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Q16716

- Q16716_HUMAN

UniProt

Q16716 - Q16716_HUMAN

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Protein

Pyruvate kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. potassium ion binding Source: InterPro
  3. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ16716.

Expressioni

Gene expression databases

ArrayExpressiQ16716.
BgeeiQ16716.

Structurei

3D structure databases

ProteinModelPortaliQ16716.
SMRiQ16716. Positions 49-565.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000941.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16716-1 [UniParc]FASTAAdd to Basket

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MPLTTQQCGA DPQRGRPREV CSGMEGPAGY LRRASVAQLT QELGTAFFQQ    50
QQLPAAMADT FLEHLCLLDI DSEPVAARST SIIATIGPAS RSVERLKEMI 100
KAGMNIARLN FSHGSHEYHA ESIANVREAV ESFAGSPLSY RPVAIALDTK 150
GPEIRTGILQ GGPESEVELV KGSQVLVTVD PAFRTRGNAN TVWVDYPNIV 200
RVVPVGGRIY IDDGLISLVV QKIGPEGLVT QVENGGVLGS RKGVNLPGAQ 250
VDLPGLSEQD VRDLRFGVEH GVDIVFASFV RKASDVAAVR AALGPEGHGI 300
KIISKIENHE GVKRFDEILE VSDGIMVARG DLGIEIPAEK VFLAQKMMIG 350
RCNLAGKPVV CATQMLESMI TKPRPTRAET SDVANAVLDG ADCIMLSGET 400
AKGNFPVEAV KMQHAIAREA EAAVYHRQLF EELRRAAPLS RDPTEVTAIG 450
AVEAAFKCCA AAIIVLTTTG RSAQLLSRYR PRAAVIAVTR SAQAARQVHL 500
CRGVFPLLYR EPPEAIWADD VDRRVQFGIE SGKLRGFLRV GDLVIVVTGW 550
RPGSGYTNIM RVLSIS 566
Length:566
Mass (Da):60,964
Last modified:November 1, 1996 - v1
Checksum:i91852BC0DD24559E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47654 Genomic DNA. Translation: AAA92536.1.
UniGeneiHs.95990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47654 Genomic DNA. Translation: AAA92536.1 .
UniGenei Hs.95990.

3D structure databases

ProteinModelPortali Q16716.
SMRi Q16716. Positions 49-565.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q16716.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000941.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Gene expression databases

ArrayExpressi Q16716.
Bgeei Q16716.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genomic sequence of the human PK-L/R-gene includes four intragenic polymorphisms defining different haplotype backgrounds of normal and mutant PK-genes."
    Lenzner C., Nurnberg P., Jacobasch G., Thiele B.J.
    DNA Seq. 8:45-53(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ16716_HUMAN
AccessioniPrimary (citable) accession number: Q16716
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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