Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q16676 (FOXD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein D1
Alternative name(s):
Forkhead-related protein FKHL8
Forkhead-related transcription factor 4
Short name=FREAC-4
Gene names
Name:FOXD1
Synonyms:FKHL8, FREAC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdichotomous subdivision of terminal units involved in ureteric bud branching

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric capsule development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric capsule specification

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of BMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred by curator Ref.2. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay Ref.2. Source: MGI

DNA binding, bending

Inferred from direct assay Ref.2. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay Ref.2. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Forkhead box protein D1
PRO_0000091811

Regions

DNA binding124 – 21592Fork-head
Compositional bias26 – 349Poly-Glu
Compositional bias39 – 435Poly-Gly
Compositional bias52 – 576Poly-Arg
Compositional bias69 – 724Poly-Glu
Compositional bias73 – 764Poly-Asp
Compositional bias97 – 11317Poly-Gly
Compositional bias231 – 2344Poly-Ala
Compositional bias252 – 2565Poly-Ala
Compositional bias259 – 2668Poly-Pro
Compositional bias293 – 30311Poly-Ala
Compositional bias309 – 3157Poly-Pro
Compositional bias375 – 39016Poly-Ala
Compositional bias428 – 4347Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q16676 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: D3E7854909CCBFAE

FASTA46546,140
        10         20         30         40         50         60 
MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA 

        70         80         90        100        110        120 
GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK 

       130        140        150        160        170        180 
NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN 

       190        200        210        220        230        240 
DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR 

       250        260        270        280        290        300 
GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA 

       310        320        330        340        350        360 
AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS 

       370        380        390        400        410        420 
PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA 

       430        440        450        460 
ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC 

« Hide

References

[1]"Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53."
Ernstsson S., Pierrou S., Hulander M., Cederberg A., Hellqvist M., Carlsson P., Enerbaeck S.
J. Biol. Chem. 271:21094-21099(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-225.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59831 Genomic DNA. Translation: AAC50660.1.
U59832 mRNA. Translation: AAC50661.1.
U13222 mRNA. Translation: AAA92039.1.
PIRG02738.
S51627.
RefSeqNP_004463.1. NM_004472.2.
UniGeneHs.519385.

3D structure databases

ProteinModelPortalQ16676.
SMRQ16676. Positions 124-220.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ16676.

Polymorphism databases

DMDM2494490.

Proteomic databases

PaxDbQ16676.
PeptideAtlasQ16676.
PRIDEQ16676.

Protocols and materials databases

DNASU2297.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2297.
KEGGhsa:2297.
UCSCuc003kcp.3. human.

Organism-specific databases

CTD2297.
GeneCardsGC05M072743.
HGNCHGNC:3802. FOXD1.
MIM601091. gene.
neXtProtNX_Q16676.
PharmGKBPA28219.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOVERGENHBG051641.
KOK09397.

Enzyme and pathway databases

SignaLinkQ16676.

Gene expression databases

CleanExHS_FOXD1.
GenevestigatorQ16676.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXD1. human.
GenomeRNAi2297.
NextBio9323.
PROQ16676.
SOURCESearch...

Entry information

Entry nameFOXD1_HUMAN
AccessionPrimary (citable) accession number: Q16676
Secondary accession number(s): Q12949
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM