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Q16661

- GUC2B_HUMAN

UniProt

Q16661 - GUC2B_HUMAN

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Protein
Guanylate cyclase activator 2B
Gene
GUCA2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

GO - Molecular functioni

  1. calcium sensitive guanylate cyclase activator activity Source: ProtInc

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. cGMP biosynthetic process Source: Ensembl
  3. excretion Source: ProtInc
  4. negative regulation of blood pressure Source: Ensembl
  5. positive regulation of guanylate cyclase activity Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following 2 chains:
Alternative name(s):
Guanylate cyclase C-activating peptide II
Short name:
GCAP-II
Uroguanylin
Short name:
UGN
Gene namesi
Name:GUCA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4683. GUCA2B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Propeptidei27 – 8862
PRO_0000013147Add
BLAST
Peptidei89 – 11224Guanylate cyclase C-activating peptide 21 Publication
PRO_0000013148Add
BLAST
Peptidei97 – 11216Uroguanylin1 Publication
PRO_0000013149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 80 By similarity
Disulfide bondi100 ↔ 1082 Publications
Disulfide bondi103 ↔ 1112 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16661.
PeptideAtlasiQ16661.
PRIDEiQ16661.

Expressioni

Tissue specificityi

Stomach and intestine.

Gene expression databases

BgeeiQ16661.
CleanExiHS_GUCA2B.
GenevestigatoriQ16661.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361662.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi105 – 1073

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UYANMR-A97-112[»]
1UYBNMR-A97-112[»]
ProteinModelPortaliQ16661.
SMRiQ16661. Positions 27-111.

Miscellaneous databases

EvolutionaryTraceiQ16661.

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45706.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiQ16661.
OMAiQSVYIQY.
OrthoDBiEOG75TMFM.
PhylomeDBiQ16661.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16661-1 [UniParc]FASTAAdd to Basket

« Hide

MGCRAASGLL PGVAVVLLLL LQSTQSVYIQ YQGFRVQLES MKKLSDLEAQ    50
WAPSPRLQAQ SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC 100
ELCVNVACTG CL 112
Length:112
Mass (Da):12,069
Last modified:November 1, 1996 - v1
Checksum:iAA3030BC3D4EE412
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111P → T.
Corresponds to variant rs2297567 [ dbSNP | Ensembl ].
VAR_053362

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34279 mRNA. Translation: AAC50416.1.
Z50753 mRNA. Translation: CAA90629.1.
Z70295 Genomic DNA. Translation: CAA94311.1.
U55058 Genomic DNA. Translation: AAC51729.1.
BC069301 mRNA. Translation: AAH69301.1.
BC093779 mRNA. Translation: AAH93779.1.
BC093781 mRNA. Translation: AAH93781.1.
CCDSiCCDS464.1.
PIRiJC4651.
RefSeqiNP_009033.1. NM_007102.2.
UniGeneiHs.32966.

Genome annotation databases

EnsembliENST00000372581; ENSP00000361662; ENSG00000044012.
GeneIDi2981.
KEGGihsa:2981.
UCSCiuc001chc.1. human.

Polymorphism databases

DMDMi2495130.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34279 mRNA. Translation: AAC50416.1 .
Z50753 mRNA. Translation: CAA90629.1 .
Z70295 Genomic DNA. Translation: CAA94311.1 .
U55058 Genomic DNA. Translation: AAC51729.1 .
BC069301 mRNA. Translation: AAH69301.1 .
BC093779 mRNA. Translation: AAH93779.1 .
BC093781 mRNA. Translation: AAH93781.1 .
CCDSi CCDS464.1.
PIRi JC4651.
RefSeqi NP_009033.1. NM_007102.2.
UniGenei Hs.32966.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UYA NMR - A 97-112 [» ]
1UYB NMR - A 97-112 [» ]
ProteinModelPortali Q16661.
SMRi Q16661. Positions 27-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000361662.

Polymorphism databases

DMDMi 2495130.

Proteomic databases

PaxDbi Q16661.
PeptideAtlasi Q16661.
PRIDEi Q16661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372581 ; ENSP00000361662 ; ENSG00000044012 .
GeneIDi 2981.
KEGGi hsa:2981.
UCSCi uc001chc.1. human.

Organism-specific databases

CTDi 2981.
GeneCardsi GC01P042621.
HGNCi HGNC:4683. GUCA2B.
MIMi 601271. gene.
neXtProti NX_Q16661.
PharmGKBi PA29066.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45706.
HOGENOMi HOG000231183.
HOVERGENi HBG051861.
InParanoidi Q16661.
OMAi QSVYIQY.
OrthoDBi EOG75TMFM.
PhylomeDBi Q16661.
TreeFami TF330731.

Miscellaneous databases

EvolutionaryTracei Q16661.
GenomeRNAii 2981.
NextBioi 11824.
PROi Q16661.
SOURCEi Search...

Gene expression databases

Bgeei Q16661.
CleanExi HS_GUCA2B.
Genevestigatori Q16661.

Family and domain databases

Gene3Di 3.90.1450.10. 1 hit.
InterProi IPR000879. Guanylin.
[Graphical view ]
PANTHERi PTHR11318. PTHR11318. 1 hit.
Pfami PF02058. Guanylin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001849. Guanylin. 1 hit.
PRINTSi PR00774. GUANYLIN.
ProDomi PD005588. Guanylin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF89890. SSF89890. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin."
    Miyazato M., Nakazato M., Yamaguchi H., Date Y., Kojima M., Kangawa K., Matsuo H., Matsukura S.
    Biochem. Biophys. Res. Commun. 219:644-648(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  2. "A new human guanylate cyclase-activating peptide (GCAP-II, uroguanylin): precursor cDNA and colonic expression."
    Hill O., Cetin Y., Cieslak A., Maegert H.-J., Forssmann W.-G.
    Biochim. Biophys. Acta 1253:146-149(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  3. "Structure of the human uroguanylin / GCAP-II gene and expression within the gastrointestinal tract."
    Maegert H.-J., Hill O., Forssmann W.-G.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  4. "Genomic structure and chromosomal localization of human uroguanylin."
    Miyazato M., Nakazato M., Matsukura S., Kangawa K., Matsuo H.
    Genomics 43:359-365(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  6. "GCAP-II: isolation and characterization of the circulating form of human uroguanylin."
    Hess R., Kuhn M., Schulz-Knappe P., Raida M., Fuchs M., Klodt J., Adermann K., Kaever V., Cetin Y., Forssmann W.-G.
    FEBS Lett. 374:34-38(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 89-112, DISULFIDE BONDS.
    Tissue: Blood.
  7. "Characterization of human uroguanylin: a member of the guanylin peptide family."
    Kita T., Smith C.E., Fok K.F., Duffin K.L., Moore W.M., Karabatsos P.J., Kachur J.F., Hamra F.K., Pidhorodeckyj N.V., Forte L.R., Currie M.G.
    Am. J. Physiol. 266:F342-F348(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 97-112, DISULFIDE BONDS.
  8. "One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers."
    Marx U.C., Klodt J., Meyer M., Gerlach H., Roesch P., Forssmann W.-G., Adermann K.
    J. Pept. Res. 52:229-240(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 97-112.

Entry informationi

Entry nameiGUC2B_HUMAN
AccessioniPrimary (citable) accession number: Q16661
Secondary accession number(s): Q52LV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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