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Protein

C-C motif chemokine 15

Gene

CCL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemoattractant activity Source: UniProtKB
  • chemokine activity Source: ProtInc
  • heparin binding Source: UniProtKB-KW
  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 15
Alternative name(s):
Chemokine CC-2
Short name:
HCC-2
Leukotactin-1
Short name:
LKN-1
MIP-1 delta
Macrophage inflammatory protein 5
Short name:
MIP-5
Mrp-2b
NCC-3
Small-inducible cytokine A15
Cleaved into the following 3 chains:
Gene namesi
Name:CCL15
Synonyms:MIP5, NCC3, SCYA15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10613. CCL15.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6359.
OpenTargetsiENSG00000275528.
ENSG00000282521.
PharmGKBiPA35546.

Polymorphism and mutation databases

BioMutaiCCL15.
DMDMi3915594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000520822 – 113C-C motif chemokine 15Add BLAST92
ChainiPRO_000004186843 – 113CCL15(22-92)Add BLAST71
ChainiPRO_000004186946 – 113CCL15(25-92)Add BLAST68
ChainiPRO_000004187050 – 113CCL15(29-92)Add BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 771 Publication
Disulfide bondi54 ↔ 931 Publication
Disulfide bondi64 ↔ 1041 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16663.
PeptideAtlasiQ16663.
PRIDEiQ16663.

Expressioni

Tissue specificityi

Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.2 Publications

Gene expression databases

BgeeiENSG00000267596.
ExpressionAtlasiQ16663. baseline and differential.
GenevisibleiQ16663. HS.

Organism-specific databases

HPAiHPA058608.

Interactioni

Subunit structurei

Monomer.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: ProtInc
  • receptor binding Source: ProtInc

Protein-protein interaction databases

DIPiDIP-6218N.
MINTiMINT-1528582.
STRINGi9606.ENSP00000432034.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi59 – 61Combined sources3
Helixi64 – 66Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi77 – 79Combined sources3
Beta strandi82 – 86Combined sources5
Turni87 – 89Combined sources3
Beta strandi90 – 94Combined sources5
Helixi101 – 107Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663.
SMRiQ16663.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16663.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16663.
KOiK05511.
OMAiICANPGH.
OrthoDBiEOG091G14Y2.
PhylomeDBiQ16663.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030592. CCL15.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF76. PTHR12015:SF76. 2 hits.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA
60 70 80 90 100
ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG
110
VQDCMKKLKP YSI
Length:113
Mass (Da):12,248
Last modified:December 15, 1998 - v2
Checksum:i0BA0FCE7B8A30A04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → I in AAD10847 (PubMed:9548457).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01164024I → T.5 PublicationsCorresponds to variant rs854625dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
CCDSiCCDS11304.1.
RefSeqiNP_116741.2. NM_032965.5.
UniGeneiHs.272493.

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528.
ENST00000617897; ENSP00000484078; ENSG00000275718.
GeneIDi6359.
KEGGihsa:6359.
UCSCiuc032gbw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL15 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
CCDSiCCDS11304.1.
RefSeqiNP_116741.2. NM_032965.5.
UniGeneiHs.272493.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663.
SMRiQ16663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6218N.
MINTiMINT-1528582.
STRINGi9606.ENSP00000432034.

Polymorphism and mutation databases

BioMutaiCCL15.
DMDMi3915594.

Proteomic databases

PaxDbiQ16663.
PeptideAtlasiQ16663.
PRIDEiQ16663.

Protocols and materials databases

DNASUi6359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528.
ENST00000617897; ENSP00000484078; ENSG00000275718.
GeneIDi6359.
KEGGihsa:6359.
UCSCiuc032gbw.1. human.

Organism-specific databases

CTDi6359.
DisGeNETi6359.
GeneCardsiCCL15.
HGNCiHGNC:10613. CCL15.
HPAiHPA058608.
MIMi601393. gene.
neXtProtiNX_Q16663.
OpenTargetsiENSG00000275528.
ENSG00000282521.
PharmGKBiPA35546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16663.
KOiK05511.
OMAiICANPGH.
OrthoDBiEOG091G14Y2.
PhylomeDBiQ16663.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161574-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ16663.
GenomeRNAii6359.
PROiQ16663.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000267596.
ExpressionAtlasiQ16663. baseline and differential.
GenevisibleiQ16663. HS.

Family and domain databases

InterProiIPR030592. CCL15.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF76. PTHR12015:SF76. 2 hits.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL15_HUMAN
AccessioniPrimary (citable) accession number: Q16663
Secondary accession number(s): B2RU34, E1P651, Q9UM74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.