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Q16667

- CDKN3_HUMAN

UniProt

Q16667 - CDKN3_HUMAN

Protein

Cyclin-dependent kinase inhibitor 3

Gene

CDKN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.3 Publications

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein serine/threonine phosphatase activity Source: MGI
    3. protein tyrosine/serine/threonine phosphatase activity Source: ProtInc
    4. protein tyrosine phosphatase activity Source: MGI

    GO - Biological processi

    1. cell cycle arrest Source: MGI
    2. G1/S transition of mitotic cell cycle Source: ProtInc
    3. negative regulation of cell proliferation Source: ProtInc
    4. peptidyl-tyrosine dephosphorylation Source: GOC
    5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    CDK2-associated dual-specificity phosphatase
    Cyclin-dependent kinase interactor 1
    Cyclin-dependent kinase-interacting protein 2
    Kinase-associated phosphatase
    Gene namesi
    Name:CDKN3
    Synonyms:CDI1, CIP2, KAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1791. CDKN3.

    Subcellular locationi

    Cytoplasmperinuclear region 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.1 Publication
    Note: The gene represented in this entry may be involved in disease pathogenesis.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311W → R in HCC; patient BX-01. 1 Publication
    VAR_013842
    Natural varianti78 – 781F → L in HCC; patient T9. 1 Publication
    VAR_013843
    Natural varianti79 – 791C → Y in HCC; patient BX-01. 1 Publication
    VAR_013844
    Natural varianti91 – 911N → K in HCC; patient BX-10. 1 Publication
    VAR_013845
    Natural varianti94 – 941D → V in HCC; patient NT1. 1 Publication
    VAR_013846
    Natural varianti95 – 951L → F in HCC; patient BX-05. 1 Publication
    VAR_013847
    Natural varianti108 – 1081I → V in HCC; patient T9. 1 Publication
    Corresponds to variant rs144479038 [ dbSNP | Ensembl ].
    VAR_013848
    Natural varianti187 – 1871N → S in HCC; patient NT4. 1 Publication
    VAR_013849
    Natural varianti195 – 1951K → I in HCC; patient NT4. 1 Publication
    VAR_013850

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi114550. phenotype.
    PharmGKBiPA26324.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Cyclin-dependent kinase inhibitor 3PRO_0000094949Add
    BLAST

    Proteomic databases

    MaxQBiQ16667.
    PaxDbiQ16667.
    PRIDEiQ16667.

    PTM databases

    PhosphoSiteiQ16667.

    Expressioni

    Inductioni

    Up-regulated in breast and prostate cancer cells.1 Publication

    Gene expression databases

    ArrayExpressiQ16667.
    BgeeiQ16667.
    GenevestigatoriQ16667.

    Organism-specific databases

    HPAiCAB005285.
    HPA039311.

    Interactioni

    Subunit structurei

    Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK2P249413EBI-1031527,EBI-375096

    Protein-protein interaction databases

    BioGridi107467. 5 interactions.
    DIPiDIP-24231N.
    DIP-245N.
    IntActiQ16667. 4 interactions.
    MINTiMINT-204916.

    Structurei

    Secondary structure

    1
    212
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 334
    Helixi35 – 373
    Beta strandi42 – 476
    Helixi60 – 7011
    Beta strandi74 – 774
    Helixi81 – 866
    Helixi92 – 987
    Beta strandi102 – 1054
    Helixi116 – 13116
    Beta strandi136 – 1394
    Beta strandi141 – 1455
    Helixi146 – 15813
    Beta strandi160 – 1623
    Helixi164 – 17512
    Helixi183 – 1897
    Helixi192 – 1976
    Turni198 – 2003

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FPZX-ray2.00A/B/C/D/E/F1-212[»]
    1FQ1X-ray3.00A1-212[»]
    ProteinModelPortaliQ16667.
    SMRiQ16667. Positions 21-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ16667.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3434Interaction with CDK2Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOVERGENiHBG075798.
    InParanoidiQ16667.
    KOiK14167.
    OMAiTVKQYNF.
    OrthoDBiEOG7M0NSV.
    PhylomeDBiQ16667.
    TreeFamiTF101040.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
    PfamiPF05706. CDKN3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037322. CDKN3. 1 hit.
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16667-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG    50
    CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG 100
    IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV 150
    AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL 200
    SSRDSQSRSV SR 212
    Length:212
    Mass (Da):23,805
    Last modified:November 1, 1996 - v1
    Checksum:iD87FAC8E28F6525F
    GO
    Isoform 2 (identifier: Q16667-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         11-50: Missing.

    Show »
    Length:172
    Mass (Da):19,359
    Checksum:iE1F3AA29AAABE3DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21K → E in AAC04932. (PubMed:8242750)Curated
    Sequence conflicti2 – 21K → E in AAV38258. 1 PublicationCurated
    Sequence conflicti10 – 101S → G in AAK06380. (PubMed:10987270)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311W → R in HCC; patient BX-01. 1 Publication
    VAR_013842
    Natural varianti78 – 781F → L in HCC; patient T9. 1 Publication
    VAR_013843
    Natural varianti79 – 791C → Y in HCC; patient BX-01. 1 Publication
    VAR_013844
    Natural varianti91 – 911N → K in HCC; patient BX-10. 1 Publication
    VAR_013845
    Natural varianti94 – 941D → V in HCC; patient NT1. 1 Publication
    VAR_013846
    Natural varianti95 – 951L → F in HCC; patient BX-05. 1 Publication
    VAR_013847
    Natural varianti108 – 1081I → V in HCC; patient T9. 1 Publication
    Corresponds to variant rs144479038 [ dbSNP | Ensembl ].
    VAR_013848
    Natural varianti159 – 1591S → F.
    Corresponds to variant rs1803843 [ dbSNP | Ensembl ].
    VAR_051769
    Natural varianti187 – 1871N → S in HCC; patient NT4. 1 Publication
    VAR_013849
    Natural varianti195 – 1951K → I in HCC; patient NT4. 1 Publication
    VAR_013850

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 5040Missing in isoform 2. 2 PublicationsVSP_036613Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02681 mRNA. Translation: AAC04932.1.
    L27711 mRNA. Translation: AAA66496.1.
    AF213033 mRNA. Translation: AAK06365.1.
    AF213036 mRNA. Translation: AAK06368.1.
    AF213038 mRNA. Translation: AAK06370.1.
    AF213039 mRNA. Translation: AAK06371.1.
    AF213041 mRNA. Translation: AAK06373.1.
    AF213042 mRNA. Translation: AAK06374.1.
    AF213046 mRNA. Translation: AAK06377.1.
    AF213047 mRNA. Translation: AAK06378.1.
    AF213049 mRNA. Translation: AAK06380.1.
    AF213053 mRNA. Translation: AAK06384.1.
    AY257474 mRNA. Translation: AAP13062.1.
    L25876 mRNA. Translation: AAA60222.1.
    EF560750 mRNA. Translation: ABQ59060.1.
    CR407666 mRNA. Translation: CAG28594.1.
    BT019451 mRNA. Translation: AAV38258.1.
    AY194117 Genomic DNA. Translation: AAN86348.1.
    CH471061 Genomic DNA. Translation: EAW80632.1.
    CH471061 Genomic DNA. Translation: EAW80634.1.
    BC064965 mRNA. Translation: AAH64965.1.
    CCDSiCCDS45109.1. [Q16667-2]
    CCDS9716.1. [Q16667-1]
    PIRiA49436.
    RefSeqiNP_001124323.1. NM_001130851.1. [Q16667-2]
    NP_005183.2. NM_005192.3. [Q16667-1]
    UniGeneiHs.84113.

    Genome annotation databases

    EnsembliENST00000335183; ENSP00000335357; ENSG00000100526. [Q16667-1]
    ENST00000442975; ENSP00000415333; ENSG00000100526. [Q16667-2]
    GeneIDi1033.
    KEGGihsa:1033.
    UCSCiuc001xap.3. human. [Q16667-1]
    uc001xar.3. human. [Q16667-2]

    Polymorphism databases

    DMDMi2499769.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02681 mRNA. Translation: AAC04932.1 .
    L27711 mRNA. Translation: AAA66496.1 .
    AF213033 mRNA. Translation: AAK06365.1 .
    AF213036 mRNA. Translation: AAK06368.1 .
    AF213038 mRNA. Translation: AAK06370.1 .
    AF213039 mRNA. Translation: AAK06371.1 .
    AF213041 mRNA. Translation: AAK06373.1 .
    AF213042 mRNA. Translation: AAK06374.1 .
    AF213046 mRNA. Translation: AAK06377.1 .
    AF213047 mRNA. Translation: AAK06378.1 .
    AF213049 mRNA. Translation: AAK06380.1 .
    AF213053 mRNA. Translation: AAK06384.1 .
    AY257474 mRNA. Translation: AAP13062.1 .
    L25876 mRNA. Translation: AAA60222.1 .
    EF560750 mRNA. Translation: ABQ59060.1 .
    CR407666 mRNA. Translation: CAG28594.1 .
    BT019451 mRNA. Translation: AAV38258.1 .
    AY194117 Genomic DNA. Translation: AAN86348.1 .
    CH471061 Genomic DNA. Translation: EAW80632.1 .
    CH471061 Genomic DNA. Translation: EAW80634.1 .
    BC064965 mRNA. Translation: AAH64965.1 .
    CCDSi CCDS45109.1. [Q16667-2 ]
    CCDS9716.1. [Q16667-1 ]
    PIRi A49436.
    RefSeqi NP_001124323.1. NM_001130851.1. [Q16667-2 ]
    NP_005183.2. NM_005192.3. [Q16667-1 ]
    UniGenei Hs.84113.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FPZ X-ray 2.00 A/B/C/D/E/F 1-212 [» ]
    1FQ1 X-ray 3.00 A 1-212 [» ]
    ProteinModelPortali Q16667.
    SMRi Q16667. Positions 21-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107467. 5 interactions.
    DIPi DIP-24231N.
    DIP-245N.
    IntActi Q16667. 4 interactions.
    MINTi MINT-204916.

    PTM databases

    PhosphoSitei Q16667.

    Polymorphism databases

    DMDMi 2499769.

    Proteomic databases

    MaxQBi Q16667.
    PaxDbi Q16667.
    PRIDEi Q16667.

    Protocols and materials databases

    DNASUi 1033.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335183 ; ENSP00000335357 ; ENSG00000100526 . [Q16667-1 ]
    ENST00000442975 ; ENSP00000415333 ; ENSG00000100526 . [Q16667-2 ]
    GeneIDi 1033.
    KEGGi hsa:1033.
    UCSCi uc001xap.3. human. [Q16667-1 ]
    uc001xar.3. human. [Q16667-2 ]

    Organism-specific databases

    CTDi 1033.
    GeneCardsi GC14P054863.
    HGNCi HGNC:1791. CDKN3.
    HPAi CAB005285.
    HPA039311.
    MIMi 114550. phenotype.
    123832. gene.
    neXtProti NX_Q16667.
    PharmGKBi PA26324.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOVERGENi HBG075798.
    InParanoidi Q16667.
    KOi K14167.
    OMAi TVKQYNF.
    OrthoDBi EOG7M0NSV.
    PhylomeDBi Q16667.
    TreeFami TF101040.

    Miscellaneous databases

    EvolutionaryTracei Q16667.
    GeneWikii CDKN3.
    GenomeRNAii 1033.
    NextBioi 4349.
    PROi Q16667.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16667.
    Bgeei Q16667.
    Genevestigatori Q16667.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
    Pfami PF05706. CDKN3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037322. CDKN3. 1 hit.
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2."
      Gyuris J., Golemis E., Chertkov H., Brent R.
      Cell 75:791-803(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDK1; CDK2 AND CDK3.
    2. "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases."
      Hannon G.J., Casso D., Beach D.
      Proc. Natl. Acad. Sci. U.S.A. 91:1731-1735(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDK1 AND CDK2.
    3. "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."
      Yeh C.-T., Lu S.-C., Chen T.-C., Peng C.-Y., Liaw Y.-F.
      Cancer Res. 60:4697-4700(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HCC ARG-31; LEU-78; TYR-79; LYS-91; VAL-94; PHE-95; VAL-108; SER-187 AND ILE-195.
    4. "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant."
      Yeh C.-T., Lu S.-C., Chao C.-H., Chao M.-L.
      Biochem. Biophys. Res. Commun. 305:311-314(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CDK2.
    5. Harper W., Elledge S.J.
      Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. Schupp I.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. NIEHS SNPs program
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Retinoblastoma.
    12. "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin."
      Poon R.Y.C., Hunter T.
      Science 270:90-93(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression."
      Lee S.W., Reimer C.L., Fang L., Iruela-Arispe M.L., Aaronson S.A.
      Mol. Cell. Biol. 20:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION.
    14. Cited for: INTERACTION WITH MS4A3.
    15. "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2."
      Chinami M., Yano Y., Yang X., Salahuddin S., Moriyama K., Shiroishi M., Turner H., Shirakawa T., Adra C.N.
      J. Biol. Chem. 280:17235-17242(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MS4A3.
    16. "Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2."
      Song H., Hanlon N., Brown N.R., Noble M.E.M., Johnson L.N., Barford D.
      Mol. Cell 7:615-626(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH THR-160 PHOSPHORYLATED CDK2.

    Entry informationi

    Entry nameiCDKN3_HUMAN
    AccessioniPrimary (citable) accession number: Q16667
    Secondary accession number(s): Q53ZU6
    , Q5U0M4, Q6P1N8, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C046, Q9C047, Q9C049, Q9C051, Q9C053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3