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Reviewed, UniProtKB/Swiss-Prot Q16763 (UBE2S_HUMAN)

Last modified November 25, 2008. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin-conjugating enzyme E2 S
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase S
    Ubiquitin carrier protein S
    Ubiquitin-conjugating enzyme E2-24 kDa
    E2-EPF5
Gene names
Name: UBE2S
Synonyms: E2EPF
ORF Names: OK/SW-cl.73
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Ubiquitin-conjugating enzyme E2 S
PRO_0000082507

Sites

Active site951Glycyl thioester intermediate By similarity

Experimental info

Sequence conflict221 – 2222RL → ALRRL Ref.1

Secondary structure

............................ 222
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q16763-1 [UniParc].

Last modified October 10, 2002. Version 2.
Checksum: 2842DC3DCD2AFCB5

FASTA22223,845
        10         20         30         40         50         60 
MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF 

        70         80         90        100        110        120 
RMKLLLGKDF PASPPKGYFL TKIFHPNVGA NGEICVNVLK RDWTAELGIR HVLLTIKCLL 

       130        140        150        160        170        180 
IHPNPESALN EEAGRLLLEN YEEYAARARL LTEIHGGAGG PSGRAEAGRA LASGTEASST 

       190        200        210        220 
DPGAPGGPGG AEGPMAKKHA GERDKKLAAK KKTDKKRALR RL 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript."
Liu Z., Diaz L.A., Haas A.L., Giudice G.J.
J. Biol. Chem. 267:15829-15835(1992) [PubMed: 1379239] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Foreskin.
[2]"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S., Itoh K.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon adenocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Skin.

Cross-references

Sequence databases

M91670 mRNA. Translation: AAA58446.1.
AB062397 mRNA. Translation: BAB93484.1.
BC004236 mRNA. Translation: AAH04236.1.
BC007554 mRNA. Translation: AAH07554.1.
BC065364 mRNA. Translation: AAH65364.1.
RefSeqNP_055316.2.
UniGeneHs.396393
Hs.592114

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1ZDNX-ray1.93A/B1-156[»]
ModBaseSearch...

PTM databases

PhosphoSiteQ16763.

Proteomic databases

PeptideAtlasQ16763.

Genome annotation databases

EnsemblENSG00000108106. Homo sapiens. [Contig view]
GeneID27338.
KEGGhsa:27338.

Organism-specific databases

H-InvDBHIX0015468.
HIX0039201.
HGNCHGNC:17895. UBE2S.
HPACAB015228.
MIM610309. gene.
PharmGKBPA134904441.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ16763.
HOVERGENQ16763.

Gene expression databases

CleanExHS_UBE2S.
GermOnlineENSG00000108106. Homo sapiens.

Family and domain databases

InterProIPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHERPTHR11621. UBQ-conjugat_E2. 1 hit.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ16763.
NextBio50400.
SOURCESearch...

Entry information

Entry nameUBE2S_HUMAN
AccessionPrimary (citable) accession number: Q16763
Secondary accession number(s): Q9BTC1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: November 25, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents