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Protein

Melanoma-derived growth regulatory protein

Gene

MIA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

GO - Biological processi

  • cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-derived growth regulatory protein
Alternative name(s):
Melanoma inhibitory activity protein
Gene namesi
Name:MIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7076. MIA.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8190.
OpenTargetsiENSG00000261857.
PharmGKBiPA30800.

Polymorphism and mutation databases

BioMutaiMIA.
DMDMi2498559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001902825 – 131Melanoma-derived growth regulatory proteinAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 41
Disulfide bondi59 ↔ 130

Post-translational modificationi

May possess two intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16674.
PeptideAtlasiQ16674.
PRIDEiQ16674.

PTM databases

iPTMnetiQ16674.
PhosphoSitePlusiQ16674.

Expressioni

Tissue specificityi

All malignant melanoma cell lines tested and infrequently in glioma cell lines.

Gene expression databases

BgeeiENSG00000261857.
CleanExiHS_MIA.
ExpressionAtlasiQ16674. baseline and differential.
GenevisibleiQ16674. HS.

Organism-specific databases

HPAiHPA042369.

Interactioni

Subunit structurei

Interacts with FASLG. Interacts with TMIGD2.2 Publications

Protein-protein interaction databases

BioGridi113834. 3 interactors.
IntActiQ16674. 1 interactor.
STRINGi9606.ENSP00000263369.

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 38Combined sources7
Beta strandi45 – 52Combined sources8
Beta strandi57 – 61Combined sources5
Beta strandi69 – 76Combined sources8
Helixi78 – 80Combined sources3
Beta strandi83 – 89Combined sources7
Beta strandi101 – 104Combined sources4
Helixi105 – 107Combined sources3
Beta strandi108 – 113Combined sources6
Beta strandi119 – 122Combined sources4
Helixi125 – 128Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HJDNMR-A31-131[»]
1I1JX-ray1.39A/B25-131[»]
1K0XNMR-A25-131[»]
5IXBX-ray1.39A/B25-131[»]
ProteinModelPortaliQ16674.
SMRiQ16674.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 113SH3PROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ16674.
KOiK16655.
OMAiFIPIRQG.
OrthoDBiEOG091G0RVX.
PhylomeDBiQ16674.
TreeFamiTF332724.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA
60 70 80 90 100
LQDYMAPDCR FLTIHRGQVV YVFSKLKGRG RLFWGGSVQG DYYGDLAARL
110 120 130
GYFPSSIVRE DQTLKPGKVD VKTDKWDFYC Q
Length:131
Mass (Da):14,509
Last modified:November 1, 1997 - v1
Checksum:i4D3BB30BD6008BDC
GO
Isoform 2 (identifier: Q16674-2) [UniParc]FASTAAdd to basket
Also known as: MIA-splice

The sequence of this isoform differs from the canonical sequence as follows:
     43-131: HPISMAVALQ...KTDKWDFYCQ → RSGRLLWRSGCSPGLFPQ

Show »
Length:60
Mass (Da):6,361
Checksum:i0DF07A3AE87FD5C5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04445043 – 131HPISM…DFYCQ → RSGRLLWRSGCSPGLFPQ in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75450 mRNA. Translation: CAA53203.1.
X84707 Genomic DNA. Translation: CAA59195.1.
BT007044 mRNA. Translation: AAP35693.1.
CR541648 mRNA. Translation: CAG46449.1.
CH471126 Genomic DNA. Translation: EAW56997.1.
BC005910 mRNA. Translation: AAH05910.1.
CCDSiCCDS12566.1. [Q16674-1]
PIRiI38019.
RefSeqiNP_001189482.1. NM_001202553.1. [Q16674-1]
NP_006524.1. NM_006533.3. [Q16674-1]
UniGeneiHs.646364.

Genome annotation databases

EnsembliENST00000263369; ENSP00000263369; ENSG00000261857. [Q16674-1]
ENST00000594436; ENSP00000470129; ENSG00000261857. [Q16674-1]
ENST00000597784; ENSP00000469499; ENSG00000261857. [Q16674-1]
GeneIDi8190.
KEGGihsa:8190.
UCSCiuc002opb.5. human. [Q16674-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75450 mRNA. Translation: CAA53203.1.
X84707 Genomic DNA. Translation: CAA59195.1.
BT007044 mRNA. Translation: AAP35693.1.
CR541648 mRNA. Translation: CAG46449.1.
CH471126 Genomic DNA. Translation: EAW56997.1.
BC005910 mRNA. Translation: AAH05910.1.
CCDSiCCDS12566.1. [Q16674-1]
PIRiI38019.
RefSeqiNP_001189482.1. NM_001202553.1. [Q16674-1]
NP_006524.1. NM_006533.3. [Q16674-1]
UniGeneiHs.646364.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HJDNMR-A31-131[»]
1I1JX-ray1.39A/B25-131[»]
1K0XNMR-A25-131[»]
5IXBX-ray1.39A/B25-131[»]
ProteinModelPortaliQ16674.
SMRiQ16674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113834. 3 interactors.
IntActiQ16674. 1 interactor.
STRINGi9606.ENSP00000263369.

PTM databases

iPTMnetiQ16674.
PhosphoSitePlusiQ16674.

Polymorphism and mutation databases

BioMutaiMIA.
DMDMi2498559.

Proteomic databases

PaxDbiQ16674.
PeptideAtlasiQ16674.
PRIDEiQ16674.

Protocols and materials databases

DNASUi8190.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263369; ENSP00000263369; ENSG00000261857. [Q16674-1]
ENST00000594436; ENSP00000470129; ENSG00000261857. [Q16674-1]
ENST00000597784; ENSP00000469499; ENSG00000261857. [Q16674-1]
GeneIDi8190.
KEGGihsa:8190.
UCSCiuc002opb.5. human. [Q16674-1]

Organism-specific databases

CTDi8190.
DisGeNETi8190.
GeneCardsiMIA.
HGNCiHGNC:7076. MIA.
HPAiHPA042369.
MIMi601340. gene.
neXtProtiNX_Q16674.
OpenTargetsiENSG00000261857.
PharmGKBiPA30800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ16674.
KOiK16655.
OMAiFIPIRQG.
OrthoDBiEOG091G0RVX.
PhylomeDBiQ16674.
TreeFamiTF332724.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105284-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ16674.
GeneWikiiMelanoma_inhibitory_activity.
GenomeRNAii8190.
PROiQ16674.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000261857.
CleanExiHS_MIA.
ExpressionAtlasiQ16674. baseline and differential.
GenevisibleiQ16674. HS.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIA_HUMAN
AccessioniPrimary (citable) accession number: Q16674
Secondary accession number(s): Q6FHV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.