Q16676 (FOXD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein D1

Alternative name(s):
Forkhead-related protein FKHL8
Forkhead-related transcription factor 4
Short name=FREAC-4

Gene names

Name:	FOXD1
Synonyms:	FKHL8, FREAC4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity.
Subcellular location	Nucleus.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension involved in axon guidance Inferred from Biological aspect of Ancestor. Source: RefGenome cartilage development Inferred from Biological aspect of Ancestor. Source: RefGenome dichotomous subdivision of terminal units involved in ureteric bud branching Inferred from sequence or structural similarity. Source: UniProtKB embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome enteric nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome iridophore differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome lateral line nerve glial cell development Inferred from Biological aspect of Ancestor. Source: RefGenome melanocyte differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome metanephric capsule specification Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell migration Inferred from Biological aspect of Ancestor. Source: RefGenome peripheral nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of kidney development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome sympathetic nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from direct assay Ref.2. Source: UniProtKB RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from direct assay Ref.2. Source: UniProtKB transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Forkhead box protein D1		PRO_0000091811
Regions
	DNA binding	124 – 215	92	Fork-head
	Compositional bias	26 – 34	9	Poly-Glu
	Compositional bias	39 – 43	5	Poly-Gly
	Compositional bias	52 – 57	6	Poly-Arg
	Compositional bias	69 – 72	4	Poly-Glu
	Compositional bias	73 – 76	4	Poly-Asp
	Compositional bias	97 – 113	17	Poly-Gly
	Compositional bias	231 – 234	4	Poly-Ala
	Compositional bias	252 – 256	5	Poly-Ala
	Compositional bias	259 – 266	8	Poly-Pro
	Compositional bias	293 – 303	11	Poly-Ala
	Compositional bias	309 – 315	7	Poly-Pro
	Compositional bias	375 – 390	16	Poly-Ala
	Compositional bias	428 – 434	7	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q16676 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: D3E7854909CCBFAE	FASTA	465	46,140
	10 20 30 40 50 60 MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA 70 80 90 100 110 120 GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK 130 140 150 160 170 180 NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN 190 200 210 220 230 240 DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR 250 260 270 280 290 300 GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA 310 320 330 340 350 360 AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS 370 380 390 400 410 420 PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA 430 440 450 460 ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC

References

[1]	"Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53." Ernstsson S., Pierrou S., Hulander M., Cederberg A., Hellqvist M., Carlsson P., Enerbaeck S. J. Biol. Chem. 271:21094-21099(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending." Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P. EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-225.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59831 Genomic DNA. Translation: AAC50660.1. U59832 mRNA. Translation: AAC50661.1. U13222 mRNA. Translation: AAA92039.1.
IPI	IPI00003449.
PIR	G02738. S51627.
RefSeq	NP_004463.1. NM_004472.2.
UniGene	Hs.519385.
3D structure databases
ProteinModelPortal	Q16676.
ModBase	Search...
PTM databases
PhosphoSite	Q16676.
Polymorphism databases
DMDM	2494490.
Proteomic databases
PaxDb	Q16676.
PeptideAtlas	Q16676.
PRIDE	Q16676.
Protocols and materials databases
DNASU	2297.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2297.
KEGG	hsa:2297.
UCSC	uc003kcp.3. human.
Organism-specific databases
CTD	2297.
GeneCards	GC05M072743.
HGNC	HGNC:3802. FOXD1.
MIM	601091. gene.
neXtProt	NX_Q16676.
PharmGKB	PA28219.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOVERGEN	HBG051641.
KO	K09397.
Gene expression databases
CleanEx	HS_FOXD1.
Genevestigator	Q16676.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXD1. human.
GenomeRNAi	2297.
NextBio	9323.
SOURCE	Search...

Entry information

Entry name

FOXD1_HUMAN

Accession

Primary (citable) accession number: Q16676
Secondary accession number(s): Q12949

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.