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Q16676

- FOXD1_HUMAN

UniProt

Q16676 - FOXD1_HUMAN

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Protein

Forkhead box protein D1

Gene

FOXD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 21592Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: UniProtKB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding Source: UniProtKB
  6. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
  3. metanephric capsule development Source: UniProtKB
  4. metanephric capsule specification Source: UniProtKB
  5. metanephric nephron development Source: Ensembl
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. nephrogenic mesenchyme development Source: Ensembl
  8. positive regulation of BMP signaling pathway Source: UniProtKB
  9. positive regulation of gene expression Source: UniProtKB
  10. positive regulation of kidney development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ16676.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D1
Alternative name(s):
Forkhead-related protein FKHL8
Forkhead-related transcription factor 4
Short name:
FREAC-4
Gene namesi
Name:FOXD1
Synonyms:FKHL8, FREAC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3802. FOXD1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Forkhead box protein D1PRO_0000091811Add
BLAST

Proteomic databases

PaxDbiQ16676.
PeptideAtlasiQ16676.
PRIDEiQ16676.

PTM databases

PhosphoSiteiQ16676.

Expressioni

Gene expression databases

CleanExiHS_FOXD1.
GenevestigatoriQ16676.

Structurei

3D structure databases

ProteinModelPortaliQ16676.
SMRiQ16676. Positions 124-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 349Poly-Glu
Compositional biasi39 – 435Poly-Gly
Compositional biasi52 – 576Poly-Arg
Compositional biasi69 – 724Poly-Glu
Compositional biasi73 – 764Poly-Asp
Compositional biasi97 – 11317Poly-GlyAdd
BLAST
Compositional biasi231 – 2344Poly-Ala
Compositional biasi252 – 2565Poly-Ala
Compositional biasi259 – 2668Poly-Pro
Compositional biasi293 – 30311Poly-AlaAdd
BLAST
Compositional biasi309 – 3157Poly-Pro
Compositional biasi375 – 39016Poly-AlaAdd
BLAST
Compositional biasi428 – 4347Poly-Ala

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOVERGENiHBG051641.
InParanoidiQ16676.
KOiK09397.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16676-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA
60 70 80 90 100
QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA
110 120 130 140 150
GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE
160 170 180 190 200
ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT
210 220 230 240 250
LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD
260 270 280 290 300
PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA
310 320 330 340 350
AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG
360 370 380 390 400
GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP
410 420 430 440 450
PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT
460
ALSSVENFTA RISNC
Length:465
Mass (Da):46,140
Last modified:November 1, 1997 - v1
Checksum:iD3E7854909CCBFAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59831 Genomic DNA. Translation: AAC50660.1.
U59832 mRNA. Translation: AAC50661.1.
U13222 mRNA. Translation: AAA92039.1.
CCDSiCCDS75259.1.
PIRiG02738.
S51627.
RefSeqiNP_004463.1. NM_004472.2.
UniGeneiHs.519385.

Genome annotation databases

EnsembliENST00000615637; ENSP00000481581; ENSG00000251493.
GeneIDi2297.
KEGGihsa:2297.
UCSCiuc003kcp.3. human.

Polymorphism databases

DMDMi2494490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59831 Genomic DNA. Translation: AAC50660.1 .
U59832 mRNA. Translation: AAC50661.1 .
U13222 mRNA. Translation: AAA92039.1 .
CCDSi CCDS75259.1.
PIRi G02738.
S51627.
RefSeqi NP_004463.1. NM_004472.2.
UniGenei Hs.519385.

3D structure databases

ProteinModelPortali Q16676.
SMRi Q16676. Positions 124-220.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q16676.

Polymorphism databases

DMDMi 2494490.

Proteomic databases

PaxDbi Q16676.
PeptideAtlasi Q16676.
PRIDEi Q16676.

Protocols and materials databases

DNASUi 2297.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000615637 ; ENSP00000481581 ; ENSG00000251493 .
GeneIDi 2297.
KEGGi hsa:2297.
UCSCi uc003kcp.3. human.

Organism-specific databases

CTDi 2297.
GeneCardsi GC05M072743.
HGNCi HGNC:3802. FOXD1.
MIMi 601091. gene.
neXtProti NX_Q16676.
PharmGKBi PA28219.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOVERGENi HBG051641.
InParanoidi Q16676.
KOi K09397.

Enzyme and pathway databases

SignaLinki Q16676.

Miscellaneous databases

ChiTaRSi FOXD1. human.
GenomeRNAii 2297.
NextBioi 9323.
PROi Q16676.
SOURCEi Search...

Gene expression databases

CleanExi HS_FOXD1.
Genevestigatori Q16676.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53."
    Ernstsson S., Pierrou S., Hulander M., Cederberg A., Hellqvist M., Carlsson P., Enerbaeck S.
    J. Biol. Chem. 271:21094-21099(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
    Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
    EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-225.

Entry informationi

Entry nameiFOXD1_HUMAN
AccessioniPrimary (citable) accession number: Q16676
Secondary accession number(s): Q12949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3