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Protein

Plasma membrane calcium-transporting ATPase 3

Gene

ATP2B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4734-aspartylphosphate intermediateBy similarity1
Metal bindingi794MagnesiumBy similarity1
Metal bindingi798MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: GO_Central
  • ion transmembrane transport Source: Reactome
  • regulation of cardiac conduction Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00921-MONOMER.
BRENDAi3.6.3.8. 2681.
ReactomeiR-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 3 (EC:3.6.3.8)
Short name:
PMCA3
Alternative name(s):
Plasma membrane calcium ATPase isoform 3
Plasma membrane calcium pump isoform 3
Gene namesi
Name:ATP2B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:816. ATP2B3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 155ExtracellularSequence analysisAdd BLAST37
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 364CytoplasmicSequence analysisAdd BLAST188
Transmembranei365 – 384HelicalSequence analysisAdd BLAST20
Topological domaini385 – 417ExtracellularSequence analysisAdd BLAST33
Transmembranei418 – 435HelicalSequence analysisAdd BLAST18
Topological domaini436 – 849CytoplasmicSequence analysisAdd BLAST414
Transmembranei850 – 869HelicalSequence analysisAdd BLAST20
Topological domaini870 – 879ExtracellularSequence analysis10
Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Topological domaini901 – 920CytoplasmicSequence analysisAdd BLAST20
Transmembranei921 – 943HelicalSequence analysisAdd BLAST23
Topological domaini944 – 961ExtracellularSequence analysisAdd BLAST18
Transmembranei962 – 983HelicalSequence analysisAdd BLAST22
Topological domaini984 – 1002CytoplasmicSequence analysisAdd BLAST19
Transmembranei1003 – 1024HelicalSequence analysisAdd BLAST22
Topological domaini1025 – 1034ExtracellularSequence analysis10
Transmembranei1035 – 1056HelicalSequence analysisAdd BLAST22
Topological domaini1057 – 1220CytoplasmicSequence analysisAdd BLAST164

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, X-linked 1 (SCAX1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAX1 is characterized by hypotonia at birth, delayed motor development, gait ataxia, difficulty standing, dysarthria, and slow eye movements. Brain MRI shows cerebellar ataxia.
See also OMIM:302500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0693081107G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant rs397514619dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi492.
MalaCardsiATP2B3.
MIMi302500. phenotype.
OpenTargetsiENSG00000067842.
Orphaneti85142. Aldosterone-producing adenoma.
314978. X-linked non progressive cerebellar ataxia.
PharmGKBiPA25109.

Polymorphism and mutation databases

BioMutaiATP2B3.
DMDMi116241261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462181 – 1220Plasma membrane calcium-transporting ATPase 3Add BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei1079PhosphothreonineBy similarity1
Modified residuei1113Phosphothreonine; by PKCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16720.
MaxQBiQ16720.
PaxDbiQ16720.
PeptideAtlasiQ16720.
PRIDEiQ16720.

PTM databases

iPTMnetiQ16720.
PhosphoSitePlusiQ16720.
SwissPalmiQ16720.

Expressioni

Tissue specificityi

Highly expressed in the cerebellum, particulary in the presynaptic terminals of parallel fibers-Purkinje neurons. Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000067842.
CleanExiHS_ATP2B3.
GenevisibleiQ16720. HS.

Organism-specific databases

HPAiHPA001583.

Interactioni

Subunit structurei

Interacts with PDZD11.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106982. 34 interactors.
IntActiQ16720. 2 interactors.
MINTiMINT-2807671.
STRINGi9606.ENSP00000263519.

Structurei

3D structure databases

ProteinModelPortaliQ16720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1097 – 1114Calmodulin-binding subdomain ABy similarityAdd BLAST18
Regioni1115 – 1124Calmodulin-binding subdomain BBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi297 – 300Poly-Glu4
Compositional biasi1174 – 1179Poly-Pro6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
HOGENOMiHOG000265623.
HOVERGENiHBG061286.
InParanoidiQ16720.
KOiK05850.
OMAiGNPIFCT.
OrthoDBiEOG091G057D.
PhylomeDBiQ16720.
TreeFamiTF300330.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.
Isoform XB (identifier: Q16720-1) [UniParc]FASTAAdd to basket
Also known as: AIICI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE
60 70 80 90 100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ
110 120 130 140 150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA
160 170 180 190 200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN
210 220 230 240 250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH
260 270 280 290 300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE
310 320 330 340 350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA
360 370 380 390 400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR
410 420 430 440 450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK
460 470 480 490 500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA
510 520 530 540 550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF
560 570 580 590 600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG
610 620 630 640 650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY
660 670 680 690 700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT
710 720 730 740 750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE
760 770 780 790 800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP
810 820 830 840 850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS
860 870 880 890 900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA
910 920 930 940 950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF
960 970 980 990 1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI
1010 1020 1030 1040 1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV
1060 1070 1080 1090 1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG
1110 1120 1130 1140 1150
QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKTSIHN FMATPEFLIN
1160 1170 1180 1190 1200
DYTHNIPLID DTDVDENEER LRAPPPPSPN QNNNAIDSGI YLTTHVTKSA
1210 1220
TSSVFSSSPG SPLHSVETSL
Length:1,220
Mass (Da):134,197
Last modified:October 17, 2006 - v3
Checksum:i03B2BA8A0A33B193
GO
Isoform XA (identifier: Q16720-2) [UniParc]FASTAAdd to basket
Also known as: AIICII

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Show »
Length:1,173
Mass (Da):128,545
Checksum:iEF3ACDF02DF40B8C
GO
Isoform ZA (identifier: Q16720-3) [UniParc]FASTAAdd to basket
Also known as: AICII

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Show »
Length:1,159
Mass (Da):127,068
Checksum:iD092487DFC13E8A3
GO
Isoform ZB (identifier: Q16720-4) [UniParc]FASTAAdd to basket
Also known as: AICI

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.

Show »
Length:1,206
Mass (Da):132,721
Checksum:i2366490D5E398C08
GO
Isoform XE (identifier: Q16720-5) [UniParc]FASTAAdd to basket
Also known as: AIICV

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Show »
Length:1,168
Mass (Da):128,110
Checksum:i79D7ED01B8F1BA88
GO
Isoform ZE (identifier: Q16720-6) [UniParc]FASTAAdd to basket
Also known as: AICV

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Show »
Length:1,154
Mass (Da):126,634
Checksum:i6E34C22E92BEAE95
GO
Isoform XG (identifier: Q16720-7) [UniParc]FASTAAdd to basket
Also known as: AIICVII

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Show »
Length:1,129
Mass (Da):124,236
Checksum:i17805052F1230AEF
GO
Isoform ZG (identifier: Q16720-8) [UniParc]FASTAAdd to basket
Also known as: AICVII

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Show »
Length:1,115
Mass (Da):122,760
Checksum:i46F7F01999CFA318
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti587I → V in AAB09762 (PubMed:8765088).Curated1
Sequence conflicti587I → V in AAB38530 (PubMed:8765088).Curated1
Sequence conflicti654S → Y in AAB09762 (PubMed:8765088).Curated1
Sequence conflicti654S → Y in AAB38530 (PubMed:8765088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027928198I → M.Corresponds to variant rs2269409dbSNPEnsembl.1
Natural variantiVAR_0693081107G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant rs397514619dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000392306 – 319Missing in isoform ZA, isoform ZB, isoform ZE and isoform ZG. CuratedAdd BLAST14
Alternative sequenceiVSP_0003931115 – 1220IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGNPGGESVP in isoform XA and isoform ZA. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_0003941115 – 1220IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGSES in isoform XE and isoform ZE. CuratedAdd BLAST106
Alternative sequenceiVSP_0003951115 – 1220IRVVK…VETSL → VCWDGKKMLRTTEVG in isoform XG and isoform ZG. CuratedAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57971 mRNA. Translation: AAB09762.1.
U60414 mRNA. Translation: AAB38530.1.
AH006061 Genomic DNA. Translation: AAC15078.1.
CH471172 Genomic DNA. Translation: EAW72859.1.
U82695 Genomic DNA. No translation available.
U15689 mRNA. Translation: AAA60986.1.
U15690 mRNA. Translation: AAA60987.1.
CCDSiCCDS14722.1. [Q16720-2]
CCDS35440.1. [Q16720-1]
RefSeqiNP_001001344.1. NM_001001344.2. [Q16720-1]
NP_068768.2. NM_021949.3. [Q16720-2]
XP_005274747.1. XM_005274690.3. [Q16720-1]
XP_005274748.1. XM_005274691.3. [Q16720-4]
XP_005274749.1. XM_005274692.3. [Q16720-2]
UniGeneiHs.533956.
Hs.658008.

Genome annotation databases

EnsembliENST00000263519; ENSP00000263519; ENSG00000067842. [Q16720-1]
ENST00000349466; ENSP00000343886; ENSG00000067842. [Q16720-1]
ENST00000359149; ENSP00000352062; ENSG00000067842. [Q16720-2]
ENST00000370186; ENSP00000359205; ENSG00000067842. [Q16720-3]
ENST00000393842; ENSP00000377425; ENSG00000067842. [Q16720-6]
GeneIDi492.
KEGGihsa:492.
UCSCiuc004fhs.2. human. [Q16720-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57971 mRNA. Translation: AAB09762.1.
U60414 mRNA. Translation: AAB38530.1.
AH006061 Genomic DNA. Translation: AAC15078.1.
CH471172 Genomic DNA. Translation: EAW72859.1.
U82695 Genomic DNA. No translation available.
U15689 mRNA. Translation: AAA60986.1.
U15690 mRNA. Translation: AAA60987.1.
CCDSiCCDS14722.1. [Q16720-2]
CCDS35440.1. [Q16720-1]
RefSeqiNP_001001344.1. NM_001001344.2. [Q16720-1]
NP_068768.2. NM_021949.3. [Q16720-2]
XP_005274747.1. XM_005274690.3. [Q16720-1]
XP_005274748.1. XM_005274691.3. [Q16720-4]
XP_005274749.1. XM_005274692.3. [Q16720-2]
UniGeneiHs.533956.
Hs.658008.

3D structure databases

ProteinModelPortaliQ16720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106982. 34 interactors.
IntActiQ16720. 2 interactors.
MINTiMINT-2807671.
STRINGi9606.ENSP00000263519.

PTM databases

iPTMnetiQ16720.
PhosphoSitePlusiQ16720.
SwissPalmiQ16720.

Polymorphism and mutation databases

BioMutaiATP2B3.
DMDMi116241261.

Proteomic databases

EPDiQ16720.
MaxQBiQ16720.
PaxDbiQ16720.
PeptideAtlasiQ16720.
PRIDEiQ16720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263519; ENSP00000263519; ENSG00000067842. [Q16720-1]
ENST00000349466; ENSP00000343886; ENSG00000067842. [Q16720-1]
ENST00000359149; ENSP00000352062; ENSG00000067842. [Q16720-2]
ENST00000370186; ENSP00000359205; ENSG00000067842. [Q16720-3]
ENST00000393842; ENSP00000377425; ENSG00000067842. [Q16720-6]
GeneIDi492.
KEGGihsa:492.
UCSCiuc004fhs.2. human. [Q16720-1]

Organism-specific databases

CTDi492.
DisGeNETi492.
GeneCardsiATP2B3.
H-InvDBHIX0017131.
HGNCiHGNC:816. ATP2B3.
HPAiHPA001583.
MalaCardsiATP2B3.
MIMi300014. gene.
302500. phenotype.
neXtProtiNX_Q16720.
OpenTargetsiENSG00000067842.
Orphaneti85142. Aldosterone-producing adenoma.
314978. X-linked non progressive cerebellar ataxia.
PharmGKBiPA25109.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
HOGENOMiHOG000265623.
HOVERGENiHBG061286.
InParanoidiQ16720.
KOiK05850.
OMAiGNPIFCT.
OrthoDBiEOG091G057D.
PhylomeDBiQ16720.
TreeFamiTF300330.

Enzyme and pathway databases

BioCyciZFISH:HS00921-MONOMER.
BRENDAi3.6.3.8. 2681.
ReactomeiR-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP2B3. human.
GeneWikiiATP2B3.
GenomeRNAii492.
PROiQ16720.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067842.
CleanExiHS_ATP2B3.
GenevisibleiQ16720. HS.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2B3_HUMAN
AccessioniPrimary (citable) accession number: Q16720
Secondary accession number(s): B7WNR8
, B7WNY5, Q12995, Q16858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.