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Q16716

- Q16716_HUMAN

UniProt

Q16716 - Q16716_HUMAN

Protein

Pyruvate kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. potassium ion binding Source: InterPro
    3. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, PyruvateImported

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Proteomic databases

    PRIDEiQ16716.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16716.
    BgeeiQ16716.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16716.
    SMRiQ16716. Positions 49-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000941.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16716-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLTTQQCGA DPQRGRPREV CSGMEGPAGY LRRASVAQLT QELGTAFFQQ    50
    QQLPAAMADT FLEHLCLLDI DSEPVAARST SIIATIGPAS RSVERLKEMI 100
    KAGMNIARLN FSHGSHEYHA ESIANVREAV ESFAGSPLSY RPVAIALDTK 150
    GPEIRTGILQ GGPESEVELV KGSQVLVTVD PAFRTRGNAN TVWVDYPNIV 200
    RVVPVGGRIY IDDGLISLVV QKIGPEGLVT QVENGGVLGS RKGVNLPGAQ 250
    VDLPGLSEQD VRDLRFGVEH GVDIVFASFV RKASDVAAVR AALGPEGHGI 300
    KIISKIENHE GVKRFDEILE VSDGIMVARG DLGIEIPAEK VFLAQKMMIG 350
    RCNLAGKPVV CATQMLESMI TKPRPTRAET SDVANAVLDG ADCIMLSGET 400
    AKGNFPVEAV KMQHAIAREA EAAVYHRQLF EELRRAAPLS RDPTEVTAIG 450
    AVEAAFKCCA AAIIVLTTTG RSAQLLSRYR PRAAVIAVTR SAQAARQVHL 500
    CRGVFPLLYR EPPEAIWADD VDRRVQFGIE SGKLRGFLRV GDLVIVVTGW 550
    RPGSGYTNIM RVLSIS 566
    Length:566
    Mass (Da):60,964
    Last modified:November 1, 1996 - v1
    Checksum:i91852BC0DD24559E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47654 Genomic DNA. Translation: AAA92536.1.
    UniGeneiHs.95990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47654 Genomic DNA. Translation: AAA92536.1 .
    UniGenei Hs.95990.

    3D structure databases

    ProteinModelPortali Q16716.
    SMRi Q16716. Positions 49-565.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q16716.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000941.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Gene expression databases

    ArrayExpressi Q16716.
    Bgeei Q16716.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of the human PK-L/R-gene includes four intragenic polymorphisms defining different haplotype backgrounds of normal and mutant PK-genes."
      Lenzner C., Nurnberg P., Jacobasch G., Thiele B.J.
      DNA Seq. 8:45-53(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ16716_HUMAN
    AccessioniPrimary (citable) accession number: Q16716
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.