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Q16661 (GUC2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate cyclase activator 2B

Cleaved into the following 2 chains:

  1. Guanylate cyclase C-activating peptide 2
    Alternative name(s):
    Guanylate cyclase C-activating peptide II
    Short name=GCAP-II
  2. Uroguanylin
    Short name=UGN
Gene names
Name:GUCA2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Subcellular location

Secreted.

Tissue specificity

Stomach and intestine.

Sequence similarities

Belongs to the guanylin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 8862
PRO_0000013147
Peptide89 – 11224Guanylate cyclase C-activating peptide 2 Ref.6
PRO_0000013148
Peptide97 – 11216Uroguanylin Ref.7
PRO_0000013149

Amino acid modifications

Disulfide bond67 ↔ 80 By similarity
Disulfide bond100 ↔ 108 Ref.6 Ref.7
Disulfide bond103 ↔ 111 Ref.6 Ref.7

Natural variations

Natural variant111P → T.
Corresponds to variant rs2297567 [ dbSNP | Ensembl ].
VAR_053362

Secondary structure

... 112
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q16661 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AA3030BC3D4EE412

FASTA11212,069
        10         20         30         40         50         60 
MGCRAASGLL PGVAVVLLLL LQSTQSVYIQ YQGFRVQLES MKKLSDLEAQ WAPSPRLQAQ 

        70         80         90        100        110 
SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC ELCVNVACTG CL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a cDNA encoding a precursor for human uroguanylin."
Miyazato M., Nakazato M., Yamaguchi H., Date Y., Kojima M., Kangawa K., Matsuo H., Matsukura S.
Biochem. Biophys. Res. Commun. 219:644-648(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon.
[2]"A new human guanylate cyclase-activating peptide (GCAP-II, uroguanylin): precursor cDNA and colonic expression."
Hill O., Cetin Y., Cieslak A., Maegert H.-J., Forssmann W.-G.
Biochim. Biophys. Acta 1253:146-149(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon.
[3]"Structure of the human uroguanylin / GCAP-II gene and expression within the gastrointestinal tract."
Maegert H.-J., Hill O., Forssmann W.-G.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[4]"Genomic structure and chromosomal localization of human uroguanylin."
Miyazato M., Nakazato M., Matsukura S., Kangawa K., Matsuo H.
Genomics 43:359-365(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[6]"GCAP-II: isolation and characterization of the circulating form of human uroguanylin."
Hess R., Kuhn M., Schulz-Knappe P., Raida M., Fuchs M., Klodt J., Adermann K., Kaever V., Cetin Y., Forssmann W.-G.
FEBS Lett. 374:34-38(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 89-112, DISULFIDE BONDS.
Tissue: Blood.
[7]"Characterization of human uroguanylin: a member of the guanylin peptide family."
Kita T., Smith C.E., Fok K.F., Duffin K.L., Moore W.M., Karabatsos P.J., Kachur J.F., Hamra F.K., Pidhorodeckyj N.V., Forte L.R., Currie M.G.
Am. J. Physiol. 266:F342-F348(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 97-112, DISULFIDE BONDS.
[8]"One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers."
Marx U.C., Klodt J., Meyer M., Gerlach H., Roesch P., Forssmann W.-G., Adermann K.
J. Pept. Res. 52:229-240(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 97-112.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34279 mRNA. Translation: AAC50416.1.
Z50753 mRNA. Translation: CAA90629.1.
Z70295 Genomic DNA. Translation: CAA94311.1.
U55058 Genomic DNA. Translation: AAC51729.1.
BC069301 mRNA. Translation: AAH69301.1.
BC093779 mRNA. Translation: AAH93779.1.
BC093781 mRNA. Translation: AAH93781.1.
PIRJC4651.
RefSeqNP_009033.1. NM_007102.2.
UniGeneHs.32966.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UYANMR-A97-112[»]
1UYBNMR-A97-112[»]
ProteinModelPortalQ16661.
SMRQ16661. Positions 27-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000361662.

Polymorphism databases

DMDM2495130.

Proteomic databases

PaxDbQ16661.
PeptideAtlasQ16661.
PRIDEQ16661.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372581; ENSP00000361662; ENSG00000044012.
GeneID2981.
KEGGhsa:2981.
UCSCuc001chc.1. human.

Organism-specific databases

CTD2981.
GeneCardsGC01P042621.
HGNCHGNC:4683. GUCA2B.
MIM601271. gene.
neXtProtNX_Q16661.
PharmGKBPA29066.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45706.
HOGENOMHOG000231183.
HOVERGENHBG051861.
InParanoidQ16661.
OMAQSVYIQY.
OrthoDBEOG75TMFM.
PhylomeDBQ16661.
TreeFamTF330731.

Gene expression databases

BgeeQ16661.
CleanExHS_GUCA2B.
GenevestigatorQ16661.

Family and domain databases

Gene3D3.90.1450.10. 1 hit.
InterProIPR000879. Guanylin.
[Graphical view]
PANTHERPTHR11318. PTHR11318. 1 hit.
PfamPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFPIRSF001849. Guanylin. 1 hit.
PRINTSPR00774. GUANYLIN.
ProDomPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF89890. SSF89890. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ16661.
GenomeRNAi2981.
NextBio11824.
PROQ16661.
SOURCESearch...

Entry information

Entry nameGUC2B_HUMAN
AccessionPrimary (citable) accession number: Q16661
Secondary accession number(s): Q52LV0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM