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Protein

C-C motif chemokine 15

Gene

CCL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.1 Publication

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. chemokine activity Source: ProtInc
  3. heparin binding Source: UniProtKB-KW
  4. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. cellular calcium ion homeostasis Source: ProtInc
  4. chemotaxis Source: ProtInc
  5. immune response Source: InterPro
  6. positive chemotaxis Source: GOC
  7. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 15
Alternative name(s):
Chemokine CC-2
Short name:
HCC-2
Leukotactin-1
Short name:
LKN-1
MIP-1 delta
Macrophage inflammatory protein 5
Short name:
MIP-5
Mrp-2b
NCC-3
Small-inducible cytokine A15
Cleaved into the following 3 chains:
Gene namesi
Name:CCL15
Synonyms:MIP5, NCC3, SCYA15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10613. CCL15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35546.

Polymorphism and mutation databases

BioMutaiCCL15.
DMDMi3915594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11392C-C motif chemokine 15PRO_0000005208Add
BLAST
Chaini43 – 11371CCL15(22-92)PRO_0000041868Add
BLAST
Chaini46 – 11368CCL15(25-92)PRO_0000041869Add
BLAST
Chaini50 – 11364CCL15(29-92)PRO_0000041870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 771 Publication
Disulfide bondi54 ↔ 931 Publication
Disulfide bondi64 ↔ 1041 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16663.
PRIDEiQ16663.

Expressioni

Tissue specificityi

Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.2 Publications

Gene expression databases

BgeeiQ16663.
GenevestigatoriQ16663.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

DIPiDIP-6218N.
MINTiMINT-1528582.
STRINGi9606.ENSP00000293276.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 613Combined sources
Helixi64 – 663Combined sources
Beta strandi67 – 726Combined sources
Beta strandi77 – 793Combined sources
Beta strandi82 – 865Combined sources
Turni87 – 893Combined sources
Beta strandi90 – 945Combined sources
Helixi101 – 1077Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663.
SMRiQ16663. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16663.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26004.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16663.
KOiK05511.
OMAiSQSIPCS.
PhylomeDBiQ16663.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030592. CCL15.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF76. PTHR12015:SF76. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA
60 70 80 90 100
ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG
110
VQDCMKKLKP YSI
Length:113
Mass (Da):12,248
Last modified:December 15, 1998 - v2
Checksum:i0BA0FCE7B8A30A04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141V → I in AAD10847 (PubMed:9548457).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241I → T.5 Publications
Corresponds to variant rs854625 [ dbSNP | Ensembl ].
VAR_011640

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
CCDSiCCDS11304.1.
RefSeqiNP_116741.2. NM_032965.5.
UniGeneiHs.272493.

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528.
ENST00000617897; ENSP00000484078; ENSG00000275718.
GeneIDi6359.
KEGGihsa:6359.
UCSCiuc010wcu.2. human.

Polymorphism and mutation databases

BioMutaiCCL15.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL15 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
CCDSiCCDS11304.1.
RefSeqiNP_116741.2. NM_032965.5.
UniGeneiHs.272493.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663.
SMRiQ16663. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6218N.
MINTiMINT-1528582.
STRINGi9606.ENSP00000293276.

Polymorphism and mutation databases

BioMutaiCCL15.
DMDMi3915594.

Proteomic databases

PaxDbiQ16663.
PRIDEiQ16663.

Protocols and materials databases

DNASUi6359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528.
ENST00000617897; ENSP00000484078; ENSG00000275718.
GeneIDi6359.
KEGGihsa:6359.
UCSCiuc010wcu.2. human.

Organism-specific databases

CTDi6359.
GeneCardsiGC17M034391.
HGNCiHGNC:10613. CCL15.
MIMi601393. gene.
neXtProtiNX_Q16663.
PharmGKBiPA35546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG26004.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16663.
KOiK05511.
OMAiSQSIPCS.
PhylomeDBiQ16663.
TreeFamiTF334888.

Miscellaneous databases

EvolutionaryTraceiQ16663.
GenomeRNAii6359.
NextBioi24704.
PROiQ16663.
SOURCEiSearch...

Gene expression databases

BgeeiQ16663.
GenevestigatoriQ16663.

Family and domain databases

InterProiIPR030592. CCL15.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF76. PTHR12015:SF76. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3."
    Youn B.-S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S.
    J. Immunol. 159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24.
  2. "Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10."
    Wang W., Bacon K.B., Oldham E.R., Schall T.J.
    J. Clin. Immunol. 18:214-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24, CHARACTERIZATION.
    Tissue: Liver.
  4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-24.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-24.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-113.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  9. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
    Wells T.N.C., Peitsch M.C.
    J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  10. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
    Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S.
    Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Proteolytic activation of alternative CCR1 ligands in inflammation."
    Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
    J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CCL15(22-92); CCL15(25-92) AND CCL15(29-92), PROTEOLYTIC PROCESSING OF N-TERMINUS, TISSUE SPECIFICITY, FUNCTION.
  12. "Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype."
    Sticht H., Escher S.E., Schweimer K., Forssmann W.G., Rosch P., Adermann K.
    Biochemistry 38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 48-113, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL15_HUMAN
AccessioniPrimary (citable) accession number: Q16663
Secondary accession number(s): B2RU34, E1P651, Q9UM74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: April 29, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.