cofactori

Divalent metal cations. Prefers magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 1371Proton donor By similarity
Binding sitei190 – 1901NAD By similarity
Active sitei208 – 2081Proton acceptor By similarity
Metal bindingi280 – 2801Divalent metal cation By similarity
Metal bindingi281 – 2811Divalent metal cation By similarity
Metal bindingi304 – 3041Divalent metal cation By similarity
Binding sitei304 – 3041NAD By similarity
Sitei304 – 3041Important for activity By similarity
Binding sitei443 – 4431NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. cofactor binding Source: UniProtKB
  3. malate dehydrogenase (decarboxylating) (NAD+) activity Source: InterPro
  4. malate dehydrogenase (decarboxylating) (NADP+) activity Source: UniProtKB
  5. malic enzyme activity Source: UniProtKB
  6. metal ion binding Source: UniProtKB-KW
  7. oxaloacetate decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: UniProtKB
  2. malate metabolic process Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB
  4. oxygen metabolic process Source: UniProtKB
  5. pyruvate metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP

Enzyme and pathway databases

SABIO-RKQ16798.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent malic enzyme, mitochondrial (EC:1.1.1.40)
Short name:
NADP-ME
Alternative name(s):
Malic enzyme 3
Gene namesi
Name:ME3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6985. ME3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 604NADP-dependent malic enzyme, mitochondrialPRO_0000018539
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ16798.
PaxDbiQ16798.
PRIDEiQ16798.

PTM databases

PhosphoSiteiQ16798.

Expressioni

Tissue specificityi

Expressed predominantly in organs with a low-division rate.

Gene expression databases

ArrayExpressiQ16798.
BgeeiQ16798.
CleanExiHS_ME3.
GenevestigatoriQ16798.

Organism-specific databases

HPAiHPA038473.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352657.

Structurei

3D structure databases

ProteinModelPortaliQ16798.
SMRiQ16798. Positions 48-602.

Family & Domainsi

Sequence similaritiesi

Belongs to the malic enzymes family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0281.
HOGENOMiHOG000042486.
HOVERGENiHBG000746.
InParanoidiQ16798.
KOiK00029.
OMAiDFAYKHN.
OrthoDBiEOG7G4QF0.
PhylomeDBiQ16798.
TreeFamiTF300537.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16798-1 [UniParc]FASTAAdd to Basket

« Hide

MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG    50
YDVTRNPHLN KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYERQ 100
QSDLDKYIIL MTLQDRNEKL FYRVLTSDVE KFMPIVYTPT VGLACQHYGL 150
TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI KAVVVTDGER ILGLGDLGCY 200
GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD PLYIGLKHQR 250
VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 300
FNDDIQGTAS VAVAGILAAL RITKNKLSNH VFVFQGAGEA AMGIAHLLVM 350
ALEKEGVPKA EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE 400
EVVRLVKPTA IIGVAAIAGA FTEQILRDMA SFHERPIIFA LSNPTSKAEC 450
TAEKCYRVTE GRGIFASGSP FKSVTLEDGK TFIPGQGNNA YVFPGVALGV 500
IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST IRDVSLRIAI 550
KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN 600
VQTV 604
Length:604
Mass (Da):67,068
Last modified:November 25, 2008 - v2
Checksum:iE0E79A75F3CAC524
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851S → G.1 Publication
Corresponds to variant rs17856661 [ dbSNP | Ensembl ].
VAR_047369
Natural varianti324 – 3241K → N.2 Publications
Corresponds to variant rs1042780 [ dbSNP | Ensembl ].
VAR_047370

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951R → G in AAH22472. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79440 mRNA. Translation: CAA55956.1.
AP001148 Genomic DNA. No translation available.
AP001831 Genomic DNA. No translation available.
AP002492 Genomic DNA. No translation available.
BC022472 mRNA. Translation: AAH22472.1.
CCDSiCCDS8277.1.
PIRiS53351.
RefSeqiNP_001014811.1. NM_001014811.1.
NP_001155058.1. NM_001161586.1.
NP_006671.2. NM_006680.2.
XP_005273774.1. XM_005273717.1.
UniGeneiHs.199743.

Genome annotation databases

EnsembliENST00000359636; ENSP00000352657; ENSG00000151376.
ENST00000393324; ENSP00000376998; ENSG00000151376.
ENST00000543262; ENSP00000440246; ENSG00000151376.
GeneIDi10873.
KEGGihsa:10873.
UCSCiuc001pbz.3. human.

Polymorphism databases

DMDMi215274021.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79440 mRNA. Translation: CAA55956.1 .
AP001148 Genomic DNA. No translation available.
AP001831 Genomic DNA. No translation available.
AP002492 Genomic DNA. No translation available.
BC022472 mRNA. Translation: AAH22472.1 .
CCDSi CCDS8277.1.
PIRi S53351.
RefSeqi NP_001014811.1. NM_001014811.1.
NP_001155058.1. NM_001161586.1.
NP_006671.2. NM_006680.2.
XP_005273774.1. XM_005273717.1.
UniGenei Hs.199743.

3D structure databases

ProteinModelPortali Q16798.
SMRi Q16798. Positions 48-602.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352657.

Chemistry

ChEMBLi CHEMBL6182.
DrugBanki DB00157. NADH.

PTM databases

PhosphoSitei Q16798.

Polymorphism databases

DMDMi 215274021.

Proteomic databases

MaxQBi Q16798.
PaxDbi Q16798.
PRIDEi Q16798.

Protocols and materials databases

DNASUi 10873.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359636 ; ENSP00000352657 ; ENSG00000151376 .
ENST00000393324 ; ENSP00000376998 ; ENSG00000151376 .
ENST00000543262 ; ENSP00000440246 ; ENSG00000151376 .
GeneIDi 10873.
KEGGi hsa:10873.
UCSCi uc001pbz.3. human.

Organism-specific databases

CTDi 10873.
GeneCardsi GC11M086152.
H-InvDB HIX0010004.
HGNCi HGNC:6985. ME3.
HPAi HPA038473.
MIMi 604626. gene.
neXtProti NX_Q16798.
PharmGKBi PA30725.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0281.
HOGENOMi HOG000042486.
HOVERGENi HBG000746.
InParanoidi Q16798.
KOi K00029.
OMAi DFAYKHN.
OrthoDBi EOG7G4QF0.
PhylomeDBi Q16798.
TreeFami TF300537.

Enzyme and pathway databases

SABIO-RK Q16798.

Miscellaneous databases

ChiTaRSi ME3. human.
GenomeRNAii 10873.
NextBioi 41285.
PROi Q16798.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16798.
Bgeei Q16798.
CleanExi HS_ME3.
Genevestigatori Q16798.

Family and domain databases

Gene3Di 3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF000106. ME. 1 hit.
PRINTSi PR00072. MALOXRDTASE.
SMARTi SM00919. Malic_M. 1 hit.
[Graphical view ]
PROSITEi PS00331. MALIC_ENZYMES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme."
    Loeber G., Maurer-Fogy I., Schwendenwein R.
    Biochem. J. 304:687-692(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-324.
    Tissue: Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-85 AND ASN-324.
    Tissue: Brain.

Entry informationi

Entry nameiMAON_HUMAN
AccessioniPrimary (citable) accession number: Q16798
Secondary accession number(s): Q8TBJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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