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Q16663

- CCL15_HUMAN

UniProt

Q16663 - CCL15_HUMAN

Protein

C-C motif chemokine 15

Gene

CCL15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.1 Publication

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. chemokine activity Source: ProtInc
    3. heparin binding Source: UniProtKB-KW
    4. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. cellular calcium ion homeostasis Source: ProtInc
    4. chemotaxis Source: ProtInc
    5. immune response Source: InterPro
    6. positive chemotaxis Source: GOC
    7. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 15
    Alternative name(s):
    Chemokine CC-2
    Short name:
    HCC-2
    Leukotactin-1
    Short name:
    LKN-1
    MIP-1 delta
    Macrophage inflammatory protein 5
    Short name:
    MIP-5
    Mrp-2b
    NCC-3
    Small-inducible cytokine A15
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CCL15
    Synonyms:MIP5, NCC3, SCYA15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10613. CCL15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 11392C-C motif chemokine 15PRO_0000005208Add
    BLAST
    Chaini43 – 11371CCL15(22-92)PRO_0000041868Add
    BLAST
    Chaini46 – 11368CCL15(25-92)PRO_0000041869Add
    BLAST
    Chaini50 – 11364CCL15(29-92)PRO_0000041870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 771 Publication
    Disulfide bondi54 ↔ 931 Publication
    Disulfide bondi64 ↔ 1041 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ16663.
    PRIDEiQ16663.

    Expressioni

    Tissue specificityi

    Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.2 Publications

    Gene expression databases

    BgeeiQ16663.
    GenevestigatoriQ16663.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    DIPiDIP-6218N.
    MINTiMINT-1528582.
    STRINGi9606.ENSP00000293276.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi59 – 613
    Helixi64 – 663
    Beta strandi67 – 726
    Beta strandi77 – 793
    Beta strandi82 – 865
    Turni87 – 893
    Beta strandi90 – 945
    Helixi101 – 1077

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HCCNMR-A48-113[»]
    ProteinModelPortaliQ16663.
    SMRiQ16663. Positions 48-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ16663.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26004.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ16663.
    KOiK05511.
    OMAiSQSIPCS.
    PhylomeDBiQ16663.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16663-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA    50
    ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG 100
    VQDCMKKLKP YSI 113
    Length:113
    Mass (Da):12,248
    Last modified:December 15, 1998 - v2
    Checksum:i0BA0FCE7B8A30A04
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141V → I in AAD10847. (PubMed:9548457)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241I → T.5 Publications
    Corresponds to variant rs854625 [ dbSNP | Ensembl ].
    VAR_011640

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58914 mRNA. Translation: AAD10847.1.
    AF031587 mRNA. Translation: AAB94617.1.
    Z70293 mRNA. Translation: CAA94308.1.
    Z70292 mRNA. Translation: CAA94306.1.
    AF088219 Genomic DNA. Translation: AAC63328.1.
    CH471147 Genomic DNA. Translation: EAW80110.1.
    CH471147 Genomic DNA. Translation: EAW80111.1.
    CH471147 Genomic DNA. Translation: EAW80112.1.
    CH471147 Genomic DNA. Translation: EAW80113.1.
    BC140941 mRNA. Translation: AAI40942.1.
    CCDSiCCDS11304.1.
    RefSeqiNP_116741.2. NM_032965.5.
    UniGeneiHs.272493.

    Genome annotation databases

    GeneIDi6359.
    KEGGihsa:6359.
    UCSCiuc010wcu.2. human.

    Polymorphism databases

    DMDMi3915594.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL15 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58914 mRNA. Translation: AAD10847.1 .
    AF031587 mRNA. Translation: AAB94617.1 .
    Z70293 mRNA. Translation: CAA94308.1 .
    Z70292 mRNA. Translation: CAA94306.1 .
    AF088219 Genomic DNA. Translation: AAC63328.1 .
    CH471147 Genomic DNA. Translation: EAW80110.1 .
    CH471147 Genomic DNA. Translation: EAW80111.1 .
    CH471147 Genomic DNA. Translation: EAW80112.1 .
    CH471147 Genomic DNA. Translation: EAW80113.1 .
    BC140941 mRNA. Translation: AAI40942.1 .
    CCDSi CCDS11304.1.
    RefSeqi NP_116741.2. NM_032965.5.
    UniGenei Hs.272493.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HCC NMR - A 48-113 [» ]
    ProteinModelPortali Q16663.
    SMRi Q16663. Positions 48-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6218N.
    MINTi MINT-1528582.
    STRINGi 9606.ENSP00000293276.

    Polymorphism databases

    DMDMi 3915594.

    Proteomic databases

    PaxDbi Q16663.
    PRIDEi Q16663.

    Protocols and materials databases

    DNASUi 6359.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6359.
    KEGGi hsa:6359.
    UCSCi uc010wcu.2. human.

    Organism-specific databases

    CTDi 6359.
    GeneCardsi GC17M034345.
    HGNCi HGNC:10613. CCL15.
    MIMi 601393. gene.
    neXtProti NX_Q16663.
    PharmGKBi PA35546.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26004.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q16663.
    KOi K05511.
    OMAi SQSIPCS.
    PhylomeDBi Q16663.
    TreeFami TF334888.

    Miscellaneous databases

    EvolutionaryTracei Q16663.
    GenomeRNAii 6359.
    NextBioi 24704.
    PROi Q16663.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16663.
    Genevestigatori Q16663.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3."
      Youn B.-S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S.
      J. Immunol. 159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24.
    2. "Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10."
      Wang W., Bacon K.B., Oldham E.R., Schall T.J.
      J. Clin. Immunol. 18:214-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24, CHARACTERIZATION.
      Tissue: Liver.
    4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
      Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
      J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-24.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-24.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-113.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.
    9. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
      Wells T.N.C., Peitsch M.C.
      J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.
    10. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
      Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S.
      Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Proteolytic activation of alternative CCR1 ligands in inflammation."
      Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
      J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF CCL15(22-92); CCL15(25-92) AND CCL15(29-92), PROTEOLYTIC PROCESSING OF N-TERMINUS, TISSUE SPECIFICITY, FUNCTION.
    12. "Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype."
      Sticht H., Escher S.E., Schweimer K., Forssmann W.G., Rosch P., Adermann K.
      Biochemistry 38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 48-113, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCCL15_HUMAN
    AccessioniPrimary (citable) accession number: Q16663
    Secondary accession number(s): B2RU34, E1P651, Q9UM74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3