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Reviewed, UniProtKB/Swiss-Prot Q16655 (MAR1_HUMAN)

Last modified June 16, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Melanoma antigen recognized by T-cells 1
      Short name=MART-1
      Short name=Melan-A protein
Alternative name(s):
    Antigen SK29-AA
    Antigen LB39-AA
Gene names
Name: MLANA
Synonyms: MART1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expression is restricted to melanoma and melanocyte cell lines and retina.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118Melanoma antigen recognized by T-cells 1
PRO_0000096238

Regions

Transmembrane27 – 4721 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q16655-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B755BFF39CFCB16E

FASTA11813,157
        10         20         30         40         50         60 
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK 

        70         80         90        100        110 
SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP

« Hide

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References

« Hide 'large scale' references
[1]"Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor."
Kawakami Y., Eliyahu S., Delgado C.H., Robbins P.F., Rivoltini L., Topalian S.L., Miki T., Rosenberg S.A.
Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994) [PubMed: 8170938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Melanoma.
[2]"A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas."
Coulie P.G., Brichard V., van Pel A., Woelfel T., Schneider J., Traversari C., Mattei S., de Plaen E., Lurquin C., Szikora J.-P., Renauld J.-C., Boon T.
J. Exp. Med. 180:35-42(1994) [PubMed: 8006593] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U06452 mRNA. Translation: AAA19238.1.
U06654 mRNA. Translation: AAA20389.1.
BC014423 mRNA. Translation: AAH14423.1.
IPIIPI00003426.
PIRA55253.
RefSeqNP_005502.1.
UniGeneHs.154069

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2GT9X-ray1.75C/F26-35[»]
2GTWX-ray1.55C/F28-35[»]
2GTZX-ray1.70C/F29-35[»]
2GUOX-ray1.90C/F27-35[»]
ModBaseSearch...

Proteomic databases

PRIDEQ16655.

Genome annotation databases

EnsemblENSG00000120215. Homo sapiens. [Contig view]
GeneID2315.
KEGGhsa:2315.

Organism-specific databases

GeneCardsGC09P005880.
H-InvDBHIX0007904.
HGNCHGNC:7124. MLANA.
HPACAB000057.
MIM605513. gene.
PharmGKBPA30842.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ16655.
HOVERGENQ16655.
OMAQ16655. YRTLTDK.

Gene expression databases

ArrayExpressQ16655.
BgeeQ16655.
CleanExHS_MLANA.
GermOnlineENSG00000120215. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio9401.
SOURCESearch...

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Entry information

Entry nameMAR1_HUMAN
AccessionPrimary (citable) accession number: Q16655
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents