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Protein

Zinc finger and SCAN domain-containing protein 26

Gene

ZSCAN26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 26
Alternative name(s):
Protein SRE-ZBP
Zinc finger protein 187
Gene namesi
Name:ZSCAN26
Synonyms:ZNF187
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000197062.11
HGNCiHGNC:12978 ZSCAN26
MIMi616474 gene
neXtProtiNX_Q16670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197062
PharmGKBiPA37559

Polymorphism and mutation databases

BioMutaiZSCAN26
DMDMi160221312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073131 – 478Zinc finger and SCAN domain-containing protein 26Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ16670
PeptideAtlasiQ16670
PRIDEiQ16670

PTM databases

iPTMnetiQ16670
PhosphoSitePlusiQ16670

Expressioni

Inductioni

By serum stimulation.1 Publication

Gene expression databases

BgeeiENSG00000197062
CleanExiHS_ZNF187
ExpressionAtlasiQ16670 baseline and differential
GenevisibleiQ16670 HS

Organism-specific databases

HPAiHPA027521

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113526, 43 interactors
IntActiQ16670, 38 interactors

Structurei

3D structure databases

ProteinModelPortaliQ16670
SMRiQ16670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118881
HOVERGENiHBG018163
InParanoidiQ16670
KOiK09230
PhylomeDBiQ16670

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALVSAHS LAPLNLKKEG LRVVREDHYS TWEQGFKLQG NSKGLGQEPL
60 70 80 90 100
CKQFRQLRYE ETTGPREALS RLRELCQQWL QPETHTKEQI LELLVLEQFL
110 120 130 140 150
IILPKELQAR VQEHHPESRE DVVVVLEDLQ LDLGETGQQD PDQPKKQKIL
160 170 180 190 200
VEEMAPLKGV QEQQVRHECE VTKPEKEKGE ETRIENGKLI VVTDSCGRVE
210 220 230 240 250
SSGKISEPME AHNEGSNLER HQAKPKEKIE YKCSEREQRF IQHLDLIEHA
260 270 280 290 300
STHTGKKLCE SDVCQSSSLT GHKKVLSREK GHQCHECGKA FQRSSHLVRH
310 320 330 340 350
QKIHLGEKPY QCNECGKVFS QNAGLLEHLR IHTGEKPYLC IHCGKNFRRS
360 370 380 390 400
SHLNRHQRIH SQEEPCECKE CGKTFSQALL LTHHQRIHSH SKSHQCNECG
410 420 430 440 450
KAFSLTSDLI RHHRIHTGEK PFKCNICQKA FRLNSHLAQH VRIHNEEKPY
460 470
QCSECGEAFR QRSGLFQHQR YHHKDKLA
Length:478
Mass (Da):55,254
Last modified:October 23, 2007 - v2
Checksum:i91D1230831FC5C77
GO
Isoform 2 (identifier: Q16670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:325
Mass (Da):37,560
Checksum:i3B7215F1B2D4621E
GO

Sequence cautioni

The sequence CAD97775 differs from that shown. Reason: Frameshift at positions 155 and 353.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230E → G in CAI46119 (PubMed:17974005).Curated1
Sequence conflicti258L → S in CAA77818 (PubMed:1569959).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05990059Y → C. Corresponds to variant dbSNP:rs16893892Ensembl.1
Natural variantiVAR_05990173R → Q. Corresponds to variant dbSNP:rs11965538Ensembl.1
Natural variantiVAR_05990283E → K. Corresponds to variant dbSNP:rs11965542Ensembl.1
Natural variantiVAR_035405220R → S1 PublicationCorresponds to variant dbSNP:rs17851075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287021 – 153Missing in isoform 2. 2 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537535 mRNA Translation: CAD97775.1 Frameshift.
AL832741 mRNA Translation: CAI46119.1
AL021997 Genomic DNA No translation available.
BC013951 mRNA Translation: AAH13951.1
BC013962 mRNA Translation: AAH13962.1
Z11773 mRNA Translation: CAA77818.1
CCDSiCCDS78119.1 [Q16670-1]
PIRiA44391
RefSeqiNP_001018854.2, NM_001023560.3
NP_001104509.1, NM_001111039.2 [Q16670-1]
NP_001274350.1, NM_001287421.1
NP_001274351.1, NM_001287422.1
NP_689949.3, NM_152736.5
XP_016866753.1, XM_017011264.1 [Q16670-1]
UniGeneiHs.157883

Genome annotation databases

EnsembliENST00000623276; ENSP00000485228; ENSG00000197062 [Q16670-1]
GeneIDi7741
KEGGihsa:7741
UCSCiuc032wpm.2 human [Q16670-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZSC26_HUMAN
AccessioniPrimary (citable) accession number: Q16670
Secondary accession number(s): Q5JPG4, Q7Z3Q6, Q96A17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health