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Q16716 (Q16716_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504

Sequence similarities

Belongs to the pyruvate kinase family. RuleBase RU000504

Sequences

Sequence LengthMass (Da)Tools
Q16716 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 91852BC0DD24559E

FASTA56660,964
        10         20         30         40         50         60 
MPLTTQQCGA DPQRGRPREV CSGMEGPAGY LRRASVAQLT QELGTAFFQQ QQLPAAMADT 

        70         80         90        100        110        120 
FLEHLCLLDI DSEPVAARST SIIATIGPAS RSVERLKEMI KAGMNIARLN FSHGSHEYHA 

       130        140        150        160        170        180 
ESIANVREAV ESFAGSPLSY RPVAIALDTK GPEIRTGILQ GGPESEVELV KGSQVLVTVD 

       190        200        210        220        230        240 
PAFRTRGNAN TVWVDYPNIV RVVPVGGRIY IDDGLISLVV QKIGPEGLVT QVENGGVLGS 

       250        260        270        280        290        300 
RKGVNLPGAQ VDLPGLSEQD VRDLRFGVEH GVDIVFASFV RKASDVAAVR AALGPEGHGI 

       310        320        330        340        350        360 
KIISKIENHE GVKRFDEILE VSDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNLAGKPVV 

       370        380        390        400        410        420 
CATQMLESMI TKPRPTRAET SDVANAVLDG ADCIMLSGET AKGNFPVEAV KMQHAIAREA 

       430        440        450        460        470        480 
EAAVYHRQLF EELRRAAPLS RDPTEVTAIG AVEAAFKCCA AAIIVLTTTG RSAQLLSRYR 

       490        500        510        520        530        540 
PRAAVIAVTR SAQAARQVHL CRGVFPLLYR EPPEAIWADD VDRRVQFGIE SGKLRGFLRV 

       550        560 
GDLVIVVTGW RPGSGYTNIM RVLSIS 

« Hide

References

[1]"Complete genomic sequence of the human PK-L/R-gene includes four intragenic polymorphisms defining different haplotype backgrounds of normal and mutant PK-genes."
Lenzner C., Nurnberg P., Jacobasch G., Thiele B.J.
DNA Seq. 8:45-53(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U47654 Genomic DNA. Translation: AAA92536.1.
UniGeneHs.95990.

3D structure databases

ProteinModelPortalQ16716.
SMRQ16716. Positions 49-565.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ16716.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000941.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Gene expression databases

ArrayExpressQ16716.
BgeeQ16716.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ16716_HUMAN
AccessionPrimary (citable) accession number: Q16716
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.