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Protein
Submitted name:

Debrisoquine 4-hydroxylase mutant allele (CYP2D6-MA1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Debrisoquine 4-hydroxylase mutant allele (CYP2D6-MA1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2318HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiQ16753.
PRIDEiQ16753.

Structurei

3D structure databases

ProteinModelPortaliQ16753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYSPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA MVTRGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGKQ RGVPGALWAR VARAEALLRL HLAQLGPGQE
160 170 180 190 200
VAGAVGDRGG RLPLCRLRQP LRRPFRPNGL LDKAVSNVIA SLTCGRRFEY
210 220 230 240 250
DDPRFLRLLD LAQEGLKEES GFLREVLNAV PVLLHIPALA GKVLRFQKAF
260 270 280 290 300
LTQLDELLTE HRMTWDPAQP PRDLTEAFLA EMEKAKGNPE SSFNDENLRI
310 320 330 340 350
VVADLFSAGM VTTSTTLAWG LLLMILHPDV QRRVQQEIDD VIGQVRRPEM
360 370 380 390 400
GDQAHMPYTT AVIHEVQRFG DIVPLGVTHM TSRDIEVQGF RIPKGTTLIT
410 420 430 440 450
NLSSVLKDEA VWEKPFRFHP EHFLDAQGHF VKPEAFLPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TSLLQHFSFS VPTGQPRPSH HGVFAFLVTP SPYELCAVPR
Length:500
Mass (Da):55,890
Last modified:November 1, 1996 - v1
Checksum:iD5293E9BF74692C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33189 Genomic DNA. Translation: AAA35737.1.
UniGeneiHs.648256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33189 Genomic DNA. Translation: AAA35737.1.
UniGeneiHs.648256.

3D structure databases

ProteinModelPortaliQ16753.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ16753.
PRIDEiQ16753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Gonzalez F.J.
    Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ16753_HUMAN
AccessioniPrimary (citable) accession number: Q16753
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.