Reviewed, UniProtKB/Swiss-Prot Q16655 (MAR1_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma antigen recognized by T-cells 1
      Short name=MART-1
      Short name=Melan-A protein
Alternative name(s):
    Antigen SK29-AA
    Antigen LB39-AA

Gene names

Name:	MLANA
Synonyms:	MART1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane proteinPotential.
Tissue specificity	Expression is restricted to melanoma and melanocyte cell lines and retina.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Gene Ontology (GO)
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	Melanoma antigen recognized by T-cells 1		PRO_0000096238
Regions
	Transmembrane	27 – 47	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q16655-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B755BFF39CFCB16E	FASTA	118	13,157
	10 20 30 40 50 60 MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK 70 80 90 100 110 SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor." Kawakami Y., Eliyahu S., Delgado C.H., Robbins P.F., Rivoltini L., Topalian S.L., Miki T., Rosenberg S.A. Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994) [PubMed: 8170938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma.
[2]	"A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas." Coulie P.G., Brichard V., van Pel A., Woelfel T., Schneider J., Traversari C., Mattei S., de Plaen E., Lurquin C., Szikora J.-P., Renauld J.-C., Boon T. J. Exp. Med. 180:35-42(1994) [PubMed: 8006593] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U06452 mRNA. Translation: AAA19238.1. U06654 mRNA. Translation: AAA20389.1. BC014423 mRNA. Translation: AAH14423.1.
PIR	A55253.
RefSeq	NP_005502.1.
UniGene	Hs.154069
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q16655.
Genome annotation databases
Ensembl	ENSG00000120215. Homo sapiens. [Contig view]
GeneID	2315.
KEGG	hsa:2315.
Organism-specific databases
H-InvDB	HIX0007904.
HGNC	HGNC:7124. MLANA.
HPA	CAB000057. CAB000138.
MIM	605513. gene.
PharmGKB	PA30842.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q16655.
HOVERGEN	Q16655.
Gene expression databases
ArrayExpress	Q16655.
CleanEx	HS_MLANA.
GermOnline	ENSG00000120215. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	9401.
SOURCE	Search...

Entry information

Entry name

MAR1_HUMAN

Accession

Primary (citable) accession number: Q16655

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)