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Protein

Zinc finger and SCAN domain-containing protein 26

Gene

ZSCAN26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 26
Alternative name(s):
Protein SRE-ZBP
Zinc finger protein 187
Gene namesi
Name:ZSCAN26
Synonyms:ZNF187
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12978. ZSCAN26.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37559.

Polymorphism and mutation databases

BioMutaiZSCAN26.
DMDMi160221312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Zinc finger and SCAN domain-containing protein 26PRO_0000307313Add
BLAST

Proteomic databases

EPDiQ16670.
MaxQBiQ16670.
PeptideAtlasiQ16670.
PRIDEiQ16670.

PTM databases

iPTMnetiQ16670.
PhosphoSiteiQ16670.

Expressioni

Inductioni

By serum stimulation.1 Publication

Gene expression databases

CleanExiHS_ZNF187.
ExpressionAtlasiQ16670. baseline and differential.
GenevisibleiQ16670. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-3920053,EBI-10171416
CCNDBP1O952733EBI-3920053,EBI-748961
FSD2A1L4K13EBI-3920053,EBI-5661036
KRTAP10-4P603723EBI-3920053,EBI-10178153
KRTAP10-5P603703EBI-3920053,EBI-10172150
KRTAP10-7P604093EBI-3920053,EBI-10172290
KRTAP10-9P604113EBI-3920053,EBI-10172052
KRTAP4-12Q9BQ663EBI-3920053,EBI-739863
MTUS2Q5JR593EBI-3920053,EBI-742948
PDE4DIPQ5VU433EBI-3920053,EBI-1105124
TRIM41Q8WV443EBI-3920053,EBI-725997

Protein-protein interaction databases

BioGridi113526. 42 interactions.
IntActiQ16670. 36 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ16670.
SMRiQ16670. Positions 52-133, 198-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13383SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiQ16670.
KOiK09230.
PhylomeDBiQ16670.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALVSAHS LAPLNLKKEG LRVVREDHYS TWEQGFKLQG NSKGLGQEPL
60 70 80 90 100
CKQFRQLRYE ETTGPREALS RLRELCQQWL QPETHTKEQI LELLVLEQFL
110 120 130 140 150
IILPKELQAR VQEHHPESRE DVVVVLEDLQ LDLGETGQQD PDQPKKQKIL
160 170 180 190 200
VEEMAPLKGV QEQQVRHECE VTKPEKEKGE ETRIENGKLI VVTDSCGRVE
210 220 230 240 250
SSGKISEPME AHNEGSNLER HQAKPKEKIE YKCSEREQRF IQHLDLIEHA
260 270 280 290 300
STHTGKKLCE SDVCQSSSLT GHKKVLSREK GHQCHECGKA FQRSSHLVRH
310 320 330 340 350
QKIHLGEKPY QCNECGKVFS QNAGLLEHLR IHTGEKPYLC IHCGKNFRRS
360 370 380 390 400
SHLNRHQRIH SQEEPCECKE CGKTFSQALL LTHHQRIHSH SKSHQCNECG
410 420 430 440 450
KAFSLTSDLI RHHRIHTGEK PFKCNICQKA FRLNSHLAQH VRIHNEEKPY
460 470
QCSECGEAFR QRSGLFQHQR YHHKDKLA
Length:478
Mass (Da):55,254
Last modified:October 23, 2007 - v2
Checksum:i91D1230831FC5C77
GO
Isoform 2 (identifier: Q16670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:325
Mass (Da):37,560
Checksum:i3B7215F1B2D4621E
GO

Sequence cautioni

The sequence CAD97775.1 differs from that shown. Reason: Frameshift at positions 155 and 353. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301E → G in CAI46119 (PubMed:17974005).Curated
Sequence conflicti258 – 2581L → S in CAA77818 (PubMed:1569959).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591Y → C.
Corresponds to variant rs16893892 [ dbSNP | Ensembl ].
VAR_059900
Natural varianti73 – 731R → Q.
Corresponds to variant rs11965538 [ dbSNP | Ensembl ].
VAR_059901
Natural varianti83 – 831E → K.
Corresponds to variant rs11965542 [ dbSNP | Ensembl ].
VAR_059902
Natural varianti220 – 2201R → S.1 Publication
Corresponds to variant rs17851075 [ dbSNP | Ensembl ].
VAR_035405

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153Missing in isoform 2. 2 PublicationsVSP_028702Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537535 mRNA. Translation: CAD97775.1. Frameshift.
AL832741 mRNA. Translation: CAI46119.1.
AL021997 Genomic DNA. No translation available.
BC013951 mRNA. Translation: AAH13951.1.
BC013962 mRNA. Translation: AAH13962.1.
Z11773 mRNA. Translation: CAA77818.1.
CCDSiCCDS78119.1. [Q16670-1]
PIRiA44391.
RefSeqiNP_001018854.2. NM_001023560.3.
NP_001104509.1. NM_001111039.2. [Q16670-1]
NP_001274350.1. NM_001287421.1.
NP_001274351.1. NM_001287422.1.
NP_689949.3. NM_152736.5.
UniGeneiHs.157883.

Genome annotation databases

EnsembliENST00000623276; ENSP00000485228; ENSG00000197062. [Q16670-1]
GeneIDi7741.
KEGGihsa:7741.
UCSCiuc032wpm.2. human. [Q16670-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537535 mRNA. Translation: CAD97775.1. Frameshift.
AL832741 mRNA. Translation: CAI46119.1.
AL021997 Genomic DNA. No translation available.
BC013951 mRNA. Translation: AAH13951.1.
BC013962 mRNA. Translation: AAH13962.1.
Z11773 mRNA. Translation: CAA77818.1.
CCDSiCCDS78119.1. [Q16670-1]
PIRiA44391.
RefSeqiNP_001018854.2. NM_001023560.3.
NP_001104509.1. NM_001111039.2. [Q16670-1]
NP_001274350.1. NM_001287421.1.
NP_001274351.1. NM_001287422.1.
NP_689949.3. NM_152736.5.
UniGeneiHs.157883.

3D structure databases

ProteinModelPortaliQ16670.
SMRiQ16670. Positions 52-133, 198-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113526. 42 interactions.
IntActiQ16670. 36 interactions.

PTM databases

iPTMnetiQ16670.
PhosphoSiteiQ16670.

Polymorphism and mutation databases

BioMutaiZSCAN26.
DMDMi160221312.

Proteomic databases

EPDiQ16670.
MaxQBiQ16670.
PeptideAtlasiQ16670.
PRIDEiQ16670.

Protocols and materials databases

DNASUi7741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623276; ENSP00000485228; ENSG00000197062. [Q16670-1]
GeneIDi7741.
KEGGihsa:7741.
UCSCiuc032wpm.2. human. [Q16670-1]

Organism-specific databases

CTDi7741.
GeneCardsiZSCAN26.
HGNCiHGNC:12978. ZSCAN26.
MIMi616474. gene.
neXtProtiNX_Q16670.
PharmGKBiPA37559.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiQ16670.
KOiK09230.
PhylomeDBiQ16670.

Miscellaneous databases

GenomeRNAii7741.
PROiQ16670.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ZNF187.
ExpressionAtlasiQ16670. baseline and differential.
GenevisibleiQ16670. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-220.
    Tissue: Kidney.
  4. "Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element."
    Attar R.M., Gilman M.Z.
    Mol. Cell. Biol. 12:2432-2443(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-478 (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiZSC26_HUMAN
AccessioniPrimary (citable) accession number: Q16670
Secondary accession number(s): Q5JPG4, Q7Z3Q6, Q96A17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.