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Q16667

- CDKN3_HUMAN

UniProt

Q16667 - CDKN3_HUMAN

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Protein

Cyclin-dependent kinase inhibitor 3

Gene

CDKN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: MGI
  2. protein tyrosine/serine/threonine phosphatase activity Source: ProtInc
  3. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. cell cycle arrest Source: MGI
  2. G1/S transition of mitotic cell cycle Source: ProtInc
  3. negative regulation of cell proliferation Source: ProtInc
  4. peptidyl-tyrosine dephosphorylation Source: GOC
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Cyclin-dependent kinase interactor 1
Cyclin-dependent kinase-interacting protein 2
Kinase-associated phosphatase
Gene namesi
Name:CDKN3
Synonyms:CDI1, CIP2, KAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1791. CDKN3.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.1 Publication
Note: The gene represented in this entry may be involved in disease pathogenesis.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311W → R in HCC; patient BX-01. 1 Publication
VAR_013842
Natural varianti78 – 781F → L in HCC; patient T9. 1 Publication
VAR_013843
Natural varianti79 – 791C → Y in HCC; patient BX-01. 1 Publication
VAR_013844
Natural varianti91 – 911N → K in HCC; patient BX-10. 1 Publication
VAR_013845
Natural varianti94 – 941D → V in HCC; patient NT1. 1 Publication
VAR_013846
Natural varianti95 – 951L → F in HCC; patient BX-05. 1 Publication
VAR_013847
Natural varianti108 – 1081I → V in HCC; patient T9. 1 Publication
Corresponds to variant rs144479038 [ dbSNP | Ensembl ].
VAR_013848
Natural varianti187 – 1871N → S in HCC; patient NT4. 1 Publication
VAR_013849
Natural varianti195 – 1951K → I in HCC; patient NT4. 1 Publication
VAR_013850

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi114550. phenotype.
PharmGKBiPA26324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cyclin-dependent kinase inhibitor 3PRO_0000094949Add
BLAST

Proteomic databases

MaxQBiQ16667.
PaxDbiQ16667.
PRIDEiQ16667.

PTM databases

PhosphoSiteiQ16667.

Expressioni

Inductioni

Up-regulated in breast and prostate cancer cells.1 Publication

Gene expression databases

BgeeiQ16667.
ExpressionAtlasiQ16667. baseline and differential.
GenevestigatoriQ16667.

Organism-specific databases

HPAiCAB005285.
HPA039311.

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249413EBI-1031527,EBI-375096

Protein-protein interaction databases

BioGridi107467. 5 interactions.
DIPiDIP-24231N.
DIP-245N.
IntActiQ16667. 4 interactions.
MINTiMINT-204916.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 334Combined sources
Helixi35 – 373Combined sources
Beta strandi42 – 476Combined sources
Helixi60 – 7011Combined sources
Beta strandi74 – 774Combined sources
Helixi81 – 866Combined sources
Helixi92 – 987Combined sources
Beta strandi102 – 1054Combined sources
Helixi116 – 13116Combined sources
Beta strandi136 – 1394Combined sources
Beta strandi141 – 1455Combined sources
Helixi146 – 15813Combined sources
Beta strandi160 – 1623Combined sources
Helixi164 – 17512Combined sources
Helixi183 – 1897Combined sources
Helixi192 – 1976Combined sources
Turni198 – 2003Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FPZX-ray2.00A/B/C/D/E/F1-212[»]
1FQ1X-ray3.00A1-212[»]
ProteinModelPortaliQ16667.
SMRiQ16667. Positions 21-203.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16667.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3434Interaction with CDK2Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00390000004717.
HOVERGENiHBG075798.
InParanoidiQ16667.
KOiK14167.
OMAiTVKQYNF.
OrthoDBiEOG7M0NSV.
PhylomeDBiQ16667.
TreeFamiTF101040.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16667-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG
110 120 130 140 150
IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV
160 170 180 190 200
AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL
210
SSRDSQSRSV SR
Length:212
Mass (Da):23,805
Last modified:November 1, 1996 - v1
Checksum:iD87FAC8E28F6525F
GO
Isoform 2 (identifier: Q16667-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-50: Missing.

Show »
Length:172
Mass (Da):19,359
Checksum:iE1F3AA29AAABE3DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → E in AAC04932. (PubMed:8242750)Curated
Sequence conflicti2 – 21K → E in AAV38258. 1 PublicationCurated
Sequence conflicti10 – 101S → G in AAK06380. (PubMed:10987270)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311W → R in HCC; patient BX-01. 1 Publication
VAR_013842
Natural varianti78 – 781F → L in HCC; patient T9. 1 Publication
VAR_013843
Natural varianti79 – 791C → Y in HCC; patient BX-01. 1 Publication
VAR_013844
Natural varianti91 – 911N → K in HCC; patient BX-10. 1 Publication
VAR_013845
Natural varianti94 – 941D → V in HCC; patient NT1. 1 Publication
VAR_013846
Natural varianti95 – 951L → F in HCC; patient BX-05. 1 Publication
VAR_013847
Natural varianti108 – 1081I → V in HCC; patient T9. 1 Publication
Corresponds to variant rs144479038 [ dbSNP | Ensembl ].
VAR_013848
Natural varianti159 – 1591S → F.
Corresponds to variant rs1803843 [ dbSNP | Ensembl ].
VAR_051769
Natural varianti187 – 1871N → S in HCC; patient NT4. 1 Publication
VAR_013849
Natural varianti195 – 1951K → I in HCC; patient NT4. 1 Publication
VAR_013850

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 5040Missing in isoform 2. 2 PublicationsVSP_036613Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02681 mRNA. Translation: AAC04932.1.
L27711 mRNA. Translation: AAA66496.1.
AF213033 mRNA. Translation: AAK06365.1.
AF213036 mRNA. Translation: AAK06368.1.
AF213038 mRNA. Translation: AAK06370.1.
AF213039 mRNA. Translation: AAK06371.1.
AF213041 mRNA. Translation: AAK06373.1.
AF213042 mRNA. Translation: AAK06374.1.
AF213046 mRNA. Translation: AAK06377.1.
AF213047 mRNA. Translation: AAK06378.1.
AF213049 mRNA. Translation: AAK06380.1.
AF213053 mRNA. Translation: AAK06384.1.
AY257474 mRNA. Translation: AAP13062.1.
L25876 mRNA. Translation: AAA60222.1.
EF560750 mRNA. Translation: ABQ59060.1.
CR407666 mRNA. Translation: CAG28594.1.
BT019451 mRNA. Translation: AAV38258.1.
AY194117 Genomic DNA. Translation: AAN86348.1.
CH471061 Genomic DNA. Translation: EAW80632.1.
CH471061 Genomic DNA. Translation: EAW80634.1.
BC064965 mRNA. Translation: AAH64965.1.
CCDSiCCDS45109.1. [Q16667-2]
CCDS9716.1. [Q16667-1]
PIRiA49436.
RefSeqiNP_001124323.1. NM_001130851.1. [Q16667-2]
NP_005183.2. NM_005192.3. [Q16667-1]
UniGeneiHs.84113.

Genome annotation databases

EnsembliENST00000335183; ENSP00000335357; ENSG00000100526. [Q16667-1]
ENST00000442975; ENSP00000415333; ENSG00000100526. [Q16667-2]
GeneIDi1033.
KEGGihsa:1033.
UCSCiuc001xap.3. human. [Q16667-1]
uc001xar.3. human. [Q16667-2]

Polymorphism databases

DMDMi2499769.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02681 mRNA. Translation: AAC04932.1 .
L27711 mRNA. Translation: AAA66496.1 .
AF213033 mRNA. Translation: AAK06365.1 .
AF213036 mRNA. Translation: AAK06368.1 .
AF213038 mRNA. Translation: AAK06370.1 .
AF213039 mRNA. Translation: AAK06371.1 .
AF213041 mRNA. Translation: AAK06373.1 .
AF213042 mRNA. Translation: AAK06374.1 .
AF213046 mRNA. Translation: AAK06377.1 .
AF213047 mRNA. Translation: AAK06378.1 .
AF213049 mRNA. Translation: AAK06380.1 .
AF213053 mRNA. Translation: AAK06384.1 .
AY257474 mRNA. Translation: AAP13062.1 .
L25876 mRNA. Translation: AAA60222.1 .
EF560750 mRNA. Translation: ABQ59060.1 .
CR407666 mRNA. Translation: CAG28594.1 .
BT019451 mRNA. Translation: AAV38258.1 .
AY194117 Genomic DNA. Translation: AAN86348.1 .
CH471061 Genomic DNA. Translation: EAW80632.1 .
CH471061 Genomic DNA. Translation: EAW80634.1 .
BC064965 mRNA. Translation: AAH64965.1 .
CCDSi CCDS45109.1. [Q16667-2 ]
CCDS9716.1. [Q16667-1 ]
PIRi A49436.
RefSeqi NP_001124323.1. NM_001130851.1. [Q16667-2 ]
NP_005183.2. NM_005192.3. [Q16667-1 ]
UniGenei Hs.84113.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FPZ X-ray 2.00 A/B/C/D/E/F 1-212 [» ]
1FQ1 X-ray 3.00 A 1-212 [» ]
ProteinModelPortali Q16667.
SMRi Q16667. Positions 21-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107467. 5 interactions.
DIPi DIP-24231N.
DIP-245N.
IntActi Q16667. 4 interactions.
MINTi MINT-204916.

PTM databases

PhosphoSitei Q16667.

Polymorphism databases

DMDMi 2499769.

Proteomic databases

MaxQBi Q16667.
PaxDbi Q16667.
PRIDEi Q16667.

Protocols and materials databases

DNASUi 1033.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335183 ; ENSP00000335357 ; ENSG00000100526 . [Q16667-1 ]
ENST00000442975 ; ENSP00000415333 ; ENSG00000100526 . [Q16667-2 ]
GeneIDi 1033.
KEGGi hsa:1033.
UCSCi uc001xap.3. human. [Q16667-1 ]
uc001xar.3. human. [Q16667-2 ]

Organism-specific databases

CTDi 1033.
GeneCardsi GC14P054863.
HGNCi HGNC:1791. CDKN3.
HPAi CAB005285.
HPA039311.
MIMi 114550. phenotype.
123832. gene.
neXtProti NX_Q16667.
PharmGKBi PA26324.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00390000004717.
HOVERGENi HBG075798.
InParanoidi Q16667.
KOi K14167.
OMAi TVKQYNF.
OrthoDBi EOG7M0NSV.
PhylomeDBi Q16667.
TreeFami TF101040.

Miscellaneous databases

ChiTaRSi CDKN3. human.
EvolutionaryTracei Q16667.
GeneWikii CDKN3.
GenomeRNAii 1033.
NextBioi 4349.
PROi Q16667.
SOURCEi Search...

Gene expression databases

Bgeei Q16667.
ExpressionAtlasi Q16667. baseline and differential.
Genevestigatori Q16667.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
Pfami PF05706. CDKN3. 1 hit.
[Graphical view ]
PIRSFi PIRSF037322. CDKN3. 1 hit.
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2."
    Gyuris J., Golemis E., Chertkov H., Brent R.
    Cell 75:791-803(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDK1; CDK2 AND CDK3.
  2. "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases."
    Hannon G.J., Casso D., Beach D.
    Proc. Natl. Acad. Sci. U.S.A. 91:1731-1735(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDK1 AND CDK2.
  3. "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."
    Yeh C.-T., Lu S.-C., Chen T.-C., Peng C.-Y., Liaw Y.-F.
    Cancer Res. 60:4697-4700(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HCC ARG-31; LEU-78; TYR-79; LYS-91; VAL-94; PHE-95; VAL-108; SER-187 AND ILE-195.
  4. "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant."
    Yeh C.-T., Lu S.-C., Chao C.-H., Chao M.-L.
    Biochem. Biophys. Res. Commun. 305:311-314(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CDK2.
  5. Harper W., Elledge S.J.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. Schupp I.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. NIEHS SNPs program
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retinoblastoma.
  12. "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin."
    Poon R.Y.C., Hunter T.
    Science 270:90-93(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression."
    Lee S.W., Reimer C.L., Fang L., Iruela-Arispe M.L., Aaronson S.A.
    Mol. Cell. Biol. 20:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  14. Cited for: INTERACTION WITH MS4A3.
  15. "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2."
    Chinami M., Yano Y., Yang X., Salahuddin S., Moriyama K., Shiroishi M., Turner H., Shirakawa T., Adra C.N.
    J. Biol. Chem. 280:17235-17242(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MS4A3.
  16. "Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2."
    Song H., Hanlon N., Brown N.R., Noble M.E.M., Johnson L.N., Barford D.
    Mol. Cell 7:615-626(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH THR-160 PHOSPHORYLATED CDK2.

Entry informationi

Entry nameiCDKN3_HUMAN
AccessioniPrimary (citable) accession number: Q16667
Secondary accession number(s): Q53ZU6
, Q5U0M4, Q6P1N8, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C046, Q9C047, Q9C049, Q9C051, Q9C053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3