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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Gene

NDUFA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: Reactome
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Alternative name(s):
Complex I subunit B13
Complex I-13kD-B
Short name:
CI-13kD-B
NADH-ubiquinone oxidoreductase 13 kDa-B subunit
Gene namesi
Name:NDUFA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128609.14
HGNCiHGNC:7688 NDUFA5
MIMi601677 gene
neXtProtiNX_Q16718

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4698
MalaCardsiNDUFA5
OpenTargetsiENSG00000128609
PharmGKBiPA31494

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

DMDMi2499316

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001186322 – 116NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei30N6-acetyllysineCombined sources1
Modified residuei46N6-acetyllysineBy similarity1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei98N6-acetyllysine; alternateBy similarity1
Modified residuei98N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ16718
MaxQBiQ16718
PaxDbiQ16718
PeptideAtlasiQ16718
PRIDEiQ16718
TopDownProteomicsiQ16718-1 [Q16718-1]

PTM databases

CarbonylDBiQ16718
iPTMnetiQ16718
PhosphoSitePlusiQ16718
SwissPalmiQ16718

Expressioni

Tissue specificityi

Expressed in all tissues examined with highest levels in heart, skeletal muscle and brain.1 Publication

Gene expression databases

BgeeiENSG00000128609
CleanExiHS_NDUFA5
ExpressionAtlasiQ16718 baseline and differential
GenevisibleiQ16718 HS

Organism-specific databases

HPAiHPA043175

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NDUFS3O754893EBI-746417,EBI-1224896

Protein-protein interaction databases

BioGridi110778, 45 interactors
CORUMiQ16718
IntActiQ16718, 32 interactors
MINTiQ16718
STRINGi9606.ENSP00000347988

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Helixi20 – 35Combined sources16
Helixi43 – 61Combined sources19
Helixi65 – 71Combined sources7
Turni77 – 79Combined sources3
Helixi80 – 94Combined sources15
Helixi95 – 97Combined sources3
Turni109 – 112Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTBelectron microscopy3.40H5-116[»]
5XTDelectron microscopy3.70H5-116[»]
5XTHelectron microscopy3.90H5-116[»]
5XTIelectron microscopy17.40BH/H5-116[»]
ProteinModelPortaliQ16718
SMRiQ16718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3365 Eukaryota
ENOG4111V89 LUCA
GeneTreeiENSGT00390000008099
HOGENOMiHOG000240009
HOVERGENiHBG001142
InParanoidiQ16718
KOiK03949
OMAiEWKAWEP
OrthoDBiEOG091G0WPV
PhylomeDBiQ16718
TreeFamiTF313785

Family and domain databases

InterProiView protein in InterPro
IPR006806 ETC_CI_29_9
PfamiView protein in Pfam
PF04716 ETC_C1_NDUFA5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16718-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVLKKTTG LVGLAVCNTP HERLRILYTK ILDVLEEIPK NAAYRKYTEQ
60 70 80 90 100
ITNEKLAMVK AEPDVKKLED QLQGGQLEEV ILQAEHELNL ARKMREWKLW
110
EPLVEEPPAD QWKWPI
Length:116
Mass (Da):13,459
Last modified:January 23, 2007 - v3
Checksum:i652339C1127E6F22
GO
Isoform 2 (identifier: Q16718-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MAGVLKK → MPYRVGQ

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,563
Checksum:iBD8CF570C1ED77EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52T → I in AAH70236 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551641 – 7MAGVLKK → MPYRVGQ in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53468 mRNA Translation: AAB02224.1
U64028 mRNA Translation: AAB37259.1
AF044418
, AF044415, AF044416, AF044417 Genomic DNA Translation: AAD21526.1
BT006695 mRNA Translation: AAP35341.1
AK315458 mRNA Translation: BAG37845.1
CR933664 mRNA Translation: CAI45962.1
AC073323 Genomic DNA Translation: AAQ96854.1
CH471070 Genomic DNA Translation: EAW83588.1
BC000813 mRNA Translation: AAH00813.1
BC020821 mRNA Translation: AAH20821.1
BC070236 mRNA Translation: AAH70236.1
BC070237 mRNA Translation: AAH70237.1
CCDSiCCDS5788.1 [Q16718-1]
CCDS64760.1 [Q16718-2]
PIRiG02526
RefSeqiNP_001269348.1, NM_001282419.2
NP_001269349.1, NM_001282420.2 [Q16718-2]
NP_001269350.1, NM_001282421.2
NP_001269351.1, NM_001282422.2
NP_004991.1, NM_005000.4 [Q16718-1]
UniGeneiHs.651219

Genome annotation databases

EnsembliENST00000355749; ENSP00000347988; ENSG00000128609 [Q16718-1]
ENST00000471770; ENSP00000417142; ENSG00000128609 [Q16718-2]
GeneIDi4698
KEGGihsa:4698
UCSCiuc003vks.4 human [Q16718-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNDUA5_HUMAN
AccessioniPrimary (citable) accession number: Q16718
Secondary accession number(s): B2RD98, Q5H9R2, Q6IRX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health