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Q16663 (CCL15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 15
Alternative name(s):
Chemokine CC-2
Short name=HCC-2
Leukotactin-1
Short name=LKN-1
MIP-1 delta
Macrophage inflammatory protein 5
Short name=MIP-5
Mrp-2b
NCC-3
Small-inducible cytokine A15

Cleaved into the following 3 chains:

  1. CCL15(22-92)
  2. CCL15(25-92)
  3. CCL15(29-92)
Gene names
Name:CCL15
Synonyms:MIP5, NCC3, SCYA15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. Ref.11

Subunit structure

Monomer. Ref.12

Subcellular location

Secreted.

Tissue specificity

Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. Ref.10 Ref.11

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.8
Chain22 – 11392C-C motif chemokine 15
PRO_0000005208
Chain43 – 11371CCL15(22-92)
PRO_0000041868
Chain46 – 11368CCL15(25-92)
PRO_0000041869
Chain50 – 11364CCL15(29-92)
PRO_0000041870

Amino acid modifications

Disulfide bond53 ↔ 77 Ref.12
Disulfide bond54 ↔ 93 Ref.12
Disulfide bond64 ↔ 104 Ref.12

Natural variations

Natural variant241I → T. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6
Corresponds to variant rs854625 [ dbSNP | Ensembl ].
VAR_011640

Experimental info

Sequence conflict141V → I in AAD10847. Ref.1

Secondary structure

.............. 113
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q16663 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 0BA0FCE7B8A30A04

FASTA11312,248
        10         20         30         40         50         60 
MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA ADCCTSYISQ 

        70         80         90        100        110 
SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG VQDCMKKLKP YSI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3."
Youn B.-S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S.
J. Immunol. 159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24.
[2]"Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10."
Wang W., Bacon K.B., Oldham E.R., Schall T.J.
J. Clin. Immunol. 18:214-222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[3]"HCC-2, a human chemokine: gene structure, expression pattern, and biological activity."
Pardigol A., Forssmann U., Zucht H.-D., Loetscher P., Schulz-Knappe P., Baggiolini M., Forssmann W.-G., Maegert H.-J.
Proc. Natl. Acad. Sci. U.S.A. 95:6308-6313(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24, CHARACTERIZATION.
Tissue: Liver.
[4]"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-24.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-24.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
Tissue: Brain.
[7]Coulin F., Power C.A., Alouani S., Peitsch M.C., Schroeder J.-M., Moshizuki M., Clark-Lewis I., Wells T.N.C.
Submitted (JAN-1997) to UniProtKB
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-113.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[9]"The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
Wells T.N.C., Peitsch M.C.
J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[10]"Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S.
Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Proteolytic activation of alternative CCR1 ligands in inflammation."
Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF CCL15(22-92); CCL15(25-92) AND CCL15(29-92), PROTEOLYTIC PROCESSING OF N-TERMINUS, TISSUE SPECIFICITY, FUNCTION.
[12]"Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype."
Sticht H., Escher S.E., Schweimer K., Forssmann W.G., Rosch P., Adermann K.
Biochemistry 38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 48-113, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL15 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
RefSeqNP_116741.1. NM_032965.4.
UniGeneHs.272493.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortalQ16663.
SMRQ16663. Positions 48-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6218N.
MINTMINT-1528582.
STRING9606.ENSP00000293276.

Polymorphism databases

DMDM3915594.

Proteomic databases

PaxDbQ16663.
PRIDEQ16663.

Protocols and materials databases

DNASU6359.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354059; ENSP00000293276; ENSG00000267596.
GeneID6359.
KEGGhsa:6359.
UCSCuc010wcu.2. human.

Organism-specific databases

CTD6359.
GeneCardsGC17M034345.
HGNCHGNC:10613. CCL15.
MIM601393. gene.
neXtProtNX_Q16663.
PharmGKBPA35546.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26004.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ16663.
KOK05511.
OMASQSIPCS.
PhylomeDBQ16663.
TreeFamTF334888.

Gene expression databases

BgeeQ16663.
GenevestigatorQ16663.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ16663.
GenomeRNAi6359.
NextBio24704.
PROQ16663.
SOURCESearch...

Entry information

Entry nameCCL15_HUMAN
AccessionPrimary (citable) accession number: Q16663
Secondary accession number(s): B2RU34, E1P651, Q9UM74
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM