Q16720 (AT2B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasma membrane calcium-transporting ATPase 3
Short name=PMCA3
EC=3.6.3.8

Alternative name(s):
Plasma membrane calcium ATPase isoform 3
Plasma membrane calcium pump isoform 3

Gene names

Name:

ATP2B3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1220 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2].
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro platelet activation Traceable author statement. Source: Reactome
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Traceable author statement. Source: ProtInc calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.

Isoform XB (identifier: Q16720-1)

Also known as: AIICI;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform XA (identifier: Q16720-2)

Also known as: AIICII;

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Isoform ZA (identifier: Q16720-3)

Also known as: AICII;

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Isoform ZB (identifier: Q16720-4)

Also known as: AICI;

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.

Isoform XE (identifier: Q16720-5)

Also known as: AIICV;

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Isoform ZE (identifier: Q16720-6)

Also known as: AICV;

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Isoform XG (identifier: Q16720-7)

Also known as: AIICVII;

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Isoform ZG (identifier: Q16720-8)

Also known as: AICVII;

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1220	1220	Plasma membrane calcium-transporting ATPase 3		PRO_0000046218
Regions
	Topological domain	1 – 97	97	Cytoplasmic Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Topological domain	119 – 155	37	Extracellular Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Topological domain	177 – 364	188	Cytoplasmic Potential
	Transmembrane	365 – 384	20	Helical; Potential
	Topological domain	385 – 417	33	Extracellular Potential
	Transmembrane	418 – 435	18	Helical; Potential
	Topological domain	436 – 849	414	Cytoplasmic Potential
	Transmembrane	850 – 869	20	Helical; Potential
	Topological domain	870 – 879	10	Extracellular Potential
	Transmembrane	880 – 900	21	Helical; Potential
	Topological domain	901 – 920	20	Cytoplasmic Potential
	Transmembrane	921 – 943	23	Helical; Potential
	Topological domain	944 – 961	18	Extracellular Potential
	Transmembrane	962 – 983	22	Helical; Potential
	Topological domain	984 – 1002	19	Cytoplasmic Potential
	Transmembrane	1003 – 1024	22	Helical; Potential
	Topological domain	1025 – 1034	10	Extracellular Potential
	Transmembrane	1035 – 1056	22	Helical; Potential
	Topological domain	1057 – 1220	164	Cytoplasmic Potential
	Region	1097 – 1114	18	Calmodulin-binding subdomain A By similarity
	Region	1115 – 1124	10	Calmodulin-binding subdomain B By similarity
	Compositional bias	297 – 300	4	Poly-Glu
	Compositional bias	1174 – 1179	6	Poly-Pro
Sites
	Active site	473	1	4-aspartylphosphate intermediate By similarity
	Metal binding	794	1	Magnesium By similarity
	Metal binding	798	1	Magnesium By similarity
Amino acid modifications
	Modified residue	1113	1	Phosphothreonine; by PKC By similarity
Natural variations
	Alternative sequence	306 – 319	14	Missing in isoform ZA, isoform ZB, isoform ZE and isoform ZG.		VSP_000392
	Alternative sequence	1115 – 1220	106	IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGNPGGESVP in isoform XA and isoform ZA.		VSP_000393
	Alternative sequence	1115 – 1220	106	IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGSES in isoform XE and isoform ZE.		VSP_000394
	Alternative sequence	1115 – 1220	106	IRVVK…VETSL → VCWDGKKMLRTTEVG in isoform XG and isoform ZG.		VSP_000395
	Natural variant	198	1	I → M. Corresponds to variant rs2269409 [ dbSNP | Ensembl ].		VAR_027928
Experimental info
	Sequence conflict	587	1	I → V in AAB09762. Ref.1
	Sequence conflict	587	1	I → V in AAB38530. Ref.1
	Sequence conflict	654	1	S → Y in AAB09762. Ref.1
	Sequence conflict	654	1	S → Y in AAB38530. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform XB (AIICI) [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 03B2BA8A0A33B193	FASTA	1,220	134,197
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NAPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR TWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY RDFSAGQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKTSIHN 1150 1160 1170 1180 1190 1200 FMATPEFLIN DYTHNIPLID DTDVDENEER LRAPPPPSPN QNNNAIDSGI YLTTHVTKSA 1210 1220 TSSVFSSSPG SPLHSVETSL
	Isoform XA (AIICII) [UniParc]. Checksum: EF3ACDF02DF40B8C	FASTA	1,173	128,545
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NAPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR TWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY RDFSAGQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSVQGA VRRRSSVLSQ 1150 1160 1170 LHDVTNLSTP THAILSAANP TSAAGNPGGE SVP
	Isoform ZA (AICII) [UniParc]. Checksum: D092487DFC13E8A3	FASTA	1,159	127,068
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL 550 560 570 580 590 600 KRDFQPVREQ IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSVQGAVRRR SSVLSQLHDV TNLSTPTHAI 1150 LSAANPTSAA GNPGGESVP
	Isoform ZB (AICI) [UniParc]. Checksum: 2366490D5E398C08	FASTA	1,206	132,721
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL 550 560 570 580 590 600 KRDFQPVREQ IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ IRVVKAFRSS LYEGLEKPES KTSIHNFMAT PEFLINDYTH 1150 1160 1170 1180 1190 1200 NIPLIDDTDV DENEERLRAP PPPSPNQNNN AIDSGIYLTT HVTKSATSSV FSSSPGSPLH SVETSL
	Isoform XE (AIICV) [UniParc]. Checksum: 79D7ED01B8F1BA88	FASTA	1,168	128,110
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NAPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR TWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY RDFSAGQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSVQGA VRRRSSVLSQ 1150 1160 LHDVTNLSTP THAILSAANP TSAAGSES
	Isoform ZE (AICV) [UniParc]. Checksum: 6E34C22E92BEAE95	FASTA	1,154	126,634
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL 550 560 570 580 590 600 KRDFQPVREQ IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSVQGAVRRR SSVLSQLHDV TNLSTPTHAI 1150 LSAANPTSAA GSES
	Isoform XG (AIICVII) [UniParc]. Checksum: 17805052F1230AEF	FASTA	1,129	124,236
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NAPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR TWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY RDFSAGQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQVCWDGK KMLRTTEVG
	Isoform ZG (AICVII) [UniParc]. Checksum: 46F7F01999CFA318	FASTA	1,115	122,760
	10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL 550 560 570 580 590 600 KRDFQPVREQ IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 RELRRGQILW FRGLNRIQTQ VCWDGKKMLR TTEVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of human plasma membrane Ca(2+)-ATPase isoform 3." Brown B., Hilfiker H., Demarco S.J., Zacharias D.A., Greenwood T.M., Carafoli E., Strehler E.E. Biochim. Biophys. Acta 1283:10-13(1996) [PubMed: 8765088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS XA AND XB). Tissue: Brain.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively." Wang M.G., Yi H., Hilfiker H., Carafoli E., Strehler E.E., McBride O.W. Cytogenet. Cell Genet. 67:41-45(1994) [PubMed: 8187550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-319, ALTERNATIVE SPLICING (ISOFORMS XB/XA/XE/XG).
[5]	"Comparative genome sequence analysis of the Bpa/Str region in mouse and man." Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M., Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D., Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K., Hunter G., Greystrong J.S., Clarke D. , Kimberley C., Goerdes M., Blechschmidt K., Rump A., Hinzmann B., Mundy C.R., Miller W., Poustka A., Herman G.E., Rhodes M., Denny P., Rosenthal A., Brown S.D.M. Genome Res. 10:758-775(2000) [PubMed: 10854409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1053, ALTERNATIVE SPLICING (ISOFORMS XB/XA/XE/XG).
[6]	"Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes." Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 268:25993-26003(1993) [PubMed: 8245032] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS XG/ZG AND XA/ZA), ALTERNATIVE SPLICING. Tissue: Brain cortex.
[7]	Erratum Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 269:32022-32022(1994) [PubMed: 7989379] [Abstract]
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57971 mRNA. Translation: AAB09762.1. U60414 mRNA. Translation: AAB38530.1. AF060498, AF060496, AF060497 Genomic DNA. Translation: AAC15078.1. CH471172 Genomic DNA. Translation: EAW72859.1. U82695 Genomic DNA. No translation available. U15689 mRNA. Translation: AAA60986.1. U15690 mRNA. Translation: AAA60987.1.
IPI	IPI00003831. IPI00219256. IPI00219257. IPI00219258. IPI00219259. IPI00219260. IPI00219261. IPI00219262.
RefSeq	NP_001001344.1. NM_001001344.2. NP_068768.2. NM_021949.3.
UniGene	Hs.533956. Hs.658008.
3D structure databases
ProteinModelPortal	Q16720.
SMR	Q16720. Positions 51-1061, 1097-1124.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16720.
PTM databases
PhosphoSite	Q16720.
Polymorphism databases
DMDM	116241261.
Proteomic databases
PRIDE	Q16720.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263519; ENSP00000263519; ENSG00000067842. ENST00000349466; ENSP00000343886; ENSG00000067842. ENST00000393842; ENSP00000377425; ENSG00000067842.
GeneID	492.
KEGG	hsa:492.
UCSC	uc004fhs.1. human. uc004fht.1. human.
Organism-specific databases
CTD	492.
GeneCards	GC0XP152783.
H-InvDB	HIX0017131.
HGNC	HGNC:816. ATP2B3.
HPA	CAB005607. HPA001583.
MIM	300014. gene.
neXtProt	NX_Q16720.
PharmGKB	PA25109.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000046331.
HOGENOM	HBG456486.
HOVERGEN	HBG061286.
InParanoid	Q16720.
OMA	MSTVIRM.
PhylomeDB	Q16720.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q16720.
Bgee	Q16720.
CleanEx	HS_ATP2B3.
Genevestigator	Q16720.
GermOnline	ENSG00000067842. Homo sapiens.
Family and domain databases
InterPro	IPR022141. ATP_Ca_trans_C. IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
KO	K05850.
Pfam	PF12424. ATP_Ca_trans_C. 1 hit. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	2065.
SOURCE	Search...

Entry information

Entry name

AT2B3_HUMAN

Accession

Primary (citable) accession number: Q16720
Secondary accession number(s): B7WNR8 , B7WNY5, Q12995, Q16858

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 118 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.