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Protein

Melanoma antigen recognized by T-cells 1

Gene

MLANA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.2 Publications

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120215-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma antigen recognized by T-cells 1
Short name:
MART-1
Alternative name(s):
Antigen LB39-AA
Antigen SK29-AA
Protein Melan-A
Gene namesi
Name:MLANA
Synonyms:MART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:7124. MLANA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 118CytoplasmicSequence analysisAdd BLAST71

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • melanosome Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2315.
OpenTargetsiENSG00000120215.
PharmGKBiPA30842.

Polymorphism and mutation databases

BioMutaiMLANA.
DMDMi2833278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962381 – 118Melanoma antigen recognized by T-cells 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Phosphoserine1 Publication1

Post-translational modificationi

Acylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ16655.
PeptideAtlasiQ16655.
PRIDEiQ16655.

PTM databases

iPTMnetiQ16655.
PhosphoSitePlusiQ16655.

Expressioni

Tissue specificityi

Expression is restricted to melanoma and melanocyte cell lines and retina.

Gene expression databases

BgeeiENSG00000120215.
CleanExiHS_MLANA.
GenevisibleiQ16655. HS.

Organism-specific databases

HPAiCAB000057.
HPA048662.

Interactioni

Subunit structurei

Interacts with PMEL. Interacts with GPR143.3 Publications

Protein-protein interaction databases

BioGridi108604. 2 interactors.
IntActiQ16655. 3 interactors.
MINTiMINT-7889633.
STRINGi9606.ENSP00000370880.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GT9X-ray1.75C/F26-35[»]
2GTWX-ray1.55C/F27-35[»]
2GTZX-ray1.70C/F27-35[»]
2GUOX-ray1.90C/F27-35[»]
3HG1X-ray3.00C26-35[»]
3L6FX-ray2.10C100-114[»]
3MROX-ray2.35P26-35[»]
3MRPX-ray2.10P26-35[»]
3MRQX-ray2.20P26-35[»]
3QDMX-ray2.80C26-35[»]
3QEQX-ray2.59C27-35[»]
3QFDX-ray1.68C/F27-35[»]
4EUPX-ray2.88C/F27-35[»]
4JFFX-ray2.43C26-35[»]
4L3EX-ray2.56C26-35[»]
4QOKX-ray3.00C26-35[»]
4WJ5X-ray1.65C/F28-34[»]
5E9DX-ray2.51C/H26-35[»]
ProteinModelPortaliQ16655.
SMRiQ16655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16655.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ4C. Eukaryota.
ENOG410ZDIV. LUCA.
GeneTreeiENSGT00390000009531.
HOGENOMiHOG000113481.
HOVERGENiHBG006327.
InParanoidiQ16655.
KOiK17303.
OMAiHQDSKLP.
OrthoDBiEOG091G0Z8N.
PhylomeDBiQ16655.
TreeFamiTF338577.

Family and domain databases

InterProiIPR029242. MLANA.
[Graphical view]
PfamiPF14991. MLANA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR
60 70 80 90 100
RNGYRALMDK SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA
110
PPAYEKLSAE QSPPPYSP
Length:118
Mass (Da):13,157
Last modified:November 1, 1996 - v1
Checksum:iB755BFF39CFCB16E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06452 mRNA. Translation: AAA19238.1.
U06654 mRNA. Translation: AAA20389.1.
CR450299 mRNA. Translation: CAG29295.1.
AK312149 mRNA. Translation: BAG35083.1.
AL365360 Genomic DNA. Translation: CAI95312.1.
CH471071 Genomic DNA. Translation: EAW58755.1.
CH471071 Genomic DNA. Translation: EAW58756.1.
BC014423 mRNA. Translation: AAH14423.1.
CCDSiCCDS6466.1.
PIRiA55253.
RefSeqiNP_005502.1. NM_005511.1.
UniGeneiHs.154069.

Genome annotation databases

EnsembliENST00000381471; ENSP00000370880; ENSG00000120215.
ENST00000381476; ENSP00000370885; ENSG00000120215.
ENST00000381477; ENSP00000370886; ENSG00000120215.
GeneIDi2315.
KEGGihsa:2315.
UCSCiuc003zjo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06452 mRNA. Translation: AAA19238.1.
U06654 mRNA. Translation: AAA20389.1.
CR450299 mRNA. Translation: CAG29295.1.
AK312149 mRNA. Translation: BAG35083.1.
AL365360 Genomic DNA. Translation: CAI95312.1.
CH471071 Genomic DNA. Translation: EAW58755.1.
CH471071 Genomic DNA. Translation: EAW58756.1.
BC014423 mRNA. Translation: AAH14423.1.
CCDSiCCDS6466.1.
PIRiA55253.
RefSeqiNP_005502.1. NM_005511.1.
UniGeneiHs.154069.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GT9X-ray1.75C/F26-35[»]
2GTWX-ray1.55C/F27-35[»]
2GTZX-ray1.70C/F27-35[»]
2GUOX-ray1.90C/F27-35[»]
3HG1X-ray3.00C26-35[»]
3L6FX-ray2.10C100-114[»]
3MROX-ray2.35P26-35[»]
3MRPX-ray2.10P26-35[»]
3MRQX-ray2.20P26-35[»]
3QDMX-ray2.80C26-35[»]
3QEQX-ray2.59C27-35[»]
3QFDX-ray1.68C/F27-35[»]
4EUPX-ray2.88C/F27-35[»]
4JFFX-ray2.43C26-35[»]
4L3EX-ray2.56C26-35[»]
4QOKX-ray3.00C26-35[»]
4WJ5X-ray1.65C/F28-34[»]
5E9DX-ray2.51C/H26-35[»]
ProteinModelPortaliQ16655.
SMRiQ16655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108604. 2 interactors.
IntActiQ16655. 3 interactors.
MINTiMINT-7889633.
STRINGi9606.ENSP00000370880.

PTM databases

iPTMnetiQ16655.
PhosphoSitePlusiQ16655.

Polymorphism and mutation databases

BioMutaiMLANA.
DMDMi2833278.

Proteomic databases

PaxDbiQ16655.
PeptideAtlasiQ16655.
PRIDEiQ16655.

Protocols and materials databases

DNASUi2315.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381471; ENSP00000370880; ENSG00000120215.
ENST00000381476; ENSP00000370885; ENSG00000120215.
ENST00000381477; ENSP00000370886; ENSG00000120215.
GeneIDi2315.
KEGGihsa:2315.
UCSCiuc003zjo.2. human.

Organism-specific databases

CTDi2315.
DisGeNETi2315.
GeneCardsiMLANA.
HGNCiHGNC:7124. MLANA.
HPAiCAB000057.
HPA048662.
MIMi605513. gene.
neXtProtiNX_Q16655.
OpenTargetsiENSG00000120215.
PharmGKBiPA30842.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ4C. Eukaryota.
ENOG410ZDIV. LUCA.
GeneTreeiENSGT00390000009531.
HOGENOMiHOG000113481.
HOVERGENiHBG006327.
InParanoidiQ16655.
KOiK17303.
OMAiHQDSKLP.
OrthoDBiEOG091G0Z8N.
PhylomeDBiQ16655.
TreeFamiTF338577.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120215-MONOMER.

Miscellaneous databases

ChiTaRSiMLANA. human.
EvolutionaryTraceiQ16655.
GeneWikiiMLANA.
GenomeRNAii2315.
PROiQ16655.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120215.
CleanExiHS_MLANA.
GenevisibleiQ16655. HS.

Family and domain databases

InterProiIPR029242. MLANA.
[Graphical view]
PfamiPF14991. MLANA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAR1_HUMAN
AccessioniPrimary (citable) accession number: Q16655
Secondary accession number(s): Q6ICU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.