Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q16676

- FOXD1_HUMAN

UniProt

Q16676 - FOXD1_HUMAN

Protein

Forkhead box protein D1

Gene

FOXD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi124 – 21592Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. DNA binding, bending Source: UniProtKB
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
    2. metanephric capsule development Source: UniProtKB
    3. metanephric capsule specification Source: UniProtKB
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of BMP signaling pathway Source: UniProtKB
    6. positive regulation of gene expression Source: UniProtKB
    7. positive regulation of kidney development Source: UniProtKB
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ16676.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein D1
    Alternative name(s):
    Forkhead-related protein FKHL8
    Forkhead-related transcription factor 4
    Short name:
    FREAC-4
    Gene namesi
    Name:FOXD1
    Synonyms:FKHL8, FREAC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:3802. FOXD1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28219.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Forkhead box protein D1PRO_0000091811Add
    BLAST

    Proteomic databases

    PaxDbiQ16676.
    PeptideAtlasiQ16676.
    PRIDEiQ16676.

    PTM databases

    PhosphoSiteiQ16676.

    Expressioni

    Gene expression databases

    CleanExiHS_FOXD1.
    GenevestigatoriQ16676.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16676.
    SMRiQ16676. Positions 124-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi26 – 349Poly-Glu
    Compositional biasi39 – 435Poly-Gly
    Compositional biasi52 – 576Poly-Arg
    Compositional biasi69 – 724Poly-Glu
    Compositional biasi73 – 764Poly-Asp
    Compositional biasi97 – 11317Poly-GlyAdd
    BLAST
    Compositional biasi231 – 2344Poly-Ala
    Compositional biasi252 – 2565Poly-Ala
    Compositional biasi259 – 2668Poly-Pro
    Compositional biasi293 – 30311Poly-AlaAdd
    BLAST
    Compositional biasi309 – 3157Poly-Pro
    Compositional biasi375 – 39016Poly-AlaAdd
    BLAST
    Compositional biasi428 – 4347Poly-Ala

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOVERGENiHBG051641.
    KOiK09397.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA    50
    QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA 100
    GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE 150
    ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT 200
    LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD 250
    PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA 300
    AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG 350
    GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP 400
    PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT 450
    ALSSVENFTA RISNC 465
    Length:465
    Mass (Da):46,140
    Last modified:November 1, 1997 - v1
    Checksum:iD3E7854909CCBFAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59831 Genomic DNA. Translation: AAC50660.1.
    U59832 mRNA. Translation: AAC50661.1.
    U13222 mRNA. Translation: AAA92039.1.
    PIRiG02738.
    S51627.
    RefSeqiNP_004463.1. NM_004472.2.
    UniGeneiHs.519385.

    Genome annotation databases

    GeneIDi2297.
    KEGGihsa:2297.
    UCSCiuc003kcp.3. human.

    Polymorphism databases

    DMDMi2494490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59831 Genomic DNA. Translation: AAC50660.1 .
    U59832 mRNA. Translation: AAC50661.1 .
    U13222 mRNA. Translation: AAA92039.1 .
    PIRi G02738.
    S51627.
    RefSeqi NP_004463.1. NM_004472.2.
    UniGenei Hs.519385.

    3D structure databases

    ProteinModelPortali Q16676.
    SMRi Q16676. Positions 124-220.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q16676.

    Polymorphism databases

    DMDMi 2494490.

    Proteomic databases

    PaxDbi Q16676.
    PeptideAtlasi Q16676.
    PRIDEi Q16676.

    Protocols and materials databases

    DNASUi 2297.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2297.
    KEGGi hsa:2297.
    UCSCi uc003kcp.3. human.

    Organism-specific databases

    CTDi 2297.
    GeneCardsi GC05M072743.
    HGNCi HGNC:3802. FOXD1.
    MIMi 601091. gene.
    neXtProti NX_Q16676.
    PharmGKBi PA28219.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOVERGENi HBG051641.
    KOi K09397.

    Enzyme and pathway databases

    SignaLinki Q16676.

    Miscellaneous databases

    ChiTaRSi FOXD1. human.
    GenomeRNAii 2297.
    NextBioi 9323.
    PROi Q16676.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_FOXD1.
    Genevestigatori Q16676.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53."
      Ernstsson S., Pierrou S., Hulander M., Cederberg A., Hellqvist M., Carlsson P., Enerbaeck S.
      J. Biol. Chem. 271:21094-21099(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
      Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
      EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-225.

    Entry informationi

    Entry nameiFOXD1_HUMAN
    AccessioniPrimary (citable) accession number: Q16676
    Secondary accession number(s): Q12949
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3