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Q16663

- CCL15_HUMAN

UniProt

Q16663 - CCL15_HUMAN

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Protein
C-C motif chemokine 15
Gene
CCL15, MIP5, NCC3, SCYA15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.1 Publication

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. chemokine activity Source: ProtInc
  3. heparin binding Source: UniProtKB-KW
  4. receptor binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cell-cell signaling Source: ProtInc
  3. cellular calcium ion homeostasis Source: ProtInc
  4. chemotaxis Source: ProtInc
  5. immune response Source: InterPro
  6. positive chemotaxis Source: GOC
  7. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 15
Alternative name(s):
Chemokine CC-2
Short name:
HCC-2
Leukotactin-1
Short name:
LKN-1
MIP-1 delta
Macrophage inflammatory protein 5
Short name:
MIP-5
Mrp-2b
NCC-3
Small-inducible cytokine A15
Cleaved into the following 3 chains:
Gene namesi
Name:CCL15
Synonyms:MIP5, NCC3, SCYA15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10613. CCL15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 Publication
Add
BLAST
Chaini22 – 11392C-C motif chemokine 15
PRO_0000005208Add
BLAST
Chaini43 – 11371CCL15(22-92)
PRO_0000041868Add
BLAST
Chaini46 – 11368CCL15(25-92)
PRO_0000041869Add
BLAST
Chaini50 – 11364CCL15(29-92)
PRO_0000041870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 771 Publication
Disulfide bondi54 ↔ 931 Publication
Disulfide bondi64 ↔ 1041 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16663.
PRIDEiQ16663.

Expressioni

Tissue specificityi

Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.2 Publications

Gene expression databases

BgeeiQ16663.
GenevestigatoriQ16663.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

DIPiDIP-6218N.
MINTiMINT-1528582.
STRINGi9606.ENSP00000293276.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 613
Helixi64 – 663
Beta strandi67 – 726
Beta strandi77 – 793
Beta strandi82 – 865
Turni87 – 893
Beta strandi90 – 945
Helixi101 – 1077

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663.
SMRiQ16663. Positions 48-113.

Miscellaneous databases

EvolutionaryTraceiQ16663.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26004.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16663.
KOiK05511.
OMAiSQSIPCS.
PhylomeDBiQ16663.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16663-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA    50
ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG 100
VQDCMKKLKP YSI 113
Length:113
Mass (Da):12,248
Last modified:December 15, 1998 - v2
Checksum:i0BA0FCE7B8A30A04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241I → T.5 Publications
Corresponds to variant rs854625 [ dbSNP | Ensembl ].
VAR_011640

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141V → I in AAD10847. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58914 mRNA. Translation: AAD10847.1.
AF031587 mRNA. Translation: AAB94617.1.
Z70293 mRNA. Translation: CAA94308.1.
Z70292 mRNA. Translation: CAA94306.1.
AF088219 Genomic DNA. Translation: AAC63328.1.
CH471147 Genomic DNA. Translation: EAW80110.1.
CH471147 Genomic DNA. Translation: EAW80111.1.
CH471147 Genomic DNA. Translation: EAW80112.1.
CH471147 Genomic DNA. Translation: EAW80113.1.
BC140941 mRNA. Translation: AAI40942.1.
CCDSiCCDS11304.1.
RefSeqiNP_116741.2. NM_032965.5.
UniGeneiHs.272493.

Genome annotation databases

EnsembliENST00000354059; ENSP00000293276; ENSG00000267596.
GeneIDi6359.
KEGGihsa:6359.
UCSCiuc010wcu.2. human.

Polymorphism databases

DMDMi3915594.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL15 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58914 mRNA. Translation: AAD10847.1 .
AF031587 mRNA. Translation: AAB94617.1 .
Z70293 mRNA. Translation: CAA94308.1 .
Z70292 mRNA. Translation: CAA94306.1 .
AF088219 Genomic DNA. Translation: AAC63328.1 .
CH471147 Genomic DNA. Translation: EAW80110.1 .
CH471147 Genomic DNA. Translation: EAW80111.1 .
CH471147 Genomic DNA. Translation: EAW80112.1 .
CH471147 Genomic DNA. Translation: EAW80113.1 .
BC140941 mRNA. Translation: AAI40942.1 .
CCDSi CCDS11304.1.
RefSeqi NP_116741.2. NM_032965.5.
UniGenei Hs.272493.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HCC NMR - A 48-113 [» ]
ProteinModelPortali Q16663.
SMRi Q16663. Positions 48-113.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-6218N.
MINTi MINT-1528582.
STRINGi 9606.ENSP00000293276.

Polymorphism databases

DMDMi 3915594.

Proteomic databases

PaxDbi Q16663.
PRIDEi Q16663.

Protocols and materials databases

DNASUi 6359.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354059 ; ENSP00000293276 ; ENSG00000267596 .
GeneIDi 6359.
KEGGi hsa:6359.
UCSCi uc010wcu.2. human.

Organism-specific databases

CTDi 6359.
GeneCardsi GC17M034345.
HGNCi HGNC:10613. CCL15.
MIMi 601393. gene.
neXtProti NX_Q16663.
PharmGKBi PA35546.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26004.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q16663.
KOi K05511.
OMAi SQSIPCS.
PhylomeDBi Q16663.
TreeFami TF334888.

Miscellaneous databases

EvolutionaryTracei Q16663.
GenomeRNAii 6359.
NextBioi 24704.
PROi Q16663.
SOURCEi Search...

Gene expression databases

Bgeei Q16663.
Genevestigatori Q16663.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3."
    Youn B.-S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S.
    J. Immunol. 159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24.
  2. "Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10."
    Wang W., Bacon K.B., Oldham E.R., Schall T.J.
    J. Clin. Immunol. 18:214-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-24, CHARACTERIZATION.
    Tissue: Liver.
  4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-24.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-24.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-113.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  9. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
    Wells T.N.C., Peitsch M.C.
    J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  10. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
    Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S.
    Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Proteolytic activation of alternative CCR1 ligands in inflammation."
    Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
    J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CCL15(22-92); CCL15(25-92) AND CCL15(29-92), PROTEOLYTIC PROCESSING OF N-TERMINUS, TISSUE SPECIFICITY, FUNCTION.
  12. "Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype."
    Sticht H., Escher S.E., Schweimer K., Forssmann W.G., Rosch P., Adermann K.
    Biochemistry 38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 48-113, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL15_HUMAN
AccessioniPrimary (citable) accession number: Q16663
Secondary accession number(s): B2RU34, E1P651, Q9UM74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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