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Protein

Melanoma antigen recognized by T-cells 1

Gene

MLANA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.2 Publications

Enzyme and pathway databases

SIGNORiQ16655.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma antigen recognized by T-cells 1
Short name:
MART-1
Alternative name(s):
Antigen LB39-AA
Antigen SK29-AA
Protein Melan-A
Gene namesi
Name:MLANA
Synonyms:MART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120215.9.
HGNCiHGNC:7124. MLANA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 118CytoplasmicSequence analysisAdd BLAST71

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2315.
OpenTargetsiENSG00000120215.
PharmGKBiPA30842.

Polymorphism and mutation databases

BioMutaiMLANA.
DMDMi2833278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962381 – 118Melanoma antigen recognized by T-cells 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Phosphoserine1 Publication1

Post-translational modificationi

Acylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ16655.
PeptideAtlasiQ16655.
PRIDEiQ16655.

PTM databases

iPTMnetiQ16655.
PhosphoSitePlusiQ16655.

Expressioni

Tissue specificityi

Expression is restricted to melanoma and melanocyte cell lines and retina.

Gene expression databases

BgeeiENSG00000120215.
CleanExiHS_MLANA.
GenevisibleiQ16655. HS.

Organism-specific databases

HPAiCAB000057.
HPA048662.

Interactioni

Subunit structurei

Interacts with PMEL. Interacts with GPR143.3 Publications

Protein-protein interaction databases

BioGridi108604. 2 interactors.
IntActiQ16655. 4 interactors.
MINTiMINT-7889633.
STRINGi9606.ENSP00000370880.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GT9X-ray1.75C/F26-35[»]
2GTWX-ray1.55C/F27-35[»]
2GTZX-ray1.70C/F27-35[»]
2GUOX-ray1.90C/F27-35[»]
3HG1X-ray3.00C26-35[»]
3L6FX-ray2.10C100-114[»]
3MROX-ray2.35P26-35[»]
3MRPX-ray2.10P26-35[»]
3MRQX-ray2.20P26-35[»]
3QDMX-ray2.80C26-35[»]
3QEQX-ray2.59C27-35[»]
3QFDX-ray1.68C/F27-35[»]
4EUPX-ray2.88C/F27-35[»]
4JFFX-ray2.43C26-35[»]
4L3EX-ray2.56C26-35[»]
4QOKX-ray3.00C26-35[»]
4WJ5X-ray1.65C/F28-34[»]
5E9DX-ray2.51C/H26-35[»]
ProteinModelPortaliQ16655.
SMRiQ16655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16655.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ4C. Eukaryota.
ENOG410ZDIV. LUCA.
GeneTreeiENSGT00390000009531.
HOGENOMiHOG000113481.
HOVERGENiHBG006327.
InParanoidiQ16655.
KOiK17303.
OMAiMPRGDFN.
OrthoDBiEOG091G0Z8N.
PhylomeDBiQ16655.
TreeFamiTF338577.

Family and domain databases

InterProiView protein in InterPro
IPR029242. MLANA.
PANTHERiPTHR15305. PTHR15305. 1 hit.
PfamiView protein in Pfam
PF14991. MLANA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR
60 70 80 90 100
RNGYRALMDK SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA
110
PPAYEKLSAE QSPPPYSP
Length:118
Mass (Da):13,157
Last modified:November 1, 1996 - v1
Checksum:iB755BFF39CFCB16E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06452 mRNA. Translation: AAA19238.1.
U06654 mRNA. Translation: AAA20389.1.
CR450299 mRNA. Translation: CAG29295.1.
AK312149 mRNA. Translation: BAG35083.1.
AL365360 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58755.1.
CH471071 Genomic DNA. Translation: EAW58756.1.
BC014423 mRNA. Translation: AAH14423.1.
CCDSiCCDS6466.1.
PIRiA55253.
RefSeqiNP_005502.1. NM_005511.1.
UniGeneiHs.154069.

Genome annotation databases

EnsembliENST00000381471; ENSP00000370880; ENSG00000120215.
ENST00000381476; ENSP00000370885; ENSG00000120215.
ENST00000381477; ENSP00000370886; ENSG00000120215.
GeneIDi2315.
KEGGihsa:2315.
UCSCiuc003zjo.2. human.

Similar proteinsi

Entry informationi

Entry nameiMAR1_HUMAN
AccessioniPrimary (citable) accession number: Q16655
Secondary accession number(s): Q6ICU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references