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Protein

Pyruvate kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS)
  2. Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase (HEL-S-68p), Phosphoglycerate kinase (HEL-S-272), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase
  3. no protein annotated in this organism
  4. Alpha-enolase (ENO1), Beta-enolase (ENO3), Enolase 4 (ENO4), Gamma-enolase (ENO2)
  5. Pyruvate kinase, Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase, Pyruvate kinase (PKM), Pyruvate kinase, Pyruvate kinase PKLR (PKLR), Pyruvate kinase, Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (HEL-S-30), Pyruvate kinase (PKM2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ16716.
PeptideAtlasiQ16716.
PRIDEiQ16716.

Structurei

3D structure databases

ProteinModelPortaliQ16716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 429PKInterPro annotationAdd BLAST352
Domaini446 – 563PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
HOVERGENiHBG000941.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTTQQCGA DPQRGRPREV CSGMEGPAGY LRRASVAQLT QELGTAFFQQ
60 70 80 90 100
QQLPAAMADT FLEHLCLLDI DSEPVAARST SIIATIGPAS RSVERLKEMI
110 120 130 140 150
KAGMNIARLN FSHGSHEYHA ESIANVREAV ESFAGSPLSY RPVAIALDTK
160 170 180 190 200
GPEIRTGILQ GGPESEVELV KGSQVLVTVD PAFRTRGNAN TVWVDYPNIV
210 220 230 240 250
RVVPVGGRIY IDDGLISLVV QKIGPEGLVT QVENGGVLGS RKGVNLPGAQ
260 270 280 290 300
VDLPGLSEQD VRDLRFGVEH GVDIVFASFV RKASDVAAVR AALGPEGHGI
310 320 330 340 350
KIISKIENHE GVKRFDEILE VSDGIMVARG DLGIEIPAEK VFLAQKMMIG
360 370 380 390 400
RCNLAGKPVV CATQMLESMI TKPRPTRAET SDVANAVLDG ADCIMLSGET
410 420 430 440 450
AKGNFPVEAV KMQHAIAREA EAAVYHRQLF EELRRAAPLS RDPTEVTAIG
460 470 480 490 500
AVEAAFKCCA AAIIVLTTTG RSAQLLSRYR PRAAVIAVTR SAQAARQVHL
510 520 530 540 550
CRGVFPLLYR EPPEAIWADD VDRRVQFGIE SGKLRGFLRV GDLVIVVTGW
560
RPGSGYTNIM RVLSIS
Length:566
Mass (Da):60,964
Last modified:November 1, 1996 - v1
Checksum:i91852BC0DD24559E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47654 Genomic DNA. Translation: AAA92536.1.
UniGeneiHs.95990.

Similar proteinsi

Entry informationi

Entry nameiQ16716_HUMAN
AccessioniPrimary (citable) accession number: Q16716
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.