Q16666 (IF16_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 126.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gamma-interferon-inducible protein 16 Short name=Ifi-16 Alternative name(s): Interferon-inducible myeloid differentiation transcriptional activator | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 785 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells. Ref.4 Ref.13 |
| Subunit structure | Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein. |
| Subcellular location | |
| Tissue specificity | Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level). Ref.4 |
| Induction | Strongly induced by IFNG/IFN-gamma and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by IFNG/IFN-gamma occurs within 12 hours whereas, for IFN-alpha, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3. Ref.4 Ref.10 Ref.11 Ref.12 |
| Post-translational modification | Phosphorylated on Ser and Thr. Ref.9 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Isoform 3 seems to show a minor degree of complex carbohydrate addition. |
| Sequence similarities | Belongs to the HIN-200 family. Contains 1 DAPIN domain. Contains 2 HIN-200 domains. |
| Sequence caution | The sequence AAF20997.1 differs from that shown. Reason: Frameshift at position 776. The sequence AAF20997.1 differs from that shown. Reason: Intron retention. The sequence BAC04462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC04462.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAD92226.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| TMEM173 | Q86WV6 | 2 | EBI-2867186,EBI-2800345 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q16666-1) Also known as: IFI 16A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q16666-2) Also known as: IFI 16B; The sequence of this isoform differs from the canonical sequence as follows: 444-499: Missing. | ||||||
| Note: Major isoform. | ||||||
| Isoform 3 (identifier: Q16666-3) Also known as: IFI 16C; The sequence of this isoform differs from the canonical sequence as follows: 444-555: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 785 | 785 | Gamma-interferon-inducible protein 16 | PRO_0000153723 | ||||||||||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 1 – 88 | 88 | DAPIN | |||||||||||||||||||||||||||||||||||||||||||
| Domain | 189 – 389 | 201 | HIN-200 1 | |||||||||||||||||||||||||||||||||||||||||||
| Domain | 562 – 761 | 200 | HIN-200 2 | |||||||||||||||||||||||||||||||||||||||||||
| Motif | 124 – 131 | 8 | Nuclear localization signal Potential | |||||||||||||||||||||||||||||||||||||||||||
| Compositional bias | 1 – 150 | 150 | Lys-rich | |||||||||||||||||||||||||||||||||||||||||||
| Compositional bias | 258 – 261 | 4 | Poly-Ile | |||||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 106 | 1 | Phosphoserine Ref.15 Ref.17 Ref.18 | |||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 153 | 1 | Phosphoserine Ref.14 Ref.16 Ref.17 Ref.18 | |||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 214 | 1 | N6-acetyllysine Ref.19 | |||||||||||||||||||||||||||||||||||||||||||
| Cross-link | 561 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1) Ref.20 | ||||||||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 444 – 555 | 112 | Missing in isoform 3. | VSP_002675 | ||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 444 – 499 | 56 | Missing in isoform 2. | VSP_002676 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 103 | 1 | D → H. Ref.1 Ref.2 Ref.3 Corresponds to variant rs1057018 [ dbSNP | Ensembl ]. | VAR_029486 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 179 | 1 | S → T. Ref.4 Ref.7 Ref.8 Corresponds to variant rs866484 [ dbSNP | Ensembl ]. | VAR_029487 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 202 | 1 | K → E. Corresponds to variant rs11585341 [ dbSNP | Ensembl ]. | VAR_029488 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 409 | 1 | R → S. Ref.4 Ref.5 Ref.7 Corresponds to variant rs1057027 [ dbSNP | Ensembl ]. | VAR_029489 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 413 | 1 | Y → N. Ref.4 Ref.5 Ref.7 Corresponds to variant rs1057028 [ dbSNP | Ensembl ]. | VAR_029490 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 723 | 1 | T → S. Corresponds to variant rs6940 [ dbSNP | Ensembl ]. | VAR_029491 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 779 | 1 | T → S. Corresponds to variant rs6940 [ dbSNP | Ensembl ]. | VAR_057582 | ||||||||||||||||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 683 | 1 | K → R in AAM96005. Ref.4 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 723 | 1 | T → N in AAA58683. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 723 | 1 | T → N in AAB32519. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 737 | 1 | C → S in AAA58683. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 737 | 1 | C → S in AAB32519. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 578 – 585 | 8 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 589 – 592 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Turn | 593 – 596 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 597 – 605 | 9 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 610 – 615 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 618 – 620 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 622 – 624 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 629 – 634 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 636 – 638 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 641 – 644 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 648 – 652 | 5 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 655 – 657 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 663 – 667 | 5 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 675 – 678 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 685 – 699 | 15 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 702 – 708 | 7 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 713 – 720 | 8 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 721 – 724 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 732 – 742 | 11 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 748 – 751 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells." Trapani J.A., Browne K.A., Dawson M.J., Ramsay R.G., Eddy R.L., Show T.B., White P.C., Dupont B. Immunogenetics 36:369-376(1992) [PubMed: 1526658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT HIS-103. Tissue: T-cell. |
| [2] | "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization." Trapani J.A., Dawson M.J., Apostolidis V.A., Browne K.A. Immunogenetics 40:415-424(1994) [PubMed: 7959953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), VARIANT HIS-103. |
| [3] | Jiang C., Zhang D., Peng Y., Zhang X., Han Z., Fu G., Chen Z. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT HIS-103. Tissue: Bone marrow. |
| [4] | "Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence." Xin H., Curry J., Johnstone R.W., Nickoloff B.J., Choubey D. Oncogene 22:4831-4840(2003) [PubMed: 12894224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION, VARIANTS THR-179; SER-409 AND ASN-413. |
| [5] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-409 AND ASN-413. Tissue: Brain. |
| [6] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS THR-179; SER-409 AND ASN-413. Tissue: Uterus. |
| [8] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-179. Tissue: Hippocampus. |
| [9] | "Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing." Johnstone R.W., Kershaw M.H., Trapani J.A. Biochemistry 37:11924-11931(1998) [PubMed: 9718316] [Abstract] Cited for: ALTERNATIVE SPLICING, PHOSPHORYLATION, GLYCOSYLATION. |
| [10] | "IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines." Dawson M.J., Trapani J.A. J. Cell. Biochem. 57:39-51(1995) [PubMed: 7536752] [Abstract] Cited for: INDUCTION, SUBCELLULAR LOCATION, DNA-BINDING. |
| [11] | "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression." Dawson M.J., Trapani J.A., Briggs R.C., Nicholl J.K., Sutherland G.R., Baker E. Immunogenetics 41:40-43(1995) [PubMed: 7806273] [Abstract] Cited for: TISSUE-SPECIFIC INDUCTION. |
| [12] | "The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations." Dawson M.J., Elwood N.J., Johnstone R.W., Trapani J.A. J. Leukoc. Biol. 64:546-554(1998) [PubMed: 9766636] [Abstract] Cited for: TISSUE SPECIFIC INDUCTION. |
| [13] | "The human interferon-inducible protein, IFI 16, is a repressor of transcription." Johnstone R.W., Kerry J.A., Trapani J.A. J. Biol. Chem. 273:17172-17177(1998) [PubMed: 9642285] [Abstract] Cited for: FUNCTION. |
| [14] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [15] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [16] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [17] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [18] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [19] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214, MASS SPECTROMETRY. |
| [20] | "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification." Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A., Eriksson J.E., Sistonen L. J. Biol. Chem. 285:19324-19329(2010) [PubMed: 20388717] [Abstract] Cited for: SUMOYLATION AT LYS-561. Tissue: Cervix carcinoma. |
| [21] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [22] | "Crystal structure of the first HIN-200 domain of interferon-inducible protein 16." Northeast structural genomics consortium (NESG) Submitted (FEB-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 192-393. |
| [23] | "Crystal structure analysis of the second HIN domain of IFI16." Northeast structural genomics consortium (NESG) Submitted (NOV-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 571-766. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M63838 mRNA. Translation: AAA58683.1. S75433 S75431 Genomic DNA. Translation: AAB32519.2.AF208043 mRNA. Translation: AAF20997.1. Sequence problems. AY138863 mRNA. Translation: AAM96005.1. AB208989 mRNA. Translation: BAD92226.1. Different initiation. AL359753 Genomic DNA. Translation: CAI15081.1. AL359753 Genomic DNA. Translation: CAI15082.1. AL359753 Genomic DNA. Translation: CAI15083.1. AL359753 Genomic DNA. Translation: CAI15084.1. AL359753 Genomic DNA. Translation: CAI15085.1. AL359753 Genomic DNA. Translation: CAI15086.1. BC017059 mRNA. Translation: AAH17059.1. AK094968 mRNA. Translation: BAC04462.1. Sequence problems. | ||||||||||||||||||
| IPI | IPI00003443. IPI00217474. IPI00217475. IPI00384836. | ||||||||||||||||||
| PIR | I54501. | ||||||||||||||||||
| RefSeq | NP_001193496.1. NM_001206567.1. NP_005522.2. NM_005531.2. | ||||||||||||||||||
| UniGene | Hs.380250. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ProteinModelPortal | Q16666. | ||||||||||||||||||
| SMR | Q16666. Positions 1-93, 198-389, 576-761. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-42868N. | ||||||||||||||||||
| IntAct | Q16666. 6 interactions. | ||||||||||||||||||
| MINT | MINT-1781545. | ||||||||||||||||||
| STRING | Q16666. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q16666. | ||||||||||||||||||
Polymorphism databases | |||||||||||||||||||
| DMDM | 118572657. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q16666. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000295809; ENSP00000295809; ENSG00000163565. | ||||||||||||||||||
| GeneID | 3428. | ||||||||||||||||||
| KEGG | hsa:3428. | ||||||||||||||||||
| NMPDR | fig|9606.3.peg.2390. | ||||||||||||||||||
| UCSC | uc001ftg.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 3428. | ||||||||||||||||||
| GeneCards | GC01P158969. | ||||||||||||||||||
| HGNC | HGNC:5395. IFI16. | ||||||||||||||||||
| HPA | CAB016293. HPA002134. | ||||||||||||||||||
| MIM | 147586. gene. | ||||||||||||||||||
| neXtProt | NX_Q16666. | ||||||||||||||||||
| PharmGKB | PA29642. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG13079. | ||||||||||||||||||
| GeneTree | ENSGT00390000013296. | ||||||||||||||||||
| HOVERGEN | HBG006122. | ||||||||||||||||||
| InParanoid | Q16666. | ||||||||||||||||||
| OMA | MTSIGPA. | ||||||||||||||||||
| PhylomeDB | Q16666. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q16666. | ||||||||||||||||||
| Bgee | Q16666. | ||||||||||||||||||
| Genevestigator | Q16666. | ||||||||||||||||||
| GermOnline | ENSG00000163565. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR011029. DEATH-like. IPR004021. HIN200/IF120x. IPR012340. NA-bd_OB-fold. IPR004020. Pyrin. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.40.50.140. OB_NA_bd_sub. 4 hits. | ||||||||||||||||||
| Pfam | PF02760. HIN. 2 hits. PF02758. PAAD_DAPIN. 1 hit. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF47986. DEATH_like. 1 hit. | ||||||||||||||||||
| PROSITE | PS50824. DAPIN. 1 hit. PS50834. HIN_200. 2 hits. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 13516. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | IF16_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16666 Secondary accession number(s): Q59GX0 Q9UH78 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with