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Q16656

- NRF1_HUMAN

UniProt

Q16656 - NRF1_HUMAN

Protein

Nuclear respiratory factor 1

Gene

NRF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi109 – 305197Add
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. generation of precursor metabolites and energy Source: ProtInc
    3. mitochondrion organization Source: Ensembl
    4. organ regeneration Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    7. response to electrical stimulus Source: Ensembl
    8. response to estradiol Source: Ensembl
    9. response to folic acid Source: Ensembl
    10. response to hypoxia Source: Ensembl
    11. response to lipopolysaccharide Source: Ensembl
    12. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear respiratory factor 1
    Short name:
    NRF-1
    Alternative name(s):
    Alpha palindromic-binding protein
    Short name:
    Alpha-pal
    Gene namesi
    Name:NRF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7996. NRF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31775.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Nuclear respiratory factor 1PRO_0000100208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391Phosphoserine; by CK21 Publication
    Modified residuei44 – 441Phosphoserine; by CK21 Publication
    Modified residuei46 – 461Phosphoserine; by CK21 Publication
    Modified residuei47 – 471Phosphoserine; by CK21 Publication
    Modified residuei52 – 521Phosphoserine; by CK21 Publication

    Post-translational modificationi

    Phosphorylation enhances DNA binding.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ16656.
    PaxDbiQ16656.
    PRIDEiQ16656.

    PTM databases

    PhosphoSiteiQ16656.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with strongest expression in skeletal muscle.

    Gene expression databases

    ArrayExpressiQ16656.
    BgeeiQ16656.
    CleanExiHS_NRF1.
    GenevestigatoriQ16656.

    Organism-specific databases

    HPAiHPA029329.

    Interactioni

    Subunit structurei

    Homodimer. Binds DNA as a dimer. Interacts with PPRC1.2 Publications

    Protein-protein interaction databases

    BioGridi110955. 2476 interactions.
    IntActiQ16656. 3 interactions.
    STRINGi9606.ENSP00000223190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16656.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7878DimerizationAdd
    BLAST
    Regioni301 – 476176Required for transcriptional activationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi88 – 11629Nuclear localization signalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 6626Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi80 – 867Poly-Ala

    Sequence similaritiesi

    Belongs to the NRF1/Ewg family.Curated

    Phylogenomic databases

    eggNOGiNOG80791.
    HOGENOMiHOG000273898.
    HOVERGENiHBG003062.
    KOiK11831.
    PhylomeDBiQ16656.
    TreeFamiTF105308.

    Family and domain databases

    InterProiIPR019526. Nrf1_activation-bd.
    IPR019525. Nrf1_NLS/DNA-bd_dimer.
    [Graphical view]
    PfamiPF10492. Nrf1_activ_bdg. 1 hit.
    PF10491. Nrf1_DNA-bind. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q16656-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED    50
    TSYDDSDILN STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN 100
    PSIRKRQQTR LLRKLRATLD EYTTRVGQQA IVLCISPSKP NPVFKVFGAA 150
    PLENVVRKYK SMILEDLESA LAEHAPAPQE VNSELPPLTI DGIPVSVDKM 200
    TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW ANVRSDVRTE 250
    EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL 300
    VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA 350
    VADGEVEQNW ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA 400
    TVTMALNSEA AAHAVATLAE ATLQGGGQIV LSGETAAAVG ALTGVQDANG 450
    LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV TTRISDSAVT MDGQAVEVVT 500
    LEQ 503
    Length:503
    Mass (Da):53,541
    Last modified:November 1, 1996 - v1
    Checksum:iF31C358278371929
    GO
    Isoform Short (identifier: Q16656-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-321: Missing.

    Show »
    Length:437
    Mass (Da):46,157
    Checksum:iD7B62154D8D015B2
    GO
    Isoform 3 (identifier: Q16656-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-161: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:342
    Mass (Da):36,051
    Checksum:i5130FF5034DC7362
    GO
    Isoform 4 (identifier: Q16656-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         449-449: N → NGLFMADRAGRKWILTDKAT

    Show »
    Length:522
    Mass (Da):55,674
    Checksum:i580AC14584586AEF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti322 – 3221V → VV in AAA79013. (PubMed:7629110)Curated
    Sequence conflicti403 – 4031T → A in BAG56867. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 161161Missing in isoform 3. 1 PublicationVSP_054330Add
    BLAST
    Alternative sequencei256 – 32166Missing in isoform Short. CuratedVSP_003598Add
    BLAST
    Alternative sequencei449 – 4491N → NGLFMADRAGRKWILTDKAT in isoform 4. 2 PublicationsVSP_054331

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22454 mRNA. Translation: AAA16918.1.
    U02683 mRNA. Translation: AAA21647.1.
    U18383
    , U18375, U18376, U18377, U18378, U18379, U18380, U18381, U18382 Genomic DNA. Translation: AAA79013.1.
    EU159452 mRNA. Translation: ABV90872.1.
    AK290891 mRNA. Translation: BAF83580.1.
    AK293351 mRNA. Translation: BAG56867.1.
    AC078846 Genomic DNA. No translation available.
    AC084864 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24100.1.
    CH471070 Genomic DNA. Translation: EAW83728.1.
    BC016925 mRNA. Translation: AAH16925.1.
    CCDSiCCDS5813.2. [Q16656-1]
    PIRiA54868.
    RefSeqiNP_001035199.1. NM_001040110.1. [Q16656-1]
    NP_005002.3. NM_005011.4. [Q16656-1]
    UniGeneiHs.654363.

    Genome annotation databases

    EnsembliENST00000223190; ENSP00000223190; ENSG00000106459. [Q16656-1]
    ENST00000311967; ENSP00000309826; ENSG00000106459. [Q16656-4]
    ENST00000353868; ENSP00000342351; ENSG00000106459. [Q16656-2]
    ENST00000393230; ENSP00000376922; ENSG00000106459. [Q16656-1]
    ENST00000393232; ENSP00000376924; ENSG00000106459. [Q16656-1]
    GeneIDi4899.
    KEGGihsa:4899.
    UCSCiuc003voz.3. human. [Q16656-1]
    uc003vpa.3. human.

    Polymorphism databases

    DMDMi12643732.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22454 mRNA. Translation: AAA16918.1 .
    U02683 mRNA. Translation: AAA21647.1 .
    U18383
    , U18375 , U18376 , U18377 , U18378 , U18379 , U18380 , U18381 , U18382 Genomic DNA. Translation: AAA79013.1 .
    EU159452 mRNA. Translation: ABV90872.1 .
    AK290891 mRNA. Translation: BAF83580.1 .
    AK293351 mRNA. Translation: BAG56867.1 .
    AC078846 Genomic DNA. No translation available.
    AC084864 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24100.1 .
    CH471070 Genomic DNA. Translation: EAW83728.1 .
    BC016925 mRNA. Translation: AAH16925.1 .
    CCDSi CCDS5813.2. [Q16656-1 ]
    PIRi A54868.
    RefSeqi NP_001035199.1. NM_001040110.1. [Q16656-1 ]
    NP_005002.3. NM_005011.4. [Q16656-1 ]
    UniGenei Hs.654363.

    3D structure databases

    ProteinModelPortali Q16656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110955. 2476 interactions.
    IntActi Q16656. 3 interactions.
    STRINGi 9606.ENSP00000223190.

    PTM databases

    PhosphoSitei Q16656.

    Polymorphism databases

    DMDMi 12643732.

    Proteomic databases

    MaxQBi Q16656.
    PaxDbi Q16656.
    PRIDEi Q16656.

    Protocols and materials databases

    DNASUi 4899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223190 ; ENSP00000223190 ; ENSG00000106459 . [Q16656-1 ]
    ENST00000311967 ; ENSP00000309826 ; ENSG00000106459 . [Q16656-4 ]
    ENST00000353868 ; ENSP00000342351 ; ENSG00000106459 . [Q16656-2 ]
    ENST00000393230 ; ENSP00000376922 ; ENSG00000106459 . [Q16656-1 ]
    ENST00000393232 ; ENSP00000376924 ; ENSG00000106459 . [Q16656-1 ]
    GeneIDi 4899.
    KEGGi hsa:4899.
    UCSCi uc003voz.3. human. [Q16656-1 ]
    uc003vpa.3. human.

    Organism-specific databases

    CTDi 4899.
    GeneCardsi GC07P129251.
    HGNCi HGNC:7996. NRF1.
    HPAi HPA029329.
    MIMi 600879. gene.
    neXtProti NX_Q16656.
    PharmGKBi PA31775.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80791.
    HOGENOMi HOG000273898.
    HOVERGENi HBG003062.
    KOi K11831.
    PhylomeDBi Q16656.
    TreeFami TF105308.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    ChiTaRSi NRF1. human.
    GeneWikii NRF1.
    GenomeRNAii 4899.
    NextBioi 18853.
    PROi Q16656.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16656.
    Bgeei Q16656.
    CleanExi HS_NRF1.
    Genevestigatori Q16656.

    Family and domain databases

    InterProi IPR019526. Nrf1_activation-bd.
    IPR019525. Nrf1_NLS/DNA-bd_dimer.
    [Graphical view ]
    Pfami PF10492. Nrf1_activ_bdg. 1 hit.
    PF10491. Nrf1_DNA-bind. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators."
      Virbasius C.A., Virbasius J.V., Scarpulla R.C.
      Genes Dev. 7:2431-2445(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF 161-186 AND 256-263.
    2. "A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development."
      Efiok B.J.S., Chiorini J.A., Safer B.
      J. Biol. Chem. 269:18921-18930(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF 161-183 AND 231-253.
    3. "Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1."
      Gopalakrishnan L., Scarpulla R.C.
      J. Biol. Chem. 270:18019-18025(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. Yang S.J., Li K.N., Zhang Y.Q.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Hepatoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3).
      Tissue: Urinary bladder.
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Duodenum.
    10. "The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines."
      Spelbrink J.N., Van den Bogert C.
      Hum. Mol. Genet. 4:1591-1596(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    11. "Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding."
      Gugneja S., Scarpulla R.C.
      J. Biol. Chem. 272:18732-18739(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF DOMAINS, PHOSPHORYLATION.
    12. "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."
      Andersson U., Scarpulla R.C.
      Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPRC1.
    13. "PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
      Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C.
      Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPRC1.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNRF1_HUMAN
    AccessioniPrimary (citable) accession number: Q16656
    Secondary accession number(s): A8K4C6
    , B4DDV6, Q15305, Q96AN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3