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Q16795 (NDUA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Alternative name(s):
Complex I-39kD
Short name=CI-39kD
NADH-ubiquinone oxidoreductase 39 kDa subunit
Gene names
Name:NDUFA9
Synonyms:NDUFS2L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cofactor

Binds 1 FAD per subunit.

Subunit structure

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4 By similarity. Ref.5 Ref.7

Subcellular location

Mitochondrion matrix.

Post-translational modification

Acetylated on lysine residues. BLOC1S1 is required for acetylation. Ref.7

Sequence similarities

Belongs to the complex I NDUFA9 subunit family.

Sequence caution

The sequence CAA54099.1 differs from that shown. Reason: Frameshift at position 18.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BLOC1S1P785373EBI-1045087,EBI-348630
NOA1Q8NC602EBI-1045087,EBI-717871

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3535Mitochondrion By similarity
Chain36 – 377342NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
PRO_0000019992

Amino acid modifications

Modified residue1751N6-succinyllysine By similarity
Modified residue1891N6-acetyllysine By similarity
Modified residue3701N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q16795 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 66A1CC7FCE86DD0E

FASTA37742,510
        10         20         30         40         50         60 
MAAAAQSRVV RVLSMSRSAI TAIATSVCHG PPCRQLHHAL MPHGKGGRSS VSGIVATVFG 

        70         80         90        100        110        120 
ATGFLGRYVV NHLGRMGSQV IIPYRCDKYD IMHLRPMGDL GQLLFLEWDA RDKDSIRRVV 

       130        140        150        160        170        180 
QHSNVVINLI GRDWETKNFD FEDVFVKIPQ AIAQLSKEAG VEKFIHVSHL NANIKSSSRY 

       190        200        210        220        230        240 
LRNKAVGEKV VRDAFPEAII VKPSDIFGRE DRFLNSFASM HRFGPIPLGS LGWKTVKQPV 

       250        260        270        280        290        300 
YVVDVSKGIV NAVKDPDANG KSFAFVGPSR YLLFHLVKYI FAVAHRLFLP FPLPLFAYRW 

       310        320        330        340        350        360 
VARVFEISPF EPWITRDKVE RMHITDMKLP HLPGLEDLGI QATPLELKAI EVLRRHRTYR 

       370 
WLSAEIEDVK PAKTVNI 

« Hide

References

« Hide 'large scale' references
[1]"39 kDa subunit of NADH-ubiquinone oxidoreductase."
Loeffen J.L.C.M., Smeets R.J.P., Triepels R., Ruitenbeek W., Smeitink J.A.M., van den Heuvel L.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Muscle and Skeletal muscle.
[3]"Purification of CpG islands using a methylated DNA binding column."
Cross S.H., Charlton J.A., Nan X., Bird A.P.
Nat. Genet. 6:236-244(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33.
Tissue: Blood.
[4]"Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid."
Baens M., Chaffanet M., Cassiman J.-J., van den Berghe H., Marynen P.
Genomics 16:214-218(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-377.
Tissue: Liver.
[5]"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1."
Scott I., Webster B.R., Li J.H., Sack M.N.
Biochem. J. 443:655-661(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BLOC1S1, ACETYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF050641 mRNA. Translation: AAD42055.1.
BC009311 mRNA. Translation: AAH09311.1.
BC015837 mRNA. Translation: AAH15837.1.
BC111546 mRNA. Translation: AAI11547.1.
X76665 Genomic DNA. Translation: CAA54099.1. Frameshift.
L04490 mRNA. Translation: AAA36350.1.
PIRI37258.
RefSeqNP_004993.1. NM_005002.4.
UniGeneHs.75227.

3D structure databases

ProteinModelPortalQ16795.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110784. 22 interactions.
DIPDIP-38526N.
IntActQ16795. 15 interactions.
MINTMINT-3033599.
STRING9606.ENSP00000266544.

Chemistry

ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteQ16795.

Polymorphism databases

DMDM2833280.

Proteomic databases

PaxDbQ16795.
PRIDEQ16795.

Protocols and materials databases

DNASU4704.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266544; ENSP00000266544; ENSG00000139180.
GeneID4704.
KEGGhsa:4704.
UCSCuc001qnc.3. human.

Organism-specific databases

CTD4704.
GeneCardsGC12P004714.
HGNCHGNC:7693. NDUFA9.
HPAHPA042268.
MIM603834. gene.
neXtProtNX_Q16795.
Orphanet2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBPA31499.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0702.
HOGENOMHOG000168008.
HOVERGENHBG006546.
InParanoidQ16795.
KOK03953.
OMAIFLEWNG.
PhylomeDBQ16795.
TreeFamTF105961.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ16795.
BgeeQ16795.
CleanExHS_NDUFA9.
GenevestigatorQ16795.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNDUFA9.
GenomeRNAi4704.
NextBio18140.
PROQ16795.
SOURCESearch...

Entry information

Entry nameNDUA9_HUMAN
AccessionPrimary (citable) accession number: Q16795
Secondary accession number(s): Q14076, Q2NKX0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM