Reviewed,
UniProtKB/Swiss-Prot Q16655 (MAR1_HUMAN)
Last modified
November 25, 2008.
Version 55.
History...
Clusters with 100%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Melanoma antigen recognized by T-cells 1 Short name=MART-1 Short name=Melan-A protein Alternative name(s): Antigen SK29-AA Antigen LB39-AA | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 118 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass membrane proteinPotential. |
| Tissue specificity | Expression is restricted to melanoma and melanocyte cell lines and retina. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane |
Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor." Kawakami Y., Eliyahu S., Delgado C.H., Robbins P.F., Rivoltini L., Topalian S.L., Miki T., Rosenberg S.A. Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994) [PubMed: 8170938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma. |
| [2] | "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas." Coulie P.G., Brichard V., van Pel A., Woelfel T., Schneider J., Traversari C., Mattei S., de Plaen E., Lurquin C., Szikora J.-P., Renauld J.-C., Boon T. J. Exp. Med. 180:35-42(1994) [PubMed: 8006593] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U06452 mRNA. Translation: AAA19238.1. U06654 mRNA. Translation: AAA20389.1. BC014423 mRNA. Translation: AAH14423.1. | |
| PIR | A55253. |
| RefSeq | NP_005502.1. |
| UniGene | Hs.154069 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q16655. |
Genome annotation databases | |
| Ensembl | ENSG00000120215. Homo sapiens. [Contig view] |
| GeneID | 2315. |
| KEGG | hsa:2315. |
Organism-specific databases | |
| H-InvDB | HIX0007904. |
| HGNC | HGNC:7124. MLANA. |
| HPA | CAB000057. CAB000138. |
| MIM | 605513. gene. |
| PharmGKB | PA30842. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q16655. |
| HOVERGEN | Q16655. |
Gene expression databases | |
| ArrayExpress | Q16655. |
| CleanEx | HS_MLANA. |
| GermOnline | ENSG00000120215. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9401. |
| SOURCE | Search... |
Entry information
| Entry name | MAR1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16655 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

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